• 한국수학교육학회지시리즈E:수학교육논문집
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• 제15권
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• pp.281-286
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• 2003

The primary purpose of this study was to investigate how and to what extent 'representations' affect the students' understanding and the growth of understanding in a technology [GSP]-based collegiate mathematics classroom. There are three themes related as frames of the study along with this purpose, which are mentioned in the first chapter and extended in the second chapter: technology in mathematics education; images on computer screen - visualization and representation; understanding and growth of understanding. Three research questions guided this study: 1) How do students present each component of representations when they study 'transformations' in a technology [GSP]-based classroom? If there is any difference between the first and second presentation for each component, how are they different?; 2) How and to what extent do representations affect the students' understanding and the growth of understanding in a technology [GSP]-based classroom?; What types of benefits and obstacles are there when students study 'transformations' in a technology [GSP]-based classroom?

• 한국수학교육학회지시리즈C:초등수학교육
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• 제9권2호
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• pp.107-118
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• 2005

The purposes of this study were to investigate the practice of performance assessment in elementary mathematics classes especially focused on 4th grade. To achieve this, three research questions were posed as follow: First, What do they prepare for performance assessment? Second, What kinds of tests do they use in mathematics performance assessment? Third, What kinds of difficulties do they have for performance assessment and what should be changed for a successful performance assessment in mathematics? To Answer the research questions, three 4th grade classes were selected from three different elementary schools in seoul and three teachers were interviewed. From the data analysis, several conclusion were drawn. First, a plan for mathematics performance assessment was not set by the class teacher who are in charge of the class. The main reason was lack of time. Second, in most of the assessment, written tests were used and the items in the tests were skill-oriented. Third, teachers thought that performance assessment was needed in mathematics. But lack of their time, knowledge and competency, it is difficult to do performance assessment in mathematics.

• Restorative Dentistry and Endodontics
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• 제6권1호
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• pp.83-86
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• 1980

Fifty human maxillary second molars were injected with china ink, decalcified, cleared, and used in vitro study to determine the number of root canals, the frequency and location of lateral canals, canals per root, and frequency of apical deltas. The results were as follows. 1. The mesiobuccal root was found to contain a single primary canal in 62% of the teeth studied and two canals in 38% of the teeth studied. 2. In mesiobuccal roots with two canals, the seperated apical foramen appeared 24% of the specimens and the common apical foramen 14% of the specimens. 3. Of the 169 canals studied, 23.1% of the canals were found to contain lateral canals and these ramifications were mainly located in the apical third of the root.

• 한국수학교육학회지시리즈C:초등수학교육
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• 제6권1호
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• pp.1-10
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• 2002

The objectives of the current study are on the practical use of geoboard in an elementary school class. To do this, we first investigate how come geoboard is significant in a practical use. Second, we present an example of practical use of geoboard connecting with the analysis of the 7th curriculum. Third, we investigate the results of geoboard which is applied to elementary school class. The results of this research are as follows: First, the instruction of using geoboard can give an interest and curiosity to all students. Second, right triangle, rectangle, square and so on can be easily constructed because geoboard is linked by dots. Third, by constructing figures on geoboard and comparing figures which is made by themselves, students could better understand the concept of figures rather than the explanation of teacher. fourth, students can be improved the ability of problem solving and spatial sense by providing experience for exploration. Fifth, students need not to have anxiety for error because geoband is used and so can be corrected easily.

• Journal of Information Science Theory and Practice
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• 제8권4호
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• pp.20-28
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• 2020

In this study, the RDA DMP Common Standard (RDCS), a data model for implementing a machine actionable Data Management Plan (maDMP), was analyzed in four aspects. First, the twelve class models proposed by RDCS were analyzed. Second, whether the DMP attribute was included in the class attribute was analyzed. Third, we analyzed the namespace used for RDCS properties. Fourth, the values and identifiers used in RDCS properties were analyzed. As a result of the analysis, four directions for improvement were derived. First, it is necessary to add an academic record class to describe information such as papers and reports, which are representative academic documents. Second, the primary research institution, responsibility, resources, option attribute, and additional attributes are needed to describe the researcher's affiliation information. Third, it is necessary to additionally use a namespace such as Friend of a Friend that can be used universally. Fourth, the use of digital object identifier should be considered to identify academic literature.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10773-10777
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• 2015

Background: Treatment for breast cancer is mainly performed by surgical resection of primary tumors and chemotherapy. However, after tumor invasion and metastases, breast cancer is hard to control. Clarification of the pathogenic mechanisms would be helpful to the prognosis or therapy for the breast cancer. The aim of this study is to investigate the clinical and prognostic implications of legumain protein Materials and Methods: In this study, we examined mastectomy specimens from 114 breast cancer and matching, 26 adjacent non-cancerous tissues using immunohistochemistry. Results: The results indicated that positive expression of legumain protein in breast cancer was 51.8 % (59/114) and the positive expression of legumain protein in adjacent non-cancerous tissue was 11.5% (3/26). It appeared to be related with lymph node metastasis of breast cancer (p=0.02) and correlation analysis indicated that legumain expression was correlated positively with the estrogen receptor (ER) and mutant-type p53 expression (both p<0.05). Positive legumain expression was significantly associated with shorter overall survival time in breast cancer patients (log-rank p<0.01). Multivariate survival analysis suggested that the positive legumain expression was an independent predictor of poorer overall survival in patients with breast cancer (HR=0.24; 95%CI 0.11-0.65, p=0.03). Conclusions: Legumain might be a new potential biomarker for breast cancer, which may reflect the prognosis and overall survival.

• Radiation Oncology Journal
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• 제13권3호
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• pp.267-275
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• 1995

방사선치료와 항암화학요법 등 암의 치료법이 점차 발전해감에 따라 치료후 장기간 생존하는 환자들이 많아지고 특히 소아암 치료후 장기 생존자가 증가하면서 여러가지 치료로 인한 합병증 및 문제점들이 발생하고 있다. 그중 중요한 하나가 이차암의 발생인데 본과에서 이차 악성 고형 종양 발생 환자 2예를 경험하였기에 보고하고자 한다. 한 예는 우측 슬와부에 발생한 rhab-domyosarcoma group II로 수술후 방사선치료 및 항암화학요법을 시행받았는데 3년7개월 후 방사선치료부위에서 osteosarcoma가 발생하였고 또 다른 한 예는 우측 하복부에 소장 악성 림프종이 발생하여 방사선치료 및 항암화학요법을 시행받았고 18년후에 방사선치료부위에 leimyosarcoma가 발생하였다. 문헌 고찰을 통해 소아암 치료후 이차암 발생의 위험 요인들을 고찰하였고 이차암에 대한 인식 및 세밀한 추적 조사가 필요함을 확인하였다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 춘계학술대회 논문집
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• pp.352-357
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• 2014

Recently the construction of stations under railway lines and railway sections passing through central area of cities are increasing, calling for an urgent establishment of countermeasures against railway vibration and its subsequent second-phase noise. Of technology developed up to now, the most efficient countermeasure is the floating slab track, a track system isolated from the sub-structure by springs. Developed in this study, anti-vibration device for floating slab track (HLRM-High Load Rubber Mount) Haman station affiliated to the primary measurement was conducted in October 2012, one year after the second measurement after 2013 to be carried out in November and we want to change that. It is expected to raise awareness for the need of technology self-support and to make a meaningful contribution to mitigating vibration and noise produced by the next-generation high-speed railway.

• Journal of Microbiology and Biotechnology
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• 제32권6호
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• pp.718-729
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• 2022

Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy with poor prognosis. Here, due to the necessity for exploring potential therapies against ESCC, we obtained the gene expression data on ESCC from the TCGA and GEO databases. Venn diagram analysis was applied to identify common targets. The protein-protein interaction network was constructed by Cytoscape software, and the hub targets were extracted from the network via cytoHubba. The potential hub nodes as drug targets were found by pharmacophore-based virtual screening and molecular modeling, and the antitumor activity was evaluated through in vitro studies. A total of 364 differentially expressed genes (DEGs) in ESCC were identified. Pathway enrichment analyses suggested that most DEGs were mainly involved in the cell cycle. Three hub targets were retrieved, including CENPF, CCNA2 (cyclin A), and CCNB1 (cyclin B1), which were highly expressed in esophageal cancer and associated with prognosis. Moreover, amentoflavone, a promising drug candidate found by pharmacophore-based virtual screening, showed antiproliferative and proapoptotic effects and induced G1 in esophageal squamous carcinoma cells. Taken together, our findings suggested that amentoflavone could be a potential cell cycle inhibitor targeting cyclin B1, and is therefore expected to serve as a great therapeutic agent for treating esophageal squamous cell carcinoma.

• 여성건강간호학회지
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• 제1권2호
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• pp.200-221
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• 1995

The confusion of the sense of value on sex is increasing because of the rapid change in social-cultural environment. Also due to a rise in the standard of living, the age of adolescence is getting lower, and so the second sexual marks appear to primary schoolers. At this time in the aspect of the education for the whole man, it's very important for primary schoolers to acquire right knowledge and desirable attitude on sex so that can overcome psychological instability caused by physical growth, be responsible for their behaviors and lead happy lives. This study was made to find out the effects of sex education for the primary schoolers' knowledge and attitude about sex. The study was designed as simulated control group pretest-posttest design, which only pretest was practiced to control group and after sex education only posttest was practiced to experimental group. The data was collected for 18 days from March 13, 1995 to March 31, 1995. The subjects of this study were 130 six-graders in a private primary school in seoul. The control group and experimental group were composed of 65 pupils, each. Sex education consisted of lecture and discussion and the materials were this researcher's own made, 'How do I grow? and related OHP film and video. This education was practiced 40 minutes at a time, at intervals of 2-4 days' six times during 3weeks. For sex knowledge tools, 20 item questionaries on the base of related reference books and contents of this study were used. For sex attitude tools, this researcher's own made 13 item questionaries were used which were revised and complemented and laying stress on the reference books. The data was analyzed through pc-SAS program. The homogeneity test in terms of the general characteristics of experimental and control group was analyzed through $x^2$-test and t-test. And the difference in the primary schoolers' score on knowledge and attitude about sex before and after the sex education was analyzed through t-test and ANCOVA. The results of this study are as follows : 1. The result of the homogeneity test in terms of the general characteristics of the experimental and control group showed that there were significant differences in economic standard($x^2$=2.92, P=0.052) and brotherly ties($x^2$=3.78, P=0.052). 2. Hypothesis 'After sex education, the score of primary schoolers' sex knowledge will be higher than before. 'showed statistically significant difference.(t=11.99, P=.0001) Sex education was practiced under control over subjective view of economic standard and brotherly ties which showed significant difference at the homogeneity test in terms of the general characteristics between the two groups. After this education, the results of comparing the score of primary schoolers' sex knowledge also showed significant difference between the two groups. So hypothesis I was supported since primary schoolers to have education showed noticeable results in the sex knowledge score. (F=16.52, P=.0001) 3. Hypothesis 'After sex education, primary schooler's sex attitude score will be higher than before' showed statistically significant(t=5.08, P=.0001) Sex education was practiced, too, under control over subjective view of economic standard and brotherly ties which showed significant difference at the homogeneity test in terms of the general characteristics between the two groups. Bat this time the results of comparing the primary schoolers' sex attitude showed no significant difference between the two groups. So hypothesis II was rejected since for primary schoolers to have sex education showed no noticeable results in sex attitude score. (F=3.52, P=.0628) These results of the study show that sex education gives affirmative change to the primary schooler's sex knowledge, bat short periods' sex education doesn't give any change to the sex attitude. For the establishment of the pupils' desirable sex attitude, systematic and concrete sex education fit for the pupils' developing stage should be practiced over a long period of time.