• Journal of Korean Biological Nursing Science
• /
• v.24 no.4
• /
• pp.209-218
• /
• 2022

Purpose: This study aimed to investigate the relationships between the characteristics of nurses' work schedules, health outcomes, and work-life balance. Methods: This was a secondary data analysis that included 422 nurses in Korean hospitals. Descriptive analysis, independent sample t-test, one-way ANOVA, Pearson correlation analysis, and multiple linear regression analysis were used to identify the associated factors. Results: Multiple linear regression analysis showed that work-life balance was lower when atypical work was performed (β=-.14, p=.010). Nurses who did not work overtime showed a higher level of work-life balance than those who worked overtime infrequently (β=-.11, p=.002) or frequently (β=-.28, p<.001). The work-life balance level increased when nurses had better subjective health status (β=.16, p<.001) or higher sleep quality (β=.29, p<.001). It was verified that the work-life balance level was higher for single-person households than for households with two (β=-.18, p=.003), three to four (β=-.16, p=.022), or five or more (β=-.21, p<.001) persons. Conclusion: This study suggests that government and hospital organizations should provide high-quality care and consideration to nurses who do atypical or overtime work as well as their subjective health status and sleep quality. Further research should focus on the development of a policy that improves the work-life balance of nurses, especially for those who work during atypical hours.

• Nuclear Engineering and Technology
• /
• v.56 no.1
• /
• pp.222-232
• /
• 2024

New modular factory-built methodologies implemented in the construction and industrial plant industries may bring down costs for modular reactors. A factory-built environment brings about benefits such as; improved equipment, tools, quality, shift patterns, training, continuous improvement learning, environmental control, standardisation, parallel working, the use of commercial off shelf equipment and much of the commissioning can be completed before leaving the factory. All these benefits combine to reduce build schedules, increase certainty, reduce risk and make financing easier and cheaper.Currently, the construction and industrial chemical plant industries have implemented successful modular design and construction techniques. Therefore, the objectives of this paper are to understand and analyse the state of the art research in these industries through a systematic literature review. The research can then be assessed and applied to modular reactors.The literature review highlighted analysis methods that may prove to be useful. These include; modularisation decision tools, stakeholder analysis, schedule, supply chain, logistics, module design tools and construction site planning. Applicable research was highlighted for further work exploration for designers to assess, develop and efficiently design their modular reactors.

• Sleep Medicine and Psychophysiology
• /
• v.17 no.1
• /
• pp.28-33
• /
• 2010

Objectives: Working at other times than the regular day shift has been reported to be a stressor associated with health consequences and mental disorders as well as disturbance of sleep. In current study, we aimed at investigating the relationship between work schedule, sleep quality and depression among police officers. Methods: Eleven hundreds and forty five police officers (male: 1040, female: 105) completed questionnaires of basic socio-demographic data, Pittsburgh Sleep Quality Index (PSQI), Korean Scale of Occupational Stress (KOSS), Impact of Event Scale - Revised (IES-R) and Center for Epidemiologic Study-Depression (CES-D). Results: After controlling for age, sex and educational level, score of CES-D was correlated positively with the score of KOSS, PSQI and IES-R on partial correlation analysis (r=-0.077; p=0.009, r=0.262; p<0.000 and r=0.421, p<0.000, respectively). Logistic regression analysis revealed that female sex, age, the score of KOSS and IES-R and schedule of rotating shift work predicted higher score than 16 score of CES-D significantly in total subjects (p=0.023, p=0.015, p=0.000, p=0.000 and p=0.022, respectively). Conclusion: Current result suggested that not only female sex, age, higher occupational stress and impact of event scale but also rotating shift work schedule might be related to depression among police officers.

• 한국HCI학회:학술대회논문집
• /
• 2009.02a
• /
• pp.650-653
• /
• 2009

Decrease in crew performance is frequently cited as a major causal factor in maritime accidents. Although considerable researches on working hours undertaken by seafarers have been conducted through interviews and record analyses, experimental studies on the effects of factors, such as high workload, shift patterns, stress, sleep deprivation, and disturbance on the cognitive performance of mariners have been limited. Other safety-critical transport industries, such as aviation and rail, have developed fatigue management tools to help managements in the work patterns of their operators. Such tools for mariners would assist shipboard crews, marine pilots, and shore managers for planning and improving work schedules. The overall aim of this paper is to determine a fatigue factor that can be applied to human performance data as a part of a software program that calculates total cognitive performance. This program enables us to establish the levels of cognitive performance in a group of marine pilots in order to test a decision-making task based on radar information. This paper addresses one of the factors that may contribute to the determination of various fatigue factors: the effects of different work patterns on the cognitive performance of a marine pilot.

• Journal of Microbiology and Biotechnology
• /
• v.23 no.9
• /
• pp.1327-1338
• /
• 2013

The humanized anti-hepatocyte growth factor (HGF) monoclonal antibody (mAb) YYB-101 is a promising therapeutic candidate for treating various cancers. In this study, we developed a bioprocess for large-scale production of YYB-101 and evaluated its therapeutic potential for tumor treatment using a xenograft mouse model. By screening diverse chemically defined basal media formulations and by assessing the effects of various feed supplements and feeding schedules on cell growth and antibody production, we established an optimal medium and feeding method to produce 757 mg/l of YYB-101 in flask cultures, representing a 7.5-fold increase in titer compared with that obtained under non-optimized conditions. The optimal dissolved oxygen concentration for antibody production was 70% $pO_2$. A pH shift from 7.2 to 7.0, rather than controlled pH of either 7.0 or 7.2, resulted in productivity improvement in 5 L and 200 L bioreactors, yielding 737 and 830 mg/ml of YYB-101, respectively. The YYB-101 mAb highly purified by affinity chromatography using a Protein A column and two-step ion exchange chromatography effectively neutralized HGF in a cell-based assay and showed potent tumor suppression activity in a mouse xenograft model established with human glioblastoma cells.

• Safety and Health at Work
• /
• v.13 no.4
• /
• pp.401-407
• /
• 2022

Background: The present study aimed to digitally evaluate the risk of overwork-related adverse effects (OrAEs) among employees from various occupational categories in Taiwan. Methods: Anonymous data of employees from seven companies/factories providing occupational health services were analyzed. The studied population comprised 5505 employees, and the data analyzed included employment duration, working hours, shift work schedules, and health checkup results. The risk for OrAEs was assessed by an index, Karo index (0-4, the larger the value, the higher the risk for OrAEs) obtained using a risk matrix made up of cardiocerebral and occupational risk factors. Karo index values of 3 and 4 were categorized as at high risk for OrAEs (h-OrAEs). Results: The 5505 employees had an average employment duration of 8.5 years and a mean age of 39.4 years. The prevalence rates for h-OrAEs of the seven companies/factories ranged from 3.9% to 34.2%. There were significant differences in prevalence rates for h-OrAEs between employees of retail stores and high-tech manufacturing factories. Multivariate analysis results indicated that workers of high-tech manufacturing factories had significantly higher risk for h-OrAEs compared with retail store workers. Conclusion: In terms of satisfying health risk management and legal requirements in Taiwan, the newly issued Karo index, which covers a wide range of occupational risk factors, can serve as an assessment and a warning tool for managing the risk of OrAEs in workplaces. To reduce risks for h-OrAEs, active and prudent control of cerebrocardiovascular risks and working hours is recommended.

• Development and Reproduction
• /
• v.16 no.3
• /
• pp.227-233
• /
• 2012

Circadian timing system plays a major role in a wide range of reproductive function. However it is plausible idea that other environmental and/or internal cue might be simultaneously participated in the optimal regulation of reproductive system. In the present study we extended the reverse feeding (RF) time regimen up to 8 weeks, then measured the general and reproductive indices of the animals. The animals of ad libitum feeding group (Control, CON) have free access to food for 4, 6 and 8 weeks, respectively. The day feeding animals (reverse feeding, RF group) have restricted access to food during daytime (09:00-18:00) for 4, 6 and 8 weeks, respectively. When the feeding schedules were over, key indices were measured. After 4 weeks and 8 weeks of feeding, body weights of animals were not significantly different. However, body weights of 6 weeks RF animals were significantly smaller than those of control animals (CON : RF = $333.46{\pm}12.71$ g : $289.91{\pm}8.31$ g, p<0.01). The blood glucose levels of 4 weeks RF animals were significantly decreased compared to the levels of control animals (CON : RF = $161.4{\pm}2.7$ mg/dL : $176.7{\pm}5$ mg/dL, p<0.01) while the levels of 6 weeks RF and 8 weeks RF animals were not different form those of control animals. Reproductive and non-reproductive tissue weights from 6 weeks RF group were significantly lowered than those from CON group (testis, CON : RF = $1.4714{\pm}0.0174$ g : $1.3724{\pm}0.0168$ g, p<0.001; epididymis, CON : RF = $0.3574{\pm}0.0059$ g : $0.3243{\pm}0.0068$ g, p<0.001; seminal vesicle, CON : RF = $0.1655{\pm}0.0068$ g : $0.1328{\pm}0.0054$ g, p<0.001; prostate, CON : RF = $0.3350{\pm}0.0231$ g : $0.2528{\pm}0.0143$ g, p<0.01). After 4 weeks and 8 weeks of reverse feeding, sperm counts in RF animals were markedly reduced than those in control animals[CON 4W : RF 4W = $121.17{\pm}9.96\;({\times}10^6)$ : $50.86{\pm}9\;({\times}10^6)$, p<0.001; CON 8W : RF 8W= $138.69{\pm}9.8\;({\times}10^6)$ : $108.94{\pm}4.22\;({\times}10^6)$, p<0.001]. Present study indicates that RF may induce an adaptable metabolic stress and cause impairment of androgen-dependent reproductive tissues. On-going longitudinal studies will allow a better understanding of the how does mealtime shift affect the reproductive function and exact nature of adaptation.

• Journal of Navigation and Port Research
• /
• v.31 no.8
• /
• pp.629-635
• /
• 2007

Reduced crew performance is frequently cited as a major causal factor in maritime accident causation. Although considerable research has been conducted on the hours of work undertaken by seafarers through interviews and the analysis of records, experimental studies to observe the effects of factors such as high workload, shift patterns, stress, sleep deprivation and disturbance on the cognitive performance of mariners have been limited. Other safety-critical transport industries, such as aviation and rail, have developed fatigue management tools to help manage the work patterns of their operators. Such a tool for mariners would assist shipboard crew, marine pilots and shore management in planning and improving work schedules. The overall aim of this paper is to determine a fatigue factor, which can be applied to human performance data, as part of a software program that calculates total cognitive performance. This program enables us to establish the levels of cognitive performance of a group of marine pilots to test a decision-making task based on radar information. This paper addresses one of the factors that may contribute to the determination of various fatigue factors: the effect of different work patterns on the cognitive performance of a marine pilot.