• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.2
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• pp.141-158
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• 2019

Objectives: An adverse outcome pathway is a biological pathway that disturbs homeostasis and causes toxicity. It is a conceptual framework for organizing existing biological knowledge and consists of the molecular initiating event, key event, and adverse output. The AOP concept provides intuitive risk identification that can be helpful in evaluating the carcinogenicity of chemicals and in the prevention of cancer through the assessment of chemical carcinogenicity predictions. Methods: We reviewed various papers and books related to the application of AOPs for the prevention of occupational cancer. We mainly used the internet to search for the necessary research data and information, such as via Google scholar(http://scholar.google.com), ScienceDirect(www.sciencedirect.com), Scopus(www.scopus. com), NDSL(http: //www.ndsl.kr/index.do) and PubMed(http://www.ncbi.nlm.nih.gov/pubmed). The key terms searched were "adverse outcome pathway," "toxicology," "risk assessment," "human exposure," "worker," "nanoparticle," "applications," and "occupational safety and health," among others. Results: Since it focused on the current state of AOP for the prediction of toxicity from chemical exposure at work and prospects for industrial health in the context of the AOP concept, respiratory and nanomaterial hazard assessments. AOP provides an intuitive understanding of the toxicity of chemicals as a conceptual means, and it works toward accurately predicting chemical toxicity. The AOP technique has emerged as a future-oriented alternative to the existing paradigm of chemical hazard and risk assessment. AOP can be applied to the assessment of chemical carcinogenicity along with efforts to understand the effects of chronic toxic chemicals in workplaces. Based on these predictive tools, it could be possible to bring about a breakthrough in the prevention of occupational and environmental cancer. Conclusions: The AOP tool has emerged as a future-oriented alternative to the existing paradigm of chemical hazard and risk assessment and has been widely used in the field of chemical risk assessment and the evaluation of carcinogenicity at work. It will be a useful tool for prediction, and it is possible that it can help bring about a breakthrough in the prevention of occupational and environmental cancer.

• Journal of Acupuncture Research
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• v.26 no.6
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• pp.21-30
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• 2009

Objectives : Being introduced in the 1980s, laser acupuncture studies have been steadily carried on such as its thermal effects on human body. However, the mechanisms of effect are not yet clearly explained. Generally, laser acupuncture could be favorable for pediatric patients or people under special conditions (hemophilia, needle-phobia, pathogen-carriers, etc.) because of lower risk of infection, bleeding, pain or fainting. But there are still problems for using laser acupuncture equivalently as the traditional metal needle. The goal of this study is to review the fundamentals, history and present trend of laser acupuncture study, and to suggest how to develop laser acupuncture as an oriental medical device. Method : We performed literature search using PubMed(http://www.ncbi.nlm.nih.gov/pubmed) and Scopus(http://www.scopus.com). Search conditions are laser acupuncture, laser needle, LLLT(as title or abstract) or Litscher G(as author). Main target studies are physical fundamentals, clinical trials, physiological results and device proposals. Results : Many research have shown the similarities of laser acupuncture and traditional metal acupuncture and have reported clinical and physiological effects of laser acupuncture. But, still laser acupuncture is not widely used in Korea due to high-cost of equipments and the lack of clear understanding of laser devices. Additionally, there are still challenges in standardization and device development. Conclusions : Frequencies, laser modes, waveguides, adaptor types, polarization and signal modulations are suggested as future study subjects on laser acupuncture. More various studies and efforts for device development have to be performed to provide oriental medical doctors with evidence based confidence about usage of laser acupuncture.

• Journal of Intelligence and Information Systems
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• v.12 no.3
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• pp.95-110
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• 2006

To enhance the rule-based reasoning capability of Semantic Web, the XRML (eXtensible Rule Markup Language) approach embraces the meta-information necessary for the extraction of explicit rules from Web pages and its maintenance. To effectuate the automatic identification of rules from unstructured texts, this research develops a framework of using rule ontology. The ontology can be acquired from a similar site first, and then can be used for multiple sites in the same domain. The procedure of ontology-based rule identification is regarded as a graph search problem with incomplete nodes, and an A* algorithm is devised to solve the problem. The procedure is demonstrated with the domain of shipping rates and return policy comparison portal, which needs rule based reasoning capability to answer the customer's inquiries. An example ontology is created from Amazon.com, and is applied to the many online retailers in the same domain. The experimental result shows a high performance of this approach.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.17 no.2
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• pp.77-89
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• 2013

Objectives Tongue diagnosis is an important diagnostic method in traditional Eastern medicine, and it has a high potential to be used in the future healthcare because of easy, quick, and non-contact measuring features. Recently, research and development efforts on computerized tongue diagnosis systems (CTDS) have been active that led to the technical advancements in the field of photographing techniques, image extraction and classification algorithms. In this study, we analyzed the trends in the CTDS patents. Using the WIPS search engine (www.wipsglobal.com), quantitative and qualitative patent analyses were performed through Korea, China, Japan, U.S.A and Europe. Methods For a systematic search and data analysis, we defined patent categories based on the application area and technical details. By applying thus-obtained categorical key words, we obtained 360 relevant patents on photographing techniques, image extraction and classification algorithms for the purpose of diagnosis or security. Results As a result, companies related to image acquisition, medical imaging and mobile devices and research groups of universities in East Asia were major patent applicants. In all the five countries, the number of patents have been increasing since 1980. In particular, technology related to color correction and image segmentation were most actively patented categories, and expected to continue a high application rate.

• Fashion & Textile Research Journal
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• v.13 no.6
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• pp.838-847
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• 2011

The object of this study is as follows. First, according to the silhouette of clothes, I will search the relationship with the embroidery design. Second, I will investigate the relation of coloration about the clothes color and embroidery color. Third, I will search the relation with the image in clothes and embroidery design characteristic. The data acquisition is selected to the total 447 pictures of embroidery clothing design from the www.style.com, www.samsungdesign.net which are the related information site. The data are limited from S/S season in 2004 till F/W season in 2008 in the Paris, Milano, and New York collection. The analytical method was made through the analyze method and statistical method. First, on the relation with the clothes silhouette and embroidery design, if the satin stitch technique is utilized as the X-shaped or A-line silhouette in the one-piece and dress, the image which is elegant and feminine can be expressed. if the satin stitch technique is utilized as the H-line silhouette in jacket and court, the mannish image can be expressed. Second, the embroidery color showed up as the contrast combination of the monotone when the clothes color was the monochrome. And the embroidery color showed up as the tone in which is bright and sober when clothes color had 2 or 3 or 4. So, if the embroidery color is utilized as the similar color scheme, it will be effective. Third, if the embroidery technique of the one-piece and dress is utilized as the the satin stitch technique and the bloom and leaf motive being stylized pattern is used in the all-over and border pattern, It will be effective to express the romantic/feminine, ethnic/folklore, active, and classic image.

• Journal of Society of Preventive Korean Medicine
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• v.21 no.1
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• pp.95-106
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• 2017

Objectives : Although interest in preventive medicine has increased recently, "Mibyeong", the preventive concept of Korean medicine, is still unfamiliar to the general public. Therefore, this study aims to investigate the concept of Mibyeong and users used on the Internet. Methods : Naver (www.naver.com), which has the highest ranking in terms of market share, number of visitors, search time share, and community category share, has been selected as a search target and jisik-iN Q&A and posts of cafe about Mibyeong were searched for recently approximately 6 years. Results : 105 cases of Jisik-iN Q&A and 283 cases of cafe posts were searched. Overall, the number of Jisik-iN Q&A and cafe posts's Mibyeong term usage was the highest in 2013. In the Internet user category, Mibyeong Term was used most commonly in the Jisik-iN Q&A by Korean medicine related medical personnel (29 cases, 28%) and in the cafe other health-related workers (87cases, 31%). In Mibyeong related cafe classification, Information Exchange (220 cases, 77%) was the most frequent and besides 39 cases (14%) used in Operation of Medical Institutions. And the concept of Mibyeong was often used as symptom-based rather than diagnostic test or disease (Cafe posts 52%, Jisik-iN Q&A 70%), in particular, topic of Mibyeong related Jisik-iN Q&A was used in the order of pain (31 cases, 16%), cancer (17 cases, 9%), fatigue (11 cases, 6%). Conclusions : This study has significance as basic research data of general Internet user group and can be used as fundamental data for awareness promotion, publicity and necessity of Mibyeong.

• International Journal of Control, Automation, and Systems
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• v.1 no.1
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• pp.101-110
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• 2003

This paper introduces an identification method for nonlinear models in the form of rule-based Fuzzy-Neural Networks (FNN). In this study, the development of the rule-based fuzzy neural networks focuses on the technologies of Computational Intelligence (CI), namely fuzzy sets, neural networks, and genetic algorithms. The FNN modeling and identification environment realizes parameter identification through synergistic usage of clustering techniques, genetic optimization and a complex search method. We use a HCM (Hard C-Means) clustering algorithm to determine initial apexes of the membership functions of the information granules used in this fuzzy model. The parameters such as apexes of membership functions, learning rates, and momentum coefficients are then adjusted using the identification algorithm of a GA hybrid scheme. The proposed GA hybrid scheme effectively combines the GA with the improved com-plex method to guarantee both global optimization and local convergence. An aggregate objective function (performance index) with a weighting factor is introduced to achieve a sound balance between approximation and generalization of the model. According to the selection and adjustment of the weighting factor of this objective function, we reveal how to design a model having sound approximation and generalization abilities. The proposed model is experimented with using several time series data (gas furnace, sewage treatment process, and NOx emission process data from gas turbine power plants).

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.245-250
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• 2003

There are currently about 6000 bacterial species with validly published names, but scientists assume that these may be less than 1% of bacterial species present on the earth. Microbial resource is one of the most important bioresources in bioinderstry and provides us with high economic values. To find missing ones, the studies of metagenome, metabolome, and proteome about microbes have started recently in developed countries. We construct the information system that integrates information on microbial genome resources and manages the information to support efficient research of microbial genome application, and name this system 'Bio-Meta Information System (Bio-MIS)'. Bio-MIS consists of integrated microbial genome resources database, microbial genome resources input system, integrated microbial genome resources search engine, microbial resources on-line distribution system, portal service and management via internet. In the future, we will include public database connection and implement useful bioinformatics software for analyzing microbial genome resources. The web-site is accessible at http://biomis.probionic.com

• Journal of Microbiology and Biotechnology
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• v.16 no.2
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• pp.178-183
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• 2006

Microbes are one of the most important bioresources in bioindustry and provide high economic values. Although there are currently about 6,000 bacterial species with validly published names, microbiologists generally assume that the number may account for less than 1% of the bacterial species present on Earth. To discover the remaining species, studies of metagenomes, metabolomes, and proteomes related to microbes have recently been carried out in various fields. We have constructed an information system that integrates various data on microbial resources and manages bioinformation to support efficient research of microorganisms. We have designated this system 'Bio-Meta Information System (Bio-MIS).' Bio-MIS consists of an integrated microbial resource database, a microbial resource input system, an integrated microbial resource search engine, a microbial resource online distribution system, a portal service, and management via the Internet. In the future, this system is expected to be connected with various public databases. We plan to implement useful bioinformatics software for analyzing microbial genome resources. The Web site is accessible at http://biomis.probionic.com.

• Transactions of Materials Processing
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• v.8 no.5
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• pp.471-481
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• 1999

The properties of deformed products are generally dependent upon the distribution of microstureture. It is, therefore, necessary to make the distribution of microstureture uniform in order to achieve the best balance of properties in the final product. This is often a demanding task, even for conventional materials. It is become essential to achieving mechanical integrity and a desired combination of microstructure and properties. The objective mechanical integrity and a desired combination of microsttucture and properties. The objective of this study is to design the optimal die profile which can yield more uniform microstructure in hot extruded product. The microstructure evolution, such as dynamic and static recrystallization as well as grain growth, is investigated using the program com-bined with yada and Senuma's empirical equations and rigid-thermoviscoplastic finite element method. The die profile of hot extrusion is represented by Bezier-curve to define all available profile. In order to obtain the optimal die profile which yields uniform microstructure in the product the FPS(Flexible Polyhedron Search) method is applied to the present study. To validate the result of present study the experimental hot extrusion is performed and the result is compared with that of simulation.