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http://dx.doi.org/10.5012/bkcs.2004.25.12.1764

Simultaneous Derivative Spectrophotometric Determination of Levodopa and Carbidopa in Pharmaceutical Preparations  

Madrakian, T. (Department of Chemistry, Faculty of Science, Bu-Ali Sina University)
Afkhami, A. (Department of Chemistry, Faculty of Science, Bu-Ali Sina University)
Borazjani, M. (Department of Chemistry, Faculty of Science, Bu-Ali Sina University)
Bahram, M. (Department of Chemistry, Faculty of Science, Bu-Ali Sina University)
Publication Information
Bulletin of the Korean Chemical Society / v.25, no.12, 2004 , pp. 1764-1768 More about this Journal
Abstract
The present work reports on the investigations based on the interaction of sodium hydroxide with catechol derivatives. The first derivative spectra allowed the simultaneous determination of levodopa and carbidopa. The calibration graph was constructed from the first derivative signals by measuring $^1D$ at 350 nm for standard samples containing between 3 and 30 mg $L^{-1}$ of levodopa and at 305 nm for standard samples containing between 3 and 80 mg $L^{-1}$ of carbidopa. This method offers the advantages of simplicity, rapidity, selectivity and higher sensitivity than most of the existing spectophotometric methods.
Keywords
Derivative spectrophotometry; Simultaneous determination; Levodopa; Carbidopa;
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1 Imai, K. J. Chromatogr. 1975, 105, 135.   DOI   ScienceOn
2 Sharma, C.; Mohanty, S.; Kumar, S.; Rao, N. G. Analyst 1996,121, 1963.   DOI
3 Li, J. G.; Lu, J. R. Fenxi. Huaxue 1997, 25, 314.
4 Michotte, Y.; Moors, M.; Deleu, D.; Herregodts, P.; Ebinger, G. J. Pharm. Biomed. Anal. 1987, 5, 659.   DOI   ScienceOn
5 Hasan, B. A.; Khalaf, K. D.; La Guardia, M. De Talanta 1995, 42,627.   DOI   ScienceOn
6 Aman, T.; Khan, I. U.; Aslam, N.; Ahmed, I. Anal. Lett. 1998, 31,1007.   DOI
7 Biryuk, I. A.; Petrenko, V. V.; Zorya, B. P. Farm. Zh. (Kiw) 1992,2, 57.
8 Nozaki, O.; Iwaeda, T.; Kato, Y. J. Biolumin. Chemilumin. 1996,11, 309.   DOI   ScienceOn
9 Ricebery, L. J.; Vanuis, H. V.; Levin, L. Anal. Biochem. 1974, 60,551.   DOI   ScienceOn
10 Sagar, A. K.; Smyth, M. R. J. Pharm. Biomed. Anal. 2000, 22,613.   DOI   ScienceOn
11 Bell, C. E.; Somerill, A. R. Biochemistry Sect. J. 1966, 98, C 1.
12 Gennaro, A. R. Remington's Pharmaceutical Sciences, 15th Ed.;Mach Publishing: Easton, PA, 1975; p 858.
13 Parsons, L. H.; Kerr, T. M.; Weiss, F. J. Chromatogr. B, Biomed.Appl. 1998, 709, 35.   DOI   ScienceOn
14 Murayama, K.; Santa, T.; Imai, K. Chromatography 1998, 19,207.
15 Coello, J.; Maspoch, S.; Villegas, N. Talanta 2000, 53, 627.   DOI   ScienceOn
16 Kozminski, K. D.; Gutman, D. A.; Davila, V.; Sulzer, D.; Ewing,A. G. Anal. Chem. 1998, 70, 3123.   DOI   ScienceOn
17 Mohamed, W. I.; Salem, F. B. Anal. Lett. 1984, 17, 191.   DOI   ScienceOn
18 Uslu, B.; Ozkan, S. A. Anal. Lett. 2002, 35, 303.   DOI   ScienceOn
19 Zhu, A. Z.; Liu, J.; Fu, C. G. Fenxl. Ceshi, Xuebao 1997, 16,47.
20 Hu, S.; Li, P. B.; Cheng, J. K. Fenxi. Shiyanshi 1996, 15, 1.
21 Lee, H. B.; Hong-you, R. L.; Fowlie, P. J. A. J. Assoc. Off. Anal.Chem. 1989, 72, 979.
22 Tsuchiya, H.; Sato, M.; Kato, H.; Okubo, T.; Juncja, L. R.; Kim,M. J. Chromatogr. B Biomed. Appl. 1997, 703, 253.   DOI   ScienceOn
23 Talebpour, Z.; Haghgoo, S.; Shamsipur, M. Anal. Chim. Acta2004, 506, 97.   DOI   ScienceOn
24 Clarke, E. G. C.; Moffat, A. C. Clarke's Isolation andIdentification of Drugs in Pharmaceuticals, Body Fluids, andPost-mortem Material, 2nd Ed.; Pharmaceutical Press: London,1986.