• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.55-55
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• 2023

With the COVID-19 pandemic, there is increasing interest in anti-obesity strategies. According to the National Statistical Office, the obesity rate in Korea was 38.3% in 2020 and 37.1% in 2021. Obesity is a risk factor for several severe diseases, including stroke, heart disease, type 2 diabetes, and certain types of cancer. Pinus rigida × Pinus taeda is a hybrid of Pinus rigida Mill and Pinus taeda Linn, and its cones are considered a by-product. Although previous studies have investigated their pharmacological effects on antioxidant activity and protection against oxidative DNA damage, few researchers have explored their potential as functional natural materials. Therefore, we evaluated the anti-obesity effects of the cone of ethyl acetate fraction of P. rigida × P. taeda (ERT), specifically its ability to inhibit lipid accumulation. Our analysis showed that ERT contains phytochemicals (catechin and caffeic acid) which are known to improve immune function and inhibit cell damage. ERT inhibited lipid droplet accumulation at the cellular levels through Oil Red O staining. Furthermore, ERT suppressed the expression of adipogenic transcription factors (PPARγ and CEBP/α) as well as downstream lipogenic target genes (FAS and SREBP-1) thereby inhibiting adipogenesis. ERT also down-regulated key adipogenic markers, including aP2α, while inducing the phosphorylation of AMPK. It has been reported that PPARγ and CEBP/α are expressed in the early stages of adipose differentiation, while SREBP-1 is expressed in the late stage. Therefore, our findings suggest that ERT activates AMPK signaling pathways, which inhibits adipogenic transcription factors (PPARγ, C/EBPα, and SREBP1) and lipogenic genes (FAS and aP2α), thereby blocking lipid accumulation and preventing obesity and related disorders. ERT showed potential as a new resource for developing a functional material for anti-obesity agents.

• 농촌의학ㆍ지역보건
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• 제31권2호
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• pp.177-185
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• 2006

2004년 5월부터 7월까지 광주광역시 일부지역 관내 28개 초등학교 31,510명(남자 16,653명, 여자 14,857명)의 신장과 체중의 자료를 수집하였다. 수집된 자료는 대한소아과학회(홍창희, 2003)에서 나온 소아발육표준치를 기준으로 신장별 표준 체중표를 이용하여 비만도(%)=(실측체중-신장별 표준체중)/신장별 표준체중*100로 산출하였다. 산출된 비만도는 20~29.9%는 경도비만, 30~49.9%는 중증도 비만, 50%이상은 고도비만으로 분류하여 SAS PC+ 8.0 program을 이용하여 분석한 결과는 다음과 같다. 1. 신장과 체중은 학년이 올라감에 따라 남학생과 여학생 모두 학년 간에 유의하게 향상하였다 (p<.001). 저학년에서는 여학생이 남학생 보다 신장이 작았으나 4학년때 키가 비슷해지고 5, 6학년에는 여학생이 남학생보다 신장이 큰것으로 나타났으며, 4학년을 제외한 모든 학년에서 남학생과 여학생의 신장은 통계적으로 유의한 차이가 있었다(p< .001). 모든 학년에서 남학생의 체중은 여학생의 체중보다 무거웠으며, 6학년을 제외하고는 남학생과 여학생의 체중은 통계적으로 유의한 차이가 있었다(p< .001). 2. 초등학교 학생의 비만율은 전체가 10.3%이었고, 남학생 (11.6%)이 여학생(8.8%)보다 비만율이 높았으며, 통계적으로 유의한 차이가 있었다(p< .001). 특히 4학년 남학생의 비만율이 13.7%로 가장 높았다. 비만아동의 분포는 남학생의 경우는 경도비만이 6.5%, 중등도비만 4.4%, 고도비만 0.7% 순이었고, 여학생의 경우는 경도비만 5.2%, 중등도비만 3.1%, 고도비만 0.4% 순으로 나타났다. 3. 비만도별 비만아동 실태는 전체 비만아동은 3,231명으로 경도비만이 57.4%, 중등도비만이 37.1%, 고도비만이 5.5%로 나타났다. 남학생의 경우는 경도비만 55.9%, 중등도비만 38.0%, 고도비만 6.0% 순이었고, 여학생의 경우는 경도비만 59.5%, 중등도비만 35.8%, 고도비만 4.7% 순으로 나타났다. 또한 비만도가 30% 이상인 중증도 이상의 비만아동은 여학생보다 남학생의 비율이 높았다. 4. 학년에 대한 성별 비만율은 1학년 (p< .05), 4-6학년 (p< .001)에서 남학생이 여학생보다 비만율 높았으며 이는 통계적으로 유의한 차이가 있었다. 5. 고학년 학생 (11.0%)의 비만율이 저학년학생(9.5%)보다 높았으며 이는 통계적으로 유의한 차이가 있었다(p< .001). 이상의 결과들을 종합하여 보면 초등학생의 비만율은 여학생보다 남학생에서, 저학년보다 고학년에서 더 높게 나타났다. 아동비만은 점차 증가하고 있고 질병의 이환과 밀접한 관계가 있으므로 비만을 예방하고 체계적으로 관리할 수 있는 프로그램을 개발 실시하되, 비만율이 높은 고학년의 남학생을 중점적으로 관리해야함을 시사한다.

• 대한불안의학회지
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• 제3권2호
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• pp.128-133
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• 2007

Objective : Obesity has been considered to be associated with numerous physical, mental and psychological diseases. Depression, which is a major psychological factor affecting occurrence and treatment of obesity, can be a cause of obesity as well as can be triggered by obesity. This study aimed to find out the need of positive consideration to the existence of depressive mood in the management of obesity. Methods : A total of 101 subjects were enrolled among those who were 60 years old and over at one local clinic. Obese group (n=49) was defined as BMI${\geqq}$25 and normal weight group (n=52) as 20$5.2{\pm}2.5$) was significantly higher than that of the normal weight group ($3.8{\pm}1.7$)(p<0.05). In male subjects, there was no significant difference in the mean GDSSF-K score between both groups, but in female subjects, the mean GDSSF-K score of the obese group, $6.4{\pm}2.6$ was significantly higher than that of the normal weight group ($4.0{\pm}1.8$)(p<0.05). Conclusion : The elderly obese group showed higher depressive scale score than elderly normal weight group, especially in female elderly. Since the elderly obese female group had a depressive predisposition, comprehensive management including mental and psychological approach is required in obesity control programs.

• 대한지역사회영양학회지
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• 제7권6호
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• pp.803-813
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• 2002

The purpose of this study was to investigate the anthropometric and blood biochemical characteristics, the dietary behaviors and health-related lifestyles of obese children in Incheon. A cross-sectional survey was conducted using anthropometric measurements, biochemical assessments and questionnaire analysis. The subjects included 7,055 obese children residing in the Incheon area (from 106 elementary schools). The degree of obesity was classified using the Obesity Index (OI) as light 20% ＜ OI ＜ 30% ; Medium 30% ＜ OI ＜ 50% ; Severe 50% ＞ OI. The statistical analysis was conducted using SPSS 10.0 program. Most subjects fell within the medium range of obesity. Most subjects had dietary problems such as overeating, unbalanced meals and skipping breakfast. The ratio of boy subjects eating green and yellow vegetables was lowe. when compared to that of the girl subjects. The boy subjects exercised more frequently and longer than the girls. As the Obesity Index increased, hypercholesterolemia significantly increased. The blood cholesterol levels of the subjects were positively correlated with body fat, waist/hip ratio and BMI; HDL cholesterol levels of the subjects were negatively correlated with the anthropometric data and the LDL cholesterol levels of the subjects were positively correlated with body fat. The blood triglycerides levels of the subjects were positively correlated with body weight, body fat, waist/hip ratio and BMI. Therefore, proper nutritional education and intervention are required for an improvement of obese children＇s dietary behavior, heath-related factors and blood lipid profiles.

• Clinical and Experimental Pediatrics
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• 제55권7호
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• pp.224-231
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• 2012

Prader-Willi syndrome (PWS) is a complex multisystem genetic disorder characterized by hypothalamic-pituitary dysfunction. The main clinical features include neonatal hypotonia, distinctive facial features, overall developmental delay, and poor growth in infancy, followed by overeating with severe obesity, short stature, and hypogonadism later in development. This paper reviews recent updates regarding the genetic aspects of this disorder. Three mechanisms (paternal deletion, maternal disomy, and deficient imprinting) are recognized. Maternal disomy can arise because of 4 possible mechanisms: trisomy rescue (TR), gamete complementation (GC), monosomy rescue (MR), and postfertilization mitotic nondisjunction (Mit). Recently, TR/GC caused by nondisjunction at maternal meiosis 1 has been identified increasingly, as a result of advanced maternal childbearing age in Korea. We verified that the d3 allele increases the responsiveness of the growth hormone (GH) receptor to endogenous GH. This paper also provides an overview of endocrine dysfunctions in children with PWS, including GH deficiency, obesity, sexual development, hypothyroidism, and adrenal insufficiency, as well as the effects of GH treatment. GH treatment coupled with a strictly controlled diet during early childhood may help to reduce obesity, improve neurodevelopment, and increase muscle mass. A more active approach to correct these hormone deficiencies would benefit patients with PWS.

• 통합자연과학논문집
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• 제4권4호
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• pp.332-338
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• 2011

This study was conducted to find associations of stress with obesity in female college students in Gwangju. 343 subjects were divided into two groups based on BMI(body mass index). BMI of normal group was $19.3{\pm}1.5$ while that of obese group was $26.4{\pm}3.6$. The measured stress level in obese subjects was higher and they were less capable of controlling obese oriented attitude compared to normal subject. Twenty four hour dietary recall revealed that nutrient intakes of obese subjects were higher in energy, lipid, P and cholesterol. However, they were more deficient in Ca, Fe and vitamin A, compared to those of normal ones. This study suggested severe stress might trigger undesirable dietary behavior leading to increase in food consumption which contribute to obesity. Effective nutrition education program targeting obese female students should be developed and implemented to relieve stress and practice desirable dietary behavior and eating pattern.

• Tuberculosis and Respiratory Diseases
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• 제53권5호
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• pp.561-568
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• 2002

비만성 자환기 증후군은 Pickwickian 증후군이라고도 불리우는 환기장애질환으로 폐쇄성 수면무호홉 증후군파 함께 비만과 관련된 대표적인 호흡기 질환이다. 비만환자가 급증하고 있는 현실로 보아 향후 임상에서 보다 자주 접하게 될 가능성이 많은 질환이지만 국내에는 현재까지 1예만이 보고되어 있다. 저자들은 과도한 주간 졸리움 등의 증상을 주소로 내원한 비만환자 3명에서 비만성 저환기 증후군을 진단하고 치료하였기에 문헌고찰과 함께 보고하는 바이다.

• 혜화의학회지
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• 제29권1호
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• pp.1-17
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• 2020

Objectives : The objectives of this study is to develop a mouse model similar to Taeeum-type by inducing Lung fibrosis with bleomycin, and to determine adequate concentration of bleomycin. Methods : The subjects were divided into six groups: normal, obesity induced group, and bleomycin administered 0.015U, 0.03U, 0.06U, and 0.09U(U/100g bw) concentrations respectively. Each concentration of bleomycin was dissolved in distilled water, and administered through Intra-Nazal-Trachea injection method. Food intake and body weight were measured at regular time weekly. At the end of the experiment, blood was gathered by cardiac puncture for biochemical examinations, organs were removed for histological examinations, and weigh and mRNA genes was analyzed. Result : Mice administered with bleomycin at 0.015U and 0.03U showed body and fat weight gain, and increased blood total cholesterol, LDL-cholesterol, glucose, and free fatty acid level. Fat related genes also showed higher level than the control group. Obesity was most strongly induced in the mice administered with 0.03U of bleomycin. On the other hand, when bleomycin was administered at concentrations above 0.06U, a model of obesity mouse was not created due to rapid emphysema inflammation and weakness. Conclusions : Mice were most vulnerable to obesity when bleomycin was administered at a concentration of 0.3 to cause liver damage. Bleomycin concentration over 0.06U did not cause obesity-induced mice, due to severe damage in liver.

• Pediatric Infection and Vaccine
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• 제29권2호
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• pp.77-83
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• 2022

소아청소년에서 코로나바이러스 감염증(coronavirus disease 2019, COVID-19)은 성인에 비해 증상이 심하지 않은 것으로 알려져 있다. 본 연구는 2021년 8월부터 11월 사이에 COVID-19으로 진단받은 후 고열과 호흡곤란이 동반되어 입원치료를 받았던 18세 미만의 소아청소년 환자 중 산소 공급에도 불구하고 지속적인 호흡곤란과 저산소증으로 항바이러스제인 remdesivir와 스테로이드(dexamethasone) 병합 치료를 시행한 환자를 대상으로 심한 폐렴의 위험인자를 알아보고자 후향적으로 의무 기록을 검토하였다. 소아청소년 8명이 심한 폐렴으로 산소치료, remdesivir와 스테로이드를 투여하였고, 남자 5명, 여자 3명이었다. 중간 나이는 16세(범위: 9-17세)였으며, 8명 중 6명의 체질량지수가 중간값이 30.5 kg/m² (범위: 29.4-38.5 kg/m²)였다. 모든 환자가 고열과 저산소증을 동반한 호흡곤란이 있었다. 흉부 단순 X-ray 검사에서 다양한 폐렴의 양상을 보였다. 7명은 remdesivir와 스테로이드 투여 후 1-2일 이내에 증상 호전되었다. 본 증례 연구에서는 심한 폐렴을 동반한 COVID-19 환자 8명 중 6명에서 비만이 있었다.

• Tuberculosis and Respiratory Diseases
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• 제87권2호
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• pp.176-184
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• 2024

Background: Results of studies investigating the association between body mass index (BMI) and mortality in patients with coronavirus disease-2019 (COVID-19) have been conflicting. Methods: This multicenter, retrospective observational study, conducted between January 2020 and August 2021, evaluated the impact of obesity on outcomes in patients with severe COVID-19 in a Korean national cohort. A total of 1,114 patients were enrolled from 22 tertiary referral hospitals or university-affiliated hospitals, of whom 1,099 were included in the analysis, excluding 15 with unavailable height and weight information. The effect(s) of BMI on patients with severe COVID-19 were analyzed. Results: According to the World Health Organization BMI classification, 59 patients were underweight, 541 were normal, 389 were overweight, and 110 were obese. The overall 28-day mortality rate was 15.3%, and there was no significant difference according to BMI. Univariate Cox analysis revealed that BMI was associated with 28-day mortality (hazard ratio, 0.96; p=0.045), but not in the multivariate analysis. Additionally, patients were divided into two groups based on BMI ≥25 kg/m² and underwent propensity score matching analysis, in which the two groups exhibited no significant difference in mortality at 28 days. The median (interquartile range) clinical frailty scale score at discharge was higher in nonobese patients (3 [3 to 5] vs. 4 [3 to 6], p<0.001). The proportion of frail patients at discharge was significantly higher in the nonobese group (28.1% vs. 46.8%, p<0.001). Conclusion: The obesity paradox was not evident in this cohort of patients with severe COVID-19. However, functional outcomes at discharge were better in the obese group.