• Toxicological Research
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• 제14권3호
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• pp.321-328
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• 1998

This study was performed to evaluate the effect of liver damage on toluene metabolism in rats pretreated with carbon tetachloride. Liver damage in rats was induced by administration of 0.1ml of carbon tetrachloride per 100g of body wight intraperitoneally every day for four weeks except the last day before sacrifice. One day before sacrifice, toluene was administered to the animals instead of carbon tetrachloride. Rats were sacrificed at the 1st, the 2nd, the 3rd and the 4th week after the first administration of carbon tetachloride. Based on the histopathological findings, liver weight and serum alanine aminotransferase, the $CCl_4$-preteated group was found to have gradual severe liver damage. Especially the degree of liver injury became increasingly severe throughout the whole course of the experiment. The contnts of hippuric acid in urine lower in the all groups pretreated with $CCl_4$than that of the control. The contents of hepatic cytochrome P450(CYP), benzylalcohol dehydrogenase and benzaldehyde dehydrogenase activities were decreased in $CCl_4$-pretreated rats than those of the control. The $CCl_4$treated animals showed the gradual decreased activities of these enzyme as injection times elapsed. Km values of the benzylalcohol dehydrogenase in pooled liver samples from $CCl_4$-pretreated or control groups were similar. On the other hand, Vmax values of the $CCl_4$-pretreated group was lower than of the control. Therefore, it can be concluded that reduction of the toluene metabolism in damaged rat liver induced with $CCl_4$was due to the inhibition of CYP content, bezylalcohol and benzaldehyde dehydrogenase activities which related with toluene metabolic enzyme system.

• Journal of Yeungnam Medical Science
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• 제12권1호
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• pp.75-83
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• 1995

광선치료는 신생아 황달의 효과적인 치료방법이나 광선에 의한 망막손상을 예방하기 위해 양안에 적절한 차폐를 실시하여야 한다. 광선치료후 급성기의 망막 손상정도와 차폐의 역할을 조사하기 위하여, 저자들은 토끼를 이용하여 광선치료시간, 조사방법, 차폐 유무 등을 변화 시키면서 광선치료를 실시하고 즉시, 간접검안경을 이용한 안저검사와 전자현미경 검사를 실시하여 광선치료후 수시간에서 수일후에 검사한 보고들과 비교 하였다. 모든 실험 토끼에서 안저검사상 정상소견을 나타 내었으나, 전자 현미경 검사상 12시간 이상 조사한 모든 실험군에서 광수용체 부종 및 망막내층의 부종 및 팽윤이 있었으나 광선치료후 수일이 경과한 후 검사하였던 경우에서 볼 수 있었던 광수용체 배열의 변화, 광수용체 내외절의 파괴, microvilli의 확장및 유착 등의 소견은 볼 수 없었고, 노출시간이 증가 할수록 손상의 정도가 심해졌으며, 광선 조사량이 같은 경우 간헐적인 방법으로 조사를 실시한 경우에서 망막손상이 심한 것으로 나타났다. 산동시킨 경우에서, 손상의 정도는 산동시키지 않은 경우와 비슷 하였으나 손상의 범위가 더 넓게 관찰 되었으며 차폐를 실시한 경우 망막손상을 예방할 수 있었다.

• Steel and Composite Structures
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• 제45권3호
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• pp.389-408
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• 2022

Residual capacity is defined as the load carrying capacity of an RC column after undergoing severe damage. Evaluation of residual capacity of RC columns is necessary to avoid damage initiation in RC structures. The central aspect of the current research is to propose an empirical formula to estimate the residual capacity of RC columns after undergoing severe damage. This formula facilitates decision making of whether a replacement or a repair of the damaged column is adequate for further use. Available literature mainly focused on the simulation of explosion loads by using simplified pressure time histories to develop residual capacity of RC columns and rarely simulated the actual explosive. Therefore, there is a gap in the literature concerning general relation between blast damage of columns with different explosive loading conditions for a reliable and quick evaluation of column behavior subjected to blast loading. In this paper, the Arbitrary Lagrangian Eulerian (ALE) technique is implemented to simulate high fidelity blast pressure propagations. LS-DYNA software is utilized to solve the finite element (FE) model. The FE model is validated against the practical blast tests, and outcomes are in good agreement with test results. Multivariate linear regression (MLR) method is utilized to derive an analytical formula. The analytical formula predicts the residual capacity of RC columns as functions of structural element parameters. Based on intensive numerical simulation data, it is found that column depth, longitudinal reinforcement ratio, concrete strength and column width have significant effects on the residual axial load carrying capacity of reinforced concrete column under blast loads. Increasing column depth and longitudinal reinforcement ratio that provides better confinement to concrete are very effective in the residual capacity of RC column subjected to blast loads. Data obtained with this study can broaden the knowledge of structural response to blast and improve FE models to simulate the blast performance of concrete structures.

• 의료법학
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• 제11권1호
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• pp.91-116
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• 2010

As Complex Regional Pain Syndrome (CRPS) is a new and rare illness, medical cause for it has not yet been clearly found out. Nevertheless, the patients continue to file lawsuits for damage compensation against wrongdoers or their insurers, claiming that the cause of the illness is certain actions of the wrongdoers. Moreover, the claim amount reaches to hundreds of millions of won through billions of won unlike other illnesses. Therefore, CRPS has become an important legal issue in the damage compensation lawsuit. Even though the wound is slight, the development and result may be serious in the case of CRPS. As a result, a sharp conflict arises even regarding medical diagnosis of CRPS in the lawsuit. And, even if the medical diagnosis of CRPS is admitted, severe debates occurs with regard to many issues, which include the causation between accident and CRPS in connection with establishment of damage compensation liability and scope of liability like anamnesis, determination standard of aftereffect disability, and scope of admitted aftereffect medical expense in connection with scope of damage compensation. In this study, I will review fundamental medical research on CRPS up to now and discuss principal legal issues in the damage compensation lawsuit focusing on lower court rulings.

• Earthquakes and Structures
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• 제9권1호
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• pp.1-27
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• 2015

In this paper Fragility Curves (FCs) relevant to existing RC framed building types representative of the Italian building population designed only to vertical load and regular in-plan have been derived from an extensive campaign of non-linear dynamic analyses. In the generation of the FCs, damage states according to the EMS98 scale have been considered while the intensity measure has been defined by adopting an integral parameter, such as the Housner intensity. FCs have been generated by varying different parameters, including building age, number of storeys, presence and position of infill panels, plan dimensions, external beams stiffness and concrete strength. In order to verify the effectiveness of the damage prediction, comparisons were made between the results obtained from the proposed FCs with those deriving from both prominent fragility studies available in the technical literature and damage distributions observed in past earthquakes. Results show that damage grades obtained by adopting the proposed FCs are generally lower than those provided by the other approaches considered. A comparison with real damage data, shows that the proposed FCs generally estimate more severe damage distributions than those observed in past earthquakes, although they give lower differences with respect to the other approaches.

• Computers and Concrete
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• 제19권3호
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• pp.315-323
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• 2017

Within the context of continuum mechanics, inelastic behaviours of constitutive responses are usually modelled by using phenomenological approaches. Elasto-plastic damage modelling is extensively used for concrete material in the case of progressive strength and stiffness deterioration. In this paper, a review of the main features of elasto-plastic damage modelling is presented for uniaxial stress-strain relationship. It has been reported in literature that the influence of Alkali-Silica Reaction (ASR) can lead to severe degradations in the modulus of elasticity and compression strength of the concrete material. In order to incorporate the effects of ASR related degradation, in this paper the constitutive model of concrete is based on the coupled damage-plasticity approach where degradation in concrete properties can be captured by adjusting the yield and damage criteria as well as the hardening moduli related parameters within the model. These parameters are adjusted according to results of concrete behaviour from the literature. The effect of ASR on the dynamic behaviour of a beam and a column are illustrated under moving load and cyclic load cases.

• Mycobiology
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• 제31권3호
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• pp.139-144
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• 2003

This study was conducted to investigate physiological characteristics of Trichoderma spp. isolated from Pleurotus spp. Damage tests of Pleurotus spp. and mycotoxins tests of Trichoderma spp. were also done. The optimal growth temperature of Trichoderma spp. was $27{\sim}30^{\circ}C$. Although, T. longibrachiatum was able to grow at $37^{\circ}C$ and grew $30{\sim}40$ times faster than Pleurotus. The colony colour on PDA medium of T. cf. virens was yellowish green, T. longibrachiatum was yellow, and T. harzianum was turning to bright green. In damage tests of Pleurotus by Trichoderma, T. cf. virens caused the most severe damage to Pleurotus. T. longibrachiatum and T. harzianum caused less damage on Pleurotus but were able to cause greater damage to P. eryngii. One of the mushroom cultivars, P. ostreatus 8 was the most resistant to all Trichoderma spp.. Chitinolytic mycotoxin released by Trichoderma spp. caused 52.7% damage to Pleurotus. Mycotoxins released by T. longibrachiatum caused the greatest damaged(78.6%) on P. eryngii.

• 한국측량학회지
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• 제37권5호
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• pp.351-357
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• 2019

UAV (Unmanned Aerial Vehicle) images can be exploited for rapid forest fire damage assessment by virtue of UAV systems' advantages. In 2019, catastrophic forest fire occurred in Goseong and Sokcho, Korea and burned 1,757 hectares of forests. We visited the town in Goseong where suffered the most severe damage and conducted UAV flights for forest fire damage assessment. In this study, economic and rapid damage assessment method for forest fire has been proposed using UAV systems equipped with only a RGB sensor. First, forest masking was performed using automatic elevation thresholding to extract forest area. Then ExG (Excess Green) vegetation index which can be calculated without near-infrared band was adopted to extract damaged forests. In addition, entropy filtering was applied to ExG for better differentiation between damaged and non-damaged forest. We could confirm that the proposed forest masking can screen out non-forest land covers such as bare soil, agriculture lands, and artificial objects. In addition, entropy filtering enhanced the ExG homogeneity difference between damaged and non-damaged forests. The automatically detected damaged forests of the proposed method showed high accuracy of 87%.

• 한국지반신소재학회논문집
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• 제17권4호
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• pp.103-108
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• 2018

본 연구에서는 지반진동 강도에 따른 콘크리트 표면차수벽 석괴댐(CFRD)의 확률론적 피해예측을 위하여 취약도 함수를 개발하였다. 댐의 손상평가에 널리 사용되는 지표인 댐마루 침하량을 손상지수로 사용하여 경미(Minor), 중간(Moderate), 심각(Severe) 손상수준을 정의하였다. 침하량은 댐 표준단면에 대한 비선형 동적 수치해석을 통하여 계산하였다. 수치해석 모델은 원심모형시험결과와 비교하여 정확성을 검증하였다. 취약도 곡선은 대수정규분포함수로 나타내어 최대지반가속도를 기준으로 도출하였다. 본 연구에서 도출된 취약도 곡선은 댐의 실시간 피해예측에 활용될 수 있을 것으로 판단된다.

• Steel and Composite Structures
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• 제45권2호
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• pp.231-248
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• 2022

Hybrid Steel-Trussed Concrete Beam (HSTCB) is structural typology suitable for light industrialization. HSTCBs usually cover long span with small depths, which lead to significant amount of longitudinal rebars. The latter make beam-column joints more prone to damage due to earthquake-induced cyclic actions. This phenomenon can be avoided using friction-based BCCs. Friction devices at Beam-to-Column Connections (BCCs) have become promising solutions to reduce the damage experienced by structural members during severe earthquakes. Few solutions have been developed for cast-in-place Reinforced Concrete (RC) and steel-concrete composite Moment Resisting Frames (MRFs), because of the difficulty of designing cost-effective damage-proof connections. This paper proposes a friction-based BCC for RC MRFs made with HSTCBs. Firstly, the proposed connection is described, and its innovative characteristics are emphasized. Secondly, the design method of the connection is outlined. A detailed 3D FE model representative of a beam-column joint fitted with the proposed connection is developed. Several monotonic and cyclic analyses are performed, investigating different design moment values. Lastly, the numerical results are discussed, which demonstrate the efficiency of the proposed solution in preventing damage to RC members, and in ensuring satisfactory dissipative capacity.