• BMB Reports
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• 제39권3호
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• pp.247-252
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• 2006

A rapid method for the detection of Hepatitis E Virus (HEV) was developed by utilizing nano-gold labeled oligonucleotide probes, silver stain enhancement and the microarray technique. The 5'-end -$NH_2$ modified oligonucleotide probes were immobilized on the surface of the chip base as the capture probe. The detection probe was made of the 3'-end -SH modified oligonucleotide probe and nano-gold colloid. The optimal concentrations of these two probes were determined. To test the detection sensitivity and specificity of this technique, a conservative fragment of the virus RNA was amplified by the RT-PCR/PCR one step amplification. The cDNA was hybridized with the capture probes and the detection probes on microarray. The detection signal was amplified by silver stain enhancement and could be identified by naked eyes. 100 fM of amplicon could be detected out on the microarray. As the results, preparation of nano-gold was improved and faster. Development time also was shortened to 2 min. Thus, considering high efficiency, low cost, good specificity and high sensitivity, this technique is alternative for the detection of HEV.

• 한국해양공학회지
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• 제34권4호
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• pp.253-262
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• 2020

This study provides a comparative analysis of experiments-based enhancements and sensitivity evaluations for the structural design of an automatic ocean salt collector under various load conditions. The sizing variables of the structural members were considered as design factors. The strength and weight performances were selected as output responses. The design of experiments used in the comparative study consisted of the orthogonal array design, Box-Behnken design, and central composite design. The response surface model, one of the metamodels, was applied to the approximate model generation. The design enhancement performance metrics, including numerical costs and weight minimization, according to the design of experiments, were compared from the best design case results. The central composite design method showed the most enhanced design results for the structural design of the automatic ocean salt collector.

• 대한전자공학회논문지SP
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• 제44권5호
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• pp.20-27
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• 2007

일반적으로 TFT-LCD영상은 휘도 분포가 불균일하며, 전체적으로 크게 변화하는 배경신호, 노이즈 신호, 그리고 결함 영역에서만 급격하게 변하는 결함 신호로 이루어져 있다. 본 논문에서는 HVS(human visual system)의 가장 큰 특징인 주파수에 따라 차이를 인지하는 정도가 다르다는 것을 나타내는 MTF(modulation transfer function)를 변형하여 TFT-LCD영상의 결함을 상대적으로 강조하는 알고리즘을 제안하였다. 이상적인 1차원 신호를 생성하여 제안한 방법의 유효성을 살펴보고 실제 TFT-LCD영상에 적용하여 제안한 알고리즘이 영상 결함 강조에 우수한 효과를 가짐을 확인하였다.

• Journal of the Optical Society of Korea
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• 제15권4호
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• pp.329-334
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• 2011

We proposed a poly-dimethylsiloxane (PDMS)-coated fiber Bragg grating (FBG) temperature sensor for enhancing temperature sensitivity. By embedding the bare FBG in a temperature-sensitive elastomeric polymer, the temperature sensitivity of the proposed structure could be effectively improved by 4.2 times higher than those of the conventional bare-type FBG sensors due to the high thermal expansion coefficient of the PDMS. We analyzed the temperature-sensitivity enhancement effect with the increased Bragg wavelength shift in our structure and dependence on the temperature sensitivity with respect to the cross-section area of the PDMS.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2000년도 International Symposium on Magnetics The 2000 Fall Conference
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• pp.187-188
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• 2000

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2017년도 춘계학술논문요약집
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• pp.413-414
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• 2017

• Korean Chemical Engineering Research
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• 제49권4호
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• pp.400-404
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• 2011

폴리다이아세틸렌(polydiacetylene: PDA)은 독특한 광학적 특성, 즉 외부자극에 의하여 파란색에서 빨간색으로 색상이 변화하는 동시에 형광이 없던 상태에서 자가형광을 발현하는 특성 때문에 화학, 바이오센서로써 응용하기 위한 많은 연구들이 진행되어 왔다. 특히, 센서의 성능에서 감지하고자 하는 물질에 대한 우수한 민감도는 매우 중요하다. 본 연구에서는 다양한 필터 사이즈를 이용하여 10,12-pentacosadynoic acid(PCDA) 베시클의 크기를 조절함과 동시에 중합온도를 조절하여 ${\alpha}$-사이클로텍스트린(CD)을 검출하여 두 가지 효과가 민감도 향상에 어떤 영향을 미치는지 조사하였다. 필터를 사용하지 않은 베시클과 0.22 ${\mu}m$로 필터한 베시클을 $25^{\circ}C$에서 고분자한 후에 ${\alpha}$-CD(5 mM)와 30분 반응하였을 때 색전이 정도(colorimetric response, CR)가 31.4%에서 74.0%로 증가하였다. 또한, 0.22 ${\mu}m$로 필터한 베시클을 $25^{\circ}C$와 $5^{\circ}C$에서 고분자한 후에 ${\alpha}$-CD(5 mM)와 30분 반응하였을 때 CR값이 74.0%에서 99.2%로 증가하였다. 이는 폴리다이아세틸렌의 크기와 고분자시 온도를 조절함으로써 민감도를 크게 증가시킬 수 있음을 보여준다. 또한, 폴리다이이아세틸렌은 감도 향상이 매우 중요한 바이오물질을 검출하는데 적용될 수 있을 것이다.

• 대한방사선기술학회지:방사선기술과학
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• 제6권1호
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• pp.43-67
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• 1983

In order to increase the sensitivity of the photographic emulsion, one of the chemical sensitizers hydroxymethane sulfonic acid sodium salt(HMS) was applied through the chemical ripening process and following four types of emulsion were prepared. Their grain sizes were determined through the electron microscope. The ranges of average grain sizes were $0.05-0.40{\mu}m$ for silver chlorobromide emulsion of low sensitivity $0.10-0.45{\mu}m$ for the silver chlorobromide emulsion of medium sensitivity, $0.60-1.05{\mu}m$ for the silver iodobromide emulsion of high sensitivity, and $0.90-1.55{\mu}m$ for the ammonical silver iodobromide emulsion of high sensitivity. Through the reduction sensitization with HMS, they showed significant sensitivity enhancement by the increment of HMS concentration above pH 5.5 and pBr 3.0. Required sensitivity was obtained above pH 6.2 and pBr 3.3 when sulfur and gold sensitization were applied. Fog formed along the reduction sensitization was successfully prevented by the addition of 5.5-dimethylhydantion.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 A
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• pp.196-198
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• 2003

The low load power factor causes various problems such as the increase of the power loss and the voltage instability. The demand of reactive power increases continuously with the growth of active power and the restructuring of electric power companies makes the integrated management of ractive power troublesome, from which the systematic control of load power factor is required. In this paper, the load power factor sensitivity of the generation cost is derived and its effects in supplying the reactive power and enhancing the load power factor are analyzed in a small-scale power system. The load power factor sensitivity of the generation cost is applied for determining the locations and capacities of reactive power compensation devices. It is shown that the generation cost can be reduced and the system power factor can be enhanced effectively using the load power factor sensitivity.

• KIEE International Transactions on Power Engineering
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• 제5A권3호
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• pp.252-259
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• 2005

Various problems such as increase of power loss and voltage instability may often occur in the case of low load power factor. The demand of reactive power increases continuously with the growth of active power and restructuring of electric power companies makes the comprehensive management of reactive power a troublesome problem, so that the systematic control of load power factor is required. In this paper, the load power factor sensitivity of generation cost is derived and it is used for effectively determining the locations of reactive power compensation devices and for enhancing the load power factor appropriately. In addition, voltage variation penalty cost is introduced and integrated costs including voltage variation penalty cost are used for determining the value of load power factor from the point of view of economic investment and voltage regulation. It is shown through application to a large-scale power system that the load power factor can be enhanced effectively using the load power factor sensitivity and the integrated cost.