• 한국임상약학회지
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• 제1권1호
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• pp.31-36
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• 1991

Tobramycin is one of the most frequently selected agents for pharmacokinetic drug monitoring because of its narrow therapeutic index and essential role for the management of serious infections, especially gram-negative infections. Its pharmacokinetic parameters are dependent on race, sex, age, ideal body weight. disease states, and etc. Therefore, to schedule the dosing of tobramycin, the individual pharmacokinetic parameters such as half-life and volume of distribution are needed. However, these pharmacokinetic parameters have never been reported in Koreans. The purposes of this study were to evaluate the volume of distribution of tobramycin in cancer patients who had normal renal function, to compare the mean values of Vd reported in the literature, and to compare the measured half-life with the expected half-life based on ABW, LBW, and IBW, respectively. Venous blood samples were collected just before and thirty minutes after dosing during steady state. Serum tobramycin concentrations were determined by $TD_x$ (fluorescence immunoassay). IBW were measured by the method of Devine: and LBW were measured by the method of Hallynck. Creatinine clearances (CLcr) of the patients were estimated using the Cockcroft and Gault equation. Elimination rate constants (kel) were determined using the Welling and Craig equation. Infusion rate (ko), volume of distribution (Vd), and half-life $(t_{1/2})$ were determined using the Saw chuk and Zaske equation. The volume of distribution Was $27\%$ greater than the Schentag's study (0.26 vs 0.33 l/kg), but the half-life was similar to the Levy's study. The predicted half-lives based on IBW were the closest to actual half-lives (1.85 vs 2.01 hr).

• Nutrition Research and Practice
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• 제4권2호
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• pp.155-162
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• 2010

Epidemiological evidence of the effects of dietary sodium, calcium, and potassium, and anthropometric indexes on blood pressure is still inconsistent. To investigate the relationship between dietary factors or anthropometric indexes and hypertension risk, we examined the association of systolic and diastolic blood pressure (SBP and DBP) with sodium, calcium, and potassium intakes and anthropometric indexes in 19~49-year-olds using data from Korean National Health and Nutrition Examination Survey (KNHANES) III. Total of 2,761 young and middle aged adults (574 aged 19~29 years and 2,187 aged 30~49 years) were selected from KNHANES III. General information, nutritional status, and anthropometric data were compared between two age groups (19~29 years old and 30~49 years old). The relevance of blood pressure and risk factors such as age, sex, body mass index (BMI), weight, waist circumference, and the intakes of sodium, potassium, and calcium was determined by multiple regression analysis. Multiple regression models showed that waist circumference, weight, and BMI were positively associated with SBP and DBP in both age groups. Sodium and potassium intakes were not associated with either SBP or DBP. Among 30~49-year-olds, calcium was inversely associated with both SBP and DBP (P = 0.012 and 0.010, respectively). Our findings suggest that encouraging calcium consumption and weight control may play an important role in the primary prevention and management of hypertension in early adulthood.

• The Korean Journal of Pain
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• 제9권2호
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• pp.326-335
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• 1996

Background: Though a number of studies have described the distribution of substance P(SP)-like immunoreactivity in the spinal cord, they have been focused on lamina I and II of the dorsal horn and there are little morphological studies on the topographic distribution and ultrastructure of the SP immunoreactive neurons especially in the ventral horn of the spinal cord. this study was conducted to identify distribution pattern of SP immunoreactive neurons and to difine the synaptic organization of their processes in ventral horn of the thoracic cord of the cat by preembbeding immunocytochemical method using SP antiserum. Methods: Five adults cats of either sex were used and deeply anesthetized by intramuscular injection of ketamine. After removal of the spinal cord, samples of thoracic cord were taken and placed in fresh fixative at $4^{\circ}C$ for 2 hours. Transverse sections $50{\mu}m$ thick were processed using the preembbeding immunocytochemical method and incubated consecutively in the specific primary antibody and the 10% normal goat serum, the rabbit anti-substance P antiserum, the biotin-labelled goat anti-rabbit IgG and finally the avidin-biotin-peroxidase complex. The processed tissue sections were throughly washed and stained in the black with 1% uranyl acetate. Section were examined on a electron microscope. Results: 1) SP immunoreactive neurons were observed in the gray matter around central canal. 2) In lamina I and II SP immunoreactivity was observed in both myelinated and unmyelinated nerve fibers, but in ventral horn only in the unmyelinated nerve fibers. 3) SP immunoreactive axon terminals with small round and large dense core vesicles made chemical synapses onto the dendrites of motor neurons in the ventral horn. Conclusion: SP immunoreactive neurons might play an important role in modulation of motor neurons in the ventral horn of the thoracic cord of the cat.

• Journal of Applied Biological Chemistry
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• 제51권1호
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• pp.1-6
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• 2008

Estrogens, a group of steroid compounds functioning as the primary female sex hormone, play an important role in the development and progression of breast cancer. In this study, using a novel annealing control primer-based GeneFishing PCR technology, five differentially expressed genes (DEGs), expressed using 10nM mitogenic estrogens, $17{\beta}$-estradiol (E2) and $16{\alpha}$-hydroxyestrone ($16{\alpha}$-OHE1), were selected from the estrogen receptor (ER)-positive MCF-7 human breast cancer cells. The DEGs, MRPL42, TUBA1B, SSBP1, KNCT2, and RUVBL1, were identified by comparison with the known genes via direct sequencing and sequence homology search in BLAST. Quantitative real-time PCR data showed that two DEGs, tubulin ${\alpha}1b$ and kinetochore associated 2, were greater than 2-fold upregulated by E2 or $16{\alpha}$-OHE1. Both genes could be new biomarkers for the treatment and prognosis of cancers, and further study may provide insights into the molecular mechanisms underlying development and progression of breast cancer.

• 한국실내디자인학회논문집
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• 제25호
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• pp.103-110
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• 2000

The material world around human is normally composed of opaque one, with which human has made the spaces. The opaque material to make space has played a role to control the relationship among people and has produced socio-cultural things since the history started. The opening of opaque material(wall) connects one space with the other. Therefore, the meaning of opening is a connection among people who are in different spaces in terms of sociology. In conjunction with this, socio-cultural situation has been deployed differently. In the traditional european domestic space, the glass has been applied to this opening since they found the glass. It disconnects two spaces physically but connects them visually. Therefore, without blocking the opening visually, the glass became to protect people with their interior space from outside environment. The important thing is that the application of the glass in a building had been restricted because of opening size. However, after Industrial Revolution with the advanced technology of architecture, the glass came to be applied to the building and it became widen. So, the concept of glass window became to be the one of glass wall. This change made a transformation of visual character between two spaces which are separated with glass wall. This means that the glass wall gave two directional visibility while the glass window gave one directional visibility from inside to outside of space. This is because the amount of the natural light to the interior space increased due to widen glass in a space. This gave a change of visual authority and the space of surveillance(interior space) became to the one of communication. The space of surveillance, Michel Foucault mentioned in his book surveillance and punishment, is a very private one that is not visually permeable from the people outside, while the space of communication is a public one which needs other eyes. In the space of publicity, there needs a rationality, morality and ethics because of public surveillance and in the space of privacy, there restores a desire for sex and assaults.

• 한국생활과학회지
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• 제9권1호
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• pp.85-95
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• 2000

This study is about psychological growth environment and style of loving among 88 men and 128 women in university students. The results of this study are following. First, the result of psychological growth environment and style of loving among university students show that men have expectation for the achievement and encouragement more than women as they are moved up the higher grade. Largely when they are moved up the higher grade, they respect individual opinion and have responsibility for their behaviors. Also they tend to have the cooperation in their home. So as they are moved up the higher grade, they have the independent spirit from their parents and are prepared to adaptability for social life. Second, the result of the style of loving show that men tend to fall in love easily and also pursuit altruistic and romantic love. According to being moved up the higher grade, they have the actual attitude in the intercourse with the other sex. Third, the result of psychological growth environment show that persons who want to come true their desire more need the friendly love, altruistic love and love for amusement. Contrarily, when they don't communicate each other in their home, they tend to pursuit love for amusement. When they have the higher level of communication and cooperation in their psychological environment, they tend to pursuit for logical love. When they have expectation of mutual role, mutual intimacy, love and respect, they pursuit friendly love. Also through they are adapt for style of social behaviors in each other, they acpuire the love and respect between family members. And they pursuit friendly love through it.

• 한국가금학회지
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• 제35권3호
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• pp.225-240
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• 2008

Marek's disease virus(MDV) is a highly cell-associated, lymphotropic $\alpha$-herpesvirus that causes paralysis and neoplastic disease in chickens. The disease has been controlled by vaccination which was provided the first evidence for a malignant cancer being controlled by an antiviral vaccine. Marek's disease pathogenesis is complex, involving cytolytic and latent infection of lymphoid cells and oncogenic transformation of $CD4^+$ T cells in susceptible chickens. MDV targets a number of different cell types during its life cycle. Lymphocytes play an essential role, although within them virus production is restricted and only virion are produced. Innate and adaptive immune responses develop in response to infection, but infection of lymphocytes results in immunosuppressive effects. Hence in MDV-infected birds, MDV makes its host more vulnerable to tumour development as well as to other pathogens. All chickens are susceptible to MDV infection, and vaccination is essential to protect the susceptible host from developing clinical disease. Nevertheless, MDV infects and replicates in vaccinated chickens, with the challenge virus being shed from the feather-follicle epithelium. The outcome of infection with MDV depends on a complex interplay of factors involving the MDV pathotype and the host genotype. Host factors that influence the course of MD are predominantly the responses of the innate and adaptive immune systems, and these are modulated by: age at infection and maturity of the immune system; vaccination status; the sex of the host; and various physiological factors.

• Radiation Oncology Journal
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• 제6권2호
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• pp.235-246
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• 1988

A total of 93 patients with rectal cancer treated with radiotherapy at department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center between January 1974 and December 1983 are retrospectively analysed. The patients are divided into three groups as follows: I. Postoperative radiotherapy, II. Postoperative recurrent, III. Unresectable or Inoperable group. In postoperative radiotherapy group, overall 5 year survival rate is $34.8\%$ and prognostic factors are presence of obstruction and degree of differentiation. In postoperative recurrent group, overall 2 year survival rate is $7.4\%$ with median survival of 13 months and prognostic factors are RT responsiveness and sex, and the local failure rate is $22.7\%$. In unresectable or inoperable group, overall 2 year survival rate is $19.8\%$ with median survival of 12.6 months and prognostic factors are RT responsiveness and RT dose. The complications for RT are not significant and are acceptable in all patients.

• 한국콘텐츠학회논문지
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• 제18권2호
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• pp.344-360
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• 2018

본 연구는 6차년도(2011년) 한국복지패널에 참여한 10,991명을 대상으로 자살생각, 자살계획 및 자살시도로 이어지는 일련의 자살에 관련된 유발요인으로 개인심리변인, 개인 및 사회환경변인을 통합적인 연구틀에서 살펴보고자 수행되었다. 연구방법은 AMOS 21.0 버전을 활용하여 자살생각, 자살계획 및 자살시도로 이어지는 일련의 자살에 영향을 미치는 유발변인의 상대적 영향력을 로지스틱 회귀분석하였다. 연구 결과, 첫째, 우울, 자존감, 주관적 건강상태, 부부폭력, 성역할은 자살생각에 유의한 영향을 미쳤다. 둘째, 주관적 건강상태, 문제음주는 자살계획에 유의한 영향을 미쳤다. 셋째, 문제음주, 부부폭력은 자살시도에 유의한 영향을 미쳤다. 이를 근거로 자살생각, 자살계획 및 자살시도를 축소 예방하기 위한 사회복지적 함의를 제시하고, 이 연구의 제한점과 추후 연구에서 고려할 점을 논의하였다.

• 한국수정란이식학회지
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• 제28권2호
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• pp.149-155
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• 2013

Mullerian inhibiting substance (MIS) is a member of the TGF-${\beta}$ (transforming growth factor-${\beta}$) family whose members play key roles in development, suppression of tumour growth, and feedback control of the pituitary-gonadal hormone axis. MIS is expressed in a highly tissue-specific manner in which it is restricted to male Sertoli cells and female granulose cells. The serum levels of MIS in prenatal and postnatal ICR mice were measured using the enzyme-linked immuno-solvent assay (ELISA) using the MIS/AMH antibody. Mice were grouped by age: the significant periods were at the onset of development. During sex organ differentiation, no remarkable difference between female and male foetus MIS serum levels (both<0.1 ng/ml) was observed. However, MIS serum levels in pregnant mice markedly changed (4.5~12.2 ng/ml). After birth, postnatal female and male mice serum MIS levels changed considerably (male: <0.1~138.5 ng/ml, female: 5.3~103.4 ng/ml), and the changing phase were diametrically opposed (male: decreasing, female: fluctuating). These findings suggest that MIS may have strong associations with not only develop-ment but also puberty. For further studies, establishing the standard MIS serum levels is of importance. Our study provides the basic information for the study of MIS interactions with reproductive organ disability, cancer, and the effect of other hormone or menopause. We hypothesise that if MIS is regularly injected into middle-age women, meno-pause will be delayed. We detected that serum MIS concentration curves change with age. The changing phase is different between males and females, and this difference is significant after birth. Moreover, MIS mRNA is expressed during the developmental period (prenatal) and also in the postnatal period. This finding indicates that MIS may play a significant role in the developmental stage and in growth after birth.