• 한국농촌생활과학회지
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• 제2권
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• pp.91-107
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• 1991

• The Korean Journal of Physiology and Pharmacology
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• 제3권6호
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• pp.555-563
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• 1999

It is well known that stress induces analgesia. This study was designed to demonstrate the stress-induced analgesia by employing hemorrhage and restraint and to investigate its mechanism and sex difference. The degree of pain was assessed by measuring the magnitude of jaw opening reflex produced by a noxious electrical stimulation in the dental pulp and by measuring the latency to withdraw the tail from a heat ray. Restraint showed an antinociceptive response. A significant increase in pain threshold on bleeding was shown and the increase was larger in male group than in female group. The tail flick latency (TFL) on bleeding after AVP antagonist injection into the ventricle was decreased and the decrease was greater in male rats than in female rats. Castration resulted in a significant reduction of TFL. This effect was reversed by treatment with sex hormones. TFL was decreased during hemorrhage in castrated rats. This response was opposite to that in non-castrated rats. TFL was further decreased during hemorrhage after infusion of AVP antagonist, and there was a significant sex difference. These results suggest that both restraint and hemorrhage produce an antinociception and that, in hemorrhage-induced analgesia, AVP and sex hormones may play an important role and male rats show a greater analgesic response.

• 한국동물생명공학회지
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• 제34권2호
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• pp.111-116
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• 2019

This study was conducted to analyze the specific genes associated with sex-determination in Korean native cow. The highly organized spermatogenesis requires accurate spatial and temporal regulation of gene expression, which is governed by transcriptional, post-transcriptional, and epigenetic processes. Recently, farmers have been interested in determining the sexual identity of the calves in their farm. We analyzed the sperm of Korean native and Holstein cows, which were supplied from Hanwoo Improvement Center. We evaluated sperm motility and expression of sperm-specific genes after treating semen with both male- and female reagents. Sperm motility in Korean native cows decreased by approximately 10% in the first 30 minutes after treatment with sex-determination reagent. However, sperm motility of Holstein cows decreased to 60-70% after 15 minutes and to 20-30% after 30 minutes. We selected six specific genes expressing in the spermatozoa to analysis the gene expression level. The Real-time PCR results suggest that the selected genes (Gimap4, Tmeff1, Rac2, Abi2, Rac1, and Clu) were highly expressed in the group treated with the male reagent compared to the group treated the female reagent and to the untreated-group (control). In the present study, we suggest that the selected genes play a pivotal role in sex-determination.

• Osteoporosis and Sarcopenia
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• 제2권3호
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• pp.140-155
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• 2016

Sex steroids influence the maintenance and growth of muscles. Decline in androgens, estrogens and progesterone by aging leads to the loss of muscular function and mass, sarcopenia. These steroid hormones can interact with different signaling pathways through their receptors. To date, sex steroid hormone receptors and their exact roles are not completely defined in skeletal and smooth muscles. Although numerous studies focused on the effects of sex steroid hormones on different types of cells, still many unexplained molecular mechanisms in both skeletal and smooth muscle cells remain to be investigated. In this paper, many different molecular mechanisms that are activated or inhibited by sex steroids and those that influence the growth, proliferation, and differentiation of skeletal and smooth muscle cells are reviewed. Also, the similarities of cellular and molecular pathways of androgens, estrogens and progesterone in both skeletal and smooth muscle cells are highlighted. The reviewed signaling pathways and participating molecules can be targeted in the future development of novel therapeutics.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.115-119
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• 2022

The 46,XX testicular disorder of sex development (DSD) is a rare condition in which 46,XX individuals develop testicular differentiation and virilization. Translocation of the sex-determining region Y (SRY) onto the X chromosome is the main cause of 46,XX testicular DSD, whereas dysregulation between pro-testis and pro-ovarian genes can induce SRY-negative 46,XX testicular DSD. Nuclear receptor subfamily 5 group A member 1 (NR5A1), a nuclear receptor transcription factor, plays an essential role in gonadal development in XY and XX embryos. Herein, we report the first Korean case of SRY-negative 46,XX testicular DSD with a heterozygous NR5A1 p.Arg92Trp variant. The patient presented with a small penis, bifid scrotum, and bilateral undescended testes. Whole exome sequencing revealed a heterozygous missense variant (c.274C>T) of NR5A1. Our case highlights that NR5A1 gene variants need to be considered important causative factors of SRY-negative non-syndromic 46,XX testicular DSD.

• 한국가정과교육학회지
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• 제22권3호
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• pp.77-94
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• 2010

본 연구는 기술 가정 교과의 2007년 교육과정의 '나와 가족의 이해' 단원과 또한 2007년 개정 교육과정의 중학교 1학년 '청소년의 이해' 단원과 중학교 2학년 '가족의 이해' 단원에 적용할 수 있는 '청소년의 성역할과 양성평등'에 대한 실천 문제 중심의 교수 학습 과정안을 개발하여 수업의 효과를 보고자 하였다. 개발된 5차시 교수 학습 과정안은 실천적 문제 '양생평등 의식 함양과 관련하여 우리는 무엇을 해야하나?'로 1, 2, 3차시를, '양성평등 의식 실천을 위하여 우리는 무엇을 해야하나?'로 4, 5차시 교수 학습 과정안을 학교 수업에 적용하였다. 적용 대상은 경기도 의정부시 소재의 중학교 1학년 남녀합반의 4개 학급, 총 150명을 대상으로 하였다. 적용 기간은 2009년 9월 14일~9월 30일까지 3주 동안이며, 수업 적용 전에 사전 설문을 하고 개발한 양성평등 수업을 적용한 후 사후 설문을 실시하였다. '청소년의 성역할과 양성평등' 단원의 하위 요소인 개인의 성역할 발달과 진로 직업역할과 양성평등, 우리 사회와 양성평등. 가족역할과 양성평등, 양성평등 실천 전략 세우기라는 주제로 나누어 대응표본 t-검정을 통해 학습자의 양성평등 의식에 대한 고양을 가져오는지와 집안일 참여도의 효과에 대해 결과를 분석하였다. '청소년의 성역할과 양성평등' 단원을 개발한 교수 학습 과정안 적용 결과 양성성 집단이 증가하고 학습자들의 양성평등적 의식 변화에 긍정적인 결과를 보였으며, 집안일 참여도라는 학습자의 실천적 행동을 높이는 결과를 가져왔다. 또한 실천적 문제 중심의 교수 학습 과정안에 대한 학습자들의 흥미와 참여, 이해에 대한 평가는 비교적 높았다. 앞으로 학년과 단원을 넓혀서 양성평등 교수 학습 과정안을 개발하고 적용하여 지속성을 검증할 것과 양성평등 실천과 관련된 척도안이 개발되어야 할 것이다.

• 한국식생활문화학회지
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• 제15권4호
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• pp.259-268
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• 2000

The purpose of this study was to describe the levels of market goods substitution of housework and find out the determinants on it in the domain of food among married female home-based workers. The data were collected from 169 married female home-based workers in Pusan and Kyungnam province, by self-administered questionnaires. Frequencies, percentiles, Cronbach's alpha, Pearson's correlations, and multiple regression were used to analyze the data. In the convenience foods, frozen foods had the highest substitution level, whereas prepared stew had the lowest. The substitution level of Korean traditional storage foods was the middle. And in dining-out service, the substitution level was mostly high: the level of delivery service was higher than that of dining-out. Compared to the previous research, these results showed that market goods substitution tended to increase, and its level in the domain of food will promote continually over time. The variables affecting the substitution level of convenience food were the number of family members, occupation, the existence of elderly/disabled person in the family, sex-role attitude, and weekly hours at home-based work. The substitution level of Korean traditional storage foods was influenced by sex-role attitude, occupation, education, monthly household income, and the existence of elderly/disabled person in the family. The significant variables affecting the substitution level of dining-out service were weekly hours at home-based work, the number of family members, occupation, monthly household income, education, and sex-role attitude.

• Ocean and Polar Research
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• 제30권1호
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• pp.11-19
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• 2008

Incubation routine and sex role of Streaked Shearwaters Calonectris leucomelas at Sasudo Island, in Jeju, South Korea, were studied during the incubation period, June to August in 2002. Incubation routine in Procellariiformes represents a sequence of alternating shifts taken in turn by female and male in a species-specific pattern. Hence, coordination of individual incubation rhythms between partners is crucial for successful breeding attempt. In Streaked Shearwaters, incubation routine represents a sequence of alternating shifts taken in turn by male and female. The first incubation shift was made by male after female had laid the egg. The mean incubation period was 50.8 days until hatching. Males had spent on average 26.5 days incubating and females 24.3 days accordingly. The mean duration of incubation shifts decreased progressively from 6th and 7th shift to hatching. Overall, males had spent more time incubating than females during the incubation period, but the mean duration of the incubation shift 5.6 days for males and 5.7 days for females did not differ between males and females. There were no effect of the body size of the breeding pair on incubation performance. For males the mean of body weight decreased during the incubation, whereas for females it remained approximately stable. In Streaked Shearwaters, the duration of incubation shift and subsequent foraging trip are related to loss of body weight during the period of fasting. In addition, coordination of individual incubation rhythms affects their incubation behaviour.

• 생물정신의학
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• 제22권4호
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• pp.205-215
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• 2015

Objectives Sex hormones exposure during the prenatal period has an effect on cerebral lateralization. Male brains are thought to be more lateralized than female brains. Bipolar disorder was known to show abnormalities in cerebral laterality whose characteristics could be estimated by electroencephalography (EEG) coherences. We studied sex-related differences of EEG coherences between healthy controls and patients with bipolar disorder to examine the sex effects in the genesis of bipolar disorder. Methods Participants were 25 patients with bipolar disorder (11 male, 14 female) and 46 healthy controls (23 male, 23 female). EEG was recorded in the eyes closed resting state. To examine dominant EEG coherence associated with sex differences in both groups within five frequency bands (delta, theta, alpha, beta, and gamma) across several brain regions, statistical analyses were performed using analysis of covariance. Results Though statistically meaningful results were not found, some remarkable findings were noted. Healthy control females showed more increased interhemispheric coherences than control males in gamma frequency band. There were no differences in the intrahemispheric coherences between the healthy control males and females. In patients with bipolar disorder, female dominant pattern in interhemispheric coherences was attenuated compared with healthy control. Conclusions Sex differences of EEG coherences, which could be a marker for cerebral laterality, were attenuated in patients with bipolar disorder compared with healthy controls. These results imply that abnormal sex hormone exposure during early development might play some role in the pathogenesis of bipolar disorder.

• 대한가정학회지
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• 제17권4호
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• pp.75-93
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• 1979

1. Partly because of Freud's greatemphaiss on the important of the child's successful weathering of the oedipal crisis and on the need to home both parents present if that period is to be successfully resolved, there has been a good deal of research on the effects of the absent father on the child's development. 2. Compared with boys whose fathers remained at home, boys were more immature and less secure in identification with their fathers. Some evidence suggests that father-absent children, particullarly boys suffer unusual difficulties in social relations wit their peers. 3. Emphasis on family quality , harmony, or climate as more important than father's absence, person is another recurrent finding among studies that attempt to analzed family factors in relation to juvenile deliquency. 4. The fatherless boys were more often judged to be anxious about sex and to be more effminated. 5. The sex-role problems of the boy without a father probably refect a number of factors, obviously they relate in part to the simple fact that he has not had a man around to provide a model of maliness. 6. Father is important to a girl's sex-role development not only because he is particularly interested in sex typing but also because he provides her with an opportunity to relate intimately to a man and to learn what it is like to invest emotionally in a male. 7. It is conceivable that children of broken marriages are more sensitive to martial problems and more ready than others to end an unhealthy relationship ; it is also conceivable that they are less likely to enter into a healthy one. 8. In some cultures it simply reflects the extreme amount of intimacy mother has with her son as compared with the amount of time compared with the amount of time father has available to spend with him.