• Journal of Microbiology and Biotechnology
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• 제27권10호
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• pp.1877-1884
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• 2017

Mesenchymal stem cells (MSCs) have been suggested as a primary candidate for cell therapy applications because they have self-renewal and differentiation capabilities. Although they can be expanded in ex vivo system, clinical application of these cells is still limited because they survive poorly and undergo senescence or apoptosis when transplanted and exposed to environmental factors such as oxidative stress. Thus, reducing oxidative stress is expected to improve the efficacy of MSC therapy. The milk protein lactoferrin is a multifunctional iron-binding glycoprotein that plays various roles, including reduction of oxidative stress. Thus, we explored the effect of lactoferrin on oxidative stress-induced senescence and apoptosis of human MSCs (hMSCs). Measurement of reactive oxygen species (ROS) revealed that lactoferrin inhibited the production of hydrogen peroxide-induced intracellular ROS, suggesting lactoferrin as a good candidate as an antioxidant in hMSCs. Pretreatment of lactoferrin suppressed hydrogen peroxide-induced senescence of hMSCs. In addition, lactoferrin reduced hydrogen peroxide-induced apoptosis via inhibition of caspase-3 and Akt activation. These results demonstrate that lactoferrin can be a promising factor to protect hMSCs from oxidative stress-induced senescence and apoptosis, thus increasing the efficacy of MSC therapy.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제20권1호
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• pp.29-38
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• 2009

Objectives : This preliminary study evaluated the efficacy of two short-term programs for reducing depressive symptoms in female adolescents with depressive disorder. Methods : The participants were 23 middle school students who were randomly assigned to three groups : the cognitive-behavioral program group, the psycho education-program group and the no-intervention control group. Results : At postintervention, the students in cognitive-behavioral program group reported significantly lower levels of depressive symptoms, negative self-statement, automatic thought and psychiatric symptoms than did those in the no-intervention group and those in the psychoeducation-program group. Conclusion : The results suggest that the cognitive-behavioral program for female adolescent with depressive disorder was more effective in reducing depressive symptoms than the psychoeducation-program.

• 아동학회지
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• 제36권3호
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• pp.35-57
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• 2015

The present study employed a pretest-posttest quasi-experimental design model in order to evaluate the effectiveness of the Respected Parents & Respected Children (RPRC) parent education program for mothers of early school-age children. Ninety mothers were randomly assigned to an intervention (n=45) group or a control group (n=45). Mothers in the intervention group participated in 8 weekly sessions of the parent education program. After the termination of the program, the differences between pretest and posttest were analyzed in terms of both maternal parenting characteristics (i.e., parenting behavior, parenting efficacy, parenting stress, and co-parenting) and children's social competence. The results indicated that only in the intervention group, self-reported positive parenting characteristics were significantly improved and negative parenting characteristics were significantly decreased. There were no significant effects of the program on children's social competence as rated by the mothers. These findings suggest that the RPRC parent education program is effective in changing parenting characteristics known as crucial predictors of child outcomes.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7257-7261
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• 2014

Background: Few Iranian women take the Papanicolaou test despite its important role in preventing cervical cancer. This study aimed to determine the effectiveness of an educational intervention based on the protection motivation theory (PMT) variables and implementation intentions in the first and second Pap test practice among Iranian women. Materials and Methods: In this quasi-randomized controlled trial, 200 women who were referred to 30 primary health care clinics in Tehran were randomly selected. PMT variables and Pap test practice were measured at baseline and again after 3 and 15 months. The 4-week educational intervention program was conducted for the intervention group. Results: Following the intervention, the mean scores of self-efficacy, perceived vulnerability, and behavior intention variables were significantly higher in the intervention group when compared to the control group (p<0.05). No significant differences were found in the perceived severity, response efficacy, response cost, and fear between the two groups following the intervention. Higher percent of women in the intervention group had obtained first and second Pap test compared to the controls. Conclusions: The PMT and implementation intentions provide a suitable theory-based framework for developing educational interventions regarding Pap test practice in Iran.

• Journal of Dental Anesthesia and Pain Medicine
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• 제21권1호
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• pp.1-14
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• 2021

This study aimed to evaluate and compare the pre-emptive analgesic efficacy of injected ketorolac to that of other agents for impacted third molar surgical removal in a healthy population. PubMed, Ovid SP, Cochrane databases were filtered from 1980 to July 2020 for potential papers using relevant MeSH terms and pre-specified inclusion and exclusion criteria independently by reviewers. Studies that compared pre-emptive intramuscular or intravenous administration of ketorolac to other agents were evaluated. The outcomes sought were self-reported postoperative pain (patient-perceived pain), median duration for rescue analgesic medication, total number of analgesics consumed in the recovery period, and global assessment (overall patient satisfaction) after the recovery period. Six studies were included in the final evaluation. The outcome of pain perception and the number of analgesics taken were significantly lower in the ketorolac group (intramuscular or intravenous) in most of the studies (n=5) than in the group of other drugs. The mean time for rescue analgesia intake was higher for the ketorolac group, and global assessment scores were also better in the ketorolac group. Although the included studies show significantly better outcomes such as postoperative pain, median time taken for rescue medication, total number of analgesics taken, and overall patient satisfaction with injected ketorolac group in comparison to injected diclofenac, dexamethasone, and tramadol, definitive conclusions cannot be made regarding the superiority of injected Ketorolac as a pre-emptive agent. A greater number of randomized control trials with a proper protocol are needed to make definitive conclusions.

• 동서간호학연구지
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• 제29권2호
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• pp.161-171
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• 2023

Purpose: The purpose of this study is to verify the effectiveness of the Environmental Hazards Exposure Prevention Program for Mothers with Young Child (EHEPP-MYC) and to provide basic data for environmental health projects in the community. Methods: EHEPP-MYC was developed based on the protection motivation theory. A quasi-experimental design was applied to evaluate the effectiveness of the program. The number of study participants was 30 in the experimental group and 31 in the control group. The intervention applied to the experimental group consisted of lectures as the main method, current affairs programs, discussions, booklets, animations, and practical training. The program was held twice a week for a total of 4 sessions of 60 minutes each. The effect of applying the program was measured three times through surveys (before, immediately after, and two weeks after the intervention) and analyzed through repeated measures ANOVA. Results: The EHEPP-MYC had significant effects on preventive behavior, perceived severity, perceived vulnerability, self-efficacy, response efficacy, and response costs at three time points. Conclusion: EHEPP-MYC has been shown to be effective in promoting environmental hazards prevention behaviors among mothers of young child. EHEPP-MYC can be used as baseline data for projects developing programs to prevent exposure to environmental hazards and improve the environmental health of communities.

• Journal of Korean Biological Nursing Science
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• 제22권4호
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• pp.232-248
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• 2020

Purpose: The purpose of this study was to develop and apply a motivation-strengthening obesity management program for obese subjects with visual impairment and evaluate its effects. Methods: The program development and evaluation periods were from March to August 2018. The study design was an experimental study of non-equality, control repeat design. 25 subjects in the experimental group participated in the 12-week obesity management program and the 26 people in the control group did not. Results: The motivation-strengthening obesity management program included stretching exercises for 30 minutes in the morning five times a week. In addition, counseling, education, and group discussions were continued once a week for motivational strengthening. Special custom exercises for blind patients were also completed once a week simultaneously. Both of these activities were continued for 50 minutes a week for a total of 12 weeks. Measurements were recorded periodically to identify the sustained effects of the program. The obese subjects with visual impairment improved their knowledge of obesity, perceived disability, self-efficacy of exercise, and quality of life related to obesity through the motivational obesity management program. Waist circumference, systolic blood pressure, diastolic blood pressure, and fasting blood sugar were also improved in obese subjects. Conclusion: The study findings indicate that this program could be an active intervention for the control of weight gain in participants with visual impairment. Therefore, the motivation-strengthening program based on the ADDIE (Analysis, Design, Development, Implementation& Evaluation) model could be an effective strategy for better health outcomes of obese subjects with visual impairment.

• 대한간호학회지
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• 제48권4호
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• pp.407-418
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• 2018

Purpose: The purpose of this study was to develop an eye-health program based on social learning theory (EPST) of preschoolers and evaluate its effectiveness. Methods: A nonequivalent control group pre-post test design was utilized and 141 six-year-old preschoolers and their parents participated (experimental group=69, control group=72) in the study. The EPST in this study included eye-health education and eye exercises. Attention, memory, replay, motivation, reinforcement, and self-efficacy were used as interventional strategies. To examine the effectiveness of EPST, proficiency in eye-health activities, refractive power, and visual acuity were measured before and after the intervention. Data were analyzed with SPSS WIN 21.0 using the Shapiro-Wilk test, ${\chi}^2$-test, Mann-Whitney U test and Wilcoxon signed rank test. Results: Following the intervention, eye-health activities, refractive power, and visual acuity significantly improved in the experimental group compared to the control group. Conclusion: The results of this study suggest that EPST is effective in improving eye-health activities, refractive power, and visual acuity in preschoolers, and its wider implementation in educational institutions will promise improved eye-health among preschoolers.

• 근관절건강학회지
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• 제2권2호
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• pp.131-146
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• 1995

Many arthritis patients experience weakness of muscles in extremities mainly due to disuse atrophy and weight gain because of the limited activities and exercises. This study examines the effects of the 6-week aquatic-exercise program on the body fat and the muscle of the rheumatoid arthritis patients. Seventeen patients in the experimental group and 18 in the control group were assigned depending on their preference and physical condition. These patients had more than 3 points of pain out of 10, deformities in knee, wrist and ankle joints. The amount of aquatic exercise increases from 35 minutes in the first week to 60 minutes in the 6th week. In the resting period they discussed their own experiences about exercise, personal and family affairs, and performed some recreation programs in order to increase the self-efficacy and promote the relationship with other patients by the group activities. Skinfold thickness and circumferences of both extremities were measured before and after experiment to compare the difference. For testing the body fat Saham Model was used. Prior to the experiment two group's body weight, skinfold thickness and skin circumferences were not significantly different which indicates the homogeneity of two groups. Body weight and most parts of skinfold thickness of the experimental group were significantly lower than the control group after 6-week aquatic exercise program. Circumference was not significantly lower than the control after the program. These findings indicate the in-crease of muscle sizes and the reduction of the body fat. Therefore a more active application of aquatic exercise into a variety of clients is strongly suggested.

• 한국콘텐츠학회논문지
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• 제22권10호
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• pp.239-251
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• 2022

본 연구는 계획된 행동이론 해체모델을 적용하여 틱톡 라이브 커머스 이용자의 구매 행동을 살펴보았다. 이를 위해 구매 의도의 선행 요인인 태도, 주관적 규범, 지각된 행동통제에 영향을 미치는 신념 구조를 라이브 커머스의 특성에 맞춰 다차원으로 구성하였다. 아직 초기 단계에 있는 한국의 라이브 커머스에 비해 성숙기에 다다른 중국의 라이브 커머스 환경을 고려하여, 중국 내 틱톡(더우인) 라이브 커머스 구매 경험이 있는 중국 이용자 512명에 대상으로 설문조사를 실시하였다. 주요 연구 결과는 다음과 같다. 첫째, 틱톡 라이브 커머스 이용자들의 태도, 주관적 규범과 지각된 행동적 통제는 모두 구매 의도에 유의미한 정적인 영향을 미치는 것으로 나타났다. 둘째, 태도에 미치는 신념 요인의 영향은 지각된 유희성, 지각된 유용성, 상호작용성 순으로 나타났으며 지각된 용이성은 유의미한 영향을 미치지 않는 것으로 나타났다. 셋째, 친구는 주관적 규범에 긍정적인 영향을 미치는 것으로 나타났다. 마지막으로, 자기효능감은 지각된 행동 통제에 대해 유의미한 영향을 미치지만 촉진 조건은 그렇지 않은 것으로 나타났다.