• 제목/요약/키워드: Selection of diseases

검색결과 356건 처리시간 0.024초

동씨침법(董氏鍼法)의 의의(意義)와 임상적(臨床的) 응용(應用) (Study on Practical Use and Historical Development of Dongssi' Acupuncture Therapy)

  • 박유리;강백규;김호겸;변지환;송정호;정종율;장진요;황재호;조명수;김경식;손인철
    • Korean Journal of Acupuncture
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    • 제19권2호
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    • pp.119-131
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    • 2002
  • In this paper, we studied Dongssi' acupuncture therapy via the consideration of development process of Oriental medicine in history. We investigated the distribution chart and naming of Dongssi' acupuncture point in human body, artificial selection principle of Dongssi' acupuncture point to therapy (選穴原則) on the various diseases, the therapy of pyo-bon (標本理論) and the therapy of Geun-Gyeal (根結理論) and compared GeoZa-principle (巨刺法) and MuZa-principle (繆刺法) with artificial selection principle of Dongssi' acupuncture point. And we also studied the acupuncture therapy of DongGi (動氣鍼法), DoMa (倒馬鍼法) and SaeIn (索引鍼法), which is the unique principle in Dongssi' acupuncture theraphy, to consider with the other Oriental medicine theory which is the theory of ZangSang (臟象學說) and BiWi (脾胃學說) etc. Our desire in this study is the giving aid to treatment diseases with the acupuncture therapy in Oriental medicine.

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Epidemiological and Clinical Characteristics of Confirmed Cases of Severe Fever With Thrombocytopenia Syndrome in Jeju Province, Korea, 2014-2018

  • Kim, Jinhee;Bae, Jong-Myon
    • Journal of Preventive Medicine and Public Health
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    • 제52권3호
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    • pp.195-199
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    • 2019
  • Objectives: Jeju Province is well known as the region showing the highest incidence of severe fever with thrombocytopenia syndrome (SFTS) in South Korea. The aim of this study was to evaluate the epidemiological and clinical characteristics of SFTS patients in Jeju Province. Methods: The primary data for this study were obtained from the Integrated Diseases and Health Control System of the Korea Centers for Disease Control and Prevention (KCDCIS). The selection criteria were confirmed cases of SFTS with a residence listed in Jeju Province at the time of diagnosis, reported to the KCDCIS between July 16, 2014 and November 30, 2018. Results: Of 55 confirmed cases of SFTS, the case fatality rate was 10.9% (95% confidence interval [CI], 4.1 to 22.2). The most common presenting symptoms at diagnosis of severe fever, myalgia, and diarrhea had incidences of 83.6% (95% Cl, 71.2 to 92.2), 45.5% (95% Cl, 32.0 to 59.5), and 40.0% (95% CI, 27.0 to 54.1), respectively. Conclusions: Compared to SFTS patients nationwide in 2013-2015, the subjects of this study exhibited a lower case fatality rate and had a lower incidence of severe fever, myalgia, and confusion.

Role of biomarkers in antimicrobial stewardship: physicians' perspectives

  • Hyeri Seok;Dae Won Park
    • The Korean journal of internal medicine
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    • 제39권3호
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    • pp.413-429
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    • 2024
  • Biomarkers are playing an increasingly important role in antimicrobial stewardship. Their applications have included use in algorithms that evaluate suspected bacterial infections or provide guidance on when to start or stop antibiotic therapy, or when therapy should be repeated over a short period (6-12 h). Diseases in which biomarkers are used as complementary tools to determine the initiation of antibiotics include sepsis, lower respiratory tract infection (LRTI), COVID-19, acute heart failure, infectious endocarditis, acute coronary syndrome, and acute pancreatitis. In addition, cut-off values of biomarkers have been used to inform the decision to discontinue antibiotics for diseases such as sepsis, LRTI, and febrile neutropenia. The biomarkers used in antimicrobial stewardship include procalcitonin (PCT), C-reactive protein (CRP), presepsin, and interleukin (IL)-1β/IL-8. The cut-off values vary depending on the disease and study, with a range of 0.25-1.0 ng/mL for PCT and 8-50 mg/L for CRP. Biomarkers can complement clinical diagnosis, but further studies of microbiological biomarkers are needed to ensure appropriate antibiotic selection.

사과 주요 병해 방제를 위한 길항미생물 분리 및 동정 (Isolation and Identification of Antagonistic Microorganisms for Biological Control to Major Diseases of Apple Tree(Malus domestica Borkh))

  • 박흥섭;조정일
    • 한국유기농업학회지
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    • 제5권1호
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    • pp.137-147
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    • 1996
  • For the purpose of acquiring microbial agents that can be utilized to biologically control the major airborne diseases to apple trees, such as canker(Botryosphaeria dothidea), bitter rot(Glomerella cingulata), alternaria leaf spot(Alternaria mali), root rot(rosellinia necatrix), canker(Valsa ceratosperma) and gray mold rot(Botrytis cinerea), the effective microorgaisms were isolated, tested for antagonistic activity to the pathogens causing major diseases to apple trees and identifed. Screening of more than 5,000 species of microorganisms collected in nature for them antagonistic action to the pathogens causing 5 major diseases to apple trees resulted in selection of effective species. Out of the 11 species, one species designated as CAP134 demonstrated outstanding activity. The bacterial strain, CAP134 exerted antagonistic efficiency of 57% on an isolated strain and 40% on a donated strain of Botryosphaeria dothidea., 52% on an isolated strain and 46% on a purchased strain of Alternaria mali, 60% on Valsa ceratosperma 25% on Glomerella cingulata, and 64% Rosellinia necatrix. The CAP134 was identified as a bacterial strain to Bacillus subtilis ATCC 6633 based on morephology, culture conditions, and physio-biochemical characteristics.

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Antibiotic Resistance Profiles of Staphylococcus pseudintermedius Isolates from Canine Patients in Korea

  • Yoon, Jang-Won;Lee, Ki-Jong;Lee, So-Young;Chae, Min-Joo;Park, Jae-Keun;Yoo, Jong-Hyun;Park, Hee-Myung
    • Journal of Microbiology and Biotechnology
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    • 제20권12호
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    • pp.1764-1768
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    • 2010
  • In this study, the prevalence of antibiotic resistance was examined among 74 Staphylococcus pseudintermedius strains recently isolated from clinical cases of canine pyoderma and otitis externa at the veterinary teaching hospital at Konkuk University, Korea. Bacterial resistance to the nine commonly used antibiotics was evaluated by a standard disk diffusion technique based on the guidelines of the Clinical and Laboratory Standards Institute. The results demonstrated that most S. pseudintermedius isolates were resistant to penicillin (95.9%) or tetracycline (91.9%), but highly susceptible to amoxicillin/clavulanic acid (90.5%). Among the 74 isolates, 13 mecA-positive and methicillin-resistant S. pseudintermedius (MRSP) strains were identified, displaying a high level of resistance (84.6-100%) to each of the individual antibiotics evaluated, with the exception of amoxicillin/clavulanic acid (46.2% resistance). Notably, all of the MRSP isolates exhibited simultaneous resistance to four or more different antibiotics, indicating that they are multiple drug resistant (MDR) strains. Taken together, these results imply that more careful selection or prescription of antibiotics for canine pyoderma and otitis externa should be required for reducing the emergence and/or spread of MDR strains, especially MDR-MRSP isolates, in veterinary pet clinics in Korea.

Receptor binding motif surrounding sites in the Spike 1 protein of infectious bronchitis virus have high susceptibility to mutation related to selective pressure

  • Seung-Min Hong;Seung-Ji Kim;Se-Hee An;Jiye Kim;Eun-Jin Ha;Howon Kim;Hyuk-Joon Kwon;Kang-Seuk Choi
    • Journal of Veterinary Science
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    • 제24권4호
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    • pp.51.1-51.17
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    • 2023
  • Background: To date, various genotypes of infectious bronchitis virus (IBV) have co-circulated and in Korea, GI-15 and GI-19 lineages were prevailing. The spike protein, particularly S1 subunit, is responsible for receptor binding, contains hypervariable regions and is also responsible for the emerging of novel variants. Objective: This study aims to investigate the putative major amino acid substitutions for the variants in GI-19. Methods: The S1 sequence data of IBV isolated from 1986 to 2021 in Korea (n = 188) were analyzed. Sequence alignments were carried out using Multiple alignment using Fast Fourier Transform of Geneious prime. The phylogenetic tree was generated using MEGA-11 (ver. 11.0.10) and Bayesian analysis was performed by BEAST v1.10.4. Selective pressure was analyzed via online server Datamonkey. Highlights and visualization of putative critical amino acid were conducted by using PyMol software (version 2.3). Results: Most (93.5%) belonged to the GI-19 lineage in Korea, and the GI-19 lineage was further divided into seven subgroups: KM91-like (Clade A and B), K40/09-like, QX-like (I-IV). Positive selection was identified at nine and six residues in S1 for KM91-like and QX-like IBVs, respectively. In addition, several positive selection sites of S1-NTD were indicated to have mutations at common locations even when new clades were generated. They were all located on the lateral surface of the quaternary structure of the S1 subunits in close proximity to the receptor-binding motif (RBM), putative RBM motif and neutralizing antigenic sites in S1. Conclusions: Our results suggest RBM surrounding sites in the S1 subunit of IBV are highly susceptible to mutation by selective pressure during evolution.

Tissue Specific Expression Levels of Apoptosis Involved Genes Have Correlations with Codon and Amino Acid Usage

  • Hajjari, Mohammadreza;Sadeghi, Iman;Salavaty, Abbas;Nasiri, Habib;Birgani, Maryam Tahmasebi
    • Genomics & Informatics
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    • 제14권4호
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    • pp.234-240
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    • 2016
  • Different mechanisms, including transcriptional and post transcriptional processes, regulate tissue specific expression of genes. In this study, we report differences in gene/protein compositional features between apoptosis involved genes selectively expressed in human tissues. We found some correlations between codon/amino acid usage and tissue specific expression level of genes. The findings can be significant for understanding the translational selection on these features. The selection may play an important role in the differentiation of human tissues and can be considered for future studies in diagnosis of some diseases such as cancer.

임상가를 위한 특집 3 - 구강솔의 발달과 구강위생관리의 고찰 (Development of oral brush and maintaining of oral hygiene)

  • 박준봉
    • 대한치과의사협회지
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    • 제52권11호
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    • pp.678-685
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    • 2014
  • The purpose of this article is reviewed the historical background and development of oral care devices in the ancient civilization. Through an evolutional process of oral care devices, the prevalence of periodontal diseases and dental caries has revealed decreasing tendency. Because of the changing the role of the toothbrush, the name of brush should be alter from toothbrush to oral brush. Recent we can apply toothbrush to tongue cleaner to diminish the oral breathe odor. Selection of the toothbrush for fittable for each and every person is the one of important point to maintain the oral hygiene. including check-up the oral hygiene status after toothbrush with disclosing solution. This review of literature suggest that the most important way to maintain the oral health shoul be included the selection of proper toothbrush for each person and confirmation of result of toothbrush in oral cavity after had learned tooth brush instruction from professional person.

FRAT을 이용한 재해평가지수 연구 - 건설업을 중심으로 - (A Study on Calamity Index Evaluation Based on FRAT - Construction Safety -)

  • 박재현
    • 대한안전경영과학회지
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    • 제9권6호
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    • pp.31-38
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    • 2007
  • The construction industry by its nature retains higher level of danger where the smallest of error may lead to a major catastrophe endangering many workers and public safety as well as provoke social criticism. With the aid of quantitative statistical data on safety-related calamity analyzed till this day, this paper handled in depth the analysis of diseases other than the accidents, and selected new variable indexes that influence the indirect sections of calamity that are mostly concealed and incorporated them in a new model. For the factor selection of new calamity evaluation model, FRAT(Frequency, Recency, Amount, Type of merchandise/service)technique of customer-related management in marketing was applied, and as for the significance of each factor in the weight selection of variables. Consequently, considering the graveness of the FRAT itself through safety management experts, the related researches must be expanded.

동의보감(東醫寶鑑) 포문(胞門)의 침구법(鍼灸法)에 관한 소고(小考) (A literature study of acupuncture and moxibustion therapy in the the uterine section (in the Naegyeong Chapter) of Dong-Ui-Bo-Gam)

  • 김경민;양기영;이병렬
    • Korean Journal of Acupuncture
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    • 제25권4호
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    • pp.59-71
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    • 2008
  • Objectives : The aim of this study was to show the rationale of point-selection for acupuncture and moxibustion in the Uterine section(in the Naegyeong Chapter) of the Dong-Ui-BO-Gam. Methods : We reviewed the causes of each disease in the Uterine section of the Dong-Ui-BO-Gam, and then explained the rationale of acupoint-selection for the treatment of those diseases referring to etiology and physiology of Oriental medicine, other applications of each acupoints in the Dong-Ui-BO-Gam, characteristic of each acupoints, flow of Gi (Qi) through meridian pathways and specific acupoints etc. Results : There are comments on acupuncture and moxibustion for abnormal menstruation, amenorrhea, metrorrhagia, leukorrhea, bleeding from uterus after menopause in the Uterine section of the Dong-Ui-BO-Gam. Conclusions : Acupoints of conception vessel, and three foot Yin meridians are preferably used for acupuncture and moxibustion in the Uterine section of the Dong-Ui-BO-Gam. Out of them, CV3 is most frequently used and SP6, CV6, BL23, LR2 are also used often.

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