• Wind and Structures
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• 제7권6호
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• pp.405-420
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• 2004

In common approaches, bridge dynamics under wind action is analyzed by modeling the interaction between fluid and structure by means of transient wind loads acting over the structure itself. Amid various possible manners to describe such types of loads, a representation based on families of 'indicial functions' is adopted here. The aim is to investigate its flexibility to capture the main features of wind-bridge interaction. A set of coefficients is involved in indicial functions. The values that one may attribute to them suffer uncertainties coming from experimental errors affecting data. Here, the sensitivity of a 2-DOF schematic model to the variations of these coefficients is investigated at fixed values of dynamic derivatives and for various types of indicial functions. It is shown how parameter variations influence phase portraits.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2001년도 가을 학술발표회 논문집
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• pp.509-514
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• 2001

It is well known that many real systems have asymmetric mass, damping and stiffness matrices. In this case, the method for calculating eigenpair sensitivity is different from that of symmetric system. To determine the derivatives of the eigenpairs in asymmetric damped case, a modal method was recently developed by Adhikari. When a dynamic system has many degrees of freedom only a few lower modes are available, and because the higher modes should be truncated to use the modal method, the errors may become significant. In this paper a procedure for determining the sensitivities of the eigenpairs of asymmetric damped system using a few lowest set of modes is proposed. Numerical examples show that proposed method achieves better calculating efficiency and highly accurate results when a few modes are used.

• 대한화학회지
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• 제35권3호
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• pp.219-225
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• 1991

고도로 효율적인 분석방법인 모세관 전기영동 시스템을 최적의 감도를 갖는 상태의 기기로 국내에서 제작하였다. 50 ${\mu}m$ 내경을 가진 모세관을 완충용액으로 채워준 후 모세관의 양끝에 20∼35 kV의 전압을 걸어주는 이 분석방법은 20분 이내에 10 nl 이하의 소량의 시료를 이론단수가 20∼50만 정도가 되도록 분리할 수 있는 매우 좋은 분리능으 가지고 있다. 모세관 전기영동법의 분리능과 분리도를 증가시키는데 영향을 주는 요소들을 알아보기 위하여 catecholamine과 adenine 유도체를 분석하였다.

• Computational Structural Engineering : An International Journal
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• 제3권1호
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• pp.39-47
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• 2003

Generalized CMAC (GCMAC) is a type of neural network known to be fast in learning. The network may be useful in structural engineering applications such as the identification and the control of structures. The derivatives of a trained GCMAC is relatively poor in accuracy. Therefore to improve the accuracy, a new algorithm is proposed. If GCMAC is directly differentiated, the accuracy of the derivative is not satisfactory. This is due to the quantization of input space and the shape of basis function used. Using the periodicity of the predicted output by GCMAC, the derivative can be improved to the extent of having almost no error. Numerical examples are considered to show the accuracy of the proposed algorithm.

• 대한전자공학회논문지
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• 제27권7호
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• pp.997-1004
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• 1990

In this paper, a design method of a robust adaptive regulator with feedfoward path based on the explicit criterion minimization is proposed. The convergence speed of parameter estimation is improved by using the stochastic Newton minimization method in the criterion minimization algorithm, and sensitivity derivatives are used in the regulator calculation for improving the robustness of the control system. Trh proposed adaptive regulator is applied to the stable minimum-phase and nonminimum-phase system, the results are shown that control performance and disturbance compensation ability of the regulator are improved. And the choosing method of input penalty is proposed.

• Bulletin of the Korean Chemical Society
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• 제25권12호
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• pp.1764-1768
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• 2004

The present work reports on the investigations based on the interaction of sodium hydroxide with catechol derivatives. The first derivative spectra allowed the simultaneous determination of levodopa and carbidopa. The calibration graph was constructed from the first derivative signals by measuring $^1D$ at 350 nm for standard samples containing between 3 and 30 mg $L^{-1}$ of levodopa and at 305 nm for standard samples containing between 3 and 80 mg $L^{-1}$ of carbidopa. This method offers the advantages of simplicity, rapidity, selectivity and higher sensitivity than most of the existing spectophotometric methods.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2000년도 가을 학술발표회논문집
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• pp.115-124
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• 2000

An efficient multi-level (EML) optimization algorithm using discrete variables of framed structures is proposed in this paper. For the efficiency of the proposed algorithm multi-level optimization techniques using a decomposition method that separates both system-level and element-level are incorporated in the algorithm In the system-level, to save the numerical efforts an efficient reanalysis technique through approximated structural responses such as moments and frequencies with respect to intermediate variables is proposed in the paper. Sensitivity analysis of dynamic structural response is executed by automatic differentiation (AD) that is a powerful technique for computing complex or implicit derivatives accurately and efficiently with minimal human effort. In the element-level, to use AISC W-sections a section search algorithm is introduced. The efficiency and robustness of the EML algorithm, compared with a conventional multi-level (CML) algorithm and single-level genetic algorithm is successfully demonstrated in the numerical examples.

• Nonlinear Functional Analysis and Applications
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• 제29권2호
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• pp.597-620
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• 2024

In this study, the conformable fractional derivative(CFD) of order 𝝔 in conjunction with the LC operator of orderρ is used to develop the model of the transmission of the A(H1N1) influenza infection. A brand-new A(H1N1) influenza infection model is presented, with a population split into four different compartments. Fixed point theorems were used to prove the existence of the solutions and uniqueness of this model. The basic reproduction number R₀ was determined. The least and most sensitive variables that could alter R₀ were then determined using normalized forward sensitivity indices. Through numerical simulations carried out with the aid of the Adams-Moulton approach, the study also investigated the effects of numerous biological characteristics on the system. The findings demonstrated that if 𝝔 < 1 and ρ < 1 under the CFD, also the findings demonstrated that if 𝝔 = 1 and ρ = 1 under the CFD, the A(H1N1) influenza infection will not vanish.

• 대한화학회지
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• 제41권6호
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• pp.304-312
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• 1997

Acetolactate Synthase(ALS)는 가지를 가진 아미노산 valine, leucine, isoleucine의 생합성 과정에서 공통적으로 작용하는 효소이다. ALS는 서로 구조적 유사성이 없는 최근에 개발된 sulfonylurea, imidazolinone, 그리고 trizolopyrimidine계 제초제들의 공통적인 작용표적이다. 완두로부터 분리한 ALS를 이용하여 새로 합성한 4,6-dimethoxypyrimidine 유도체들의 저해활성을 측정하였다. 가장 우수한 저해활성을 나타내는 유도체는 K11570으로 $IC_{50}$값이 0.2 ${\mu}M$이다. 완두의 ALS에 대한 K11570의 저해활성은 incubation 시간이 증가함에 따라 증가하였으며, 기질 pyruvate에 대해 혼합형 저해유형을 보여주었다. K11570와 sulfonylurea Ally, 그리고 feedback 저해제 leucine에 대한 dual inhibition 실험결과 이들 저해제의 결합부위가 최소한 부분적으로 겹치는 것으로 생각된다. Arg을 변형시킨 효소는 K11570, sulfonylurea Ally, 그리고 leucine의 저해 민감도의 변화가 관찰되었으나, Trp의 변형은 저해 민감도에 영향이 없었다.

• Biomolecules & Therapeutics
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• 제15권4호
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• pp.266-272
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• 2007

A rapid analytical method was developed to quantify very long-chain fatty acids (VLCFAs, C22:0, C24:0, C26:0) in human plasma with good sensitivity and specificity using tert-butyldimethylsilyl (TBDMS) derivatization and stable isotope GC-MS selective ion monitoring (GC-MS/SIM). Two-hundred and fifty ${\mu}L$ of plasma was fortified with deuterated stable isotope internal standards (d3-C22:0, d3-C24:0, d3-C26:0) and standard mixtures of chloroform and methanol, and then extracted with hexane and acetonitrile. To upper layer of liquid-liquid-extraction, N-(t-Butyldimethylsilyl)-N-methyltrifluoroacetamide was added and then heated to $60^{\circ}C$ for 30 min to produce the TBDMS derivatives. Derivatives of VLCFAs were analyzed by GC-MS/SIM. Calibration curves showed a linear relationship for the target compounds in the concentration range of $10^{-4}{\sim}2{\times}10^3\;{\mu}g/mL$ with the correlation coefficient ranging from 0.996 to 0.999. The limit of quantification for the plasma was $10^{-4}{\sim}2{\times}10^{-4}\;{\mu}g/mL$ (S/N=3). When applied to the plasma specimens of patients with peroxisomal disorder, X-linked adrenoleucodystropy (ALD, Mckusick 202370), the method clearly differentiated normal subjects from ALD patients. The C24:0/C22:0 and C26:0/C22:0 ratios were significantly elevated in the plasma of patients with X-linked ALD compared to normal subjects. The new developed method might be useful for a rapid and sensitive diagnosis of X-linked ALD and other peroxisomal disorders.