• 한국임상약학회지
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• 제12권1호
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• pp.39-50
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• 2002

Hypercholesterolemia is one of main causes of coronary heart disease(CHD). Clinical trials demonstrated that lowering serum cholesterol levels would reduce incidence of new cardiovascular events and mortality by primary or secondary preventions. The objective of this retrospective study was to compare efficacy and side effects of lovartatin and simvastatin in treatement of hypercholesterolemia. In Boramae Hospital, patients were included when they have taken lovastatin 20 mg or simvastatin 10 mg for 52 weeks with laboratory monitoring for cholesterol at baseline, 3, 6 and 12 month period. As results, total 128 outpatients were included with their total cholesterol level <240 mg/dl and triglyceride level <400 mg/dl at baseline. Total cholesterol and LDL cholesterol of lovastatin group (n=60) and simvastatin group (n=68) were significantly reduced from baseline (p=0.001). Lovastatin maximally reduced total cholesterol by $23.9\%,\;triglyceride\;by\;12.3\%$, LDL cholesterol by $36.1\;\%$ and increased HDL cholerterol by $7.8\%$ and simvastatin reduced by $24.1\%,\;20.5\%,\;34.3\%\;respectively$ and HDL increased by $11.2\%$. There were no significant differences between lovastatin and simvastatin in mean percent change of lipid levels at 12, 24 and 52 weeks from baseline. Cumulative percentage of patients reaching the target LDL cholesterol concentration by 24 weeks was $61.7\%$ in lovastatin and $64.7\%$ in simvastatin. Average time to reach the target LDL goal was 100.1 days in lovastatin and 99.8 days in simvastatin. Both lovastatin and simvastatin also significantly reduced total cholesterol and LDL cholesterol in all subgroups (diabetes mellitus, hypertension, and coronary heart disease). In this study, treatment efficacy in patients with coronary heart disease was lower than other patients. Considering clinical importance of secondary prevention, more intensive treatment is necessary to decrease LDL cholesterol level of 100 mg/dl or lower in patients with coronary heart disease or other clinical atherosclerotic disease. There were no serious side effects during the study period. Digestive side effects were most frequently reported (lovastatin $8.3\%\;vs\;simvastatin\;8.8\%$). In conclusion, both lovastatin and simvastatin were similar in lipid lowering effects and there was no difference in incidence of side effects.

• Journal of Chest Surgery
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• 제32권4호
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• pp.383-387
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• 1999

배경: 일차성 자연기흉은 대개 기포가 터져서 발생하며 상당수에서 재발이 되는 것으로 알려져 있다. 그러나 단순 흉부촬영에서 기포의 발견률은 높지 않다. 이에 저자들은 고해상CT를 이용하여 치료방향 설정과 수술적 치료시 지침을 제공하고, 단순촬영에서 찾을 수 없으나 재발의 원인이 될 수 있는 숨겨진 기포를 숙지하기위해 이 연구를 시행하였다. 대상 및 방법: 외상성 기흉을 제외한 70명의 자연기흉 환자들을 대상으로 고해상 CT를 시행하여 병변측 및 반대측의 기포의 유무, 개수, 동반된 폐질환, 그리고 치료의 종류와 빈도를 후향적으로 분석하였다. 결과: 70명의 대상군중 45명은 원인질환이 분명하지 않은 일차성이었고 25명은 폐결핵에 의한 이차성으로 모두 이전에 앓은 후유증의 소견들을 보였으며 활동성 폐결핵의 소견을 보인 경우는 없었다. 일차성과 이차성 기흉의 평균 연령은 각각 25.9세와 44.1세로 일차성에서 더 젊었다. 단순촬영에서는 30.2%에서 기포를 찾을 수 있었다. 고해상 CT에서는 75.7%에서 기포를 찾을 수 있었고(병변측에 68.6%, 반대측에 55.7%) 48.6%에서는 양쪽폐에서 관찰되었다. 기포의 개수가 10개이상으로 다발성인 경우는 이차성 기흉에서 일차성 기흉에서보다 더 흔히 관찰되었다. 대부분의 환자을 흉강삽관술(36명)이나 기포제거술(27명)로 치료하였다. 결론: 자연기흉환자들에서 고해상 CT가 단순촬영보다 동반된 기포를 찾는데 훨씬 더 우수하였고 동반 질환의 평가에도 유용하였다. 따라서 고해상CT가 재발의 고위험군등에서 재발을 막는 예방적 치료를 결정하는등 치료방법의 선택에 도움을 줄 수 있고, 수술적 치료시 수술의 지침을 제공할 수도 있으며 나아가 재발의 원인이 될 수 있는 잠복된 기포를 환자에 주지시킬 수 있다는 점에서 큰 도움이 될 것으로 생각한다.

• Childhood Kidney Diseases
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• 제5권2호
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• pp.117-124
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• 2001

목 적 : 1990년 Mendoza등이 스테로이드 저항성 신증후군에서 Mendoza protocol에 의한 장기간의 methylprednisolone pulse therapy (이하 MP 요법)가 관해를 유도하고 유지시키는 효과적인 치료방법인 것으로 보고한 이후, 스테로이드 저항성 신증후군에서 이 치료법의 효과에 관한 보고는 있어 왔지만 스테로이드 의존성 신증후군과 2차성 신증후군에서 이 치료법의 효과에 관한 보고는 아직까지 없는 실정이다. 본 연구에서는 면역억제제 또는 세포독성물질로도 스테로이드 의존성을 없애거나 재발율을 낮출 수 없었던 스테로이드 의존성 미세변화형 신증후군과 난치성 국소성 분절성 사구체 경화증 및 2차성 신증후군에서 Mendoza protocol에 따른 장기간의 MP 요법의 치료 효과를 알아보고자 하였다. 대상 및 방법 : 1997년부터 2000년사이에 세브란스병원 소아과에서 신생검에 의해 1차성 또는 2차성 신증후군을 진단받고 면역억제제 또는 세포독성 물질 치료로 스테로이드 의존성을 없애거나 재발률을 낮출 수 없었던 스테로이드 의존성 미세변화형 신증후군과 기존의 스테로이드 및 면역억제제 치료에 반응을 보이지 않았던 난치성 국소성 결절성 사구체 경화증 및 2차성 신증후군 환아 21명을 대상으로 하여 Mendoza protocol에 따라 82주 동안 MP요법을 시행하였다. 결 과 : 대상 환아를 신조직검사 소견에 따라 분류하면 1차성 신증후군이 16례($76\%$)로 이중 미세변화형 신증후군이 10례, 국소성 분절성 사구체 경화증이 6례였으며, 2차성 신증후군은 5례($24\%$)였다. 스테로이드 의존성 미세변화형 신증후군 10례 모두 ($100\%$)에서 MP요법 시작후 평균 $18{\pm}9일$ 내에 완전관해가 되었으나 전례에서 치료중 또는 치료후에 재발하였고, 연간 평균 재발횟수가 치료전에 $2.1{\pm}1.0회$, 치료중에 $1.4{\pm}0.9회$로 치료전보다 감소하였으나 통계적 의미는 없었고 치료후에는 $2.7{\pm}1.2회$로 치료전보다 증가하였다. 국소성 분절성 사구체 경화증 6례중 3례($50\%$)에서 완전관해, 1례($17\%$)에서 부분관해가 유도되었고 2례($33\%$)에서 여전히 반응하지 않았으며, 치료후 평균 $1.2{\pm}0.7$년간 추적관찰 기간 동안 관해된 4례($57\%$)중 3례($50\%$)에서 관해가 유지되었고 1례에서 재발하였다. 2차성 신증후군 5례중 4례($80\%$)에서 완전관해, 1례($20\%$)에서 부분 관해가 유도되었고 치료후 평균 $1.7{\pm}0.6$년간 추적 관찰 기간 동안 재발한 예는 없었다. MP요법의 부작용으로는 21례중 10례($48\%$)에서 methylprednisolone 정맥주사시 일시적인 고혈압이 있었다. 결 론 : Mendoza protocol에 의한 장기간의 IV-methylprednisolone pulse therapy는 난치성 국소성 분절성 사구체경화증과 2차성 신증후군의 관해유도와 관해유지에는 효과가 있는 것으로 생각되었으며 면역억제제 또는 세포독성물질로도 스테로이드 의존성을 없애거나 재발율을 낮출 수 없었던 스테로이드 의존성 미세변화형 신증후군의 치료에서는 스테로이드 의존성 혹은 재발율의 변화를 나타내지 못하였다. 따라서 장기간의 MP 요법은 스테로이드 및 면역억제제 치료에 저항성을 보이는 1차성 또는 2차성 신증후군의 치료에 시도해볼만한 치료법으로 생각된다.

• 한방안이비인후피부과학회지
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• 제25권1호
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• pp.55-74
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• 2012

Objective : The purpose of this study is to investigate the skin disease in Sanghanron"傷寒論" and Geumgweyoryak"金匱要略". Methods : We conducted a study on the original text paragraphs of Sanghanron and Geumgweyoryak containing the skin disease and analysis of Woo, Oh, Sung, Zhang, etc. We drew a parallel between skin disease from Sanghanron and Geumgweyoryak and matching diagnoses from western medicine. Results : The results were as follows. 1. In Sanghanron and Geumgweyoryak pruritus was related to psychogenic pruritus and similar to skin disease caused by decrease of sweating, dry skin in cholinergic urticaria, atopic dermatitis and eczema, etc. in western medicine. 2. In Geumgweyoryak ichthyosis was caused by woman's disease, after menopause, chronic disease and malnutrition and related to winter itch and xerotic eczema in western medicine. 3. In Sanghanron Goose bumps, keratosis follicularis, acute and chronic urticaria and cold urticaria were occurred because of poorly managed fever care and side effect of antibiotic. 4. In Geumgweyoryak red face was similar to face flushing and side effects, which is after drug and laser treatment on face, in western medicine. 5. In Geumgweyoryak urticaria was, in a broad sense, skin disease with pruritus and secondary infection resulted from scratch. Skin diseases with pruritus are similar to urticaria, dermatitis herpetiformis, lichen planus, atopic dermatitis, contact dermatitis, psoriasis, nummular eczema, lichen simplex chronicus, prurigo nodularis, neurodermatitis and internal disease with pruritus in western medicine. 6. In Geumgweyoryak spots in the skin were caused by fever and similar to allergic purpura and SLE symptom in western medicine. 7. In Geumgweyoryak bullous disease with yellowish discharge was similar to eczema, pustule, atopic eczema, etc. in western medicine. 8. In Geumgweyoryak repeated inflammation of oral cavity, genitals, eyes and skin was similar to Behcet's disease in western medicine. 9. In Sanghanron and Geumgweyoryak boil was similar to abscess and acute lymphadenitis in western medicine caused by oily foods and infections. 10. In Geumgweyoryak swelling and boil were occurred in a poor health. Damage from metalic material could cause a convulsion and was similar to tetanus in western medicine. Conclusion : We analyzed the original text paragraphs of Sanghanron and Geumgweyoryak and explanations about skin disease. As a results, we found out etiology, pathogenesis, treatments of the skin disease in Sanghanron and Geumgweyoryak. Further we compared with western medicine to develop better understanding of the skin disease.

• 대한기관식도과학회지
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• 제2권1호
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• pp.140-144
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• 1996

Despite the incidence of tuberculosis has been greatly reduced with chemotherpy, it is still a common disease in Korea. The pharyngeal and laryngeal tuberculosis usually result from direct contamination of the laryngeal or pharyngeal mucosa by sputum heavily laden with Mycobacterium tuberculosis, secondary infection from the lungs via lymphatic or hematogenous routes, or a primary affection from inhaled tubercle bacilli. Recently the authors experienced a pharyngolaryngeal tuberculosis and report this case with brief literatures review.

• Clinics in Shoulder and Elbow
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• 제19권4호
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• pp.252-255
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• 2016

We reported the two cases of olecranon osteomyelitis secondary to the iatrogenic chronic relapsing septic olecranon bursitis. Infection was well eradicated by excision of the infected bursa and curettage of the eroded olecranon under the coverage of antibiotic therapy

• 한국임상수의학회지
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• 제19권2호
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• pp.247-249
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• 2002

A 6-month-old female Pekingese was euthanized due to poor progrosis after 1 month history of neurologic signs that include depression, ataxia, urination and defecation difficulty. At necropsy, no significant gross abnormalities were noted Histologically, neuronal vacuolation was noted in the brain, primarily cerebellum and occasionally in the brain stem area. Neuronal necrosis and secondary axonal swelling were also observed. Differential diagnoses were able to rule out other diseases which can induce neuronal vacuolation such as lysosomal storage disease, prion infection, and postvaccinal change.

• 대한수의학회지
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• 제20권2호
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• pp.123-125
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• 1980

Ununited Anconeal Process (UAP) is defined as a disease of young dogs due to developmental abnormality in which there is a seperation of the anconeal process from the diaphysis of the ulna, leading to a front leg lameness and secondary osteoarthritis. A six -year-old German Shepherd dog was presented because of intermittent right front leg lameness. Diagnosis was made of ununited anconeal process with moderate osteoarthritis by radiographic examination. Surgical removal of ununited anconeal process and curettage of osteoarthritic growth within the elbow joint relieved significant clinical signs despite of size and age of the dog.

• 대한기관식도과학회지
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• 제5권1호
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• pp.90-95
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• 1999

Dermoids are rare disease which arise during embryogenesis. They are the most common variety of teratomas occurring in the head and neck region and most arsies in the nasopharynx or oropharynx. They are invariably benign and derived from only two germinal layers, ectoderm and mesoderm. They usually present as repiratory distress and swallowing difficulty at or soon after birth. Treatment consists of surgical resection. We recently experienced a case of a neonatal nasopharyngeal dermoid which led to severe airway obstruction and feeding difficulty and necessitated the endotracheal intubation.

• Journal of Chest Surgery
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• 제23권3호
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• pp.542-545
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• 1990

Benign esophagobronchial fistula without esophageal atresia is a relatively rare disease. Fistula between the esophagus and bronchi may be congenital, traumatic, inflammatory or neoplastic. In our country, several case reports have been presented and the causes were either congenital, spontaneous, or inflammatory, such as, tuberculosis and diverticulum of esophagus. A 36 year old man experienced cough secondary to swallowing a Korean soup, frequent URIs and dyspnea. Esophagobronchial fistula was diagnosis by the esophagogram. Treatment was by resection with mid-lobectomy of the Rt. lung. After surgery, the patient`s general condition was stable.