• 한국자기공명학회:학술대회논문집
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• 한국자기공명학회 2002년도 International Symposium on Magnetic Resonance
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• pp.21-25
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• 2002

We report a preliminary fMRI evidence of modulation of somatomotor areas by acupuncture in GB34 acupoint. GB34, located in the back of the knee, is known to be effective in recovering motor function after stroke. Using 3T MR scanner, functional MR imaging was performed in five normal volunteers in two stimulation paradigms; acupuncture manipulation on GB34 and sham points. Group analysis from five individuals showed that bilateral sensorimotor areas (BA 3,4,6 and 7) showed stimulation related BOLD signal contrast of approximately 6％ whereas very few areas were activated when sham stimulation is given. Our results suggest that acupuncture fMRI study can be safely conducted in 3T environment, and stimulation in GB34 modulate the cortical activities of the somatomotor area in human.

• 수면정신생리
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• 제28권2호
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• pp.43-52
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• 2021

Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a sleep disorder characterized by sensorimotor symptoms such as unpleasant sensations before sleep, akathisia, and periodic limb movements during sleep. It is also closely related to hyperarousal and is often accompanied by insomnia. Although the mechanism is not clear, the understanding of etiology and pathophysiology has greatly expanded through recent advances in genetic and neurobiological research. The most important pathophysiology of RLS/WED is brain iron deficiency. Such iron deficiency in the brain is caused by complex interactions between several genetic factors and various environmental factors, including comorbidities. Iron deficiency in the brain results in dysfunction of several neurotransmitters. A decrease in adenosine activity appears first, followed by an increase in the activity of glutamate and dopamine. A decrease in adenosine activity and an increase in glutamate activity stimulate the brain arousal system, resulting in hyperarousal. In addition, overproduction of dopamine and glutamate leads to dysfunction of the cortical-striatal-thalamic circuit, resulting in symptoms such as akathisia and periodic limb movements during sleep.

• Journal of Korean Neurosurgical Society
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• 제62권3호
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• pp.265-271
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• 2019

The expansion and folding of the cerebral cortex occur during brain development and are critical factors that influence cognitive ability and sensorimotor skills. The disruption of cortical growth and folding may cause neurological disorders, resulting in severe intellectual disability and intractable epilepsy in humans. Therefore, understanding the mechanism that regulates cortical growth and folding will be crucial in deciphering the key steps of brain development and finding new therapeutic targets for the congenital anomalies of the cerebral cortex. This review will start with a brief introduction describing the anatomy of the brain cortex, followed by a description of our understanding of the proliferation, differentiation, and migration of neural progenitors and important genes and molecules that are involved in these processes. Finally, various types of disorders that develop due to malformation of the cerebral cortex will be discussed.

• Journal of Medicine and Life Science
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• 제21권1호
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• pp.11-14
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• 2024

Excess of pyridoxine, in contrast to other nutrients, may result in neuropathy. Case reports are sparse, and little is known about the clinical and electrophysiological findings. Eight patients with pyridoxine-induced neuropathy were investigated, and a review of the literature was undertaken. Nerve conduction studies showed axonal sensory or sensorimotor polyneuropathy. And the blood levels of vitamin B6 were markedly elevated. After discontinuation of vitamin supplements, all patients showed no significant improvement in clinical and electrophysiological findings. Supplementation with pyridoxine at doses greater than 50 mg/day for extended durations may be harmful and should be discouraged.

• The Korean Journal of Physiology and Pharmacology
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• 제1권6호
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• pp.603-611
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• 1997

The motor evoked potentials (MEPs) have been advocated as a method of monitoring the integrity of spinal efferent pathways in various injury models of the central nervous system. However, there were many disputes about origin sites of MEPs generated by transcranial electrical stimulation. The purpose of present study was to investigate the effect of major extrapyramidal motor nuclei such as lateral vestibular nucleus (VN) and medullary reticular nucleus (mRTN) on any components of the MEPs in adult Sprague-Dalwey rats. MEPs were evoked by electrical stimulation of the right sensorimotor cortex through a stainless steel screw with 0.5mm in diameter, and recorded epidurally at T9 - T10 spinal cord levels by using a pair of teflon-coated stainless steel wire electrodes with 1mm exposed tip. In order to inject lidocaine and make a lesion, insulated long dental needle with noninsulated tips were placed stareotoxically in VN and mRTN. Lidocaine of $2{\sim}3\;{\mu}l$ was injected into either VN or mRTN. The normal MEPs were composed of typical four reproducible waves; P1, P2, P3, P4. The first wave (P1) was shown at a mean latency of 1.2 ms, corresponding to a conduction velocity of 67.5 m/sec. The latencies of MEPs were shortened and the amplitudes were increased as stimulus intensity was increased. The amplitudes of P1 and P2 were more decreased among 4 waves of MEPs after lidocaine microinjection into mRTN. Especially, the amplitude of P1 was decreased by 50% after lidocaine microinjection into bilateral mRTN. On the other hand, lidocaine microinjection into VN reduced the amplitudes of P3 and P4 than other MEP waves. However, the latencies of MEPs were not changed by lidocaine microinjection into either VN or mRTN. These results suggest that the vestibular and reticular nuclei contribute to partially different role in generation of MEPs elicited by transcranial electrical stimulation.

• 전자공학회논문지
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• 제51권5호
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• pp.197-206
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• 2014

운동심상(Motor imagery) 기반의 뇌-컴퓨터 인터페이스(Brain-computer Interface)는 주로 뇌전도(Electroencephalography, EEG)를 이용하여 사용자의 자발적인 운동 의지를 읽는 기술로 최근 주목받고 있다. 이 중에서도 피실험자의 운동 의지를 정확히 해석하기 위해 감각운동 영역(sensorimotor area)의 일부분에서 나타나는 ${\mu}$-대역(8-13Hz)의 전위 감소 현상인 event related desynchronization(ERD)을 분석하는 연구가 많이 진행되고 있다. 하지만 EEG는 공간 해상도가 낮고 사용자에 따라 ERD가 발생하는 주파수 대역이 다소 차이가 있어 추정에 어려움이 있다. 이에 대한 개선 방법의 하나로서 공간 필터를 구현하는 common spatial pattern (CSP)과 필터 뱅크(filter bank)를 결합한 형태인 discriminative filter bank common spatial pattern(DFBCSP)이 제안되었다. 그러나 DFBCSP는 EEG 신호의 평균 전력(power)의 Fisher ratio를 이용하여 사용자에 따른 효과적인 주파수 대역을 포함하는 discriminative filter bank(DFB)를 구성하여 분류 정확도를 향상시켰지만 ERD의 공간 패턴이 나타나는 적절한 필터를 선택하지 않는 경우가 발생한다. 이러한 문제를 해결하기 위해 본 논문에서는 EEG 신호의 평균전력 대신 CSP의 특성 벡터를 이용하여 DFB를 구성하는 방법을 제안한다. 기존의 방법과 제안한 방법의 필터 선택 결과와 분류 정확도 분석을 통해 CSP 특성 벡터가 DFB 구성에 더욱 효과적임을 보인다.

• Investigative Magnetic Resonance Imaging
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• 제4권1호
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• pp.52-57
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• 2000

목적: 기능적 자기공명영상을 이용하여 정신분열증 환자에서 운동자극에 의한 뇌 피질의 반응양상을 정상인과 비교하여 알아보고자 하였다. 대상 및 방법: 9 명의 오른손잡이 정신분열증 환자와 정신과학적으로 이상이 없는 6 명의 건강한 오른손잡이 자원자를 대조군으로 하였다. EPI 기법을 이용하여 한 절편 당 120 개의 연속영상 중 3 번의 휴식기와 활성화 시기를 반복하여 전체 4개의 절편에서 총 480개의 영상들을 얻었으며 오른손 운동을 운동자극으로 사용하였다. 영상 후 처리는 교차상관(cross correlation)을 이용하였고 운동자극 시에 우세 대뇌반구를 결정하기 위해 편측화 지수(lateralization index)를 측정하여 환자와 정상인 사이에서 비교하였다. 결과: 정상군에서는 오른손 운동자극시 좌측 감각운동중추에서 우측에 비해 월등히 많은 활성화를 나타내어 높은 펀측화 지수를 보인 반면 정신분열증 환자군의 경우는 좌측 감각운동중추의 활성화는 상대적으로 감소하고 동측인 우측의 활성화가 증가하여 정상군에 비해 낮은 편측화 지수를 나타냈다. 한 명의 환자에서는 우측 감각운동중추가 좌측에 비해 높은 활성화를 보이는 경우도 있었다(역편측화 reversed lateralization) 결론: 정상인에서 관찰되는 좌-우 감각운동피질의 기능적 비대칭성이 정신분열증환자에서는 다른 양상으로 관찰되었다. 이는 이 질환에서 뇌 피질내 운동회로의 기능적 이상이 있음을 반영하는 소견이며, 앞으로 기능적 자기공명영상이 이 질환의 진단과 연구에 많은 도움을 줄 것으로 생각한다.

• 대한핵의학회지
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• 제35권4호
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• pp.231-240
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• 2001

Purpose: Normal aging results in detectable changes in the brain structure and function. We evaluated the changes of regional cerebral glucose metabolism in the normal aging process with FDG PET. Materials and Methods: Brain PET images were obtained in 44 healthy volunteers (age range 20-69 'y'; M:F = 29:15) who had no history of neuropsychiatric disorders. On 6 representative transaxial images, ROIs were drawn in the cortical and subcortical areas. Regional FDG uptake was normalized using whole brain uptake to adjust for the injection dose and correct for nonspecific declines of glucose metabolism affecting all brain areas equally. Results: In the prefrontal, temporoparietal and primary sensorimotor cortex, the normalized FDG uptake (NFU) reached a peak in subjects in their 30s. The NFU in the prefrontal and primary sensorimotor cortex declined with age after 30s at a rate of 3.15%/decade and 1.93%/decade, respectively. However, the NFU in the temporoparietal cortex did not change significantly with age after 30s. The anterior (prefrontal) posterior (temporoparietal) gradient peaked in subjects in their 30s and declined with age thereafter at a rate of 2.35%/decade. The NFU in the caudate nucleus was decreased with age after 20s at a rate of 2.39%/decade. On the primary visual cortex, putamen, and thalamus, the NFU values did not change significantly throughout the ages covered. These patterns were not significantly different between right and left cerebral hemispheres. Of interest was that the NFU in the left cerebellar cortex was increased with age after 20s at a rate of 2.86%/decade. Conclusion: These data demonstrate regional variation of the age-related changes in the cerebral glucose metabolism, with the most prominent age-related decline of metabolism in the prefrontal cortex. The increase in the cerebellar metabolism with age might reflect a process of neuronal plasticity associated with aging.

• 재활치료과학
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• 제10권1호
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• pp.53-61
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• 2021

서론 : 구강운동촉진기술(OMFT)은 감각-운동, 운동 조절, 운동 학습의 이론적 배경을 바탕으로 한 치료기법으로 주요 목표는 구강 운동 기능 증진이다. OMFT에서는 구강 운동 기능의 개념적 위계 및 발달 단계는 5단계이며, 1) 감각-운동 단계, 2) 운동요소 통합 단계, 3) 구조적 움직임 단계, 4) 기능적 구강 운동 단계, 5) 통합적 구강 운동 단계로 구분하였다. 본론 : OMFT는 총 3개의 기법, 10개 범주, 50개 하위 항목으로 구성되어 있다. 자세히 살펴보면, 1) 준비 기법: 감각 인식 및 적응, 치료 적응과 목의 움직임을 통한 준비 과정으로 2범주, 12하위 항목, 2) 핵심기법: 얼굴, 입술, 볼, 잇몸, 혀, 턱 등의 구강 구조물에 치료사의 직접적인 자극을 통한 구강 운동 기술 촉진과 씹기 기능 증진을 목적으로 7개 범주, 30개 하위 항목, 3) 응용기법: 음식 섭취와 삼킬 때 도움을 줄 수 있는 치료적 접근법 1개 범주, 8개 하위 항목으로 구성된다. 결론 : 본 논문은 OMFT의 실제적 적용을 위한 구강 관련 구조물의 기능 증진을 목표로 하는 준비 기법과 핵심 기법 및 섭식을 포함한 구강 기능의 종합적인 접근을 고려한 응용 기법에 대하여 소개하는 것을 목적으로 한다.

• 대한감각통합치료학회지
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• 제1권1호
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• pp.61-72
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• 2003

The suck/swallow/breathe(SSB) synchrony, serving as the earlist primary motor mechanism, is the rhythmical, coordinated pattern of sucking, swallowing and breathing. The development of an intact SSB is an important precursor for further sensorimotor and cognitive development including speech and language development, state regulation, postural control, feeding, eye/hand coordination and social/emotional development. Arousal means a neurological mechanism for preparing one's body to orienting stimulus. Its levels are regulated with an interaction of the reticular formation, the limbic system, the hypothalamus and the autonomic nervous system. General strategies such as blowing, sucking, chewing, munching and licking to effectively modulate arousal state are related to SSB. The SSB synchrony is an important treatment principle for children with sensory integration disorder and problems with the modulation of arousal. The purpose of this article is to review concepts of SSB synchrony and the underlying relation between the modulation of arousal and SSB synchrony.