• Title/Summary/Keyword: Selective mechanism

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Highly Sensitive and Naked Eye Dual-readout Method for ʟ-Cysteine Detection Based on the NSET of Fluorophore Functionalized Gold Nanoparticles

  • Fu, Xin;Liu, Yuan;Wu, Zhitao;Zhang, He
    • Bulletin of the Korean Chemical Society
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    • v.35 no.4
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    • pp.1159-1164
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    • 2014
  • A simple, highly sensitive and selective method based on the rhodamine B-covered gold nanoparticle with dual-readout (colorimetric and fluorometric) detection for $\small{L}$-cysteine is proposed. A mechanism is that citrate-stabilized AuNPs were modified with RB by electrostatic interaction, which enables the nanometal surface energy transfer (NSET) from the RB to the AuNPs, quenching the fluorescence. In the presence of $\small{L}$-cysteine, it was used as a competitor in the NSET by the strongly Au-S bonding to release RB from the Au surface and recover the fluorescence, and the red-to-purple color change quickly, which was monitored simply by the naked eye. Under the optimum conditions, the detection limit is as low as 10 nM. The method possessed the advantages of simplicity, rapidity and sensitivity at the same time. The method was also successfully applied to the determination of $\small{L}$-cysteine in human urine samples, and the results were satisfying.

Dopamine-dependent synaptic plasticity in an amygdala inhibitory circuit controls fear memory expression

  • Lee, Joo Han;Kim, Joung-Hun
    • BMB Reports
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    • v.49 no.1
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    • pp.1-2
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    • 2016
  • Of the numerous events that occur in daily life, we readily remember salient information, but do not retain most less-salient events for a prolonged period. Although some of the episodes contain putatively emotional aspects, the information with lower saliency is rarely stored in neural circuits via an unknown mechanism. We provided substantial evidence indicating that synaptic plasticity in the dorsal ITC of amygdala allows for selective storage of salient emotional experiences, while it deters less-salient experience from entering long-term memory. After activation of D4R or weak fear conditioning, STDP stimulation induces LTD in the LA-ITC synapses. This form of LTD is dependent upon presynaptic D4R, and is likely to result from enhancement of GABA release. Both optogenetic abrogation of LTD and ablation of D4R at the dorsal ITC in vivo lead to heightened and over-generalized fear responses. Finally, we demonstrated that LTD was impaired at the dorsal ITC of PTSD model mice, which suggests that maladaptation of GABAergic signaling and the resultant LTD impairment contribute to the endophenotypes of PTSD. [BMB Reports 2016; 49(1): 1-2]

Characterization of the Galvanizing Behavior Depending on Annealing Dew Point and Chemical Composition in Dual-Phase Steels

  • Shin, K.S.;Park, S.H.;Jeon, S.H.;Bae, D.C.;Choi, Y.M.
    • Corrosion Science and Technology
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    • v.9 no.6
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    • pp.247-253
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    • 2010
  • The characteristics of selective oxidation prior to hot-dip galvanizing with the annealing atmosphere dew point and chemical composition in dual-phase steels and their effect on the inhibition layer formation relevant to coating adhesion have been studied using a combination of electron microscopic and surface analytical techniques. The annealed and also galvanized samples of 3 kinds of Si/Mn ratios with varied amounts of Si addition were prepared by galvanizing simulator. The dew point was controlled at soaking temperature $800^{\circ}C$ in 15%$H_2$ -85%$N_2$ atmosphere. It was shown that good adhesion factors were mainly uniformity of oxide particle distribution of low number density and low Si/Mn ratio prior to hot-dip galvanizing. Their effect was the greatly reduced coating bare spots and the formation of uniform inhibition layer leading to good adhesion of Zn overlay. The mechanism of good adhesion is suggested by two processes: the formation of inhibition layer on the oxide free surface uncovered with no $SiO_2$-containing particles in particular, and the inhibition layer bridging of oxide particles. The growth of inhibition layer was enhanced markedly by the delayed reaction of Fe and Al with the increase of Si/Mn ratio.

An Efficient Selective Method for Audio Watermarking Against De-synchronization Attacks

  • Mushgil, Baydaa Mohammad;Adnan, Wan Azizun Wan;Al-hadad, Syed Abdul-Rahman;Ahmad, Sharifah Mumtazah Syed
    • Journal of Electrical Engineering and Technology
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    • v.13 no.1
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    • pp.476-484
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    • 2018
  • The high capacity audio watermarking algorithms are facing a main challenge in satisfying the robustness against attacks especially on de-synchronization attacks. In this paper, a robust and a high capacity algorithm is proposed using segment selection, Stationary Wavelet Transform (SWT) and the Quantization Index Modulation (QIM) techniques along with new synchronization mechanism. The proposed algorithm provides enhanced trade-off between robustness, imperceptibility, and capacity. The achieved watermarking improves the reliability of the available watermarking methods and shows high robustness towards signal processing (manipulating) attacks especially the de-synchronization attacks such as cropping, jittering, and zero inserting attacks. For imperceptibility evaluation, high signal to noise ratio values of above 22 dB has been achieved. Also subjective test with volunteer listeners shows that the proposed method has high imperceptibility with Subjective Difference Grade (SDG) of 4.76. Meanwhile, high rational capacity up to 176.4 bps is also achieved.

Fast Responding Gas Sensors Using Sb-Doped SnO2 Nanowire Networks (Sb-첨가 SnO2 나노선 네트워크를 이용한 고속응답 가스센서)

  • Kwak, Chang-Hoon;Woo, Hyung-Sik;Lee, Jong-Heun
    • Journal of Sensor Science and Technology
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    • v.22 no.4
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    • pp.302-307
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    • 2013
  • The Sb-doped $SnO_2$ nanowire network sensors were prepared by thermal evaporation of the mixtures between tin and antimony powders. Pure $SnO_2$ nanowire networks showed high sensor resistance in air ($99M{\Omega}$), similar gas responses to 4 diffferent gases (5 ppm $C_2H_5OH$, CO, $H_2$, and trimethylamine), and very sluggish recovery speed (90% recovery time > 800 s). In contrast, 2 wt% Sb-doped $SnO_2$ showed the selective detection toward $C_2H_5OH$ and trimethylamine, relatively low resistance ($176k{\Omega}$) for facile measurement, and ultrafast recovery speed (90% recovery times: 6 - 18 s). The change of gas sensing charactersitics by Sb doping was discussed in relation to gas sensing mechanism.

Increased Expression of Nitric Oxide Synthases in Left and Right Ventricular Hypertrophy

  • Lee, Jong-Un;Oh, Yoon-Wha;Kim, Sun-Mi;Kang, Dae-Gill;Lee, Won-Jung
    • The Korean Journal of Physiology and Pharmacology
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    • v.5 no.1
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    • pp.65-70
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    • 2001
  • The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney, one clip (2K1C) hypertensive and treated with monocrotaline (MCT), respectively. Six weeks later, the hearts were taken and their ventricular tissue mRNA and protein expression of endothelial constitutive isoform of nitric oxide synthase (NOS) were determined by reverse transcription-polymerase chain reaction and Western blot analysis, respectively. In 2K1C hypertensive rats, the expression of NOS mRNA was increased in parallel with its proteins in the left ventricle, but not in the right ventricle. In MCT-treated rats, the expression of NOS mRNA and proteins were proportionally increased in the right ventricle, but not in the left ventricle. These results suggest that the expression of NOS is specifically increased in association with the ventricular hypertrophy, which may be a mechanism counteracting the hypertrophy.

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A Cost-Effective IP Paging Scheme for Hierarchical Mobile IP Networks (계층적 이동 IP 네트워크에서의 비용 효율적인 IP 페이징 기법)

  • Kong, Ki-Sik
    • Journal of Satellite, Information and Communications
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    • v.6 no.2
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    • pp.84-90
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    • 2011
  • Handling paging mechanism at the IP layer (i.e., IP paging) makes it possible to support heterogeneous wireless access technologies, providing energy-saving and reduced location registration signaling overhead over IP-based mobile networks. However, IP paging may rather cause adverse effects under active communication environments because of significant paging signaling overhead and frequent paging delay. Therefore, in order to solve these problems, a cost-effective IP paging scheme is proposed in this paper, which enables a mobile node to perform selective registration and paging based on its profile information. Numerical results indicate that the proposed scheme has apparent potential to mitigate considerable paging signaling overhead and frequent paging delay in IP-based hierarchical mobile networks.

Sleep Inducing Effect of Gastrodia elata Fermented with Lactic Acid Bacteria (유산균 발효 천마의 수면유도 효과)

  • Lee, Keyong Ho;Rhee, Ki-Hyeong;Kim, Byung-Soo;Choi, Yong-Ho;Kim, Choong-Hwan
    • Korean Journal of Pharmacognosy
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    • v.44 no.3
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    • pp.281-285
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    • 2013
  • Ethanol extract of Gastrodia elata fermented with Lactobacillus brevis was highly effective on the duration of pentobarbital hypnosis in mice. Pretreatment of mice with ethanol extract of the fermented Gastrodia elata (200 mg/kg, p.o.) prolonged markedly the duration of pentobarbital sleeping time and reduced the sleep latency. The mechanism of the extract of the fermented Gastrodia elata was investigated to inhibit the binding of $^3H$-Flumazenil, a selective benzodiazepine receptor antagonist, to benzodiazepine receptor of mice cortices. $IC_{50}$ value from displacement of $^3H$-Flumazenil binding was 62 ${\mu}g/mL$ at the treatment of the fermented Gastrodia elata. Therefore, these finding, such as increase of sleeping time and reduction of sleep latency, was examined by elevated concentration of GABA and parishin C, which were increased by Lactobacillus brevis.

Recurrent True Brachial Artery Aneurysm

  • Ko, Seong-Min;Han, Il-Yong;Cho, Kwang-Hyun;Lee, Yang-Haeng;Park, Kyung-Taek;Kang, Mee-Sun
    • Journal of Chest Surgery
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    • v.44 no.5
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    • pp.364-367
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    • 2011
  • True aneurysm of the brachial artery is a rare disease entity. The mechanism of aneurysm formation is considered to be compression of the arterial wall, producing contusion of the media and subsequent weakness of the wall and fusiform dilatation. It can be caused by arteriosclerotic, congenital, and metabolic disorders, and can be associated with diseases such as Kawasaki's disease. Doppler ultrasonography, computed tomography, arteriography, and selective upper extremity angiography may be performed for establishing the diagnosis of aneurysm. The best therapeutic option is operative repair, and it should be performed without any delay, in order to prevent upper extremity ischemic or thrombotic sequelae. Here, we report a case of recurrent brachial artery aneurysm with review of the literature.

Efficient Electron Transfer in CdSe-py-SWNTs FETs

  • Jeong, So-Hee;Shim, H.C.;Han, Chang-Soo
    • Proceedings of the Korean Vacuum Society Conference
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    • 2010.02a
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    • pp.63-63
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    • 2010
  • Ability to transport extracted carriers from NQDs is essential for the development of most NQD based applications. Strategies to facilitate carrier transport while preserving NQDs' optical characteristics include: 1) Fabricating neat films of NQDs with modified surfaces either by adapting series of ligands with certain limitations or by applying physical processes such as heat annealing 2) Coupling of NQDs to one-dimensional nanostructures such as single walled carbon nanotubes (SWNTs) or various types of nanowires. NQD-nanowire hybrid nanostructures are expected to facilitate selective wavelength absorption, charge transfer to 1-D nanostructures, and efficient carrier transport. Even with the vast interests in using NQD-SWNT hybrid materials in optoelectric applications, still, no reports so far have clearly elucidated the optoelectric behavior when they were assembled on the FET mainly because the complexity involving in both components in their preparation and characterization. We have monitored the optical properties of both components (NQDs, SWNTs) from the synthesis, to the assembly, and to the device. More importantly, by using pyridine molecules as a linker to non-covalently attach NQDs to SWNTs, we were able to assemble NQDs on SWNTs with precise density control without harming their electronic structures. Furthermore, by measuring electrical signals from the fabricated aligned SWNTs-FET using dielectrophoresis (DEP), we were able to elucidate the charge transfer mechanism.

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