• Journal of Korean Society of Transportation
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• v.28 no.2
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• pp.45-52
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• 2010

The objective of this paper is to develop and apply a method that estimates the amount of traffic congestion (vehicle hours of delay) caused by traffic accidents that occur on freeways in Korea. A key feature of this research is the development of a method to separate the non- recurrent delay from any recurrent delay that is present on the road at the time and place of a reported accident. The main idea to separate these two delays is to use the speed difference between speed under accident condition and speed under normal flow condition. For the case study application, two datasets were combined to accomplish the objective of the study: (1) accident data and (2) traffic flow data. Eventually, the results can be useful for the performance evaluation of accident reduction program, for strategic plans to cope with congestion caused by traffic accidents, and for rectification of the estimation method for traffic congestion costs.

• Korean Journal of Acupuncture
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• v.22 no.1
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• pp.85-93
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• 2005

목적 : 본 연구는 봉독 약침액이 BV2 microglial cell에서 LPS로 유발된 염증반응에 대한 억제효과를 관찰하고자 하였다. 방법 : 봉독 약침액의 항염증작용을 관찰하기 위하여 BV2 microglial cell에 봉독약침액을 1시간전에 농도별$(0.1,\;1,\;100\;{\mu}g/ml)$로 전처치한 후 LPS $(5\;{\mu}g/ml)$로 24시간 동안 처리하여 RT-PCR, western blot, $PGE_2$, assay, NO synthesis assay등의 방법으로 관찰하였다. 결과 : LPS 염증유발에 의해서 BV2 microglial cell에서 COX-2 및 NOS 발현이 증가하였고, 이 러한 증가는 prostaglandin E2 및 NO 합성을 증가시켰다. 이에 반하여 봉독약침액으로 전처치한 군에서는 COX-2 및 NOS 발현을 억제시켜 결과적으로 prostaglandin 합성 및 NO 합성을 억제시킴을 확인할 수 있었다. 또한 LPS 염증유발에 의해서 활성화된 NF-kB의 발현을 억제 시켰다. 결론 : 봉독약침 액은 LPS 염증유발에 의해서 증가된 prostaglandin E2 및 NO 합성을 억제시킴으로써 여러 가지 염종질환의 치료에 유효한 효과가 있을 것으로 사려 된다.

• Molecules and Cells
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• v.23 no.3
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• pp.363-369
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• 2007

Mitochondria play a central role in energy-generating processes and may be involved in the regulation of channels and receptors. Here we investigated TRPM7, an ion channel and functional kinase, and its regulation by mitochondria. Proton ionophores such as CCCP elicited a rapid decrease in outward TRPM7 whole-cell currents but a slight increase in inward currents with pipette solutions containing no MgATP. With pipette solutions containing 3 mM MgATP, however, CCCP increased both outward and inward TRPM7 currents. This effect was reproducible and fully reversible, and repeated application of CCCP yielded similar decreases in current amplitude. Oligomycin, an inhibitor of $F_1/F_O$-ATP synthase, inhibited outward whole-cell currents but did not affect inward currents. The respiratory chain complex I inhibitor, rotenone, and complex III inhibitor, antimycin A, were without effect as were kaempferol, an activator of the mitochondrial $Ca^{2+}$ uniporter, and ruthenium red, an inhibitor of the mitochondrial $Ca^{2+}$ uniporter. These results suggest that the inner membrane potential (as regulated by proton ionophores) and the $F_1/F_O$-ATP synthase of mitochondria are important in regulating TRPM7 channels.

• Journal of the Korean Chemical Society
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• v.38 no.2
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• pp.160-168
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• 1994

Pentadentate Schiff base molybdenum(Ⅴ) complexes such as [Mo(Ⅴ)O(Sal-DET)(NCS)] and [Mo(Ⅴ)O(Sal-DPT)(NCS)] were synthesized by Sabat method. The structure of these complexes were identified by elemental analysis, spectroscopy, and thermogravimetric analysis(T.G.A.). It was found that the mole ratio of Schiff base ligand to the complexes was found to be 1 : 1. The redox processes of the complexes were investigated by cyclic voltammetric and differential pulse polarographic technique in nonaqueous solvent containing 0. 1 M tetraethyl ammonium perchlorate(TEAP) as supporting electrolyte at glassy carbon electrode. It was found that diffusion controlled reduction processes of four steps with one electron were 2Mo(Ⅴ)$\rightleftarrow^{e-}$ Mo(Ⅴ)Mo(Ⅳ) $\longrightarrow^{e-}$ 2Mo(Ⅳ), Mo(Ⅳ) $\longrightarrow^{e-}$ Mo(Ⅲ) $\longrightarrow^{e-}$ Mo(Ⅱ)

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.5.1-5.15
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• 2018

Targeting hair follicle regeneration has been investigated for the treatment of hair loss, and fundamental studies investigating stem cells and their niche have been described. However, knowledge of stem cell metabolism and the specific regulation of bioenergetics during the hair regeneration process is currently insufficient. Here, we report the hair regrowth-promoting effect of a newly synthesized novel small molecule, IM176OUT05 (IM), which activates stem cell metabolism. IM facilitated stemness induction and maintenance during an induced pluripotent stem cell generation process. IM treatment mildly inhibited mitochondrial oxidative phosphorylation and concurrently increased glycolysis, which accelerated stemness induction during the early phase of reprogramming. More importantly, the topical application of IM accelerated hair follicle regeneration by stimulating the progression of the hair follicle cycle to the anagen phase and increased the hair follicle number in mice. Furthermore, the stem cell population with a glycolytic metabotype appeared slightly earlier in the IM-treated mice. Stem cell and niche signaling involved in the hair regeneration process was also activated by the IM treatment during the early phase of hair follicle regeneration. Overall, these results show that the novel small molecule IM promotes tissue regeneration, specifically in hair regrowth, by restructuring the metabolic configuration of stem cells.

• Polymer(Korea)
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• v.34 no.4
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• pp.376-380
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• 2010

Donor-$\pi$-acceptor (D-$\pi$-A) type chromophore-based polymers were newly synthesized. These polymers exhibited absorption peak due to intramolecular charge transfer (ICT) in a visible range as well as absorption peak due to carbonyl group in both solution and film state by measuring UV visible spectra. The addition of $Eu^{3+}$ ion into the polymers induced red-shift in absorption due to ICT and the color changes from yellow to red in the solution and film were observed by naked eyes. The contents of crosslinking agent influenced the features and solubility of the polymers. In addition, the contents of crosslinking agent and the $Eu^{3+}$ ion addition improved film-forming ability.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.2
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• pp.68-78
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• 2011

Objective : The purpose of this clinical research was to investigate the effects of herbal cosmetics containing Momordica charntia L. extracts on the anti-wrinkle and whitening effects. Methods : A total of 25 subjects who visited Daegu Hanny Oriental Medical Center from November 1st, 2010 to December 31th, 2010 were included in this study. In this study, we observed change of R1, R2, R3, R4, R5 for using products, change of average melanin content and pigmental area, analysis results of subjective wrinkle improvement, Analysis results of subjective whitening improvement. Statistical analysis was performed by using paired t-test and wilcoxon signed ranks test. Statistical significance was achieved if the probability was less than 5%(p<0.05) Results : Statistically, herbal cosmetics containing Momordica charntia L. extracts showed siginificant effect on change of R1, R2, R3, R4, R5 for using products, change of average melanin content and pigmental area, analysis results of subjective wrinkle improvement, Analysis results of subjective whitening improvement(p<0.05). And satisfaction after using herbal cosmetics was near good. Conclusions : Considering the above results, we have concluded that herbal cosmetics containing Momordica charntia L. extracts have the remarkable effects on the anti-wrinkle and whitening effects.

• Journal of Korean society of Dental Hygiene
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• v.21 no.5
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• pp.491-498
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• 2021

Objectives: This study aimed to review the definition, qualification conditions, accreditation field, and system of Japanese recognized dental hygienists. It is expected that it will be used as basic data for the system introduction of the Korean advanced dental hygienists. Methods: From May to November 2020, a literature review was conducted on Japanese dental hygienists and Japanese certified dental hygienists. Results: The lifelong education system training courses to become Japanese certified dental hygienists consisted of basic training, special training, and specific training. Each training session lasted for 15 h, and the number of training hours required to complete the course was 30 h. The training items for the field of recognition A were prevention of lifestyle disease, home care, oral function management, rehabilitation for dysphagia, prevention of diabetes, and oral management by medical and dental partnership. The training items for the field of recognition B were dentistry for the disabled, dentistry for the aged, community oral health, and oral health care. Conclusions: The Japanese recognized that dental hygienist system is valuable as a demonstration model in introducing the Korean advanced dental hygienist system.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.4
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• pp.661-674
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• 2021

Edwardsiellosis is difficult to treat in cultured olive flounder, Paralichthys olivaceus. It is present in the fish for a long period during all growth stages, and it often leads to mass mortalites. In this paper, the clinical patterns of Edwardsiellosis were analyzed by dividing the data into the whole-water temperature, low-water temperature, low-high water temperature, high-water temperature, and high-low water temperature groups based on various clinical signs of diseased cultured olive flounder using a decision tree technique. In the clinical sign patterns in the decision trees analyzed in the experiment, clinical signs in the liver, such as liver nodules, liver hemorrhages, and liver degeneration, were selected as the criteria for determining Edwardsiellosis. The selected clinical signs were known as the major clinical signs of Edwardsiellosis, and through consultation with fishery disease experts, the analysis confirmed that the clinical signs of Edwardsiellosis were successfully found in this study.

• Journal of Korean society of Dental Hygiene
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• v.19 no.2
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• pp.207-219
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• 2019

Objectives: This study investigates the dental hygienist's main duties in clinical dental practice and examine whether dental hygienists can safely perform each duty by referring to the educational contents of dental hygiene departments and national examinations of dental hygienists. Methods: A questionnaire on the main duties of dental hygienists was administered to 477 clinical dental hygienists working at dental clinics and hospitals, general dental hospitals, and university dental hospitals in Seoul, Gyeonggi-do, and Incheon. We divide the dental hygienists' clinical dental hygiene practice and clinical dental assist and analyze the legal scope of practice, university educational contents, and national examination contents. Statistical analysis was performed through frequency analysis, and multi-frequency data were analyzed using Excel 2013. Results: All 48 items (except 2 items of 29 dental hygiene practice and 21 assist practice items) surveyed were covered in the National Examination for Dental Hygienists and included in the Dental Hygiene Education Learning Objective. The multi-frequency clinical dental practice of eight items of clinical dental hygiene practice and two assist practice items were within the legal scope of the dental hygienist's role. Conclusions: Further discussions are needed to redefine the legal scope of the role of the dental hygienist.