• Biomolecules & Therapeutics
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• 제21권1호
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• pp.84-88
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• 2013

High risk of cardiovascular diseases caused by existing PPAR-${\gamma}$ agonists such as rosiglitazone and pioglitazone has been recently reported. CKD-501 is a novel selective PPAR-${\gamma}$ agonist as a potential target to reduce cardiovascular risk in non-insulin dependent diabetes mellitus (NIDDM). In this study, We investigated potential cardiotoxicity of CKD-501 and compared its toxicity with that of rosiglitazone or pioglitazone using db/db mice. After 12-week repeated administration of CKD-501 at doses of 3, 10 and 30 mg/kg/day or rosiglitazone at doses of 10 and 30 mg/kg/day or pioglitazone at doses of 200 and 540 mg/kg/day, animals were sacrificed for investigation of potential toxicities. Diameters of left ventricles and areas of cardiomyocytes were measured. And lipid accumulation and apoptosis in heart muscle were examined by oil red O staining and TUNEL staining, respectively. Diameters of left ventricles were significantly increased in high dose treatment group of pioglitazone compared to control (p<0.05), while other groups showed a tendency for an increase. All test articles induced significantly the increase of area of cardiomyocytes in heart compared to control (p<0.01), in regular order as pioglitazone > CKD-501 ${\geq}$ rosiglitazone. However, lipid accumulation and apoptotic changes in heart were not observed in all dosing groups. Taken together, the myocardial cell hypertrophy of CKD-501 are relatively lower than that of pioglitazone and similar to rosiglitazone. And it is suggested that the myocardial cell hypertrophy of CKD-501 are less adverse in clinical use for the management of the NIDDM.

• 디지털융복합연구
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• 제11권11호
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• pp.529-536
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• 2013

본 실험의 목적은 TSE-CHESS 지방소거와 TSE-SPAIR 지방소거 기법을 비교하여 인체굴곡부위 지방소거에 있어서 TSE-SPAIR 기법의 임상적 유용성을 알아보고자 하였다. 총 25명의 경추질환이 없는 정상인을 대상으로 3.0 T MRI 기기를 이용하여 검사를 하였고, 사용된 두 기법에 대한 인체굴곡 부위 지방소거에 대한 정량적 분석으로 PSNR과 CNR을 평가하였다. 실험결과로 굴곡부위에 대한 PSNRs 과 CNRs 값은 TSE-SPAIR 기법이 유의성 있는 결과를 얻었다. 결론적으로, TSE-CHESS 지방소거와 TSE-SPAIR 지방소거 기법을 비교했을 때, 인체굴곡 부위에 대한 지방소거 평가에서 증가된 PSNRs 과 CNRs 값을 얻었다. 이러한 결과는 향후 인체굴곡 부위 지방소거 진단에 유용성 있는 정보를 제공 할 것이다.

• 한국정보통신학회논문지
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• 제11권6호
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• pp.1190-1194
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• 2007

센서 네트워크에서 신뢰성 높은 데이터 전송에 대한 중요성이 증가하고 있다. 노드와 싱크로 구성된 센서 네트워크에서, 노드에서 싱크로의 통신은 어느 정도 에러 발생에 민감하지 않으나 싱크에서 노드로의 통신은 관리 및 제어에 대한 메시지 전송이기 때문에 에러 발생에 아주 민감하다. 본 논문에서는 에러에 민감한 전송 영역인 싱크에서 노드로의 통신에 중점을 두고 에러 복구에 대한 기법을 제시한다. 신뢰구간을 end-to-end가 아닌 hop-by-hop으로 형성하여 에러가 발생하거나 데이터 손실이 일어나는 경우 고정 윈도우를 사용하는 선택적 응답으로 에러 복구를 한다. 추가로, 각 노드의 버퍼 상태에 따른 트래픽 혼잡 제어를 지원한다. 시뮬레이션을 통해, 제시하는 기법이 센서 네트워크에서 에러 복구에 우수한 성능을 가짐을 보인다.

• Journal of Information Technology Applications and Management
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• 제30권2호
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• pp.45-57
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• 2023

Efforts to build metaverse platform services and expand profit structure are developing in a more realistic direction. The metaverse, which has been centered on 'creation and economy' and 'discovery', will evolve into an 'experience' metaverse, creating tangible business effects where satisfaction with the user experience leads directly to purchase. In this paper, the condition of the avatar used as a medium of economic activity between the metaverse platformer and the user and the business utilization plan were sought. In addition, a new 'metaverse business model' was proposed based on 'experience, discovery, creation and economy', and in particular, it was intended to lay the foundation for the experience metaverse to further develop in the form of 'business experience'. In addition, a survey was conducted on the 'application of metaverse service and avatar' targeting the MZ generation, the main customer base of the current metaverse service. In order to provide a service that satisfies the user, it was concluded that the appearance of the avatar needs to be changed according to the purpose and function. Accordingly, we propose an 'selective switch mode' that can change the avatar's appearance at the desired timing according to the 'experience' and 'purchase purpose' of each metaverse service area. In addition, by strategically utilizing the 'Digilog' psychology, we believe that it will be possible to promote the influx of new users while increasing the loyalty of existing users to the platform. Through the establishment of 'avatar purchase system' by 'selective switch mode' and 'avatar decorating system' by 'digilog' strategy, the experience metaverse, which has been focused on 'digital twin experience' so far, is As it develops into 'business experience', it is expected that the user experience can be further satisfied.

• International Journal of Precision Engineering and Manufacturing
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• 제7권1호
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• pp.13-17
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• 2006

Self-Assembled Monolayers (SAMs) formed by alkanethiol adsorption to thin metal film are widely being investigated for applications as coating layer for anti-stiction or friction reduction and in fabrication of micro structure of molecules and bio molecules. Recently, there have been many researches on micro patterning using the advantages of very thin thickness and etching resistance of Self-Assembled Monolayers in selective etching of thin metal film. In this report, we present the several machining method to form the nanoscale structure by Mask-Less laser patterning using alknanethiolate Self-Assembled Monolayers such as thin metal film etching and heterogeneous SAM structure formation.

• Journal of Information Technology Applications and Management
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• 제22권3호
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• pp.1-18
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• 2015

Financial markets are characterized by large numbers of complex and interacting factors which are ill-understood and frequently difficult to measure. Mathematical models developed in finance are precise formulations of theories of how these factors interact to produce the market value of financial asset. While these models are quite good at predicting these market values, because these forces and their interactions are not precisely understood, the model value nevertheless deviates to some extent from the observable market value. In this paper we propose a framework for augmenting the predictive capabilities of mathematical model with a learning component which is primed with an initial set of historical data and then adjusts its behavior after the event of prediction.

• Tuberculosis and Respiratory Diseases
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• 제38권4호
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• pp.396-400
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• 1991

Massive and untreated hemoptysis is associated with a mortality of greater than 50 percents. Since the bleeding was from a bronchial arterial source in the vast majority of patients, embolization of the bronchial arteries has become an accepted treatment in the management of massive hemoptysis because it achieves immediate control of the patients. We have controlled massive hemoptysis in a case with selective bronchial arteral embolization with Gelfoam.

• 가정과삶의질연구
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• 제28권4호
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• pp.103-115
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• 2010

This study approached the leisure with the step of life cycle, analyzing the process of leisure career and leisure development in individual life. The leisure life cycle leads the other related studies by examining the concepts of continuity, change, leisure socialization, and leisure career. It also analyzes the patterns and the structures of the use of life time, using '2004 Time Use Survey' from the Korea National Statistical Office. As a result, this study suggests new 3 steps of leisure life cycle: participating and expanding stages, selective and concentrating stage, and continuing and absorbed stage. These steps set up the goal of leisure program by the periods. They also can help setting the direction of leisure activities, and can be used as basic data that can make up the leisure activity program models step by step. Moreover, the development of model can be used as valuable information to draw up the plans that can prepare for aging society and demand the support of policy.

• 생물정신의학
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• 제2권1호
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• pp.20-27
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• 1995

Therapeutic montitoring of drugs is a well established clinical 1001. However, the state of art is somewhat less advanced for psychotrpoic agents than it is for other classes of drugs, for several reasons. Most psychotropics have large volumes of distribution and achieve relatively low plasma concentrations following therapeutic doses. Many have one or more active metabolites. As a consequene, the analytical methodologies are often complex and not always reliable; well-controlled clinical studies are difficult to perform; and therapeutic ranges have been difficult to establish. Despite these limitations, prudent and selective monitoring of serum drug concentrations, particularly of the tricyclic antidepressants can be helpful in clinical management. This paper presents an overview of clinical and mothodological issues surrounding the utility of blood level measurement.

• 한국주거학회논문집
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• 제12권4호
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• pp.19-31
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• 2001

The purpose of this study is to investigate the meaning and the function of the shared space in the existing multi-family housing through analyzing the reality and resident's requirement for it, and additionally to develop the research project to investigate its activation strategy. The method of this study was through analyzing the related literature and the existing study. The followings were found out from this study concerning the shared space: 1) Both the supplier and resident of multi-family housing started to recognize the importance of its role with relation to the quality of the home environment. 2) In residents' requirements for it, there was its common elements, and selective differences according to the size of housing, life cycle, and whether housewife has a job or not etc. 3) In order to activate the shared space, we need to search abut using behavior for that, its flexibility of housing regulations, and to develop an effective management program. Finally this study emphasized on the necessity of planning focused on the shared space for the community design in multi-family housing.