• Title/Summary/Keyword: Separation delay

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Estrogenic Activity, and Developmental Toxicity Studies of Pyrethroid Insecticides

  • Kim, Soon-Sun;Rhee, Gyu-Seek;Lee, Rhee-Da;Kwack, Seung-Jun;Lim, Kwon-Jo;Yhun, Hyo-Jung;Park, Kui-Lea
    • Proceedings of the Korea Society of Environmental Toocicology Conference
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    • 2003.10a
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    • pp.57-69
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    • 2003
  • It is well known that many pesticides possess hormonal activity, and affect the developments of wildlife and mammals including human. Currently, pyrethroid insecticides are in worldwide use to control in and outdoor pests, providing potential far environmental exposure. Hormonal activities of these pyrethroid insecticides, however, have been little studied, and the developmental effects of them were no reported. Therefore, we firstly examined the potential estrogenic activities of some pyrethroid insecticides (permethrin, cypermethrin, tetramethrin, deltamethrin, sumithrin, fenvalerate and bioallethrin) by immature rat uterotrophic assay, luciferase reporter gene assay and Calbindin-D$\sub$9k/ (CaBP-9k) gene expression assay. Uterine wet weights were increased by permethrin and the permethrin-induced weights were inhibited by ICI 182780 in the uterolrophic assay. On the other hand tetramethrin significantly reduced uterine and vaginal wet weights, and also inhibited the E2-induced weight increases at all doses tested. Cypermethrin and sumithrin had a tendency to increase uterine weights, although not statistically significant. Permethrin and cypermethrin dose-dependently increased the luciferase activity in reporter gene assay. Northern blot analysis showed that permethrin induced CaBP-9k mRNA expression whereas tetramethrin inhibted. Subsequent studies were conducted to investigate the possible developmental effects of four pyrethroid insecricides (permethrin, cypermethrin, sumithrin and teramethrin). Either diethlbestrol (DES) or 17${\beta}$ -estradiol (E2) was used as a reference control in this study. Pyrethroid insecticides were administered to Sprague Dawley rats via subcutaneous injection at 6 to 18 days of gestation or 1 to 5 days after birth. In utero treatment of permethrin (10mg/kg/day) in female rat resulted in significant increases in uterine and ovarian weights while significant decreases in serum E2 concentration, uterine and ovarian ER${\alpha}$ mRNA levels. Sumithrin and permethrin led to acceleration in vaginal opening of female rat, while delay in preputial separation of male after neonatal treatment. Anogenital distances of PND 18 were significantly reduced in sumthrin-treated, and permerhrin-treated male rats after neonatal treatment. All the pyrethroid insecticides tested caused significant increases in uterine weights on PND 18, while significant reductions in the first diestrus phase when neonataly treated. In addition, exposure to pyrethroids in neonatal period led to significant reduction in relative brain weight in female rat on PND 18, but its weight was recovered in diestrus phase. In summary, Our experimental data demonstrate the possibilities of developmental effects of pyrethroid insecticides via estrogenic or antiestrogenic activity.

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A Study on the Performance Analysis and synthesis for a Differentiated Service Networks (차등 서비스 네트워크에 대한 성능 분석과 합성에 대한 연구)

  • Jeon, Yong-Hui;Park, Su-Yeong
    • The KIPS Transactions:PartC
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    • v.9C no.1
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    • pp.123-134
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    • 2002
  • The requirement for QoS (Quality of Service) has become an important Issue as real-time or high bandwidth services are increasing, such as Internet Telephony, Internet broadcasting, and multimedia service etc. In order to guarantee the QoS of Internet application services, several approaches are being sought including IntServ (Integrated Service) DiffServ(Differentiated Srvices), and MPLS(Multi-Protocol Label Switching). In this paper, we describe the performance analysis of QoS guarantee mechanism using the DiffServ. To analyze how the DiffServ performance was affected by diverse input traffic models and the weight value in WFQ(Weighted Fair Queueing), we simulated and performed performance evaluation under a random, bursty, and self-similar input traffic models and for diverse input parameters. leased on the results of performance analysis, it was confirmed that significant difference exist in packet delay and loss depending on the input traffic models used. However, it was revealed that QoS guarantee is possible to the EF (expedited Forwarding) class and the service separation between RF and BE (Best Effort) classes may also be achieved. Next, we discussed the performance synthesis problem. (i. e. derived the conservation laws for a DiffServ networks, and analysed the performance variation and dynamic behavior based on the resource allocation (i.e., weight value) in WFQ.

Reviews on Post-synthetic Modification of Metal-Organic Frameworks Membranes (다결정 금속 유기 골격체 분리막의 후처리 성능 제어기술 개발 동향)

  • Hyuk Taek, Kwon;Kiwon, Eum
    • Membrane Journal
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    • v.32 no.6
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    • pp.367-382
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    • 2022
  • Numerous metal-organic frameworks (MOFs) produced by periodic combinations of organic ligands and metal ions or metal-oxo clusters have led the way for the creation of energy-efficient membrane-based separations that may serve as viable replacements for traditional thermal counterparts. Although tremendous progress has been made over the past decade in the synthesis of polycrystalline MOF membranes, only a small number of MOFs have been exploited in the relevant research. Intercrystalline defects, or nonselective diffusion routes in polycrystalline membranes, are likely the reason behind the delay. Postsynthetic modifications (PSMs) are newly emerging strategies for providing polycrystalline MOF membrane diversity by leveraging advanced membranes as a platform and improving their separation capabilities via physical and/or chemical treatments; therefore, neither designing and developing MOFs nor tailoring membrane synthesis techniques for focused MOFs is necessary. In this minireview, seven subclasses of PSM techniques that have recently been adapted to polycrystalline MOF membranes are outlined, along with obstacles and future directions.

Development of a Listener Position Adaptive Real-Time Sound Reproduction System (청취자 위치 적응 실시간 사운드 재생 시스템의 개발)

  • Lee, Ki-Seung;Lee, Seok-Pil
    • The Journal of the Acoustical Society of Korea
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    • v.29 no.7
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    • pp.458-467
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    • 2010
  • In this paper, a new audio reproduction system was developed in which the cross-talk signals would be reasonably cancelled at an arbitrary listener position. To adaptively remove the cross-talk signals according to the listener's position, a method of tracking the listener position was employed. This was achieved using the two microphones, where the listener direction was estimated using the time-delay between the two signals from the two microphones, respectively. Moreover, room reverberation effects were taken into consideration where linear prediction analysis was involved. To remove the cross-talk signals at the left-and right-ears, the paths between the sources and the ears were represented using the KEMAR head-related transfer functions (HRTFs) which were measured from the artificial dummy head. To evaluate the usefulness of the proposed listener tracking system, the performance of cross-talk cancellation was evaluated at the estimated listener positions. The performance was evaluated in terms of the channel separation ration (CSR), a -10 dB of CSR was experimentally achieved although the listener positions were more or less deviated. A real-time system was implemented using a floating-point digital signal processor (DSP). It was confirmed that the average errors of the listener direction was 5 degree and the subjects indicated that 80 % of the stimuli was perceived as the correct directions.

Real-Time Scheduling Scheme based on Reinforcement Learning Considering Minimizing Setup Cost (작업 준비비용 최소화를 고려한 강화학습 기반의 실시간 일정계획 수립기법)

  • Yoo, Woosik;Kim, Sungjae;Kim, Kwanho
    • The Journal of Society for e-Business Studies
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    • v.25 no.2
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    • pp.15-27
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    • 2020
  • This study starts with the idea that the process of creating a Gantt Chart for schedule planning is similar to Tetris game with only a straight line. In Tetris games, the X axis is M machines and the Y axis is time. It is assumed that all types of orders can be worked without separation in all machines, but if the types of orders are different, setup cost will be incurred without delay. In this study, the game described above was named Gantris and the game environment was implemented. The AI-scheduling table through in-depth reinforcement learning compares the real-time scheduling table with the human-made game schedule. In the comparative study, the learning environment was studied in single order list learning environment and random order list learning environment. The two systems to be compared in this study are four machines (Machine)-two types of system (4M2T) and ten machines-six types of system (10M6T). As a performance indicator of the generated schedule, a weighted sum of setup cost, makespan and idle time in processing 100 orders were scheduled. As a result of the comparative study, in 4M2T system, regardless of the learning environment, the learned system generated schedule plan with better performance index than the experimenter. In the case of 10M6T system, the AI system generated a schedule of better performance indicators than the experimenter in a single learning environment, but showed a bad performance index than the experimenter in random learning environment. However, in comparing the number of job changes, the learning system showed better results than those of the 4M2T and 10M6T, showing excellent scheduling performance.

The Design of Wireless Underwater Telephone -Analysis of Underwater Background Noise for Wireless Underwater Telephone Design - (수중 무선 전화기의 설계 - 수중무선전화기 설계를 위한 수중소음분석을 중심으로-)

  • 박문갑;윤갑동;김석제;윤종락
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.37 no.4
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    • pp.302-307
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    • 2001
  • The underwater background noise measured in Geoje and Tongyoung diving fishing ground from May to December, 2000 and analyzed to get optimum carrier frequency and transmitter power level for underwater wireless telephone design. The results obtained are summarized as follows: 1. At the Geoje and Tongyoung diving fishing ground, the lowest ambient noise band was 25~30kHz with 57dB and 52dB re 1$\mu$Pa, respectively. 2. At the Geoje and Tongyoung diving fishing ground, the lowest noise band during fishing activity was 67dB and 62dB re 1$\mu$Pa, respectively. 3. At the Geoje diving fishing ground, the noise of water jetter which is a digging machine for subbottom shells was 102dB re 1$\mu$Pa. 4. Considering the design parameters of underwater wireless telephone, it is found that the optimum carrier frequency band is around 30kHz and the transmitter source level should be at least 131dB re 1$\mu$Pa for 500m range telephone.

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