• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.14.1-14.14
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• 2018

The link between antibiotic treatment and IF-associated liver disease (IFALD) is unclear. Here, we study the effect of antibiotic treatment on bile acid (BA) metabolism and investigate the involved mechanisms. The results showed that pediatric IF patients with cholestasis had a significantly lower abundance of BA-biotransforming bacteria than patients without cholestasis. In addition, the BA composition was altered in the serum, feces, and liver of pediatric IF patients with cholestasis, as reflected by the increased proportion of primary BAs. In the ileum, farnesoid X receptor (FXR) expression was reduced in patients with cholestasis. Correspondingly, the serum FGF19 levels decreased significantly in patients with cholestasis. In the liver, the expression of the rate-limiting enzyme in bile salt synthesis, cytochrome P450 7a1 (CYP7A1), increased noticeably in IF patients with cholestasis. In mice, we showed that oral antibiotics (gentamicin, GM or vancomycin, VCM) reduced colonic microbial diversity, with a decrease in both Gram-negative bacteria (GM affected Eubacterium and Bacteroides) and Gram-positive bacteria (VCM affected Clostridium, Bifidobacterium and Lactobacillus). Concomitantly, treatment with GM or VCM decreased secondary BAs in the colonic contents, with a simultaneous increase in primary BAs in plasma. Moreover, the changes in the colonic BA profile especially that of tauro-beta-muricholic acid ($T{\beta}MCA$), were predominantly associated with the inhibition of the FXR and further altered BA synthesis and transport. In conclusion, the administration of antibiotics significantly decreased the intestinal microbiota diversity and subsequently altered the BA composition. The alterations in BA composition contributed to cholestasis in IF patients by regulating FXR signaling.

• Geomechanics and Engineering
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• v.6 no.2
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• pp.153-172
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• 2014

In order to investigate the effect of different perforation angles (the angle between the perforation direction and the maximum horizontal principal stress) on the fracture initiation and propagation during hydraulic fracturing of highly deviated well in oil & gas saturated formation, laboratory experiments of the hydraulic fracturing had been carried out on the basis of non-dimensional similar criteria by using 400^3 $mm^3$ cement cubes. A plane fracture can be produced when the perforations are placed in the direction of the maximum horizontal principal stress. When the perforation angle is $45^{\circ}$, the fractures firstly initiate from the perforations at the upper side of the wellbore, and then turn to the maximum horizontal principal stress direction. When the well deviation angle and perforation angle are both between $45^{\circ}$ and $90^{\circ}$, the fractures hardly initiate from the perforations at the lower side of the wellbore. Well azimuth (the angle between the wellbore axis and the maximum horizontal principal stress) has a little influence on the fracture geometries; however it mainly increases the fracture roughness, fracture continuity and the number of secondary fractures, and also increases the fracture initiation and propagation pressure. Oriented perforating technology should be applied in highly deviated well to obtain a single plane fracture. If the well deviation angle is smaller, the fractures may link up.

• Journal of Practical Engineering Education
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• v.13 no.2
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• pp.301-304
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• 2021

In this study, we developed a module that can perform two functions at the same time through interworking between a personal recognition module and a heat detection module in the era of COVID-19. This can simultaneously solve the problem of compatibility of the personal recognition module that occurs in the existing system and the problem of secondary infection that can occur during congestion due to the separate implementation of heat detection. Therefore, in this study, NFC and Bluetooth motherboards were developed, and an array-type non-contact temperature sensor was applied to detect heat. The developed system is expected to be able to realize both access control of floating population and effective quarantine at the same time in public institutions or private companies that require AI automated access control. In addition, it is judged that it is possible to link the embedded programming and web programming implementation method using the module of the development system to the educational program.

• Journal of the Korean School Mathematics Society
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• v.21 no.4
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• pp.469-483
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• 2018

The purpose of this study is to find out how pre-service mathematics teachers should prepare for the teaching of probability and statistics in school mathematics and to help improve teacher education. To do this, questionnaires and evaluation of probabilistic and statistical curriculum were conducted for pre-service teachers, and regression analysis and correlation between them were examined. Through the investigation, the items with low evaluation results due to level of difficulty were extracted and analyzed. As a result, first, it is necessary to teach pre-service mathematics teachers with link the contents curriculum of college and secondary school about probability and statistics. Second, accurate diagnosis of pre-service mathematics teachers' understanding of probability and statistics is needed. Third, the misconceptions and causes of pre-service mathematics teachers were analyzed in detail. And suggests that various follow-up studies related to this are needed.

• The Journal of the Korea Contents Association
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• v.19 no.5
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• pp.472-483
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• 2019

This study purposed to analyze how teacher experience of instructional change (EIC), teacher morale (TM), and school climate (SC) mediate or moderate the relationship between teacher efforts on instructional improvement (EII) and teacher efficacy (TE). For the purpose, the 6th year data of Gyeonggi Education Panel Study (GEPS) which was administered in 2017 for the 9th grade students and their teachers from 197 middle schools in Gyeonggi Province was used. As results, the mediation effects of EIC on the link between EII and TE was found only under the innovative climate. The moderation effects of TM on the connection between EIC and TE were appeared in both of the permissive and the innovative climate. Finally, the moderated mediation effects of the TM in the innovative climate were bigger rather than in the permissive climate.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.6
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• pp.768-777
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• 2020

In this paper, we describe recent research results on AODV routing protocol, which is widely deployed at mobile ad hoc networks, and AODV related routing protocols with multi-path routing schemes. We suggest the critical problems which minimum hop routing schemes have, such as AODV routing protocol, and then, propose a new C-AODV routing protocol with two routing metrics: the primary metric is the hop count, the secondary metric is the sum of link delay times. We implemented C-AODV protocol by modifying AODV at the NS-3, and thus, elaborate on how we change the original AODV source code of NS-3 in order to implement the C-AODV scheme. We show numerical comparison of C-AODV scheme with the original AODV scheme and then, discuss how much the C-AODV enhances routing performance over AODV protocol. In conclusion, we present future research items.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.1387-1390
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• 2008

In a wireless network, handover latency is very important in supporting user mobility with the required quality of service (QoS). In view of this many schemes have been developed which aim to reduce the handover latency. The Hierarchical Mobile IPv6 (HMIPv6) approach is one such scheme which reduces the high handover latency that arises when mobile nodes perform frequent handover in Mobile IPv6 wireless networks. Although HMIPv6 reduces handoff latency, failures in the mobility anchor point (MAP) results in severe disruption or total disconnection that can seriously affect user satisfaction in ongoing sessions between the mobile and its correspondent nodes. HMIPv6 can avoid this situation by using more than one mobility anchor point for each link. In [3], an improved Robust Hierarchical Mobile IPv6 (RH-MIPv6) scheme is presented which enhances the HMIPv6 method by providing a fault-tolerant mobile service using two different MAPs (Primary and Secondary). It has been shown that the RH-MIPv6 scheme can achieve approximately 60% faster recovery times compared with the standard HMIPv6 approach. However, if mobile nodes perform frequent handover in RH-MIPv6, these changes incur a high communication overhead which is configured by two local binding update units (LBUs) as to two MAPs. To reduce this communication overhead, a new cost-reduced binding update scheme is proposed here, which reduces the communication overhead compared to previous schemes, by using an increased number of MAP switches. Using this new proposed method, it is shown that there is a 19.6% performance improvement in terms of the total handover latency.

• Journal of The Korean Association For Science Education
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• v.35 no.6
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• pp.1039-1048
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• 2015

The purpose of this study is to examine implications of pre-service science teacher training by analyzing science field integration and connection between learning content presented in 'Integrated Science' for high school students based on the 2015 revised science curriculum, and in pre-service science learning materials (textbooks) of the college of education. For this study, the 2015 revised 'Integrated Science' curriculum and 11 types of pre-service science teachers' learning materials related to physics, chemistry, biological science, and earth science were selected. The results were as follows. Most of the learning content presented in the 2015 revised 'Integrated Science' curriculum had integrated two or more science fields. Also, almost all learning content presented in the 2015 revised 'Integrated Science' curriculum were included in pre-service science teachers' education content, with educational content for chemistry introduced at the highest rate. The textbooks for pre-service science teachers had the most learning contents of 'Energy and Environment' domain of 'Integrated Science' for high school students. Accordingly, these results suggest that 'integrated science materials' should be developed for proper the curriculum implementation. Also, training courses for science teachers responsible for 'Integrated Science' are required. Furthermore, a revised curriculum for the college of education and a method to link with certification examinations for secondary school teachers are needed.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.10
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• pp.4678-4702
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• 2018

Traffic Matrix estimation has always caught attention from researchers for better network management and future planning. With the advent of high traffic loads due to Cloud Computing platforms and Software Defined Networking based tunable routing and traffic management algorithms on the Internet, it is more necessary as ever to be able to predict current and future traffic volumes on the network. For large networks such origin-destination traffic prediction problem takes the form of a large under- constrained and under-determined system of equations with a dynamic measurement matrix. Previously, the researchers had relied on the assumption that the measurement (routing) matrix is stationary due to which the schemes are not suitable for modern software defined networks. In this work, we present our Compressed Sensing with Dynamic Model Estimation (CS-DME) architecture suitable for modern software defined networks. Our main contributions are: (1) we formulate an approach in which measurement matrix in the compressed sensing scheme can be accurately and dynamically estimated through a reformulation of the problem based on traffic demands. (2) We show that the problem formulation using a dynamic measurement matrix based on instantaneous traffic demands may be used instead of a stationary binary routing matrix which is more suitable to modern Software Defined Networks that are constantly evolving in terms of routing by inspection of its Eigen Spectrum using two real world datasets. (3) We also show that linking this compressed measurement matrix dynamically with the measured parameters can lead to acceptable estimation of Origin Destination (OD) Traffic flows with marginally poor results with other state-of-art schemes relying on fixed measurement matrices. (4) Furthermore, using this compressed reformulated problem, a new strategy for selection of vantage points for most efficient traffic matrix estimation is also presented through a secondary compression technique based on subset of link measurements. Experimental evaluation of proposed technique using real world datasets Abilene and GEANT shows that the technique is practical to be used in modern software defined networks. Further, the performance of the scheme is compared with recent state of the art techniques proposed in research literature.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2000.11a
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• pp.257-266
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• 2000

산업 및 가정용 기기들이 점차 복잡해짐에 따라 다양한 공학 분야의 해석 기술을 동시에 고려하면서 이들 원리를 적용한 최적의 설계를 결정하는 방법론의 필요성이 대두되고 있다. 다분야통합최적설계 또는 MDO(Multidisciplinary Design Optimization)라 일컫는 새로운 기술은 이러한 필요에 대응하는 기술로서 국내외적으로 활발한 연구가 진행되고 있다. 이러한 MDO 기술을 구현하는 소프트웨어와 하드웨어 복합 체계를 MDO 프레임웍(framework)이라 한다. 일반적으로 프레임웍이란 실제 응용프로그램의 용도에 맞는 주문제작(customization)이 가능한 일종의 전단계 프로그램이라 할 수 있다 MDO 프레임웍은 설계 및 해석 도구들간의 인터페이스를 제공하고, 이들 도구들이 사용하는 설계 데이터를 효율적으로 공유할 수 있도록 지원하여, 설계 작업을 정의, 실행, 관리하는 역할을 한다. 이러한 MDO 프레임웍은 설계 작업을 통합적으로 관리하고 자동화하여 설계 도구간의 데이터 전달과 변환에 소묘되는 설계자의 부담을 경감시키며 다분야 전문가가 참여하는 공통 작업 환경을 제공함으로써 설계 효율성을 증진시킨다. 본 논문에서는 이러한 효용을 달성하기 위한 MDO 프레임웍(framework)을 제시하고 프레임웍 설계의 논리적 근저와 타당성을 밝힌다. 본 논문에서 제안하는 다분야 통합 최적화를 위한 분산형 지능 시스템인 DisMDO는 사용자가 GUI를 동해서 편리하게 다분야통합최적화 문제를 해결할 수 있도록 지원하며, 제공되는 스크립트 언어를 동해서도 이를 정의할 수 있도록 지원하여 일괄처리도 가능하도록 한다. 또한, 집중화된 데이터베이스를 관리하여 다분야 전문가들이 공통의 데이터를 안전하게 공유할 수 있도록 지원하며, 외부에서 제공되는 해석 도구나 최적화 모듈을 손쉽게 프레임웍에 통합시킬 수 있도록 하는 인터페이스 제작기(factory) 기능을 제공한다.ackscattering spectroscopy, X-ray diffraction, secondary electron microscopy, atomic force microscoy, $\alpha$-step, Raman scattering spectroscopu, Fourier transform infrared spectroscopy 및 micro hardness tester를 이용하여 기판 bias 전압이 DLC 박막의 특성에 미치는 영향을 조사하였다. 분석결과 본 연구에서 제작된 DLC 박막은 탄소와 수소만으로 구성되어 있으며, 비정질 상태임을 알 수 있었다. 기판 bias 전압의 증가에 따라 박막의 두께가 감소됨을 알 수 있었고, -150V에서는 박막이 거의 만들어지지 않았으며, -200V에서는 기판 표면이 식각되었다. 이것은 기판 bias 전압과 ECR 플라즈마에 의한 이온충돌 효과 때문으로 판단되며, 150V 이하에서는 증착되는 양보다 re-sputtering 되는 양이 더 많을 것으로 생각된다. 기판 bias 전압을 증가시킬수록 플라즈마에 의한 이온충돌 현상이 두드러져 탄소와 결합하고 있던 수소원자들이 떨어져 나가는 탈수소화 (dehydrogenation) 현상을 확인할 수 있었으며, 이것은 C-H 결합에너지가 C-C 결합이나 C=C 결합보다 약하여 수소 원자가 비교적 해리가 잘되므로 이러한 현상이 일어난다고 판단된다. 결합이 끊어진 탄소 원자들은 다른 탄소원자들과 결합하여 3차원적 cross-link를 형성시켜 나가면서 내부 압축응력을 증가시키는 것으로 알려져 있으며, hardness 시험 결과로 이것을 확인할 수 있었다. 그리고 표면거칠기는 기판 bias 전압을 증가시킬수록 더 smooth 해짐을 확인하였다.인하였다.을 알 수 있었다. 즉 계면에서의 반응에 의해 편석되는 Ga에 의해 박막의 strain이 이완되면, pinhole 등의 박막결함