• Journal of the Korean Association of Geographic Information Studies
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• v.23 no.4
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• pp.140-155
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• 2020

This study was conducted to identify the location characteristics of infected farms in the areas where livestock diseases were clustered(southern Gyeonggi-do and Chungcheong-do), analyze the probability of disease occurrence in poultry farms, find out the areas corresponding to the conditions, and use them as the basis for prevention of livestock diseases, selection of discriminatory prevention zones, and establishment of prevention strategies and as the basic data for complementary measures. The increase of one poultry farm within a radius of 3-kilometers increases the risk of HPAI infection by 10.9% compared to the previous situation. The increase of 1m in distance from major roads with two lanes or more reduces the probability of HPAI infection by 0.001% compared to the previous situation. If the distance of the poultry farm located with 15 kilometers from a major migratory bird habitat increases by 15 to 30 kilometers, the chance of infection with HPAI is reduced by 46.0%. And if the distance of the same poultry farm increase by more than 30 kilometers, the chances of HPAI infection are reduced by 88.5%. Based on the results of logistic regression, the predicted probability was generated and the actual area of the location condition with 'more than 15 poultry farms within 3km a radius of, within 1km distance from major roads, and within 30km distance from major migratory birds habitat was determined and the infection rate was measured. It is expected that the results of this study will be used as basic data for preparing the data and supplementary measures when the quarantine authorities establish discriminatory quarantine areas and prevention strategies, such as preventive measures for the target areas and farms, or control of vehicles, by identifying the areas where livestock diseases are likely to occur in the region.

• Korean Journal of Radiology
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• v.22 no.12
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• pp.1946-1963
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• 2021

Cardiac computed tomography (CT) and cardiac magnetic resonance imaging (CMR) can reveal the detailed anatomy and function of the tricuspid valve and right ventricle (RV). Quantification of tricuspid regurgitation (TR) and analysis of RV function have prognostic implications. With the recently available transcatheter treatment options for diseases of the tricuspid valve, evaluation of the tricuspid valve using CT and CMR has become important in terms of patient selection and procedural guidance. Moreover, CT enables post-procedural investigation of the causes of valve dysfunction, such as pannus or thrombus. This review describes the anatomy of the tricuspid valve and CT and CMR imaging protocols for right heart evaluation, including RV function and TR analyses. We also demonstrate the pre-procedural planning for transcatheter treatment of TR and imaging of postoperative complications using CT.

• The Korean Journal of Pesticide Science
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• v.4 no.1
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• pp.38-43
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• 2000

As the first step of a research on the establishment of control strategy for grapevine diseases and insects, the current status of pest control and yield losses by them were surveyed from grapevine growers of Korea. For insects, the most difficult to control was a grapevine stem borer and a grapevine clearwing moth was the next. On the other hand, several diseases including anthracnose, downy mildew, powdery mildew, bird's eye rot, leaf blight, were answered by the growers. The occurrence of the pests varied to the cultural practices. Yield loss was more serious in rainfall intercept culture than in plastic film house culture and diseases caused more loss in yield than insects did. However, the grapevine grower's potential for the identification of the kinds of pests was not high enough. When the pest was observed, the growers consulted mainly with local pesticide dealers or neighbouring growers and usually applied the pesticides prescribed by the dealer. More than half of the growers did not use pest control calendar, and most of the growers applied pesticides before any symptom appeared. Also, more than half of the growers applied mixture of at least more than 1 kind of pesticide and nutrients. Insecticides were applied less than 5 times during the season, but it was more than 6 times for fungicides. In the pesticide selection, the growers checked control effect first, regardless of the registration, and the pest control cost per unit area varied very much depending on the growers.

• Journal of Plant Biotechnology
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• v.3 no.2
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• pp.67-81
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• 2001

Traditionally, genetic variability is generated by an extensive crossing program, which is complemented by strict selection to identify useful new recombinants. Plant biotechnology offers many opportunities for breeders to solve certain breeding problems at the molecular level. The tissue culture methodology and the genetic modification of economically important monocotyledons have undergone a revolution in the last decade. As the production of transgenic plants is a complex procedure, including the uptake of DNA molecules into the cells, the integration of foreign nucleotide sequences into the host genomic DNA and the expression of new genes in a controlled way, and as there are still many unsolved questions, further development is necessary. The methodology opens up the possibility of introducing novel genes that may induce resistance to diseases and abiotic stresses, allow the modification of dough quality and the dietetic quality of proteins, and increase the levels of micronutrients such as iron, zinc, and vitamins. In the present review, the authors would like to summarise the most important advances in wheat transformation.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 1998.05a
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• pp.12-28
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• 1998

The technology of creating transgenic animals has a potential value in improving productivity and disease resistance of animals, gene therapy, drug pharming and production of model animals for certain diseases. Up to date, fairly low success rate of production of transgenic animals and a pronounced variability with respect to the expression of transgenes have been much observed. The mechanisms how to integrate the injected genes with a certain part of the genomes are unknown yet. Many techniques in gene transfer, beside microinjection, have been introduced and explored thus to improve the production efficiency of transgenic animals. In this article, the methods and efficiency of gene-transfer techniques, the detection and preselection of transgenes in embryos by PCR- and GFP-screenings and cloning of preselected transgenic embryos by nuclear transplantation are described and discussed. Some experimental results showed that the early screening and selection of integration of the injected gene with embryonic genome by polymerase chain reaction(PCR) and green fluorecence protein(GFP) were promising methods. Further, the application of nuclear transplantation technology to cloning and multiplication of the positively integrated genes in the cleaving embryos and embryonic cells will be beneficially used for the mass production of transgenic embryos and consequently improving the production efficiency in transgenic animals.

• Journal of Oral Medicine and Pain
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• v.20 no.1
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• pp.89-96
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• 1995

The purpose of this study was to assess the pain-relieving effect of iontophoretically applied prednisolone on the patients with temporomandibular joint (TMJ) pain. 30 TMJ pain patients participated in this study. Inclusion criteria for subject selection were 1) tenderness of TMJ on palpation and 2) visual analog scales (VAS) of above 20 mm. The patients with polyarthralgia, rheumatic arthralgia, and systemic diseases were excluded for this experiment. The patients were randomly assigned to one of three groups; (1) Group 1 for administration of 2% prednisolone, (2) Group 2 for administration of 1% prednisolone, and (3) Group 3 for administration of saline. Phoresor PM600(Motion Control Utah, U.S.A) was used for administration of drugs by iontophoresis. Baseline and post-medication pain levels were recorded by VAS, pressure pain threshold (PPT), and palpation index (PI). Post-medication data were compared with baseline data for each group. The results were as follows : 1. All the groups showed significant decrease of VAS scores after treatment. 2. PPT was significantly increase only in Group 1 and 2 not in Group 3. 3. PI was significantly decreased only in Group 1 and 2 not in group 3.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.35 no.1
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• pp.97-107
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• 1990

The epidemiology of plant disease deals with the dynamic processes of host-pathogen interactions, which determine the prevalence and severity of the disease. Epidemic processes for most foliar diseases of plants follow a series of steps: arrival of pathogens on plant surfaces, initial infection, incubation period, latent period, sporulation, dissemination of secondary inoculum, and infectious period. These complex biological processes are influenced by the environment-Man also often interfers with these processes by altering the host and pathogen populations and the environment. Slowing or halting any of the epidemic processes can delay the development of the epidemic, so that serious losses in yield due to disease do not occur. It is generally recognized that the most effective and efficient method of minimizing disease damage is through the use of resistant cultivars, particularly when other methods such as fungicide applications are not economically feasible-Populations of plant pathogens are not genetically uniform nor are they necessarily stable. Cultivars bred for resistance to current populations of a pathogen may not be resistant in the future due to selection pressures placed on the pathogen populations. Understanding population development and genetic variability in the pathogen, and knowledge of the genetics of resistance in the plant should help in developing breeding strategies that wi1l provide effective and stable disease control through genetic resistance. In the United States, soybeans have ranked first in value of crops sold off the farm in recent years. Soybeans have been the leading U. S.

• Journal of Gastric Cancer
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• v.18 no.1
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• pp.1-19
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• 2018

Gastric cancer (GC) is the second leading cause of cancer mortality and the fourth most commonly diagnosed malignant diseases. While continued efforts have been focused on GC treatment, the introduction of trastuzumab marked the beginning of a new era of target-specific treatments. Considering the diversity of mutations in GC, satisfactory results obtained from various target-specific therapies were expected, yet most of them were unsuccessful in controlled clinical trials. There are several possible reasons underlying the failures, including the absence of patient selection depending on validated predictive biomarkers, the inappropriate combination of drugs, and tumor heterogeneity. In contrast to targeted agents, immuno-oncologic agents are designed to regulate and boost immunity, are not target-specific, and may overcome tumor heterogeneity. With the successful establishment of predictive biomarkers, including Epstein-Barr virus pattern, microsatellite instability status, and programmed death-ligand 1 (PD-L1) expression, as well as ideal combination regimens, a new frontier in the immuno-oncology of GC treatment is on the horizon. Since the field of immuno-oncology has witnessed innovative, practice-changing successes in other cancer types, several trials on GC are ongoing. Among immuno-oncologic therapies, immune checkpoint inhibitors are the mainstay of clinical trials performed on GC. In this article, we review target-specific agents currently used in clinics or are undergoing clinical trials, and highlight the future clinical application of immuno-oncologic agents in inoperable GC.

• Journal of Yeungnam Medical Science
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• v.28 no.1
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• pp.13-19
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• 2011

The emergence of antibiotic-resistant pathogens is a Serious clinical problem in the treatment of infectious diseases that increase mortality, morbidity, hospitalization length, and the cost of healthcare. In particular, $Streptococcus$ $pneumoniae$ is a major etiologic pathogen of pneumonia, sinusitis, otitis media, and meningitis. As the definition of penicillin resistance to $S.$ $pneumoniae$ was recently changed, macrolide-resistant $S.$ $pneumoniae$ is a major resistant pathogen in the community. Infections caused by antibiotic-resistant strains are associated with incorrect use of antibiotics and critical clinical outcomes. For the appropriate use of antibiotics to treat infections, physicians always should have up-to-date information on the current epidemiologic status of antibiotic resistance for common pathogens and their susceptibility to antimicrobials. Appropriate selection of antimicrobials, strict control of infection, vaccination, and development of a feasible national policy of infection control are important strategies for the control of antimicrobial resistance. This review article focuses on the current status of antibiotic-resistant $S.$ $pneumoniae$ in community-acquired pneumonia in Korea.

• Journal of Biomedical Engineering Research
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• v.26 no.4
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• pp.243-249
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• 2005

The number of people who have lost limbs due to amputation has increased due to various accidents and diseases. Numerous attempts have been made to provide these people with prosthetic devices. These devices are often controlled using myoelectric signals. Although the success of fitting myoelectric signals (EMG) for single device control is apparent, extension of this control to more than one device has been difficult. The lack of success can be attributed to inadequate multifunctional control strategies. Therefore, the objective of this study was to develop multifunctional myoelectric control strategies that can generate a number of output control signals. We demonstrated the feasibility of a neural network classification control method that could generate 12 functions using three EMG channels. The results of evaluating this control strategy suggested that the neural network pattern classification method could be a potential control method to support reliability and convenience in operation. In order to make this artificial neural network control technique a successful control scheme for each amputee who may have different conditions, more investigation of a careful selection of the number of EMG channels, pre-determined contractile motions, and feature values that are estimated from the EMG signals is needed.