• International Journal of Oral Biology
• /
• v.35 no.2
• /
• pp.61-67
• /
• 2010

Selenoprotein S (SelS) is widely expressed in diverse tissues where it localizes in the plasma membrane and endoplasmic reticulum. We studied the potential function of SelS in erythrocyte differentiation using K562 cells stably over-expressing SelS wild-type (WT) or one of two SelS point mutants, $U_{188}S$ or $U_{188}C$. We found that in the K562 cells treated with $1\;{\mu}M$ Ara-C, SelS gradually declined over five days of treatment. On day 4, intracellular ROS levels were higher in cells expressing SelS-WT than in those expressing a SelS mutant. Moreover, the cell cycle patterns in cells expressing SelS-WT or $U_{188}C$ were similar to the controls. The expression and activation of SIRT1 were also reduced during K562 differentiation. Cells expressing SelS-WT showed elevated SIRT1 expression and activation (phosphorylation), as well as higher levels of FoxO3a expression. SIRT1 activation was diminished slightly in cells expressing SelS-WT after treatment with the ROS scavenger NAC (12 mM), but not in those expressing a SelS mutant. After four days of Ara-C treatment, SelS-WT-expressing cells showed elevated transcription of $\beta$-globin, $\gamma$-globin, $\varepsilon$-globin, GATA-1 and zfpm-1, whereas cells expressing a SelS mutant did not. These results suggest that the suppression of SelS acts as a trigger for proerythrocyte differentiation via the ROS-mediated downregulation of SIRT1.

• Journal of Korean Neurosurgical Society
• /
• v.55 no.6
• /
• pp.365-369
• /
• 2014

Spinal epidural lipomatosis (SEL) is a rare disorder, regarded in literature as a consequence of administration of exogenous steroids, associated with a variety of systemic diseases, endocrinopathies and the Cushing's syndrome. Occasionally, SEL may occur in patients not exposed to steroids or suffering from endocrinopathies, namely, idiopathic SEL. Thus far, case studies of SEL among Korean have been published rather sporadically. We reviewed the clinical features of SEL cases, among Koreans with journal review, including this report of three operated cases. According to this study, there were some differences between Korean and western cases. Koreans had higher incidences of idiopathic SEL, predominant involvement in the lumbar segments, very few thoracic involvement and lower MBI, as opposed to westerners.

• The Journal of Korean Philosophical History
• /
• no.25
• /
• pp.7-40
• /
• 2009

The aim of this paper is to establish the theoretical foundation on "the integrative study of the character education for the promotion of social and emotional competencies of children.". Based on the social and emotional learning(SEL), this paper is tried to find out the effective ways to develop children's good character. According to SEL, social and emotional competence is the ability to understand, manage, and express the social and emotional aspects of one's life in ways that enable the successful management of life tasks such as learning, forming relationships, solving everyday problems, and adapting to the complex demands of growth and development. And it is also the process of acquiring and effectively applying the knowledge, attitudes, and skills necessary to recognize and manage emotions. Five key competencies such as self-awareness, social awareness, responsible decision making, self-management, relationship skills are taught, practiced, and reinforced through SEL programming. Both the social and emotional learning movement and the character education share in common the idea that much of human character can be modified for the better through learning. While character educators engage in developing civic virtue and moral character in our youth for more compassionate and responsible society, SEL educators engage in educating for a safe, secure, caring society. To effectively teach social and emotional competencies, the teachers themselves must embrace a teaching and learning philosophy that models the attitudes, feelings, and behaviors we aim to teach.

• Asian-Australasian Journal of Animal Sciences
• /
• v.18 no.12
• /
• pp.1715-1720
• /
• 2005

Two promising varieties of forage sorghum viz. HD-15 and J. Sel-10 were identified for their higher forage yield (350-400 quintals per hectare) compared to traditional/existing variety, HC-136 at Indian Grassland and Fodder Research Institute, Jhansi. Silage of these three forage sorghum varieties viz., HD-15, J.Sel-10 and HC-136 were prepared in three concrete silos for their nutritional evaluation in sheep. Twelve adult Muzaffarnagari Ewes, divided into three equal groups of 4 each, were offered a particular variety of sorghum silage ad libitum over a period of 30 days followed by a 6 day metabolism trial and a collection of rumen liquor and blood samples. The HD-15 variety of forage sorghum silage contained higher crude protein (CP) than both the J.Sel-10 and HC-136. Average daily dry matter (DM) intake (% of live weight) differed significantly (p<0.05) in sheep that were fed the different varieties of silage, with the maximum amount in HD-15 (2.55) followed by J.Sel-10 (2.49) and HC-136 (1.84). The average apparent digestibility of all the nutrients was low in the sheep that were fed the HC-136 variety of sorghum silage when compared to both HD-15 and J.Sel-10. However, digestibility of organic matter (p<0.05) and crude protein (p<0.01) was significantly low in the HC-136 variety. The average daily nitrogen retention was-0.19, 2.15 and 0.42 g in HC-136, HD-15 and J.Sel-10, respectively which differed significantly (p<0.01). The average digestible crude protein and total digestible nutrient (TDN) contents (%) of the silage varieties were higher in HD-15 (3.14 and 55.3) than HC-136 (0.25 and 58.6) and J.Sel-10 (1.58 and 55.3) varieties. On comparing to the maintenance requirements (ICAR, 1985) for dry matter, crude protein and total digestible nutrients, both the improved varieties (HD-15 and J.Sel-10) almost met the requirements except crude protein, which met only 73.3% of the requirement by J.Sel-10, while the HC-136 variety was unable to meet the requirements. The average rumen pH and total volatile fatty acids concentrations were comparable among the groups. However, concentrations of nitrogen metabolites were higher in the animals fed the HD-15 variety of silage. Varieties of sorghum silage also did not have any influence on the concentration of the blood metabolites. It was concluded that the HD-15 variety of sorghum silage was nutritionally superior to both J.Sel-10 and HC-136 silage.

• The KIPS Transactions:PartA
• /
• v.13A no.1 s.98
• /
• pp.79-86
• /
• 2006

Recently the tagSNP selection problem has been researched for reducing the cost of association studies between human's diversities and SNPs. General approach for this problem is that all of SNPs are separated into appropriate blocks and then tagSNPs are chosen in each block. Marsel in this paper is the system that involved the concept of linkage disequilibrium for overcoming the problem that the existing block partitioning approaches have short of biological meanings. In most approaches, the contiguous regions, which recombinations have LD coefficient |D'| and then tagSNP selection step is performed. And MarSel guarantees the minimum tagSNP selection using entropy-based optimal selection algorithm when tagSNPs are chosen in each block, and enables chromosome-level association studies using efficient memory management technique when input is very large-scale dataset that is impossible to be processed in the existing systems.

• The Journal of Korean Philosophical History
• /
• no.29
• /
• pp.375-396
• /
• 2010

The aim of this paper is to suggest some ways of moral education for the building of children's social awareness and relationship skills as social and emotional competencies. Based on the social and emotional learning(SEL), this paper is tried to provide the effective ways to develop children's social awareness and relationship skill. According to SEL, social and emotional competence is the ability to understand, manage, and express the social and emotional aspects of one's life in ways that enable the successful management of life tasks such as learning, forming relationships, solving everyday problems, and adapting to the complex demands of growth and development. And it is also the process of acquiring and effectively applying the knowledge, attitudes, and skills necessary to recognize and manage emotions. Five key competencies such as self-awareness, social awareness, responsible decision making, self-management, relationship skills are taught, practiced, and reinforced through SEL programming. Moral education and social and emotional learning have emerged as two prominent formal approaches used schools to provide guidance for students' behavior. social awareness and relationship skills are necessary for succeeding in school, in the family, in the community, in life in general. Equipped with such skills, attitudes and beliefs, young children are more likely to make healty, caring, ethical, and responsible decisions and to avoid engaging in behaviors with negative consequences such as interpersonal violence and bullying.

• Molecules and Cells
• /
• v.27 no.5
• /
• pp.609-613
• /
• 2009

It has been reported that selenoprotein W (SelW) mRNA is highly expressed in the developing central nerve system of rats, and its expression is maintained until the early postnatal stage. We here found that SelW protein significantly increased in mouse brains of postnatal day 8 and 20 relative to embryonic day 15. This was accompanied by increased expression of SOD1 and SOD2. When the expression of SelW in primary cultured cells derived from embryonic cerebral cortex was knocked down with small interfering RNAs (siRNAs), SelW siRNA-transfected neuronal cells were more sensitive to the oxidative stress induced by treatment of $H_2O_2$ than control cells. TUNEL assays revealed that $H_2O_2$-induced apoptotic cell death occurred at a higher frequency in the siRNA-transfected cells than in the control cells. Taken together, our findings suggest that SelW plays an important role in protection of neurons from oxidative stress during neuronal development.

• Proceedings of the KIEE Conference
• /
• 2004.07c
• /
• pp.1605-1608
• /
• 2004

Single phase $CuInS_2$ thin film with a highest diffraction peak (112) at a diffraction angle ($2{\theta}$) of 27.7$^{\circ}$ was well made by SEL method at annealing temperature of 250 $^{\circ}C$ and annealing hour of 60 min in vacuum of $10^{-3}$ Torr or in S ambience for an hour. And the peak of diffraction intensity at miller index (112) of $CuInS_2$ thin film annealed in S ambience was shown a little higher about 11 % than in only vacuum. Single phase $CuInS_2$ thin films were appeared from 0.85 to 1.26 of Cu/In composition ratio and sulfur composition ratios of $CuInS_2$ thin films fabricated in S ambience were all over 50 atom%. Also when Cu/In composition ratio was 1.03, $CuInS_2$ thin film with chalcopyrite structure had the highest XRD peak (112). And lattice constant a and grain size of the thin film in S ambience were appeared a little larger than those in only vacuum. The largest lattice constant of a and grain size of $CuInS_2$ thin film in S ambience was 5.63 ${\AA}$ and 1.2 ${\mu}$m respectively. And the films in S ambience were all p-conduction type with resistivities of around $10^{-1}{\Omega}cm$.

• Journal of Food Hygiene and Safety
• /
• v.34 no.6
• /
• pp.576-582
• /
• 2019

Staphylococcus pseudintermedius is an opportunistic pathogen in dogs and is recognized as a zoonotic pathogen causing public health concern. Although canine-associated S. pseudintermedius has mainly been recognized for its antimicrobial resistance and ability to cause skin infections in dogs, information on antimicrobial resistance profiles and enterotoxigenicity of S. pseudintermedius in livestock is very limited. In this study, we investigated the prevalence of 18 different staphylococcal enterotoxin (SE) genes and toxic shock syndrome toxin gene (tst-1) in S. pseudintermedius strains isolated from dogs, pigs, and beef cattle. Moreover, antimicrobial resistance profiles of the strains were determined along with the presence of mecA and SCCmec types. Except for one bovine isolate, all S. pseudintermedius isolates from dogs and pigs were resistant to multiple drugs (≥ 4 different drugs). Four out of six canine isolates were methicillin resistant and carried SCCmec type V. In addition, 11 different SE genes (seb, sec, see, seg, sei, sej, sel, seo, sep, seq, and seu) and tst-1 were identified in S. pseudintermedius isolates from dogs, pigs, and beef cattle. Most S. pseudintermedius isolates (83%) harbored multiple SE genes, and sel (42%) and sep (42%) were most frequently detected in the isolates. Our results suggested that S. pseudintermedius isolates from livestock and companion animals may serve as a reservoir for SE genes and antimicrobial resistance.

• The Journal of the Korea Contents Association
• /
• v.9 no.8
• /
• pp.49-56
• /
• 2009

In this paper, we propose a method of energy level, node degree and selection information based CDS(Connected Dominating Set) construction algorithm for more efficient routing in ad-hoc wireless networks. Constructing CDS in ad-hoc wireless network, it is necessary to make more efficient algorithm that is faster, more simple and has low power consumption. A CDS must be minimized because nodes in the CDS consume more energy in order to handle various bypass traffics than nodes outside the set. It is better not to reconstruct CDS after constructing the most efficient CDS. To overcome this problem, we proposed the CDS construction algorithms based on EL+ND+Sel method. We compared and estimated the performance in each situation of EL + ND and EL + ND + Sel.