• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.37 no.2
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• pp.97-108
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• 2011

Cancer stem cells have stem cell-like features, such as the ability for self-renewal and differentiation but show unlimited growth because they have the lost normal regulation of cell growth. Cancer stem cells and normal stem cells have similar features. They show high motility, diversity of progeny, robust proliferative potential, association with blood vessels, immature expression profiles, nestin expression, epidermal growth factor (EGF)-receptor expression, phosphatase and tensin homolog (PTEN) expression, hedgehog pathway activity, telomerase activity, and Wnt pathway activity. On the other hand, with cancer cells, some of these signaling pathways are abnormally modified. In 1875, Cohnheim suggested the concept of cancer stem cells. Recently, evidence for the existence of cancer stem cells was identified. In 1994, the cancer stem cells' specific cell surface marker for leukemia was identified. Since then, other specific cell surface markers for cancer stem cells in solid tumors (e.g. breast and colon cancer) have been identified. In oral cancer, studies on cancer stem cells have been performed mainly with squamous cell carcinomas. Oral cancer specific cell surface markers, which are genes strongly expressed in oral cancer and cancer stem cell specific side populations, have been identified. Cancer stem cells are resistant to radiotherapy and chemotherapy. Therefore, to eliminate malignant tumors efficiently and reduce the recurrence rate, therapy targeting cancer stem cells needs to be performed. Currently, studies targeting the cancer stem cells' specific signaling pathways, telomerase and tumor vasculatures are being done.

• Nuclear Engineering and Technology
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• v.51 no.8
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• pp.1871-1885
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• 2019

The deterministic MOC code STREAM of the Computational Reactor Physics and Experiment (CORE) laboratory of Ulsan National Institute of Science and Technology (UNIST), was initially designed for the calculation of pressurized water reactor two- and three-dimensional assemblies and cores. Since fast reactors play an important role in the generation-IV concept, it was decided that the code should be upgraded for the analysis of fast neutron spectrum reactors. This paper presents a coupled code - TULIP/STREAM, developed for the fast reactor assembly and core calculations. The TULIP code produces self-shielded multi-group cross-sections using a one-dimensional cylindrical model. The generated cross-section library is used in the STREAM code which solves eigenvalue problems for a two-dimensional assembly and a multi-assembly whole reactor core. Multiplication factors and steady-state power distributions were compared with the reference solutions obtained by the continuous energy Monte-Carlo code MCS. With the developed code, a sensitivity study of the number of energy groups, the order of anisotropic P_N scattering, and the multi-group cross-section generation model was performed on the k_eff and power distribution. The 2D core simulation calculations show that the TULIP/STREAM code gives a k_eff error smaller than 200 pcm and the root mean square errors of the pin-wise power distributions within 2%.

• Journal of Sasang Constitutional Medicine
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• v.21 no.2
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• pp.11-26
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• 2009

1. Objectives : This research was purposed to reconsider the Dong-Mu's Theory of Nature and Mind(生情論). 2. Methods : The Dong-Mu's interpretation on the first chapter of "The Doctrine of Mean(中庸)", and the related contents of Nature and Emotion(性情) in his literature such as "Gyukchigo(格致藁)", "Donguisusebowon-Sasang chobongyun(東醫壽世保元四象草本卷)" and "Donguisusebowon(東醫壽世保元)" were reviewed. 3. Results and Conclusions : 1. Dong-Mu reinterpreted the concepts about 'Providence(天命) and Human Nature(人性)', 'Not-yet-intentional state(未發) and Intentional state(已發)', 'Nature and Mind(性情)' and 'Equilibrium and Harmony(中和)' in "The Doctrine of Mean", and used these concepts as logical tools in explanation of his thoughts of Human being and medical theory. 2. The generating principle of Nature and Mind(性情) presented as sorrow, anger, joy and pleasure is 'the Principle of Human nature(性理)', which is embodied as 'the Principle of Organ(臟理)' in "Donguisusebowon". The Principle of Organ(臟理) is originated from Heart and lie at lung, spleen, liver and kidney as the form of Four Virtue(四德). 3. The Principle of Organ(臟理) has the position of superintendence and is the generating principle of Nature and Emotion(性情), by which the structural and functional variations between different constitutional types are formed. 4. Dong-Mu's newly established concept of Nature and Emotion(性情) is the core logic in his idea of physiology, pathology and self-cultivation.

• Journal of The Korean Society of Agricultural Engineers
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• v.60 no.1
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• pp.37-45
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• 2018

This study is aims to voluntary participation in rural development projects, voluntary participation by analyzing the individual competence factors, how the what and how much influence affect the continued involvement and participation as a concept of strengthening community capacity the plan for it to present. The results of survey, through factor analysis and reliability analysis for extracting the components of individual competence areas and life satisfaction, self acting capacity, was extracted with recognized competence, was the factor analysis and reliability analysis for ongoing involvement and participation. Personal competence was a multiple regression analysis, the participation of three elements as independent variables as dependent variables to evaluate the impact of continuing involvement, and the resulting Regional and life satisfaction (${\beta}=0.301$) have the greatest impact It showed. In addition, regional analysis and life satisfaction (${\beta}=0.247$) on the impact of enlargement on the individual capabilities showed the highest participation. The elements of local life satisfaction and personal competencies exerts the greatest influence on the continued involvement and participation in the study was obtained. It based on the results in rural development for the voluntary participation and participation of the population should be considered with a plan to enhance the regional and life satisfaction, "the software business, which is carried out in rural areas developed for them by local residents the measures to increase life satisfaction will be provided.

• Journal of The Korean Association of Information Education
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• v.22 no.5
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• pp.593-603
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• 2018

In this study, we tried to develop STEAM integrated program using virtual reality(VR) equipment and to evaluate the learners' satisfaction in order to cultivate the convergent talent. The pre-test and the post-test were used to compare the mean scores of the assessed candidates and sub-areas. The post-test results were higher than pre-test results. The area with statistically significant mean height was derived as the 'self-concept' area of 'science' which is a sub-area of 'care and communication'.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.2
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• pp.103-110
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• 2008

When there is uncertainty in topological rate of change, motility model and terrain condition, the performance severely degrades in MANET. The concept of transition of routing protocol on the fly according to the network parameters such as coverage, connectivity and mobility etc. may counterbalance the problems stated above. The mathematical modeling of feedback parameters has been derived, and the architecture for the multi-routing protocol system providing an adaptation from one routing protocol to another is also investigated. This paper is extensively devoted on the analysis of mobility, connectivity and their effects on the network and finally transition into another routing protocol according to them.

• Research in Community and Public Health Nursing
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• v.7 no.1
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• pp.38-51
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• 1996

There is a increasingly growing emphasis on health promotion, disease prevention and optimum functioning for peaple including the chronically ill and disabled. According as the purpose of the nursing is the promotion of health, the value and belief of heal th within the nursing paradigm need to be defined in every culture. The paradigm components must be explored for meaning given by the aged in their traditional thought and philosophy, The problem addressed by this qualitative study was how the aged recognize value and belief of health, which contribute to the development of Korean nursing theory. Theoretical support for the study was from Leininger's cultural care theory and Korean philosophy and traditional oriented thought. Literature review refers to literature on the aged, health of the aged, and definition and meaning of general health concept. Grounded theory methodology guied the research methodology and analysis to build a substantive theory. The informants were 119 from a variety of social levels and family patterns; traditionally the aged are responsible for the health. The concentrated interviewing period was from may to june, 1995 ; the interviews were done by the researcher with two supporter and most were recorded on audio tape. Result from analysis of base datas follows; The value and belief of health that emerged from the categories and properties were the physical stability, the stability of mind, the stability of mind and body, the smoothness (harmony) of body function, the family concord, and the perfection of self. These values and beliefs of health are affected by the cosmic dual forces thought is based on the Great Absolute, family principle of confucian scholar, and Buddism. Among the values and beliefs of health, family concord is found out Korean culture peculiarities. These values and beliefs are all integrated into the idea of health. The study provided implications for nursing theory research, education, and practice change and development.

• Sleep Medicine and Psychophysiology
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• v.4 no.1
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• pp.15-28
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• 1997

Longterm memory is encoded in the neuronal connectivities of the brain. The most successful models of human memory in their operations are models of distributed and self-organized associative memory, which are founded in the principle of simulaneous convergence in network formation. Memory is not perceived as the qualities inherent in physical objects or events, but as a set of relations previously established in a neural net by simultaneousy occuring experiences. When it is easy to find correlations with existing neural networks through analysis of network structures, memory is automatically encoded in cerebral cortex. However, in the emergence of informations which are complicated to classify and correlated with existing networks, and conflictual with other networks, those informations are sent to the subcortex including hippocampus. Memory is stored in the form of templates distributed across several different cortical regions. The hippocampus provides detailed maps for the conjoint binding and calling up of widely distributed informations. Knowledge about the distribution of correlated networks can transform the existing networks into new one. Then, hippocampus consolidats new formed network. Amygdala may enable the emotions to influence the information processing and memory as well as providing the visceral informations to them. Cortico-striatal-pallido-thalamo-cortical loop also play an important role in memory function with analysis of language and concept. In case of difficulty in processing in spite of parallel process of informations, frontal lobe organizes theses complicated informations of network analysis through temporal processing. With understanding of brain mechanism of memory and information processing, the brain mechanism of mental phenomena including psychopathology can be better explained in terms of neurobiology and meuropsychology.

• Korean Institute of Interior Design Journal
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• v.26 no.6
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• pp.97-105
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• 2017

Korea is promoted STEAM education since 2011. Furthermore, in high school education, based on the in-depth elective course's teaching and learning contents of science. The STEAM program can improve students' competence because it encourages to self-directed learning through the vocational project performance. Therefore, in this study, we researched a design education program for the experience of fusion and complex design based on STEAM education concept. We developed an education program to design insulation wall systems using up-cycling concepts to increase energy efficiency. As a result, the characteristics of the fusion education and the theoretical study about the learner-centered education curriculum, the analysis of the high school curriculum, the STEAM elements, The program was revised and supplemented through consultation with STEAM experts. In addition, the developed program was applied to high school students, and each step were analyzed based on the educational method theory. The following results were obtained. First, this study presented a program to cope with the needs of high school intensive education. Second, it provided learning motivation by combining flipped-learning as a way to train STEAM education contents. Third, it is required to develop differentiated and continuous program development and data sharing Fourth, in order to operate and promote the future environment design STEAM school, it is necessary to expand educational programs for high school students in the region through linkage with various universities.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.3
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• pp.209-222
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• 2014

NCW is a new operational concept for modern warfare to improve the ability to conduct combat by connecting command and control system via network. To realize NCW integrating information sharing system between multiple platforms, CDL is considered as a key component for high-speed transmission of ISR data. Accordingly, further studies to enhance the performance of CDL are being performed around the world, and our government has also developed self-reliant CDL, MPI-CDL. However, the maximum data rate and networking performance of current CDL still fall short of the objective to enable multiple systems to share the large ISR data. Therefore, in this paper, we analyze the development flow and international technical trends of CDL, and present an approach for enhancing data rate and networking capacity of the next generation CDL.