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Potential Role of Bioactive Phytochemicals in Combination Therapies against Antimicrobial Activity

  • Choudhury, Ananta
    • Journal of Pharmacopuncture
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    • v.25 no.2
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    • pp.79-87
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    • 2022
  • Since ancient times, plants have been a major source of novel drug molecules and have been used in the treatment of different infectious diseases. Secondary plant metabolites have miraculous healing properties and show potent therapeutic responses when used in combination drug therapy. The prime objective of this review is to summarize the concept of drug combination with special emphasis on the synergistic interactions between plant-derived bioactive phytochemicals with commercially available antimicrobial agents. The study also assesses the roles, importance, and applicability of phytochemicals in the management of different diseases. The review focuses on different aspects of combined antimicrobial activities, the possible mechanisms involved, and the current status of research in the field. The study was conducted based on an extensive literature survey that resulted in the following hypothesis: secondary metabolites derived from plants possess remarkable therapeutic activities. The study was designed as a systematic review that ensures unbiased and accurate representations of the relevant data and information. Jadad scale selection criteria were used for qualitative analysis of the articles to assess them based on the relevant secure score (minimum and maximum scores range between 1 and 5, respectively). Articles with secure scores > 3 were considered for the study. A comprehensive literature survey was conducted using resource databases including PubMed, Google Scholar, Bielefeld Academic Search Engine, Research Gate, Scopus, Medline, and Science Direct up to June 2019. This article contains concise information about the most commonly used bioactive phytochemicals with potent antifungal and antibacterial effects.

Material Properties Evaluation of Cement Mortar Mixed with Organic/Inorganic Combined Water-repellent (유/무기 복합 발수제를 혼입한 모르타르의 재료특성 평가)

  • Kim, Wan-Su;Yoon, Chang-Bok;Cho, In-Sung;Lee, Han-Seung
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.24 no.6
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    • pp.50-58
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    • 2020
  • When the concrete surface layer is damaged, The method of impregnating the concrete surface with a water repellent cannot secure the expected durability. Recently, various waterproofing and water-repellent materials were mixed into concrete or mortar to secure water repellency even inside cracks, but compressive strength was greatly reduced. In order to overcome the decrease in compressive strength, there has not yet been a study using the merits of organic and inorganic materials at the same time, so in this study, the physical properties and water repellency performance were evaluated by mixing an organic/inorganic composite water repellent appropriately mixed with an organic and inorganic material into the mortar. When mixed with organic/inorganic water repellent, the flow and air content were reduced by about 10% and 50% compared to the Liquid specimen. In the case of the P6L1 specimen, it was confirmed that the compressive strength decreased by about 3.5% compared to the non-mixed mortar at 39.5 MPa, the same as the existing water repellent, Powder. Water-repellent performance The organic-inorganic composite water repellent mixture specimen confirmed higher water repellency than the existing water repellent mixture powder, and the chloride penetration resistance evaluation result showed that the organic-inorganic composite water repellent mixture specimen reduced the passing charge by about 45% compared to the non-mixed mortar. In summary, it is judged that the P5L1 organic/inorganic composite water repellent mixed with a powder water repellent and a liquid water repellent in a ratio of 5:1 is the most reasonable to prevent the decrease in compressive strength and secure water repellency.

A Study on particle crushing of rock-fill material (록필댐 축조재료의 입자파쇄에 대한 연구)

  • Im, Eun-Sang;Snin, Dong-Hoon;Kim, Jea-Hong;Kim, Kwang-Il
    • Proceedings of the Korean Geotechical Society Conference
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    • 2009.09a
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    • pp.1025-1028
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    • 2009
  • Earth and rock fill dam is our typical dam because of their inherent flexibility and adaptability to various fundation conditions. In order to secure structural safety, rockfill materials are used angular particles obtained by blasting parent rock or rounded particles collected from river beds. Concrete-faces rockfill dams(CFRD) and Concrete-faces gravelfill dams(CFGD) have become popular in the last 20 years as s result of their good performance and low cost compared with the rockfill dam. These Dams are also constructed by the materials. A key factor in the design of the dams is the deformations induced during construction and upon reservoir filling. These can be predicted using the stress-strain and strength properties can be adequately define. However the stress-strain properties of rockfill are difficult to determine because the properties are affected by such factors as particle grading, size and shape of particles, stress conditions, and particle crushing. In our study, testing of the behavior of the rockfill materials are essential prerequisites to the realistic analysis and design of the CFGD. This paper deals with laboratory testing of particle crushing among the study.

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Evaluation on Mechanical Properties of Tungsten by Sintering Additive Content (소결첨가재에 의한 텅스텐의 기계적 특성평가)

  • Lee, Sang-Pill;Lee, Jin-Kyung
    • Journal of the Korean Society of Industry Convergence
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    • v.25 no.4_2
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    • pp.621-626
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    • 2022
  • Tungsten is a high melting point metal unlike other steel materials, and it is difficult to manufacture because of its high melting temperature. In this study, pressure sintering process method was applied to manufacture the tungsten materials at low temperature. Therefore, it is necessary to densify the sintered material by using a sintering additive. Studies have been conducted on how the amount of titanium for sintering tungsten affects the mechanical properties of tungsten in this study. In order to secure the densification mechanism of tungsten powder during the sintering process, the characteristics of the sintered tungsten material according to the change of titanium content were evaluated. It was investigated the relationship between sintering parameters and mechanical properties for densification of microstructures. The sintered tungsten materials according to sintering additive content showed high sintered density (about 16.31g/cm3) and flexural strength (about 584 MPa) when the content of sintering additive was 3 wt%. However, as the content of the sintering additive increases, mechanical property of flexural strength is decreased, and the porosity is increased due to the heterogeneous sintering around titanium.

Creep Damage and Hardness Properties for 9Cr Steel by SP-Creep Test Technique (SP-Creep 시험기법에 의한 9Cr강의 크리프 손상과 경도 특성)

  • Baek, Seung-Se;Lyu, Dae-Young;Kim, Jeong-Ki;Kwon, Il-Hyun;Chung, Se-Hee;Yu, Hyo-Sun
    • Proceedings of the KSME Conference
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    • 2001.11a
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    • pp.105-110
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    • 2001
  • It has recently been raised main issue how solve the problem of insufficient energy. One of the solution is to increase the thermal efficiency of power generation system. For the purpose of high efficiency, it is necessary to increase the steam temperature and pressure. So, the use of modified $9{\sim}12%Cr$ steel having superior creep rupture strength and oxidation resistance is required to endure such severe environment. The evaluation of creep properties of those heat resistance material is very important to secure the reliability of high temperature and pressure structural components. Since creep properties are determined by microstructural change such as carbide precipitation and coarsening, It is certain that there are some relationship between creep properties and hardness affected by microstructure. In this study, SP-Creep ruptured test for newly developed 9Cr steel being used as boiler valve material was performed, and creep properties of the material were evaluated. Also, hardness test were performed and hardness results were related to the creep properties such as LMP and creep strength to verify the availability of SP-Creep test as creep test method.

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Mechanical Properties Assessment of Steels Obtained from an Aged Naval Ship (노후 함정 강재의 기계적 특성 평가)

  • Sang-Hyun Park;Young-Sik Jang;Su-Min Lee;Sang-Rai Cho;Sang Su Jeon;Ju Young Hwang;Nam-Ki Baek
    • Journal of the Society of Naval Architects of Korea
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    • v.60 no.2
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    • pp.65-75
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    • 2023
  • Ships operated at sea for a long time are subjected to various kinds of loads, which may cause various types of damage. Such damages will eventually reduce the strength of hull structures. Therefore, it is necessary to estimate and evaluate the residual strength and remaining fatigue life of aging ships in order to secure structural safety, establish a reasonable maintenance plan, and make a judgment of life extension. For this purpose, the corrosion damage and local denting damage should be measured, fatigue damage estimation should be performed, and material properties of aged steel should be identified. For this study, in order to investigate the mechanical properties of aged steel, steel plates were obtained from a naval ship that reached the end of her life span. The specimens were manufactured from the obtained steel plates, and static and dynamic tensile tests, fatigue tests, and metallographic tests were performed. The mechanical properties obtained from the aged steel plates were compared with those of new steel plates to quantify the aging effect on the mechanical properties of marine steel materials.

A Study on the Analysis of Disaster Prevention Characteristics According to the Surrounding Environments of State-designated Cultural Properties in Gyeongsangnam-do and Gyeongsangbuk-do Provinces (경상남·북도 국가지정 중요목조문화재 주변 환경에 따른 방재특성 분석 연구)

  • Koo, Wonhoi;Baek, Minho
    • Journal of the Society of Disaster Information
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    • v.15 no.1
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    • pp.1-11
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    • 2019
  • Purpose: This study intends to determine how disaster prevention characteristics of important state-designated wooden cultural properties in Gyeongsangnam-do vary according to the surrounding environments and to examine disaster prevention measures for wooden cultural properties that fit their surrounding environments accordingly. Method: The designation status and characteristics of cultural properties in Gyeongsangnam-do and Gyeongsangbuk-do were identified, and the damage status of cultural properties in Gyeongsangnam-do and Gyeongsangbuk-do was reviewed based on the history of disasters. Also, the disaster prevention environments for 58 state-designated wooden cultural properties in Gyeongsangnam-do and Gyeongsangbuk-do were analyzed separately into mountainous area, rural area and urban area, topographic characteristics were drawn. Results: For cultural properties located in urban areas, it was found that security guards were arranged properly and disaster prevention training was carried out well. In addition, access condition to the cultural properties was adequate; prompt access to such properties was possible. In rural areas, flame retardant works have been undertaken properly and many cultural properties were found to be located on a flat ground. Mountainous areas had highly inadequate access condition to cultural properties and disasters occurred most frequently in these areas in the past. Conclution: First, for wooden cultural properties located in urban areas, it is necessary to secure the self-defense fire service manpower for an initial response and reinforce the disaster prevention education. Second, for wooden cultural properties located in rural areas, prevention projects such as insect control project and disaster prevention insurance should be carried out in order to protect the cultural properties. Third, as for wooden cultural properties located in mountainous areas, it is necessary to prepare establish to reinforce self-response capability.

Highly functional materials for Electric power (초전도 전력용 재료)

  • Lee, Sang-Heon;Koo, Kyoung-Whan
    • Proceedings of the KIEE Conference
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    • 2011.07a
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    • pp.2152-2153
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    • 2011
  • According to a sharp increase in demand for electricity supply secure, and $CO_2$ regulation in accordance with global environmental problems and to solve problems, etc. These factor less pollution, higher energy conversion hyoyulin way that the new electrical equipment, nano-composites The rapid degeneration of the unit study utilizing the power that is required is Free. Accordingly, cables, transformers and switchgear (GIS)-capacity of power equipment, such as, high-voltage high-density along with the miniaturization of equipment have made angry the reliability of these devices is becoming a very important issue. Insulation materials used in electrical equipment for high voltage withstand, power equipment, power equipment due to aging and overloading caused by a weakening of the insulation failure and replacement in accordance with the age due to increased costs because of the reliability of electrical equipment should be secured should. Therefore, improved performance and longevity of insulation material is recognized as an important challenge. In this study, power isolation and degeneration of the unit for use in various parts of the molding epoxy resin to improve the insulation performance of the epoxy resin by varying the added amount of nano-SiO2 nanocomposites made epoxy/SiO2 analysis and breakdown properties of the experiment want to improve the electrical properties through the geometry.

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A Safety Study Using Impact and Fatigue Analyses According to Headrest Shape (헤드레스트의 형상에 따른 충돌 및 피로해석을 통한 안전성 연구)

  • Han, Moonsik;Cho, Jaeung
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.17 no.3
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    • pp.39-44
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    • 2018
  • The automotive headrest is intended to provide comfort, safety, convenience and durability to a vehicle's passengers and driver. In this study, impact and fatigue analyses were carried out for three headrest shape models-A, B and C. These models have the same material properties and the same force was applied to them. Impact and fatigue analyses demonstrated that all of the models obtained almost the exact same result values. This study found that all models had similar equivalent stress, deformation, fatigue life and main damage parts due to the fact that the shared same material properties. Better safety and fatigue life can be anticipated by changing the material of the headrest in order to secure more stable safety. An automotive headrest optimized for safety and durability is thought to have been developed through the impact and fatigue analyses of this study.

Development of Polymetallic Nodules in the NE Equatorial Pacific: Past, Present and Future (심해저 망간단괴 개발의 현황과 미래)

  • Chi, Sang Bum;Hong, Sup
    • Ocean and Polar Research
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    • v.36 no.4
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    • pp.367-371
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    • 2014
  • In early 1990s, the Korean government has launched a deep-sea research program to secure the stable long-term supply of strategic metallic minerals including Cr, Cu and Ni. Through the pioneering surveys, Korea registered $150,000km^2$ of Mn-nodule field in the Clarion-Clipperton area, the NE equatorial Pacific to the international sea-bed authority (ISA) in 1994. Following the ISA exploration code, the final exclusive exploration area of $75,000km^2$ was assigned in 2002, based on results of eight-year researches of chemico-physical properties of nodules, bottom profiles and sediment properties. Since that time, environmental studies, mining technical developments including robot miner and lifting system and establishment of smelting systems were accompanied with the detailed geophysical studies to decipher the priori mining area until 2009. Major points of the recent Korea Mn-nodule program are deployed on a commercial scale until 2015. In order to meet the goals, we developed a 1/5 scaled robot miner compared to commercial one in 2012 and performed a mining test at the water depth of 1,370 m in 2013. In addition, detailed 25,000 scaled mining maps in the priori area, which can provide operation roots of the miner, will be prepared and an environmental-friendly mining strategy will be pursued based on the environmental impact test and environmental monitoring.