• Clinical and Experimental Pediatrics
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• v.50 no.12
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• pp.1165-1172
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• 2007

Self/non-self discrimination and unresponsiveness to self is the fundamental properties of the immune system. Self-tolerance is a state in which the individual is incapable of developing an immune response to an individual's own antigens and it underlies the ability to remain tolerant of individual's own tissue components. Several mechanisms have been postulated to explain the tolerant state. They can be broadly classified into two groups: central tolerance and peripheral tolerance. Several mechanisms exist, some of which are shared between T cells and B cells. In central tolerance, the recognition of self-antigen by lymphocytes in bone marrow or thymus during development is required, resulting in receptor editing (revision), clonal deletion, anergy or generation of regulatory T cells. Not all self-reactive B or T cells are centrally purged from the repertoire. Additional mechanisms of peripheral tolerance are required, such as anergy, suppression, deletion or clonal ignorance. Tolerance is antigen specific. Generating and maintaining the self-tolerance for T cells and B cells are complex. Failure of self-tolerance results in immune responses against self-antigens. Such reactions are called autoimmunity and may give rise to autoimmune diseases. Development of autoimmune disease is affected by properties of the genes of the individual and the environment, both infectious and non-infectious. The host's genes affect its susceptibility to autoimmunity and the environmental factors promote the activation of self-reactive lymphocytes, developing the autoimmunity. The changes in participating antigens (epitope spreading), cells, cytokines or other inflammatory mediators contribute to the progress from initial activation to a chronic state of autoimmune diseases.

• Nuclear Engineering and Technology
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• v.51 no.3
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• pp.904-907
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• 2019

Nuclear energy remains one of the world's major energy sources, making up over 10% of global electricity generation in 2017. Public acceptance of nuclear energy is essential for its adoption. From a practical perspective, it is beneficial to have a simple indicator that can predict the actual adoption of nuclear energy. Based on practical experience, the authors suggest tolerance and self-sufficiency as potential indicators that may predict the adoption of nuclear energy. By evaluating the cross-sectional data of 18 countries in 2013, this research assesses the actual impact of tolerance and self-sufficiency on public acceptance in order to identify the validity of the two variables. The results indicate that the two variables are statistically significant, while public acceptance is insignificant in explaining national adoption of nuclear energy. This may be because tolerance reflects national willingness to accept potential risk, while self-sufficiency explains a government's likelihood of developing non-carbon energy sources.

• Proceedings of the Korean Association for Survey Research Conference
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• 2000.06a
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• pp.59-87
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• 2000

The hypothesis of this study is that change acceptance and work adaptation of change agents are influenced by positive self-image and risk tolerance. In order to examine the hypothesis, this study was performed with 305 change agents from six branches of a conglomerate company. Specifically, self-image was measured by locus of control, self-efficacy, self-esteem, and positive affectivity; risk tolerance was measured by tolerance for ambiguity, risk aversion, and openness to experience. The result of this study indicated that self-image and risk tolerance significantly predicted change acceptance and work adaptation. Especially, the results of structural model revealed that change acceptance mediated the relationship between characteristic variables (such as self image and risk tolerance in this study) and work adaptation. Based on the results, we suggest that change agents keep developing positive self-image and risk tolerance in order to play the key role in leading organizational change.

• Survey Research
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• v.1 no.2
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• pp.59-87
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• 2000

The hypothesis of this study is that change acceptance and work adaptation of change agents are influenced by positive self-image and risk tolerance. In order to examine the hypothesis, this study was performed with 305 change agents from six branches of a conglomerate company. Specifically, self-image was measured by locus of control, self-efficacy, self-esteem, and positive affectivity; risk tolerance was measured by tolerance for ambiguity, risk aversion, and openness to experience. The result of this study indicated that self-image and risk tolerance significantly predicted change acceptance and work adaptation. Especially, the results of structural model revealed that change acceptance mediated the relationship between characteristic variables (such as self image and risk tolerance in this study) and work adaptation. Based on the results, we suggest that change agents keep developing positive self-image and risk tolerance in order to play the key role in leading organizational change.

• The Journal of Korean Academic Society of Nursing Education
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• v.22 no.2
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• pp.171-181
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• 2016

Purpose: This study examined the effects of nursing professionalism, academic failure tolerance and social self-efficacy on college life satisfaction among nursing students. Methods: Data were collected between September 1 and October 16, 2015 via a self-reported questionnaire from 170 nursing students using convenient sampling methods. The survey included questions about nursing professionalism, academic failure tolerance, social self-efficacy, and college life satisfaction. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficient, and hierarchical multiple regression with IBM SPSS/WIN 20.0. Results: Establishment vision about nursing science (${\beta}=.27$, p=.006), academic failure tolerance (${\beta}=.17$, p=.031) and social self-efficacy (${\beta}=.19$, p=.012) of nursing students were identified as significant predictors of college life satisfaction, after adjusting for establishment vision about nursing science and satisfaction in nursing science. This model explained 21.0% of the college life satisfaction in nursing students (F=6.38, p<.001). Conclusion: These results suggest that academic failure tolerance and social self-efficacy were significant factors influencing the college life satisfaction of nursing students. Also, as a strategy for improving the college life satisfaction of nursing students, it is necessary to develop programs that can help to establish apparent vision and to improve satisfaction in nursing science.

• Journal of Engineering Education Research
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• v.18 no.5
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• pp.11-21
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• 2015

The purpose of this study was to examine the effects of goal contents on failure tolerance in engineers (i.e., students and experts in engineering). Based on the goal contents theory, which is a sub-theory of self-determination theory, three intrinsic goals (i.e., self-growth, help, social concern) and two extrinsic goals (i.e., money, fame) were under investigation. A total of 398 participants (118 undergraduate students, 181 graduate students, 99 experts) answered survey questions. In the hierarchical multiple regressions, self-growth goal was entered as the first model, then, to the second model, the other four goals were added. The results showed that social concern goal significantly predicted failure tolerance among all engineer groups. Self-growth goal was closely associated with failure tolerance in undergraduate students and graduate students. Help goal was significant only among graduate students. These results suggest that pursuing intrinsic goals, especially, social concern goal is important to increase failure tolerance. Establishing infrastructure and educational climate for pursuing social concern goal can facilitate the development of personal expertise in engineers as well as the improvement of society.

• Journal of the Korean Society of School Health
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• v.30 no.3
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• pp.295-305
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• 2017

Purpose: This study was conducted to evaluate the effect of Mindfulness-based Emotion Management Training for adolescents immersed in self-harm behaviors. Methods: The participants were 61 middle school students located in Seoul. Thirty students were assigned to the Mindfulness-based Emotion Management Training (M-EMT) group and the other 31 students were assigned to the waitlist group. The students in the M-EMT group participated in a total of 12 sessions, twice a week, for 6 weeks. The modules of the program comprised of mindfulness for emotion, mindfulness for behavior/impulse, mindfulness for thought, and coping with self-harming behavior. The Distress Tolerance Scale, Deliberate Self-Harm Inventory, Cognitive Emotion Regulation Questionnaire, and Scale Suicidal Ideation were assessed at baseline and post-intervention. Results: Compared to the waitlist group, the intervention group exhibited a statistically significant improvement in distress tolerance and cognitive emotion regulation and a statistically significant reduction in self-harming behaviors and suicidal ideation. Conclusion: These results support the hypothesis that mindfulness-based emotional management training has a positive effect on reducing self-harming behaviors and enhancing distress tolerance and cognitive emotional regulation.

• Journal of Korea Multimedia Society
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• v.22 no.3
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• pp.403-416
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• 2019

The purpose of this paper was to analyze multicultural elements and propose measures to strengthen them in the 2009and the 2015 school curriculum. Based on Kim Cheong-ha (2015), the multi-cultural guidance elements and Bennett (2003:32-35) the target system and Choi Moo-sung and Kim Soon-ja (2009) were reconstructed and analyzed. Multicultural elements shown in the 2015 revised curriculum were analyzed for cultural diversity, recognition and tolerance, community awareness, and self-identity. The analysis targets analyzed multicultural elements of 'seeking human beings', 'core competences' and 'school organization and operation' during the elementary education curriculum in 2009. As a result of analyzing the multicultural elements of the former primary education process, 'cultural diversity' is 1,Recognition and tolerance'0, community spirit'3, and 'self-reliant'2 total6. In the new elementary school curriculum, 18 were analyzed as 'cultural diversity'1, 'Recognition and tolerance'1, 'community spirit'8, and 'self-identity'8. The first analysis of multi-cultural factors appearing in the new elementary school curriculum should include the addition of multicultural elements 'cultural diversity' and 'cultural diversity area' and 'education and tolerance' to the following: Second, to grow into a balanced multicultural society member, it proposes an enhanced multicultural curriculum in four areas: cultural diversity, recognition and tolerance, ccommunity spirit, and self-identity.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.12
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• pp.7160-7169
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• 2014

This study examined the relationship of academic failure tolerance, academic self-efficacy and academic achievement of nursing students. The data was obtained from August 27 to September 17. The participants were 198 students in a university in D city. The data was analyzed using descriptive statistics, Pearson correlation coefficients and multiple regression. A positive correlation was observed between all the variables. The factor that significantly affected academic achievement was academic self-efficacy, which explained 7.5% of the variances. The subdomain of the academic failure tolerance affecting academic achievement was found to be the behavior, which explained 8.0% of variances. The subdomains of academic self-efficacy affecting the academic achievement was the self-regulatory efficacy. This factor explained 15.4% of the variances. This study suggests that it is necessary to enhance the academic failure tolerance and academic self-efficacy for the learning achievement and working performance of nursing students.

• Journal of the Korean Society of Clothing and Textiles
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• v.42 no.3
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• pp.530-543
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• 2018

This study investigated elderly winter wearing habits and self-identified thermal tolerance in order to compare differences between older males and older females. We surveyed 269 participants: 119 males (age $76.9{\pm}5.9yr$) and 150 females (age $76.1{\pm}5.7yr$). Thirty one questionnaires were used: Self-identified cold and heat tolerance, clothing behavior, lifestyles related to the cold and health care, etc. High percentage of respondents (both males and females) felt vulnerable to the cold. The total number of outdoor clothes were $9.6{\pm}1.6$ and $10.6{\pm}1.6$ in males and females, respectively (p<.05). Wearing frequencies for thermal underwear were 84.0% and 82.4% in males and females, respectively. The using percentage of auxiliary heating devices was higher in females compared to males (p<.01). Males felt more cold in the head and face compared to females (p<.01). Self-identified cold tolerance had negative relationships with the total number of winter outdoor clothes for both males (r=-0.260) and females (r=-0.222) (p<.01). The perceived old age for both males and females was 72.4 yr. Sex differences should be considered when developing guidelines for winter clothing behavior for the elderly and educating them on how to improve health and cold tolerance.