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Effects of acute heat stress on salivary metabolites in growing pigs: an analysis using nuclear magnetic resonance-based metabolomics profiling

  • Kim, Byeonghyeon;Kim, Hye Ran;Kim, Ki Hyun;Ji, Sang Yun;Kim, Minji;Lee, Yookyung;Lee, Sung Dae;Jeong, Jin Young
    • Journal of Animal Science and Technology
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    • v.63 no.2
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    • pp.319-331
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    • 2021
  • Heat stress (HS) causes adverse impacts on pig production and health. A potential biomarker of HS is required to predict its occurrence and thereby better manage pigs under HS. Information about the saliva metabolome in heat-stressed pigs is limited. Therefore, this study was aimed to investigate the effects of acute HS on the saliva metabolome and identify metabolites that could be used as potential biomarkers. Growing pigs (n = 6, 3 boars, and 3 gilts) were raised in a thermal neutral (TN; 25℃) environment for a 5-d adaptation period (CON). After adaptation, the pigs were first exposed to HS (30℃; HS30) and then exposed to higher HS (33℃; HS33) for 24 h. Saliva was collected after adaptation, first HS, and second HS, respectively, for metabolomic analysis using 1H-nuclear magnetic resonance spectroscopy. Four metabolites had significantly variable importance in the projection (VIP > 1; p < 0.05) different levels in TN compared to HS groups from all genders (boars and gilts). However, sex-specific characteristics affected metabolites (glutamate and leucine) by showing the opposite results, indicating that HS was less severe in females than in males. A decrease in creatine levels in males and an increase in creatine phosphate levels in females would have contributed to a protective effect from protein degradation by muscle damage. The results showed that HS led to an alteration in metabolites related to energy and protein. Protection from muscle damage may be attributed to the alteration in protein-related metabolites. However, energy-related metabolites showed opposing results according to sex-specific characteristics, such as sex hormone levels and subcutaneous fat layer. This study had shown that saliva samples could be used as a noninvasive method to evaluate heat-stressed pigs. And the results in this study could be contributed to the development of a diagnostic tool as a noninvasive biomarker for managing heat-stressed pigs.

Preference of Consumers After Late 40's for Developing Future Home Network Services (고령친화 홈네트워크 서비스개발을 위한 중장년층 소비자 선호에 관한 연구)

  • Kim, Min Soo;Lee, Yeun Sook
    • KIEAE Journal
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    • v.7 no.2
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    • pp.47-55
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    • 2007
  • Development of digital technology has become closely connected with housing environment. Especially for the matured population, it is very important because they need substantial support in their daily lives. Therefore, the purpose of this paper is to identify needs of digital network services for future housing development. Previous researches were limited to digital technology of network systems and its usages. On the other hand, this study focuses on not only the technology but services. This study consists of literatures review and empirical survey. The subjects were the mid-age and pre-elderly between 45 to 65. The analysis of this study results outlined as follows: First, the pre-elderly appeared to have, in general, positive perceptions about digital services of the housing environment. The results of needs for each space's, showed strongly in basic safety and aiding system for memories. Second, there are differences in needs according to respondent's characteristics such as sex, income, job, house type, experience in digital system. Third, there are differences between what they think and what they really responded in both spaces and services. It menas that present planning elements may not attractive and suitable to residents. Therefore it is necessary to redesign the services. In the future, the most important thing is, making comfortable space not convenient space. That is, excluding unnecessary elements and pick up the right ones for resident's real demands.

CONSCIOUS SEDATIVE DRUGS: A CLINICAL STUDY (의식하 진정에 사용된 약물에 관한 임상적 연구)

  • Kim, Sang-Ryul;Kim, Su-Gwan;Yeo, Hwan-Ho
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.22 no.4
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    • pp.436-441
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    • 2000
  • The purpose of this retrospective study is to investigate the effects of conscious sedation in an outpatient setting. Data from 292 patients (154 males, 138 females), sedated for minor oral surgery, were studied using various parameters including age and sex distribution, as well as according to procedures and each drug group. Results show that this intravenous conscious sedation technique is a safe and effective method of controlling behaviour, but one has to be prepared to deal with any emergencies or complications. The specific results are as follows: 1. Most procedures (265/292) were used to Valium mixed with Demerol and Midazolam mixed with Demerol. 2. Valium revealed a high incidence of pain upon injection and symptoms limited to daily activity and thrombophlebitis. 3. Nausea and vomiting manifested in the procedure using Demerol. 4. The patient manifested comfort similar in response to the same drugs used in another treatment.

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IL-17A Levels in the Sera of Patients with Gastric Cancer Show Limited Elevation

  • Malek-Hosseini, Zahra;Taherinejad, Marziye;Malekzadeh, Mahyar;Ghaderi, Abbas;Doroudchi, Mehrnoosh
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.16
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    • pp.7149-7153
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    • 2015
  • Background: Inflammation plays a major role in the development and progression of gastric and other gastrointestinal tumors. The IL-17 family of cytokines has been under investigation as targets of immunotherapy. Materials and Methods: We investigated the levels of IL-17A inflammatory cytokine in the sera of 57 patients with gastric cancer (GC) and 90 healthy age/sex matched controls using ELISA methods. Results: In only 5 (8.8%) of the patients' sera was IL-17A detectable. No IL-17A was apparent in the sera of healthy controls. The maximum concentration of IL-17A in patients was 7.004 pg/ml. Vascular and lymphatic invasions were only seen in one of the 5 positive cases. Although all of them were in the age group >60 years, no correlation was seen between age and IL-17A level. These results are somewhat different from our findings for colorectal cancer (CRC) in the same population. Conclusions: It is possible that the inflammopathology of CRC and GC are rather different, at least in Fars, a southern province of Iran.

An approach of Eastern Nursing Science for Regimen on the Oldman (노인 양생에 대한 한방간호학적 접근)

  • Wang, Myung-Ja;Cha, Nam-Hyun
    • Journal of East-West Nursing Research
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    • v.7 no.1
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    • pp.7-17
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    • 2002
  • This study attempted to develop fundamental data for East nursing intervention of nourish of life and health care from chronic disease augmented on the elderly. I understood that a point of nursing view and knowledges have limited to progress of life of quality on the oldman. In this context, this study was aimed to find out a possible of Eastern Nursing Sciences for the management of nourish of life and health care on the elderly and to suggest a distinct frame of Korean nursing intervention method which is unique. From the literature, this study identified that there are needed to intervene of livelihood of nourish of life, such as food and clothing, a feeling of moderation, moving and living(activity, sleeping, recumbency), sex for healthy and quality of life on the oldman. To propose, I suggested the traditional health method physically as Nursing intervention, such as Qi Kyong, Tae Kuk Kyun, Yuk Ja Kyoul, Oh Keum Hee etc and Moxibustion. Through there understand and percept importance and need of nourish of life on the elderly on results of literature view, as above, concrete East Nursing intervention of nourish of life on the elderly will be researched. Hence, we are needed to regain and to adapt Korean traditional health method which is the first draft on Korean Nursing tightly.

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Surgical Treatment of Acute Traumatic Peroneal Tendon Dislocation (급성 외상성 비골근 탈구의 수술적 치료)

  • Choi, Eun-Seok;Park, Hong-Ki
    • Journal of Korean Foot and Ankle Society
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    • v.9 no.2
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    • pp.179-183
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    • 2005
  • Purpose: Acute traumatic peroneal tendon dislocation is relatively rare disease and their methods of treatment is controversial, that we want to assess the characters and outcomes of 8 patients with early surgical treatments. Materials and Methods: We evaluated the results of 8 patients who can follow up more than 28 months using sex, age, side, injury sports, concomitant injuries, Eckert and Davis classifications, anatomic variants, results and complications. Results: All of 8 patients was male, average age was 27, Right side was dominant (5/8), causal sports was variable. Concomitant injuries were distal tibiofibular ligament syndesmosis injury, Peroneus longus injury, lateral collateral ligament injury. On behalf of Eckert and Davis classifications 5 patients were Grade 1 and other 3 patients were Grade 2. 1 case of low lying peroneus brevis belly was found as an anatomic variants. 6 of patients shown excellent results, 2 patients were good. Post operative complications were discomfort of operation site and mild limited dorsiflexion on ankle joint. Conclusion: Careful history and physical exam is important for diagnosis. And surgical treatments can expect good results.

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The Prognostic Factors and Survival Rate in Thyroid Carcinoma (갑상선암의 예후적 인자와 생존율)

  • Lee Seung-Jae;Kim Sang-Hyo;Paik Nak-Whan
    • Korean Journal of Head & Neck Oncology
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    • v.9 no.1
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    • pp.33-41
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    • 1993
  • A multivariate analysis of the prognostic factors and five year survival rate was carried out on a series of 72 thyroid cancers treated surgically from 1980 to 1987 and followed for 1 to 11 years. The prognosis of the disease was significantly influenced by age at diagnosis, extracapsular invasion, angioinvasion and pathologic type, but the disease was not influenced by sex, lymph node metastasis, and 'risk' category. The overall five year survival rate was 89.7%. Six patients were dead of tumor after surviving for six months to two and half years, and the cause of death was local recurrence in three, lung metastasis in two and bone metastasis in one patient. Five year survival rate in age above fifty, presence of capsule and angioinvasion, follicular carcinoma, and extrathyroidal lesion was significantly shorter than that of patients with age below fifty, absence of capsule and angioinvasion, papillary carcinoma, and intrathyroidal lesion. Patients at low risk or with small carcinomas had long survival over 5 years with only lobectomy. Lymph node dissection was done with a limited type in no jugular metastasis, radical neck disscetion was performed only therapeutically in proved jugular node metastasis. Thyroid hormone was administered for the period of 3 to 5 years to suppress endogenous TSH production.

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Video-assisted Thoracoscopic Stapled Resection for Spontaneous Pneumothorax (비디오 흉강경을 이용한 자연성 기흉의 치료)

  • 박진상
    • Journal of Chest Surgery
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    • v.28 no.3
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    • pp.297-302
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    • 1995
  • Video-assisted thoracic surgery [VATS is emerging as a viable alternatives to thoracotomy when surgical treatment of spontaneous pneumothorax is required.Apical blebs and bullaes of the lung can be resected,and pleural abrasion can be accomplished with minimal postoperative pain and a shorter postoperative stay in hospital. We compared our results with thoracoscopic management of spontaneous pneumothorax in 20 patients [group I with a group of 32 patients previously subjected to lateral limited thoracotomy [group II . Indications for operation, sex distribution, and average age [groupI, 24.7 years ; group II, 34.4 years were comparable. Operation time [112.42 54.7 min versus 124.8 35.3 min ; P 0.03 and chest tube duration [64.4 52.3 hours versus 97.7 45.4 hours ; P 0.01 were less in group I. Postoperative hospital stay was less in group I[3.84 0.99 days;P 0.01 , as was the use of parenteral narcotics after 48 hours. [5/20=25% versus25/32=78% . Pain was quantitated by verbal rating scale in postoperative 1 to 3 days. Patients undergoing VATS experienced significantly less postoperative pain. Postoperative complication was less in group I[1/20=5% versus 3/32=8.3% . In conclusion, Video-assisted thoracoscopic management of spontaneous pneumothrax allows performance of the standard surgical procedure while avoiding the thoracotomy incision.Video-assisted thoracic surgery [VATS is safe and offers the potential benefits of shorter postoperative hospital stays and less pain with cosmetic benefits.

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The Ways in which Clothes worn by Game Characters as Expressed in Contemporary Fashion (현대패션에 포함된 게임 캐릭터 의상의 조형성)

  • Lee, Hyo-Jin;Yang, A-Rang
    • Journal of the Korean Society of Costume
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    • v.58 no.4
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    • pp.86-98
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    • 2008
  • This study is purposed to determine the correlation between contemporary fashion and game characters' clothes and to analyze the formative property of the game characters' clothes expressed in the contemporary fashion. The temporal scope of this study is from 2004 to 2007 based on general online game ranks, while the game type is limited to 3D-online role playing game. The most popular clothes of game characters are analyzed and found to have imaginary, sensualistic, and cross-sexual features. These are also expressed as Cyber resistance image, Femme fatal image and Asexual image in the contemporary fashion. Firstly, the Cyber resistance image in the recent fashion is shown as belligerent, destructive and surrealistic image in contemporary fashion. Secondly, the Femme fatal image represents bewitching, brutal and narcissistic image with sleek materials and glowing colors in contemporary fashion. Thirdly, the Asexual image means the concept of sex as the neuter gender. Especially, this image has been introduced by simple and straight silhouette, black, silver, khaki colors in fashion. Accordingly, the clothes of game characters with the popularity and formative property have close correlation with contemporary fashion even if they do not pursue for practical creativity. In this respect, they can consolidate the position as a new fashion trend if they are developed with various design ideas.

Analysis of the Rate of Sensitization to Food Allergen in Children with Atopic Dermatitis (아토피피부염 환아의 식품 알레르겐에 대한 감작률 분석을 통한 식품알레르기의 고찰)

  • 한영신;정상진;조영연;최혜미;안강모;이상일
    • Korean Journal of Community Nutrition
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    • v.9 no.1
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    • pp.90-97
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    • 2004
  • The purpose of this study was to determined the rate of sensitization to food allergen in children with Atopic Dermatitis (AD) in Korea. A total of 3,783 patients (male = 1983, female = 1800) with AD (age under 18 years) who had visited Samsung Medical Center from 1998 to 2003 were enrolled in the study. Food hypersensitivity was measured by specific IgE to egg, cow's milk, soy, peanut, wheat, buckwheat, beef, pork, chicken, shrimp, crab, salmon, mackerel, etc. Specific IgE levels > 0.7 kU/L. by Captured Allergen Product (CAP) assay were considered positive. Chi-square test at p value < 0.05 was used to examine the difference of the prevalence by sex and age. The rate of sensitization to multiple food allergens was 31.2% and decreased with age. Hypersensitivity to egg showed highest prevalence, which was 24.3%, compared to the prevalence of other foods. High prevalence of hypersensitivity to milk. wheat, soy, peanut, crab or shrimp was observed (11.6- 17.7%). Low prevalence of hypersensitivity to beef, pork, tuna or chicken was observed (1.9-3.5%). Children aged under 3 years had significantly higher prevalence of hypersensitivity to egg, milk, soy and beef than children aged at least 3 years. Our results stress the need for examination of food hypersensitivity aimed at identified and limited each food allergen among children with AD caused by food to help patients outgrow their food allergy.