• Geomechanics and Engineering
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• 제18권5호
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• pp.515-525
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• 2019

A karst collapse, as a natural hazard, is totally different to a normal collapse. In recent years, karst collapses have caused substantial economic losses and even threatened human safety. A risk assessment model for karst collapse was developed based on the fuzzy analytic hierarchy process (FAHP) and grey relational analysis (GRA), which is a simple and effective mathematical algorithm. An evaluation index played an important role in the process of completing the risk assessment model. In this study, the proposed model was applied to Jiaobai village in southwest China. First, the main controlling factors were summarized as an evaluation index of the model based on an investigation and statistical analysis of the natural formation law of karst collapse. Second, the FAHP was used to determine the relative weights and GRA was used to calculate the grey relational coefficient among the indices. Finally, the relational sequence of evaluation objects was established by calculating the grey weighted relational degree. According to the maximum relational rule, the greater the relational degree the better the relational degree with the hierarchy set. The results showed that the model accurately simulated the field condition. It is also demonstrated the contribution of various control factors to the process of karst collapse and the degree of collapse in the study area.

• 지능정보연구
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• 제26권2호
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• pp.43-56
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• 2020

추천 시스템은 사용자가 다양한 옵션 중에서 최선의 선택을 할 수 있도록 도와준다. 그러나 추천 시스템이 상업적으로 성공하기 위해서는 극복할 몇 개의 문제점이 존재한다. 첫째, 추천시스템의 투명성 부족 문제이다. 즉, 추천된 상품이 왜 추천되었는지 사용자들이 알 수 없다. 둘째, 추천시스템이 사용자 선호의 변화를 즉각적으로 반영할 수 없는 문제이다. 즉, 사용자의 상품에 대한 선호는 시간이 지남에 따라 변함에도 불구하고, 추천시스템이 사용자 선호를 반영하기 위해서는 다시 모델을 재구축해야 한다. 따라서 본연구에서는 이러한 문제를 해결하기 위해 토픽 모델링과 순차 연관 규칙을 이용한 추천 방법론을 제안하였다. 토픽 모델링은 사용자에게 아이템이 왜 추천되었는지 설명하는데 유용하며, 순차 연관 규칙은 변화하는 사용자의 선호를 파악하는데 유용하다. 본 연구에서 제안한 방법은 크게 토픽 모델링 및 사용자 프로파일 생성 등 토픽 모델링에 기반한 사용자 프로파일 생성 단계와 토픽에 사용자 선호 확인 및 순차 연관 규칙 발견 등 순차 연관 규칙에 기반한 추천 단계로 구분된다. 벤치마크 시스템으로 협업 필터링 기반 추천 시스템을 개발하고, 아마존의 리뷰 데이터 셋을 이용하여 제안한 방법론의 성능을 비교 평가하였다. 비교 분석 결과, 제안한 방법론이 협업 필터링 기반 추천시스템보다 뛰어난 성능을 보였다. 따라서 본 연구에서 제안하는 추천 방법을 통해 추천 시스템의 투명성을 확보할 수 있을 뿐만 아니라, 시간에 따라 변화하는 사용자의 선호를 반영할 수 있다. 그러나 본 연구는 토픽과 관련된 상품을 추천하기 때문에, 토픽에 포함된 상품의 수가 많을 경우 추천이 정교하지 못하는 한계점이 있다. 또한 토픽의 수가 적기 때문에 토픽에 대한 순차 연관 규칙이 너무 적은 문제점이 있다. 향후 연구에서 이러한 문제점을 해결한다면 좋은 연구가 될 것으로 판단된다.

• 대한기계학회논문집
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• 제18권3호
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• pp.768-776
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• 1994

This paper describes computer-aided forging design for rib/web shaped parts. In manufacturing a part by means of forging process, the first step is to design the forging. This is done by modifying the given machined part geometry according to the requirements of the forging process. Traditionally, this is done by experienced forging designers using empirical forging design guidelines. Generally, it would be neither possible nor practical to develop a system which encompasses the design of all types of forgings. Accordingly, forging design can be simplified by considering critical two dimensional cross sections of the machined part geometry. This system is composed of three modules(process variable decision module, forging design module and redesign module) and each module is carried out in regular sequence. In the process variable decision module, first of all, the undercut is checked and modified, and then deep recesses and holes difficult to forge are eliminated. Also parting line, forging plane, forging plan view area, forging weight and maximum size(maximum height or width)are determined. In the forging design module, the magnitude of various allowances, draft angle, minimum web thickness, corner and fillet radius are determined and then geometry modification is performed. Finally, since the design rules and databases used in this system are based on parameters of the forging geometry, such as the trimmed forging plan area, forging weight, forging maxmum size, plausible estimates need to be made for these parameters. Therefore, in the re-design module, the design process is iterated until a satisfactory forging is obtained.

• Genomics & Informatics
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• 제5권4호
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• pp.174-178
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• 2007

The earliest stages of mammalian embryogenesis are governed by the activity of maternally inherited transcripts and proteins. Cytoplasmic polyadenylation of selected maternal mRNA has been reported to be a major control mechanism of delayed translation during preimplantation embryogenesis in mice. The presence of cis-elements required for cytoplasmic polyadenylation (e.g., CPE) can serve as a useful tag in the screening of maternal genes partaking in key functions in the transcriptionally dormant egg and early embryo. However, due to its relative simplicity, UA-rich sequences satisfying the canonical rule of known CPE consensus sequences are often found in the 3'-UTR of maternal transcripts that do not actually undergo cytoplasmic polyadenylation. In this study, we developed a method to confirm the validity of candidate CPE sequences in a given gene by a multiplex comparison of 3'-UTR sequences between mammalian homologs. We found that genes undergoing cytoplasmic polyadenylation tend to create a conserved block around the CPE, while CPE-like sequences in the 3'-UTR of genes lacking cytoplasmic polyadenylation do not exhibit such conservation between species. Through this cross-species comparison, we also identified an alternative CPE in the 3'-UTR of tissue-type plasminogen activator (tPA), which is more likely to serve as a functional element. We suggest that verification of CPEs based on sequence conservation can provide a convenient tool for mass screening of factors governing the earliest processes of mammalian embryogenesis.

• Journal of Microbiology and Biotechnology
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• 제25권12호
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• pp.2082-2089
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• 2015

Avian beta-defensin 9 (AvBD9) is a small cationic peptide consisting of 41 amino acids that plays a crucial rule in innate immunity and acquired immunity in chickens. Owing to its wide antibacterial spectrum, lack of a residue, and failure to induce bacterial drug resistance, AvBD9 is expected to become a substitute for conventional antibiotics in the livestock and poultry industries. Using the preferred codon of Pichia pastoris, the mature AvBD9 peptide was designed and synthesized, based on the sequence from GenBank. The P. pastoris constitutive expression vector pGHKα was used to construct a pGHKα-AvBD9 recombinant plasmid. Restriction enzyme digestion was performed using SacI and BglII to remove the ampicillin resistance gene, and the plasmid was electrotransformed into P. pastoris GS115. High-expression strains with G418 resistance were screened, and the culture supernatant was analyzed by Tricine-SDS-PAGE and western blot assay to identify target bands of about 6 kDa. A concentrate of the supernatant containing AvBD9 was used for determination of antimicrobial activity. The supernatant concentrate was effective against Escherichia coli, Salmonella paratyphi, Salmonella pullorum, Pseudomonas aeruginosa, Enterococcus faecalis, and Enterobacter cloacae. The fermentation product of P. pastoris carrying the recombinant AvBD9 plasmid was adjusted to 1.0 × 10⁸ CFU/ml and added to the drinking water of white feather broilers at different concentrations. The daily average weight gain and immune organ indices in broilers older than 7 days were significantly improved by the AvBD9 treatment.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 A
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• pp.295-298
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• 2003

In this paper, a novel maximum a posterion (MAP) estimation for the channel decoding of H.264 codes in the presence of transmission error is presented. Arithmetic codes with a forbidden symbol and trellis search techniques are employed in order to estimate the best transmitted. And, there has been growing interest of communication, the research about transmission of exact data is increasing. Unlike the case of voice transmission, noise has a fatal effect on the image transmission. The reason is that video coding standards have used the variable length coding. So, only one bit error affects the all video data compressed before resynchronization. For reasons of that, channel needs the channel codec, which is robust to channel error. But, usual channel decoder corrects the error only by channel error probability. So, designing source codec and channel codec, Instead of separating them, it is tried to combine them jointly. And many researches used the information of source redundancy In received data. But, these methods do not match to the video coding standards, because video ceding standards use not only one symbol but also many symbols in same data sequence. In this thesis, We try to design combined source-channel codec that is compatible with video coding standards. This MAP decoder is proposed by adding semantic structure and semantic constraint of video coding standards to the method using redundancy of the MAP decoders proposed previously. Then, We get the better performance than usual channel coder's.

• 한국정보통신학회논문지
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• 제3권3호
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• pp.485-499
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• 1999

1989년 뉴질랜드에서 전파관리에 시장메커니즘이 도입된 이후 전세계적으로 동 방식에 대한 관심이 증대되고 있으며, 그 도입도 점차 확산되고 있다. 이러한 추세에 따라 한국에서도 전파관리에 시장메커니즘 도입에 관한 논의가 최근 들어 활발하게 이루어지고 있다. 이와 같은 배경 하에서 최근 정보통신부가 입법예고한 전파법 개정(안)에는 주파수에 재산권을 도입하고, 도입된 주파수 재산권을 경매방식을 통하여 배분하는 내용이 포함되어 있다. 경매는 자원의 가격결정과 배분이라는 두 가지 문제를 풀기 위해 적용될 수 있기 때문에 매력적인 시장방식의 메커니즘으로 인식되고 있다. 그럼에도 불구하고 경매방식의 유효성은 주파수 재산권 배분에서 당연한 것으로 받아들여져서는 안될 것이다. 경매가 잘 못 설계될 경우 당초에 의도하였던 것과는 달리 비효율적인 주파수 배분이 이루어 질 수도 있게 될 뿐만 아니라, 전파관리에 부정적인 영향을 줄 수 있기 때문이다. 본 논문에서는 주파수 재산권 경매방식 설계시 고려해야 할 핵심요소와 논점들을 기존의 경매이론과 주요국의 경험을 토대로 논의하였다.

• 산업경영시스템학회지
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• 제38권4호
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• pp.159-167
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• 2015

We consider a wafer lot transfer/release planning problem from semiconductor wafer fabrication facilities to probing facilities with the objective of minimizing the deviation of workload and total tardiness of customers' orders. Due to the complexity of the considered problem, we propose a two-level hierarchical production planning method for the lot transfer problem between two parallel facilities to obtain an executable production plan and schedule. In the higher level, the solution for the reduced mathematical model with Lagrangian relaxation method can be regarded as a coarse good lot transfer/release plan with daily time bucket, and discrete-event simulation is performed to obtain detailed lot processing schedules at the machines with a priority-rule-based scheduling method and the lot transfer/release plan is evaluated in the lower level. To evaluate the performance of the suggested planning method, we provide computational tests on the problems obtained from a set of real data and additional test scenarios in which the several levels of variations are added in the customers' demands. Results of computational tests showed that the proposed lot transfer/planning architecture generates executable plans within acceptable computational time in the real factories and the total tardiness of orders can be reduced more effectively by using more sophisticated lot transfer methods, such as considering the due date and ready times of lots associated the same order with the mathematical formulation. The proposed method may be implemented for the problem of job assignment in back-end process such as the assignment of chips to be tested from assembly facilities to final test facilities. Also, the proposed method can be improved by considering the sequence dependent setup in the probing facilities.

• 한국통신학회논문지
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• 제30권7C호
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• pp.675-686
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• 2005

본 논문에서는 효율적인 얼굴 영역 검출 기법을 제안하고 얼굴 객체 검출을 통해 인물 기반의 비디오 시스템을 제공한다. 비디오 분할을 위해 비디오 시퀀스로부터 장면 전환점을 검출하고 분할된 장면들로부터 대표 프레임을 선정한다. 대표 프레임은 인접 프레임 간 변화량이 가장 적은 프레임으로 선정하였으며 추출된 대표 프레임에 대해서 얼굴 영역 검출 알고리즘을 적용하여 등장인물을 포함하는 프레임들을 정보로 제공한다. 얼굴영역 검출을 위해 피부색의 통계적 특성을 이용한 Bayes 분류기를 이용한다. 피부색 검출 결과 영상으로부터 수직 및 수평 투영 기법을 이용하여 영상 분할을 수행하고 후보군들을 생성한다. 생성된 후보군 중 오검출 영역을 최소화하기 위해서 이진 분류 나무(CART)를 이용하여 분류기를 생성한다. 특징 값으로는 SGLD(spatial gray level dependence) 매트릭스로부터 Inertial, Inverse Difference, Correlation 등의 질감 정보를 이용하여 최적의 이진 분류 나무를 생성한다. 실험 결과 제안된 얼굴 영역 검출 알고리즘은 복잡하고 다양한 배경에서도 우수한 성능을 보였으며, 얼굴 객체를 포함하는 프레임들을 비디오 정보로 제공한다. 제안하는 시스템은 향후 화자 인식 기법을 이용하여 등장인물 기반의 비디오 분석 및 에 활용될 수 있을 것이다.

• Journal of Pharmaceutical Investigation
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• 제38권2호
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• pp.135-142
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• 2008

The present study describes the evaluation of the bioequivalence of two atorvastatin tablets, Lipitor $Tablet^{(R)}$ (Pfizer, reference drug) and Atorva $Tablet^{(R)}$ (Yuhan, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Forty-nine healthy male Korean volunteers received each medicine at the atorvastatin dose of 40 mg in a $2{\times}2$ crossover study with a two weeks washout interval. After drug administration, serial blood samples were collected at a specific time interval from 0-48 hours. The plasma atorvastatin concentrations were monitored by an high performance liquid chromatography -tandem mass spectrometer (LC-MS/MS) employing electrospray ionization technique and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.5 min and calibration curves were linear over the concentration range of 0.1-100 ng/mL for atorvastatin. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48hr) was calculated by the linear log trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were complied trom the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Atorva $Tablet^{(R)}$ / Lipitor $Tablet^{(R)}$ were ${\log}\;0.9413{\sim}{\log}\;1.0179$ and ${\log}\;0.831{\sim}{\log}\;1.0569$, respectively. These values were within the acceptable bioequivalence intervals of ${\log}\;0.8{\sim}{\log}\;1.25$. Based on these statistical considerations, it was concluded that the test drug, Atorva $Tablet^{(R)}$ was bioequivalent to the reference drug, Lipitor $Tablet^{(R)}$.