• 한국전자통신학회논문지
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• 제13권2호
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• pp.481-486
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• 2018

본 논문에서는 음악적 자극이 인간의 수리적 두뇌활동에 미치는 영향을 조사하는 것을 목적으로 하여 피험자의 뇌파를 분석한 결과를 제시한다. 음악적 자극으로는 진정성향의 음악과 자극성향의 음악을 선정하였고, 피험자의 뇌파에서는 집중력과 상관성이 높은 SMR파와 중간 베타파를 분석하여 비교하였다. 본 논문의 실험결과에서는 음악적 자극과 동시에 과제를 수행할 때의 파워가 더 높게 관측되었고, 진정성향의 음악적 자극이 자극성향의 음악적 자극보다 인간의 집중력에 방해되지 않는 것으로 나타났다.

• 한국전자통신학회논문지
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• 제18권2호
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• pp.367-372
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• 2023

본 논문에서는 기본적으로 음악 청각자극이 학습활동에 어떤 영향을 미치게 되는지를 뇌파를 통하여 분석하였다. 음악적 청각자극은 진정성향과 자극성향 그리고 선호음악과 비선호음악으로 나누어서 실험을 하였고, 학습활동 과제는 수학과제와 암기과제로 구분하여 실험하였다. 뇌파 실험에서 계측한 데이터는 인간의 집중과 관련이 있는 것으로 알려진 SMR파의 파워 스펙트럼으로 분석하여 정량적 비교에 활용하였다. 본 논문의 결과에서는, 음악이 자극으로 주어진 경우가 주어지지 않은 경우보다 파워가 크게 관측되었고, 과제의 유형과 관계없이 진정성향의 경우가 자극성향의 경우보다 뇌파의 파워가 더 크게 관측되었으며, 선호음악의 경우가 비선호음악의 경우보다 뇌파의 파워가 더 크게 관측되었다. 이들 결과로부터 음악 청각자극이 있는 경우, 진정성향의 음악의 경우, 선호음악의 경우가 상대적 경우보다 집중력을 높일 수 있을 것으로 추정한다.

• 한국전자통신학회논문지
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• 제14권3호
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• pp.607-612
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• 2019

본 논문에서는 음악적 자극이 인간의 기억에 관련된 집중력에 미치는 영향을 조사하기 위하여 인간의 뇌파를 계측 및 분석하였다. 뇌파 실험에서는 음악적 자극과 함께 기억 관련 과제를 수행하게 하였는데, 기억 관련 과제로는 영어단어를 암기하는 것을 선정하였다. 음악적 자극은 진정성향 및 자극성향의 음악으로 나누어 제시하였고, 피험자의 뇌파는 주파수 대역에 따라 나누어 분석한 결과를 각각 제시하였다.

• 한국임상수의학회지
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• 제1권1호
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• pp.49-52
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• 1984

Ponies were administered at the level of 0.1mg per kg of body weight of acetylpromazine malate through the jugular vein. Sedative effect, clinical signs such as body temperature, and changes of red blood cell counts and serum glucose concentration were investigated. Sedation was induced 5 to 6 minutes after injection of acepromazine and sedative effect was lasted for 30 to 40 minutes. Responsive reactions, however, to external stimuli were remained. Change of body temperature was not observed and heart beat was increased at the stage of induction and respiratory rate was decreased during the sedative period. Red blood cell count was considerably decreased during sedation, and concentration of serum glucose showed a tendency to increase gradually from the induction.

• 대한수의학회지
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• 제19권1호
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• pp.69-73
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• 1979

In order to detect the influence of overdosed combelen on the Korean native goats, 5mg of combelen per kg of body weight were injected intramusculary. Clinical findings, electrocardiograms and some blood chemical values were determined and the results obtained were as follows: 1. After administration of 5 mg/kg dose of combelen the animals were moderately depressed and often tried to take sitting position but showed moderate response to pinching stimulation of skin. 2. Body temperature and respiratory rate were not suppressed but heart rate were accelerated during sedative stage. 3. During sedation a slight change in the QRS complex and T wave appeared but it was not significant. 4. Hemoglobin concentration showed a tendency to decrease. SGOT activities were markedly increased 24 hours after administration of combelen and BUN values were slightly lowered. Blood sugar values were markedly elevated during sedative stage.

• 대한수의학회지
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• 제18권1호
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• pp.1-7
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• 1978

In order to detect the clinical effect of combelen which is used for sedation of domestic animals, 10 heads of clinically healthy Korean native goats were used in this study. They were divided into two groups; one is dose level of 1ml per 10 kg of body weight with 1% combelen and the other is dose level of 3 ml. Clinical observations and changes in blood components after administration of combelen were made. 1. There was no adverse effect due to combelen, but sedative effect was insufficient. 2. During sedative period the changes in heart rate and respiratory rate showed noticeable change, and body temperature was slightly decreased. 3. In ECG recordings, except for slight changes in T wave, significant change was not observed. 4. Erythrocytes, leukocytes, hemoglobin concentration and packed cell volume showed tendency to decrease during the period of sedation. 5. SGOT activity showed a remarkable increase and BUN showed a great decrease 24 hours after administration in the group of 3ml/10kg. Blood glucose level increased during the period of sedation in both groups.

• 대한수의학회지
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• 제45권2호
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• pp.263-271
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• 2005

To compare the sedative effects using intermittent intravenous bolus injection with tiletamine-zolazepam (n = 5, TZ group), xylazine-ketamine (n = 5, XK group) and propofol (n = 5, PI group), we investigated the changes of hemodynamic (heart rate, arterial pressure), $SpO_2$, rectal temperature, respiratory rate and pain score during 60 minute sedation and 40 minute recovery period in beagle dogs. The value of rectal temperature was significantly higher in PI groups (p<0.05) during recovery period. The value of heart rate was significantly lower in XK group (p<0.05) during sedation. The changes of respiratory rate were similar tendency in all groups. The change of $SpO_2$ was stable during sedation and value was significantly higher in PI group (p<0.05) during recovery period. The value of systolic arterial pressure (SAP) was significantly lower in XK group (p<0.05) than PI group during sedation and recovery period. Low analgesic effect occurred in PI group. We concluded that intravenous anesthesia by intermittent bolus injection with propofol is useful in stabilizing rectal temperature, $SpO_2$ and hemodynamic during sedation and provide fast recovery, but have low analgesic effect.

• Natural Product Sciences
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• 제25권2호
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• pp.157-164
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• 2019

The study was conducted to investigate the acute and sub-acute toxicity effect of Aquilaria malaccensis leaves aqueous extract (AEAM) towards male ICR mice in terms of body weight, relative organ weight, mortality rate and sperm parameters. In acute toxicity study, a single dose at of 2000 mg/kg was performed. In sub-acute toxicity study, the mice were received normal saline (control group), 50, 100, 150, 200, 500, or 1000 mg/kg of AEAM orally for 21 days of treatment. In sub-acute toxicity study, the number of abnormal sperm were significantly decreased in AEAM 100, 150, 200, 500, and 1000 when compared to the control group. While, the motility of sperm were found to be significantly increased in AEAM 100, 150, 200, and 1000 as compared to the control group. No mortality was recorded in the control group and treated groups in both toxicity studies except for one mouse from AEAM 1000 group. However, the mild sedative effect in terms of the tendency to sleep was clearly noticeable in both toxicity studies. Results indicated that the AEAM can be one of the useful alternative medicine to enhance fertility rate by increasing healthy sperm production.

• The Korean Journal of Pain
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• 제33권2호
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• pp.108-120
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• 2020

From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of the emotional pain component includes antianxiety drugs, antidepressants, and antipsychotics. The anti-anxiety drugs have anti-anxious, sedative, and somnolent effects. The antipsychotics are effective in patients with positive symptoms of psychosis. On the other hand, the sensory pain component can be divided into nociceptive and neuropathic pain. Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are usually applied for somatic and visceral nociceptive pain, respectively; anticonvulsants and antidepressants are administered for the treatment of neuropathic pain with positive and negative symptoms, respectively. The NSAIDs, which inhibit the cyclo-oxygenase pathway, exhibit anti-inflammatory, antipyretic, and analgesic effects; however, they have a therapeutic ceiling. The adverse reactions (ADRs) of the NSAIDs include gastrointestinal problems, generalized edema, and increased bleeding tendency. The opioids, which bind to the opioid receptors, present an analgesic effect only, without anti-inflammatory, antipyretic, or ceiling effects. The ADRs of the opioids start from itching and nausea/vomiting to cardiovascular and respiratory depression, as well as constipation. The anticonvulsants include carbamazepine, related to sodium channel blockade, and gabapentin and pregabalin, related to calcium blockade. The antidepressants show their analgesic actions mainly through inhibiting the reuptake of serotonin or norepinephrine. Most drugs, except NSAIDs, need an updose titration period. The principle of polypharmacy for analgesia in case of mixed components of pain is increasing therapeutic effects while reducing ADRs, based on the origin of the pain.

• 대한소아치과학회지
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• 제45권1호
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• pp.75-81
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• 2018

최근 진정법은 소아치과의 영역에서 협조도가 부족한 어린이를 대상으로 흔히 사용되고 있다. 본 연구의 목적은 5년간 단국대학교 치과병원 소아 치과에서 시행된 진정법에 대한 정보를 다각도로 분석하는 것이다. 종합의료정보시스템(Order Communication System)을 사용하여 2011년 1 월부터 2015년 12월까지 단국대학교 치과병원 소아치과에서 시행된 치과 치료에 대한 정보를 수집하였다. 수집된 정보는 환자의 성별, 연령, 진정법 시행여부 및 약물 종류, 시술 날짜 및 유형이었다. 전체 증례에 대한 의식하진정법 사용 증례의 비율은 2011년에서 2014년까지 지속적으로 감소하였다. 반면 전신마취 증례의 빈도는 점진적으로 증가하였다. 의식하진정 유도를 위한 방법 중 midazolam 근육주사와 아산화질소 흡입진정의 사용빈도는 최근 증가하였다. 의식하진정법의 사용은 환아의 나이가 만3세 이상인 경우 그 빈도가 크게 감소하였으나, 전신마취는 전 연령대에서 사용 빈도가 비슷하였다. 환아가 여아인 경우보다 남아인 경우에, 그리고 수복치료만을 시행하는 경우보다 신경치료를 함께 시행하는 경우에 더 깊은 진정 상태에서 치료를 시행하려는 경향이 관찰되었다. 또한 진정의 심도가 깊을수록 수복치료 이후 90일 이내에 재치료를 시행하는 빈도는 감소하였다.