Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 12 Issue 1
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- Pages.39-50
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- 2002
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
A Comparison of Lovastatin and Simvastatin in Treatment of Hyperlipidemia
Lovastatin과 Simvastatin의 고지혈증 치료 비교
- Cho, Jeong Ju (Graduate School of Clinical Pharmacy, Sookmyung Women's University) ;
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Lee, Suk Hyang
(Graduate School of Clinical Pharmacy, Sookmyung Women's University)
- Published : 2002.03.01
Abstract
Hypercholesterolemia is one of main causes of coronary heart disease(CHD). Clinical trials demonstrated that lowering serum cholesterol levels would reduce incidence of new cardiovascular events and mortality by primary or secondary preventions. The objective of this retrospective study was to compare efficacy and side effects of lovartatin and simvastatin in treatement of hypercholesterolemia. In Boramae Hospital, patients were included when they have taken lovastatin 20 mg or simvastatin 10 mg for 52 weeks with laboratory monitoring for cholesterol at baseline, 3, 6 and 12 month period. As results, total 128 outpatients were included with their total cholesterol level <240 mg/dl and triglyceride level <400 mg/dl at baseline. Total cholesterol and LDL cholesterol of lovastatin group (n=60) and simvastatin group (n=68) were significantly reduced from baseline (p=0.001). Lovastatin maximally reduced total cholesterol by