• Journal of Advanced Marine Engineering and Technology
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• v.27 no.4
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• pp.511-519
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• 2003

A stratified flow is simulated using the finite difference lattice Boltzmann method (FDLBM). The effect of body force (gravity) in a simple one-dimensional model with the lattice BGK 9 velocity is examined. The effect of body force in the compressible fluid is greatly different from that of the incompressible fluid In a compressible fluid under gravitational force, the density stratification is not sufficient and the entropy stratification is essential. The numerical simulation of a line sink compressible stratified flow in two-dimensional channel is also carried out. The results show that selective withdrawal is established when the entropy of the upper part increases. and the simulated results using FDLB method are satisfactory compared with the theoretical one.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.1879-1883
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• 2009

우리나라는 1960년대를 기점으로 수자원의 효율적 이용을 위하여 각종 수리시설물이 건설되었으며 이 중 하나의 방안으로 대형 인공 저수지와 같은 시설물이 건설되었다. 저수지에는 강우시 탁수가 유입되는데 특히, 여름철에 집중되는 우리나라의 강우 특성상 이 시기에는 고탁도의 탁수가 유입된다. 탁수는 쉽게 정화되지 않고 저수지 내에서 성층화 현상을 일으키는데 성층화된 탁수는 물의 연직방향운동을 방해하여 심층부의 산소를 고갈시키고 이는 수질오염과 같은 결과로 이어진다. 그리고 방류시 하류하천까지 흘러가서 피해를 발생시킨다. 이러한 현상은 수질관리에 많은 어려움을 주고 있어 적절한 해결책이 요구되는 바이다. 본 연구에서는 성층구조와 방류유량에 의한 방류특성의 변화를 알아보고자 하였다. 염수를 이용하여 실험 수로 내 밀도성층을 구현하였으며, 선택배제 시 성층구조의 변화 및 흐름특성 파악을 위해 전도율계를 통한 염도측정을 이용하였다. 다양한 밀도성층 조건과 방류유량에 의한 선택배제 특성을 파악하기 위하여 밀도프루드수를 기준으로 실험조건을 설정하여, 다양한 조건에서의 밀도성층수체의 거동양상을 관찰하였다. 이상의 과정들을 통해 효율적인 선택배제 조건을 찾을 수 있었다.

• Proceedings of the Korea Information Processing Society Conference
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• 2005.11a
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• pp.1179-1182
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• 2005

공공 부문이나 대기업에서 운영하는 웹 사이트의 규모가 커지면서 분야별로 사이트가 나누어지게 되는데, 사이트를 이동할 때 마다 로그인을 다시 해야 하는 불편이 있다. 따라서 최근 이용자들의 불편을 줄이기 위하여 SSO(Single Sign-On) 통합인증 체제를 도입하는 사례가 늘고 있으나 전체 패밀리 사이트를 일괄적으로 가입과 탈퇴되는 문제가 발생한다. 이에 이용자의 필요에 따라 선택적으로 가입과 탈퇴가 가능한 통합 인증체제 방안을 제안하고자 한다.

• Journal of Korean Society on Water Environment
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• v.35 no.6
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• pp.470-480
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• 2019

The Doam lake watershed was designated as a non-point pollution management area in 2007 to improve water quality based on watershed management implementation. There have been studies of non-point source reduction with respect to the watershed management impacting the pollutant transport of the reservoir. However, a little attention has been focused on the impact of water quality improvement by the management of the dam operation or the guidelines on the dam operation. In this study, the impact of in-lake management practices combined with watershed management is analyzed, and the appropriate guidelines on the operation of the dam are suggested. The integrated modeling system by coupling with the watershed model (HSPF) and reservoir water quality model (CE-QUAL-W2) was applied for analyzing the impact of water quality management practices. A scenario implemented with sedimentation basin and suspended matter barrier showed decrease in SS concentration up to 4.6%. The SS concentration increased in the scenarios adjusting withdrawal location from EL.673 m to the upper direction(EL.683 m and EL.688 m). The water quality was comparably high when the scenario implemented all in-lake practices with water intake at EL.673 m. However, there was improvement in water quality when the height of the water intake was moved to EL.688 m during the summer by preventing sediments inflow after the rainfall. Therefore, to manage water quality of the Doam lake, it is essential to control the water quality by modulating the height of water intake through consistent turbidity monitoring during rainfall.

• The Korean Journal of Pain
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• v.28 no.1
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• pp.4-10
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• 2015

Etifoxine (etafenoxine, $Stresam^{(R)}$) is a non-benzodiazepine anxiolytic with an anticonvulsant effect. It was developed in the 1960s for anxiety disorders and is currently being studied for its ability to promote peripheral nerve healing and to treat chemotherapy-induced pain. In addition to being mediated by $GABA_A{\alpha}2$ receptors like benzodiazepines, etifoxine appears to produce anxiolytic effects directly by binding to ${\beta}2$ or ${\beta}3$ subunits of the $GABA_A$ receptor complex. It also modulates $GABA_A$ receptors indirectly via stimulation of neurosteroid production after etifoxine binds to the 18 kDa translocator protein (TSPO) of the outer mitochondrial membrane in the central and peripheral nervous systems, previously known as the peripheral benzodiazepine receptor (PBR). Therefore, the effects of etifoxine are not completely reversed by the benzodiazepine antagonist flumazenil. Etifoxine is used for various emotional and bodily reactions followed by anxiety. It is contraindicated in situations such as shock, severely impaired liver or kidney function, and severe respiratory failure. The average dosage is 150 mg per day for no more than 12 weeks. The most common adverse effect is drowsiness at the initial stage. It does not usually cause any withdrawal syndromes. In conclusion, etifoxine shows less adverse effects of anterograde amnesia, sedation, impaired psychomotor performance, and withdrawal syndromes than those of benzodiazepines. It potentiates $GABA_A$ receptor-function by a direct allosteric effect and by an indirect mechanism involving the activation of TSPO. It seems promising that non-benzodiazepine anxiolytics including etifoxine will replenish shortcomings of benzodiazepines and selective serotonin reuptake inhibitors according to animated studies related to TSPO.

• Molecules and Cells
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• v.25 no.2
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• pp.242-246
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• 2008

To assess the role of $\alpha_{1G}$ T-type $Ca^{2+}$ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking $Ca_{V}3.1$ (${\alpha}_{1G}{^{-/-}}$), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The ${{\alpha}_{1G}}^{-/-}$ mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of ${\alpha}_{1G}$ T-type $Ca^{2+}$ channels in the development of neuropathic pain, and suggest that selective modulation of ${\alpha}_{1G}$ subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.1383-1386
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• 2007

하절기 고탁수로 문제가 되고 있는 임하호에 원활한 탁수배제를 위하여 선택취수시설이 설치되어 2006년 운영되었다. 본 연구는 이러한 선택취수시설에 대한 효과를 분석하기 위하여 CE-QUAL-W2 모형을 이용하여 호내의 탁수 분포를 분석하고 보정된 모형을 이용하여 선택취수와 표면취수(표층${\sim}7\;m$)에 따른 탁수의 저감효과에 대한 분석을 수행하였다. 임하댐 유입부의 탁도 자동 측정 시스템에서 측정된 수온 및 탁도자료를 입력자료로 사용하였고, 모형의 호내의 4개지점의 수심별 자료에 대하여 보정을 실시하였다. 보정결과 관측값과 비교에서 절대 평균 오차(RMSE)는 5.2로 산정되었으며 수심별 수온 및 탁도 분포와 최고 탁도층이 발생하는 수심을 적절히 모의하였다. 선택취수시설을 적용한 경우 표면취수의 경우와 비교해서 100 NTU 이상의 고탁수층에 대해서는 (1) 호내의 탁수량이 $35\;Mm^3$이상이 저감되는 것으로 나타났고, (2) 고탁수의 방류량이 3배이상 증대되는 것으로 나타났다. 선택취수는 표면취수에 비해 고탁수층의 배제에 효과적이며 취수구의 위치 변경등 지속적인 관리를 통하여 효율적인 운영이 가능할 것으로 판단된다. 또한, 효과분석 결과를 바탕으로 시설에 대한 운영방안을 수립할 수 있을 것으로 기대된다.

• The Korean Journal of Pain
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• v.34 no.1
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• pp.27-34
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• 2021

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major reason for stopping or changing anticancer therapy. Among the proposed pathomechanisms underlying CIPN, proinflammatory processes have attracted increasing attention. Here we assessed the role of prostaglandin D2 (PGD2) signaling in cisplatin-induced neuropathic pain. Methods: CIPN was induced by intraperitoneal administration of cisplatin 2 mg/kg for 4 consecutive days using adult male Sprague-Dawley rats. PGD2 receptor DP1 and/or DP2 antagonists were administered intrathecally and the paw withdrawal thresholds were measured using von Frey filaments. Spinal expression of DP1, DP2, hematopoietic PGD synthase (H-PGDS), and lipocalin PGD synthase (L-PGDS) proteins were analyzed by western blotting. Results: The DP1 and DP2 antagonist AMG 853 and the selective DP2 antagonist CAY10471, but not the DP1 antagonist MK0524, significantly increased the paw withdrawal threshold compared to vehicle controls (P = 0.004 and P < 0.001, respectively). Western blotting analyses revealed comparable protein expression levels in DP1 and DP2 in the spinal cord. In the CIPN group the protein expression level of L-PGDS, but not of H-PGDS, was significantly increased compared to the control group (P < 0.001). Conclusions: The findings presented here indicate that enhanced PGD2 signaling, via upregulation of L-PGDS in the spinal cord, contributes to mechanical allodynia via DP2 receptors in a cisplatin-induced neuropathic pain model in rats, and that a blockade of DP2 receptor activation may present a novel therapeutic target for managing CIPN.

• The Korean Journal of Pain
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• v.12 no.1
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• pp.1-7
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• 1999

Background: To study the role of spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in pain behaviors caused by mild burn, we examined the effect of intrathecal administered ACEA 2085, which has been recently characterized as a high potency competitive AMPA receptor antagonist, on the thermal hyperalgesia state induced by mild burn. Methods: A thermal injury was induced by applying the left hind paw to a thermal surface ($52.5^{\circ}C$) for 45 sec. Thermal escape latency of the hind paw was determined using an underglass thermal stimulus. Thirty min after thermal injury, the paw withdrawal latency (PWL) in injured paw of all groups fell from 10~12 sec to 5~7 sec. At that time, ACEA 2085 (0.01~0.1 mcg) and 6-cyano-7-nitroquinoxalinedione (CNQX, 1~30 mcg) were injected through intrathecal heters in rats with mild burn injury on the right hindpaw. And then, PWL were measured in the both hindpaw every 30 minutes for about three hours. Results: The intrathecal injection of ACEA 2085 produced a dose dependent reversal of the hyperalgesia in the right hindpaw and more potent than CNQX, but had no effect upon the response latency of the normal left hind paw even at the largest doses. All effects were observed at doses that had no significant effect upon motor function. Conclusions: Intrathecal ACEA 2085, highly selective AMPA receptor antagonist produce a dose- dependent reversal of the thermal hyperalgesia evoked mild burn injury. These results suggested that spinal AMPA receptor play an important role in the hyperalgesia induced by mild burn injury.

• Journal of Korean Society on Water Environment
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• v.22 no.5
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• pp.933-942
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• 2006

In this study, temperature, turbidity, suspended paniculate matter (SPM) distribution and mineral characteristics were investigated to explain spatial distribution of the turbid-water environment of Yongdam reservoir in July, 2005. Six stations were selected along a longitudinal axis of the reservoir and sampling was conducted in four depths of each station. Water temperature was showed the typical stratified structure by the effects of irradiance and inflow. Content of inorganic matter in suspended particles increased with the concentration of suspended particulate matter (SPM) due to the reduction of ash-free dry matter (AFDM). Turbidity ranged from 0.6 to 95.1 NTU and the maximum turbidity value of each station sharply increased toward downstream from upstream. The high turbidity layers were located at the depth between 12~16 m. Particle size ranged from 0.435 to $482.9{\mu}m$. day and silt-sized particles corresponded 91.9~98.9% and 1.1~8.0% in total numbers of SPM, respectively. Turbidity showed high correlations with clay (r=0.763, p<0.05) and silt content (r=0.870, p<0.05).Inorganic matter content (r=0.960, p<0.01) was more correlated with turbidity than organic matter (r=0.823, p<0.05). Mineral characterization using x-ray diffraction and electron probe microanalyzer demonstrated that the major minerals contained in the SPM were kaolinite, illite, vermiculite and smectite. As results of this study, surface water discharge as well as small size of the SPM were suggested as long-term interfering factors in settling down the turbid water in the reservoir.