• 한국임상약학회지
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• 제20권2호
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• pp.128-137
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• 2010

This review summarizes gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions. Gender differences in pharmacokinetics are categorized by four major factors: absorption/bioavailability, distribution, metabolism, and elimination. There are sex-based differences in gastric emptying time, gastric alcohol dehydrogenase activity, apparent volume of distribution, ${\alpha}1$-acid glycoprotein level, phase I (CYP) and phase II metabolizing enzymes, glomerular filtration rate, and drug transporters. This review also reports gender differences in pharmacokinetics and pharmacodynamics of cardiovascular agents, central nervous system acting agents and antiviral agents. In addition, it has been reported that females experience more adverse reactions such as coughing, tachycardia, nausea, vomiting, rash, hypersensitivity, hepatotoxicity, and metabolic disorder after taking cardiovascular, central nervous system acting and antiviral agents. Therefore, in order to provide optimal drug dosage regimens both in male and female, gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions must be considered.

• 한국심리학회지 : 문화 및 사회문제
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• 제15권3호
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• pp.377-398
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• 2009

본 연구는 남성들의 성구매 경험에 따른 의식차이를 비교 조사하여, 성매매에 대한 의식전환을 위한 운동과 추후연구를 계획하기 위한 탐색적 조사연구로 실시되었다. 경기지역 19세 이상 남성 1328명을 대상으로 성매매에 대한 의식과 태도, 성행위에 대한 허용도, 성 역할 평등의식에 대해 설문 조사를 실시하였다. 성구매 경험에 따라 구분된 집단은 성구매 경험 집단이 향후 성구매 의향이 더 많고 부부나 애인관계의 성적만족도가 낮으며, 성지식 습득 경로가 다른 것으로 나타났다. 집단별 비교 연구결과 성구매 경험자들이 성구매 무경험자들 보다 성매매에 대해 남성중심의 왜곡된 고정관념을 가지고, 성행동에 대해 허용적 태도를 가지며, 성역할에 대한 전통적 사고를 하는 것으로 나타났다. 성구매경험과 성매매에 대한 고정관념, 성행위 허용도, 성역할 평등의식 하위요인들과의 상관관계 분석결과 성매매 여성에 대한 피해자 인정을 제외한 모든 요인들과 정적인 상관관계를 나타내었다. 이는 성구매 경험이 성매매, 성행동과 성역할에 대한 전통적이거나 남성중심적 사고와 관련이 있음을 보이는 것이다. 연구결과를 여성주의적 관점에서 논의하고, 추후 연구를 위한 제언과 함께 연구의의와 제한점을 정리하였다.

• 여성건강간호학회지
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• 제29권2호
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• pp.115-127
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• 2023

Purpose: The aim of this study was to determine the factors that influence safe sexual behaviors of Korean young adults and identify differences by gender. Methods: This study aimed to determine which factors affected safe sexual behaviors based on the Theory of Planned Behavior. Data from 437 Korean young adults (in their 20s and 30s) were collected via online survey between January 3 and January 28, 2022. The questionnaire included items on sexual body image, sexual role perception, sexual attitudes, sexual socialization, sexual communication, and safe sexual behaviors. Structural equation modeling was performed. Results: According to the overall model fit of the hypothetical model, the final model was acceptable and explained 49% of safe sexual behaviors. Sexual attitudes (β=h-.70, p<.001) and sexual communication (β=.53, p<.001) directly affected safe sexual behaviors, and sexual role perception (β=.42, p<.001) indirectly affected safe sexual behaviors in a combined model. There were gender differences in the path from sexual attitudes (β=-.94, p<.001) and sexual communication (β=.66, p<.001) to safe sexual behaviors and from sexual body image (β=.27, p<.001) to sexual communication. Conclusion: Sexual attitudes and sexual communication were predictors of safe sexual behaviors, which differed by gender. Strategies that consider sexual attitudes, sexual communication, sexual role perception, and differences between men and women should be developed to improve the safe sexual behaviors of young adults.

• 한국병원경영학회지
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• 제28권3호
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• pp.27-38
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• 2023

Objectives: This study explores the impact of age groups on social presence and trust among users of medical artificial intelligence chatbots. Furthermore, we investigate the existence of gender differences within these relationships. Method: We collected data through a survey from people who had interacted with general hospital chatbot services, either by making reservations or seeking consultations. Multiple linear regression analysis was conducted to examine the relationship between general characteristics of study population and social presence and trust of artificial intelligence chatbots. Additionally, we conducted stratified analysis to confirm the presence of gender differences within these relationship. Results: Among 300 participants, those aged 50 and older had higher social presence of artificial intelligence chatbots and greater trust of artificial intelligence chatbots (social presence, 𝛽=0.543, p=0.003; trust, 𝛽=0.787, p=0.000). In stratified by sex, women aged 50 and older had higher social presence and trust of artificial intelligence chatbots compared to those in their 30s age group (social presence, 𝛽 = 0.925, p=0.002; trust, 𝛽=0.645, p=:0.007). However, there was no statistically significant relationship between age and chatbot social presence and trust in men. Conclusion: This study demonstrates that advanced age plays a significant roles in users' social presence and trust in medical artificial intelligence chatbots. Futhermore, our findings reveal gender differences with women aged 50 and older showing the most substantial levels of social presence and trust. Therefore, it is expected that this finding can serve as valuable evidence to enhance the satisfaction of medical institution service users, offering crucial insights into the effective utilization of chatbot services.

• 지역사회간호학회지
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• 제10권1호
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• pp.239-251
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• 1999

The purpose of this survey is to measure the sexual knowledge, attitude, and experience in college students in order to provide better sex education programs and direction. For this study, questionnaires were given to 259 students in K college of Kyongnam and collected during the period of June 1 to June 20, 1998. Data was analyzed using a statistical computer package: SPSS to manipulate the data along with frequency, mean, t-test, F-test and Pearson correlation coeffiency. The results from this study were summarized as follows: 1. Sex related knowledge marked 12.01 at a maximum level of 25. In the areas of Sex physiology(51.8%), genital physiology(49.9%), venereal diseases(44.3%) and contraceptive methods (38.1%), students were shown to have certain levels of knowledge. 2. Sex related attitudes marked 15.35 at a maximum level of 35. The most frank attitudes concerned 'premartial coitus in males' and the most conservative attitudes concerned 'extramarital coitus in females'. 3. Concerning sexual behavior 80.7% of the respondents had associated with the opposite sex. The most frequent behaviors were walking arm in arm (male : 28.6%, female: 36.2%). Their main problems were relationships with the opposite sex(male : 39.2%, female: 24.5%), frustrated sexual desire(male : 26.0%, female: 9.8%) and unwanted pregnacy(male: 15.2%, female: 7.8%) To solve sex problems, respondents intended to consult their friends(male : 35.7%, female: 46. 7%) and become active in sports or recreation (male: 23.4%, female: 11.4%). About 81.2% of male students had a masturbation experience, but only 11.4% of female did, 40.0% of male students had a sexual intercourse experience, but only 13.3% of females did, 7.8% of male students used contraceptive methods, but only 2.9% of females did. 12.3% of male students had a rape experience, but only 10.5% of females did. The proportion of male students who made someone pregnant was 12.3%,however pregnant female were only 6.8% and the proportion of male students who forced someone to have an abortion was 12.3%, females who experienced an abortion were only 5.7%. 4. Regarding genital physiology, there was a statistically significant differences in gender ( t = -7.342, p=0.000). Regarding contraceptive methods, there was a statistically significant difference in the father's education level(F= 2.421, p=0.036) 5. In sexual attitudes, there were statistically significant differences in gender( t = 4.456, p = 0.000), religion(F=4.315, p=0.000), high school(F=3.150, p=0.045), habitation form(F= 3.164, p=0.0025 and methods of acquiring sexual knowledge(F=2.990, p=0.012). 6. The variables regarding sexual experience were gender, high school, economic status, habitation form, method of acquiring sexual knowledge, and parental attitudes toward sex. From the result of the study, sex education is required and must be taught as a regular course in the curriculum of all Korean schools at all levels.

• Biomolecules & Therapeutics
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• 제8권1호
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• pp.38-43
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• 2000

Several studies have shown that the stomach has sufficient alcohol dehydrogenase (ADH) activity to metabolize some amount of orally administered alcohol and the sex-related differences in the first-pass metabolism of alcohol might be associated with differences in the activity of gastric ADH(GADH). The aim of this study was to asses the sex-related differences in GADH in 48 male and 48 female Sprague-Dawley rats aged 1, 4, 10, 15, 20, and 30 weeks which each aged group had same sex ratio. The GADH activity was determined spectrophotometrically at 37$^{\circ}C$. The formation of NADH was monitored at 340nm for 10 minutes in the 1 ml of reaction mixture (0.5 M of Tris-HCl, pH 7.2 + 1.5 M of ethanol + 2.8 mM of NAD + 30 $\mu$l gastric mucosal supernatant). The GADH activity (nM of NADH/min/mg of cytosolic protein) was calculated using molecular extinction coefficient of 6.22 $\textrm{cm}^2$/$\mu$M for NADH. The GADH activities were 2.94$\pm$0.82 (n=48) in female rats and 3.34$\pm$2.17 (n=48) in male rats and had not significant difference between sex. However, the GADH activities were significantly (p<0.01) higher in female (1.91$\pm$0.59 and 3.30$\pm$0.49) than in male (0.68$\pm$0.43 and 1.92$\pm$0.81) of 1 and 4 weeks rats. However, it was significantly (p<0.05) higher in male (6.48$\pm$1.81, 3.65$\pm$1.04 and 5.13$\pm$1.30) than in female (4.23$\pm$1.23, 2.18$\pm$0.77 and 2.56$\pm$0.93) of 10, 20 and 30 weeks rats, respectively. Therefore, the results suggested that sex-related differences of the GADH activities in same aged rats were existed by age.

• 대한가정학회지
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• 제39권10호
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• pp.187-204
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• 2001

The purpose of this study was to investigate the relationship of care-oriented morality and justice-oriented morality with gender and sex-role identity in high school students. Care-oriented morality was assessed by Modified Care-based Morality Measure based on Gilligan's(1982) theory. Justice-oriented morality was assessed by the Korean Defining Issues Test(DIT). Sex role identity was assessed by the Korean Sex Role Inventory(KSRI). The subjects of this study were 157 females and 143 males, the age of 17 to 19 years old. The average level of care-oriented morality of the subjects was on level 1.5(transition from survival to responsibility) and the P score(post conventional level) of justice-oriented morality was pretty high. There were significant differences between females and males in the levels of care-oriented morality as well as justice-oriented morality. There were significant differences in sex role identity types by level of care-oriented morality. On the other hand, there was no significant difference in sex role identity types by level of justice-oriented morality.

• 대한가정학회지
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• 제39권12호
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• pp.225-238
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• 2001

This study investigated the relationships of care-oriented morality and justice-oriented morality to gender and sex role identity in young adults. The subjects of this study were 42 males and 46 females, the age of 30 to 39 years old. Care-oriented morality was assessed by the Ethic of Care Interview(ECI) and justice-oriented morality was assessed by the Korean Defining Issues Test(DIT) while sex role identity was assessed by the Korean Sex Role Inventory(KSRI). Care-oriented morality of most of the subjects was on level 2. The P(%) score of justice-oriented morality of most of the subjects was found to be pretty high. Sex differences were found both in the levels of care-oriented morality and justice-oriented morality. That is, women were higherthan men both in care-oriented morality and justice-oriented morality. However, no significant difference in sex role identity types was found both in the levels of care-oriented morality and justice-oriented morality.

• 한국심리학회지 : 문화 및 사회문제
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• 제26권4호
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• pp.351-378
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• 2020

본 연구는 성별 간 갈등이 가장 극심하게 나타나는 성인초기 남녀의 성차별 메타-인식 양상을 탐색하기 위해 '여성의 남성을 향한 양가성에 대한 인식'과 '남성의 양가적 성차별에 대한 인식', '한국 사회의 성차별 실태'에 대한 지각을 측정하여 잠재프로파일 분석을 실시하고, 각 유형에 따른 성역할갈등, 이성과의 거리감, 성차별 논쟁에 대한 지지도의 차이를 살펴보았다. 이를 위하여 만 18세 이상 39세 이하 남녀 330명을 대상으로 자료를 수집하였고, SPSS 20.0과 Mplus 7.4 프로그램을 사용하여 자료를 분석하였다. 그 결과, 여성은 '성차별 둔감형 여성', '성차별 민감형 여성', '성차별 저항형 여성' 총 3가지 유형, 남성은 '성평등 인식형 남성', '역차별 인식형 남성' 총 2가지 유형이 도출되었다. 여성들은 성차별 메타-인식이 높은 유형일수록 성차별에 대한 지각과 성차별 논쟁에 대한 지지도가 높아진 반면, 남성들은 성차별 메타-인식이 높은 유형일수록 역차별에 대한 지각이 높아졌다. 남녀 모두 성차별 메타-인식 수준이 높은 유형일수록 더 높은 성역할갈등과 이성과의 거리감을 나타내었다. 이러한 결과를 토대로 현 한국 사회의 성별 갈등 현상에 대한 시사점과 본 연구의 제한점, 후속 연구를 위한 제언을 논의하였다.

• Toxicological Research
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• 제33권4호
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• pp.315-323
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• 2017

Preconceptual sex selection is still a highly debatable process whereby X- and Y-chromosome-bearing spermatozoa are isolated prior to fertilization of the oocyte. Although various separation techniques are available, none can guarantee 100% accuracy. The aim of this study was to separate X- and Y-chromosome-bearing spermatozoa using methods based on the viability difference between the X- and Y-chromosome-bearing spermatozoa. A total of 18 experimental semen samples were used, written consent was obtained from all donors and results were analysed in a blinded fashion. Spermatozoa were exposed to different pH values (5.5, 6.5, 7.5, 8.5, and 9.5), increased temperatures ($37^{\circ}C$, $41^{\circ}C$, and $45^{\circ}C$) and ROS level ($50{\mu}M$, $750{\mu}M$, and $1,000{\mu}M$). The live and dead cell separation was done through a modified swim-up technique. Changes in the sex-chromosome ratio of samples were established by double-label fluorescent in situ hybridization (FISH) before and after processing. The results indicated successful enrichment of X-chromosome-bearing spermatozoa upon incubation in acidic media, increased temperatures, and elevated $H_2O_2$. This study demonstrated the potential role for exploring the physiological differences between X-and Y-chromosome-bearing spermatozoa in the development of preconceptual gender selection.