• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.2
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• pp.481-486
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• 2018

In this paper, we aimed to analysis EEG signals related to the relativity between musical stimuli and human brain activity for the arithmetical calculation and present the experimental results. We use two kinds of musical stimuli, one is a sedative tendency music and the other is a stimulative tendency music. The SMR wave and Mid-beta wave are analyzed because of the concentration. In our results, the sedative tendency music is not more interfere with human brain activity for the arithmetical calculations than the stimulative tendency music.

• The Journal of the Korea institute of electronic communication sciences
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• v.18 no.2
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• pp.367-372
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• 2023

In this paper, we analyzed through the EEG signals how musical stimulus affects learning activities. Musical stimuli were divided into sedative and stimulative tendency music, preferred and non-preferred music, and the learning activity tasks were divided into mathematics tasks and memorization tasks. The signals measured in the EEG experiments were analyzed with the power spectrum of SMR waves known to be related to human concentration. Those spectra used for quantitative comparison in this paper. As a result the power of the EEG signals was observed to be greater than the case where music was given as a stimulus. Regardless of the type of task, the power of the EEG signals was observed to be greater in the case of sedative tendency than in the case of stimulative tendency, and the power of the EEG signals was observed to be greater in the case of favorite music than in the case of unfavorite music. From these results, it is estimated that if the musical stimulus exists, in the case of sedative tendency music, and in the case of favorite music, concentration can be increased than in the relative case.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.3
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• pp.607-612
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• 2019

In this paper, we measured and analyzed the EEG signals related to the relativity between musical stimuli and human concentration for memorization. In our experiments, the subjects carried out the tasks related to human memorization exposing to musical stimuli and the tasks are to memorize the english words. We used two kinds of musical stimuli, one is a sedative tendency music and the other is a stimulative tendency music. We presented the results that are analyzed as the EEG signals by frequency bands, respectively.

• Journal of Veterinary Clinics
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• v.1 no.1
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• pp.49-52
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• 1984

Ponies were administered at the level of 0.1mg per kg of body weight of acetylpromazine malate through the jugular vein. Sedative effect, clinical signs such as body temperature, and changes of red blood cell counts and serum glucose concentration were investigated. Sedation was induced 5 to 6 minutes after injection of acepromazine and sedative effect was lasted for 30 to 40 minutes. Responsive reactions, however, to external stimuli were remained. Change of body temperature was not observed and heart beat was increased at the stage of induction and respiratory rate was decreased during the sedative period. Red blood cell count was considerably decreased during sedation, and concentration of serum glucose showed a tendency to increase gradually from the induction.

• Korean Journal of Veterinary Research
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• v.19 no.1
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• pp.69-73
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• 1979

In order to detect the influence of overdosed combelen on the Korean native goats, 5mg of combelen per kg of body weight were injected intramusculary. Clinical findings, electrocardiograms and some blood chemical values were determined and the results obtained were as follows: 1. After administration of 5 mg/kg dose of combelen the animals were moderately depressed and often tried to take sitting position but showed moderate response to pinching stimulation of skin. 2. Body temperature and respiratory rate were not suppressed but heart rate were accelerated during sedative stage. 3. During sedation a slight change in the QRS complex and T wave appeared but it was not significant. 4. Hemoglobin concentration showed a tendency to decrease. SGOT activities were markedly increased 24 hours after administration of combelen and BUN values were slightly lowered. Blood sugar values were markedly elevated during sedative stage.

• Korean Journal of Veterinary Research
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• v.18 no.1
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• pp.1-7
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• 1978

In order to detect the clinical effect of combelen which is used for sedation of domestic animals, 10 heads of clinically healthy Korean native goats were used in this study. They were divided into two groups; one is dose level of 1ml per 10 kg of body weight with 1% combelen and the other is dose level of 3 ml. Clinical observations and changes in blood components after administration of combelen were made. 1. There was no adverse effect due to combelen, but sedative effect was insufficient. 2. During sedative period the changes in heart rate and respiratory rate showed noticeable change, and body temperature was slightly decreased. 3. In ECG recordings, except for slight changes in T wave, significant change was not observed. 4. Erythrocytes, leukocytes, hemoglobin concentration and packed cell volume showed tendency to decrease during the period of sedation. 5. SGOT activity showed a remarkable increase and BUN showed a great decrease 24 hours after administration in the group of 3ml/10kg. Blood glucose level increased during the period of sedation in both groups.

• Korean Journal of Veterinary Research
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• v.45 no.2
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• pp.263-271
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• 2005

To compare the sedative effects using intermittent intravenous bolus injection with tiletamine-zolazepam (n = 5, TZ group), xylazine-ketamine (n = 5, XK group) and propofol (n = 5, PI group), we investigated the changes of hemodynamic (heart rate, arterial pressure), $SpO_2$, rectal temperature, respiratory rate and pain score during 60 minute sedation and 40 minute recovery period in beagle dogs. The value of rectal temperature was significantly higher in PI groups (p<0.05) during recovery period. The value of heart rate was significantly lower in XK group (p<0.05) during sedation. The changes of respiratory rate were similar tendency in all groups. The change of $SpO_2$ was stable during sedation and value was significantly higher in PI group (p<0.05) during recovery period. The value of systolic arterial pressure (SAP) was significantly lower in XK group (p<0.05) than PI group during sedation and recovery period. Low analgesic effect occurred in PI group. We concluded that intravenous anesthesia by intermittent bolus injection with propofol is useful in stabilizing rectal temperature, $SpO_2$ and hemodynamic during sedation and provide fast recovery, but have low analgesic effect.

• Natural Product Sciences
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• v.25 no.2
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• pp.157-164
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• 2019

The study was conducted to investigate the acute and sub-acute toxicity effect of Aquilaria malaccensis leaves aqueous extract (AEAM) towards male ICR mice in terms of body weight, relative organ weight, mortality rate and sperm parameters. In acute toxicity study, a single dose at of 2000 mg/kg was performed. In sub-acute toxicity study, the mice were received normal saline (control group), 50, 100, 150, 200, 500, or 1000 mg/kg of AEAM orally for 21 days of treatment. In sub-acute toxicity study, the number of abnormal sperm were significantly decreased in AEAM 100, 150, 200, 500, and 1000 when compared to the control group. While, the motility of sperm were found to be significantly increased in AEAM 100, 150, 200, and 1000 as compared to the control group. No mortality was recorded in the control group and treated groups in both toxicity studies except for one mouse from AEAM 1000 group. However, the mild sedative effect in terms of the tendency to sleep was clearly noticeable in both toxicity studies. Results indicated that the AEAM can be one of the useful alternative medicine to enhance fertility rate by increasing healthy sperm production.

• The Korean Journal of Pain
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• v.33 no.2
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• pp.108-120
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• 2020

From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of the emotional pain component includes antianxiety drugs, antidepressants, and antipsychotics. The anti-anxiety drugs have anti-anxious, sedative, and somnolent effects. The antipsychotics are effective in patients with positive symptoms of psychosis. On the other hand, the sensory pain component can be divided into nociceptive and neuropathic pain. Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are usually applied for somatic and visceral nociceptive pain, respectively; anticonvulsants and antidepressants are administered for the treatment of neuropathic pain with positive and negative symptoms, respectively. The NSAIDs, which inhibit the cyclo-oxygenase pathway, exhibit anti-inflammatory, antipyretic, and analgesic effects; however, they have a therapeutic ceiling. The adverse reactions (ADRs) of the NSAIDs include gastrointestinal problems, generalized edema, and increased bleeding tendency. The opioids, which bind to the opioid receptors, present an analgesic effect only, without anti-inflammatory, antipyretic, or ceiling effects. The ADRs of the opioids start from itching and nausea/vomiting to cardiovascular and respiratory depression, as well as constipation. The anticonvulsants include carbamazepine, related to sodium channel blockade, and gabapentin and pregabalin, related to calcium blockade. The antidepressants show their analgesic actions mainly through inhibiting the reuptake of serotonin or norepinephrine. Most drugs, except NSAIDs, need an updose titration period. The principle of polypharmacy for analgesia in case of mixed components of pain is increasing therapeutic effects while reducing ADRs, based on the origin of the pain.

• Journal of the korean academy of Pediatric Dentistry
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• v.45 no.1
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• pp.75-81
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• 2018

Recently, sedation is routinely used in children who lacked cooperation in pediatric dental clinics. The purpose of this study is to analyze dental treatment cases in department of pediatric dentistry at Dankook University Dental Hospital associating with sedation during 5 years. From January 2011 to December 2015, information about dental treatment cases in department of pediatric dentistry was collected and reviewed. The information gathered included patient gender, age, sedation type, sedative agents, date of operation, and type of procedure. The proportion of treatment cases with conscious sedation for total treatment cases continued to decline until 2014. On the other hand, the incidence of general anesthesia increased gradually. The frequency of midazolam administration and nitrous oxide inhalation sedation increased recently. The use of conscious sedation was significantly decreased when the age of patient was 3 years or older. The frequency of general anesthesia was similar in all age groups. There was a tendency to perform treatment with deeper sedation when the patient was male than female, and when the pulp treatment was performed together with the restorative treatment than not performed. The frequency of re-treatment within 90 days after restoration treatment decreased as the depth of sedation increased.