• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6823-6827
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• 2014

Objective: This study was conducted to investigate the efficacy of pancreatic drainage for pain relief in advanced pancreatic cancer. Method: Seventy-one patients with pancreatic carcinoma were divided into two groups: dilated and non-dilated pancreatic ducts. All patients underwent endoscopic retrograde cholangiopancreatography (ERCP), endoscopic biliary stenting and pancreatic stenting. Visual Analog Scale (VAS) scores, pain remission rates and survival time were evaluated during follow-up. Results: The post-ERCP VAS score of the dilated group was lower than that of the non-dilated group at 1 and 3 months post-ERCP. There was no difference at 6 months. The pain remission rate in the dilated duct group was significantly higher than that in non-dilated duct group in 1 and 3 months post-ERCP. The median survival times were 8.17 and 8.22 months respectively. Conclusion: Endoscopic pancreatic drainage can relieve pain of advanced pancreatic cancer accompanied by safe dilation of the pancreatic duct.

• Archives of Pharmacal Research
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• v.28 no.8
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• pp.977-982
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• 2005

The aim of this study was to compare two formulations of film-coated pellets containing c1arithromycin after single oral dose study in healthy male volunteers. Two formulations with different coating polymers were prepared: formulation-1 (F-1) was prepared by incorporating three kinds of pH-dependent gradient-release coated pellets into capsules and formulation-2 (F-2) was prepared by coated with an insoluble semiosmotic film. Release profiles of filmcoated pellets were evaluated using paddle method under different conditions. Pharmacokinetic profiles of these formulations were obtained in three healthy male volunteers and compared to commercially available immediate release (IR) tablets. The relative bioavailability based on the $AUC_{0-24h}$ was found to be $96.2\%\;and\;58.7\%$ for F-1 and F-2 compared with IR, and the $T_{max}$ was delayed.

• Journal of Fashion Business
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• v.12 no.3
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• pp.1-15
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• 2008

The purpose of this study is to analyze women's street fashion in Shenyang and to understand the regional design preference. The city, Shenyang is not only known as the one of three major northeastern province in China, but also known as the city where large numbers of Korean fashion companies have launched in. The observation focused mainly on young/young adults and missy in Oe Market and ZungJie(中街) which are the most busy streets in Shenyang. A digital camera or a camcorder were used to take photos of these women. In addition, video captures or photos were analyzed by three fashion experts. Finally, the photos were classified by item and data was coded for statistics and reviewed through frequency and percentage. As a result, it was found that most young women in Shenyang liked to wear a casual style such as easy t-shirt, denim pants or skirt and a feminine style such as a one-piece dress in summer. Top items that were favoured by young women in Shenyang were t-shirts and blouse types, while they favoured to wear denim pants of indigo blue for bottom items. Frequently found colors among these womens' clothing were white, black, vivid blue, red and red purple. I strongly believe this study will provide basic but significant information for the establishment of design and marketing strategies to the Korean fashion brands, who is trying to access Chinese fashion market.

• Structural Engineering and Mechanics
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• v.80 no.6
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• pp.737-747
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• 2021

The objective of seismic resilience is to maintain or rapidly restore the function of a building after an earthquake. An efficient tilt mechanism at the member level is crucial for the restoration of the main structure function; however, the damage resistance of the members should be the main focus. In this study, through a comparison with the classical Flamant theory of local loading in the elastic half-space, an elastomechanical solution for the axial-stress distribution of a reinforced-concrete (RC) rocking column was derived. Furthermore, assuming that the lateral displacement of the rocking column is determined by the contact surface rotation angle of the column end and bending and shear deformation of the column body, the load-lateral displacement mechanical model of the RC rocking column was established and validated through a comparison with finite-element simulation results. The axial-compression ratio and column-end strength were analyzed, and the results indicated that on the premise of column damage resistance, simply increasing the axial-compression ratio increases the lateral loading capacity of the column but is ineffective for improving the lateral-displacement capacity. The lateral loading and displacement of the column are significantly improved as the strength of the column end material increases. Therefore, it is feasible to improve the working performance of RC rocking columns via local reinforcement of the column end.

• (The)Study of the Eastern Classic
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• no.34
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• pp.133-165
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• 2009

'Travelogue to Shenyang(瀋陽日記)' is a documentary literature that Seon Yak-hae (宣若海) who was a military official of Joseon(朝鮮) Dynasty, described matters happened in Shenyang when he visited there as an envoy during early 17th century when Qing(淸) Dynasty and Ming(明) Dynasty coexisted and had diplomatic conflict with Joseon Dynasty. This documentary literature is included in the data collection of China that gathers important historical data of China and has been published and delivered in China, but it hasn't caught attention in Korean academic society. There's another 'Travelogue to Shenyang' which is known in the academic society that is a record of eight years of hostage period of Crown Prince Sohyeon and his group in Shenyang. However, this 'Travelogue to Shenyangl' of Seon Yak-hae is a record of Joseon and other countries' status at that time as well as the Joseon intellectual's activities while visiting Shenyang before the outbreak of the Manchurian Invasion (to Korea) in 1636. Seon Yak-hae who wrote this 'Travelogue to Shenyang' recorded his successful works as an envoy with proud, and showed a unique appearance as a military official and intellect who wanted to observe political and military status of Qing Dynasty secretly and report to his country. Since he was an intellect who had military background, he responded bravely when dealing with diplomatic problem and collected data strategically. He also had the ability as an intellectual official, so he wrote realistic articles and also wrote some poems to express his honest feelings in this peculia Travelogue. Therefore, this ' Travelogue to Shenyang' has both values as a historic records that showed diplomatic status of Joseon in the 17th century and literature records that showed unique spirit to record as an intellect who also had military mind.

• Animal Bioscience
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• v.36 no.4
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• pp.555-569
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• 2023

Objective: The objective of this study was to investigate the effects of N⁶-Methyladenosine modification-circRNA-zinc finger protein 638 (m⁶A-circRNA-ZNF638) on the induced activation of secondary hair follicle (SHF) stem cells with its potential mechanisms in cashmere goats. Methods: The m⁶A modification of ZNF638 was analyzed using methylation immunoprecipitation with real-time quantitative polymerase chain reaction technique in SHF stem cells. The effects of circRNA-ZNF638 on the induced activation of SHF stem cells in m⁶A dependence were evaluated through the overexpression of circRNA-ZNF638/its m⁶A-deficient mutants in circRNA-ZNF638 knockdown SHF stem cells. The competitive binding of miR-361-5p to circRNA-ZNF638/Wnt5a 3'- untranslated region was analyzed through Dual-luciferase reporter assay. Results: The m⁶A-circRNA-ZNF638 had significantly higher transcription at anagen SHF bulge of cashmere goats compared with that at telogen, as well as it positively regulated the induced activation of SHF-stem cells in cashmere goats. Mechanismly, m⁶A-circRNA-ZNF638 sponged miR-361-5p to heighten the transcriptional expression of Wnt5a gene in SHF-stem cells. We further demonstrated that the internal m⁶A modification within circRNA-ZNF638 is required for mediating the miR-361-5p/Wnt5a pathway to regulate the induced activation of SHF stem cells through an introducing of m⁶A-deficient mutant of circRNA-ZNF638. Conclusion: The circRNA-ZNF638 contributes the proper induced activation of SHF-stem cells in cashmere goats in m⁶A-dependent manner through miR-361-5p/Wnt5a axis.

• BMB Reports
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• v.46 no.5
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• pp.264-269
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• 2013

Pattern recognition receptors are known to participate in the activation of Prophenoloxidase system. In this study, a 1,3-${\beta}$-D-glucan recognition protein was detected for the first time in Antheraea pernyi larvae (Ap-${\beta}GRP$). Ap-${\beta}GRP$ was purified to 99.9% homogeneity from the hemolymph using traditional chromatographic methods. Ap-${\beta}GRP$ specifically bind 1,3-${\beta}$-D-glucan and yeast, but not E. coli or M. luteus. The 1,3-${\beta}$-D-glucan dependent phenoloxidase (PO) activity of the hemolymph inhibited by anti-Ap-${\beta}GRP$ antibody could be recovered by addition of purified Ap-${\beta}GRP$. These results demonstrate that Ap-${\beta}GRP$ acts as a biosensor of 1,3-${\beta}$-Dglucan to trigger the Prophenoloxidase system. A trace mount of 1,3-${\beta}$-D-glucan or Ap-${\beta}GRP$ alone was unable to trigger the proPO system, but they both did. Ap-${\beta}GRP$ was specifically degraded following the activation of proPO with 1,3-${\beta}$-Dglucan. These results indicate the variation in the amount of Ap-${\beta}GRP$ after specific immune challenge in A. pernyi hemolymph is an important regulation mechanism to immune response.

• Journal of Ginseng Research
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• v.45 no.1
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• pp.86-97
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• 2021

Background: Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on α-glucosidase and protein tyrosine phosphatase 1B, and protected cardiocytes (H9c2) through PI3K/Akt pathway. Methods: In the research, in order to optimize the 25-OH-PPT enrichment process, optimal macroporous resins and optimal purification conditions were studied. Meanwhile, the hypoglycemic effect and mechanism of 25-OH-PPT were evaluated by using STZ to establish insulin-dependent diabetic mice and the spontaneous type 2 diabetes DB/DB mice. Results and Conclusion: Research found that 25-OH-PPT can reduce blood glucose and enhance glucose tolerance in STZ model mice. It increases insulin sensitivity by upregulating GLUT4 and AMPK in skeletal muscle, and activating insulin signaling pathways. In DB/DB mice, 25-OH-PPT achieves hypoglycemic effects mainly by activating the insulin signaling pathway. Meanwhile, through the influence of liver inflammatory factors and lipids in serum, it can be seen that 25-OH-PPT has obvious anti-inflammatory and lipid-lowering effects. These results provide new insights into the study of ginseng as a functional food.

• 한국균학회소식:학술대회논문집
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• 2015.05a
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• pp.42-42
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• 2015

Plasmodiophora brassicae, the causal agent of clubroot disease, does the most serious damage to the Brassica crops. The limited control approaches make that the identification of clubroot resistance (CR) is more important for developing CR cultivars of the Brassica crops. So far, 8 CR loci were mapped. However, the variation of P. brassicae leads to the rapid erosion of its resistance. To identify novel CR genes, we employed three mapping population, derived from crosses between Chinese cabbage and turnip inbred lines ($59-1{\times}ECD04$ and $BJN3-1{\times}Siloga$) or between Chinese cabbage inbred lines ($BJN3-1{\times}85-I-II$), to perform QTL analysis. Totally, 8 CR loci were indentified and showed race-specific resistance. Physical mapping of these 8 loci suggested that 4 were located previously mapped position, indicating they might be the same allele or different alleles of the same genes. Other 4 loci were found to be novel. Further, CR near isogenic line carrying each CR locus was developed based on the marker assisted selection. Verification of these CR loci was underway. Identification of these novel CR genes would facilitate to breed broad-spectrum and durable CR cultivars of B. rapa by pyramiding strategies.

• Transactions on Electrical and Electronic Materials
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• v.17 no.6
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• pp.335-340
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• 2016

The vibrational energy is prevalent in the natural environment, which is studied by energy researchers as a new energy resource in recent years. Vibration generation utilizes electromagnetic induction technology, piezoelectric technology and certain characteristics of smart materials to convert mechanical energy into electrical energy. In this paper, a new method of using MSMA (magnetic shape memory alloy) to generate electricity is proposed and the principle of generating electricity is demonstrated. Martensitic variants and magnetic domain characteristics of MSMA are analyzed. Combining with Gibbs free energy function thermal theory, the mathematics model of MSMA vibration generator is established. The basic structure of MSMA vibration generator is designed and simulation is done to analyze that the effects of generator output voltage when the input amplitude and frequency of vibration stress change. The simulation experiments verify the feasibility of using MSMA to make the micro vibration generators and the correctness of the mathematical model, which lays a good foundation for the further research and application of MSMA vibration generator.