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Secondary Metabolites from Enzymatic Oxidation of Caffeic Acid with Pancreatic Lipase Inhibitory Activity (카페인산의 효소적 산화반응으로부터 췌장 지방분해효소 저해 물질의 분리)

  • Kim, Tae Hoon;Kim, Myoung Kwon
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.12
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    • pp.1912-1917
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    • 2015
  • Pancreatic lipase is a potential therapeutic target for the treatment of diet-induced obesity in humans. As part of our continuing search for novel bioactive compounds, the convenient enzymatic transformation of caffeic acid into neolignans as well as related oxidized-products enhanced pancreatic lipase inhibitory activity. Enzymatic transformation of caffeic acid (1) using polyphenol oxidase originating from Korean pear yielded four oxidized metabolites, which were identified by different spectroscopic techniques ($^1H$,$^{13}C$ NMR, DEP/T, $^1H-^1H$ COSY, HMBC, HMQC, and NOESY). The anti-obesity efficacy of caffeic acid reactant was tested by in vitro porcine pancreatic lipase assay. All tested samples showed dose-dependent pancreatic lipase inhibitory activities. Four oxidative products including phellinsin A (2), caffeicinic acid (3), isocaffeicinic acid (4), and 7,8-erythro-caffeicin (5) were isolated and identified. The major metabolites (2~5) were evaluated for their pancreatic lipase inhibitory activity, and oxidized-products (2~3) improved potency against pancreatic lipase when compared to original caffeic acid. This result suggested that the neolignans isolated from oxidative transformation of caffeic acid might be beneficial in the treatment of obesity and relevant diseases, and the convenient enzymatic transformation by polyphenol oxidase may be a valuable method for structural modification and enhancement of activity.

Fast Decision Method of Geometric Partitioning Mode and Block Partitioning Mode using Hough Transform in VVC (허프 변환을 이용한 VVC의 기하학 분할 모드 및 블록 분할 고속 결정 방법)

  • Lee, Minhun;Park, Juntaek;Bang, Gun;Lim, Woong;Sim, Donggyu;Oh, Seoung-Jun
    • Journal of Broadcast Engineering
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    • v.25 no.5
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    • pp.698-708
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    • 2020
  • VVC (Versatile Video Coding), which has been developing as a next generation video coding standard. Compared to HEVC (High Efficiency Video Coding), VVC is improved by about 34% in RA (Random Access) configuration and about 30% in LDB (Low-Delay B) configuration by adopting various techniques such as recursive block partitioning structure and GPM (Geometric Partitioning Mode). But the encoding complexity is increased by about 10x and 7x, respectively. In this paper, we propose a fast decision method of GPM mode and block partitioning using directionality of block to reduce encoding complexity of VVC. The proposed method is to apply the Hough transform to the current block to identify the directionality of the block, thereby determining the GPM mode and the specific block partitioning method to be skipped in the rate-distortion cost search process. As a result, compared to VTM8.0, the proposed method reduces about 31.01% and 29.84% encoding complexity for RA and LDB configuration with 2.48% and 2.69% BD-rate loss, respectively.

Determinants of Credit Default Swap Spreads: The Case of Korean Firms (한국 기업들의 신용부도스왑 스프레드에 대한 결정요인 분석)

  • Park, Yoon-S.;Kim, Han-Joon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.10
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    • pp.4359-4368
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    • 2011
  • Among several macroeconomic missteps blamed for the recent global financial crisis including the social problems of income distribution and the lack of proper financial remedies, two of them have received particular attention: the global BOP(Balance of Payment) imbalance and the misguided monetary policy. Such BOP imbalance was blamed for massive foreign exchange investment flows from Asia into the U.S., triggering the financial and real estate bubble in America. The latter refers to the excessively loose monetary policy of the U.S. Federal Reserve, which pushed financial institutions and households into reckless investment behavior in search of higher returns. Given the abuse of certain innovative financial techniques and new investment instruments that have been created in recent decades, both collateralized debt obligations (CDOs) and credit default swaps (CDS) enjoyed a symbiotic and toxic relationship prior to the financial crisis This paper is organized as follows: The first section analyzes the real causes of the recent financial crisis. The second details the role of CDOs and CDS. Then, to identify key determinants of the CDS spreads in an emerging capital market, the sample data of major Korean firms' CDS spreads are used to estimate the risk premium by utilizing the multiple regression analysis. The empirical test result indicates that Korean 3-year treasury bond rate(TYIELD), market to book value ratio(MV/BV), and assets size(INASSETS) are shown to demonstrate statistically significant influences on the changes of the CDS premium for sample firms.

Design and Implementation of B-Tree on Flash Memory (플래시 메모리 상에서 B-트리 설계 및 구현)

  • Nam, Jung-Hyun;Park, Dong-Joo
    • Journal of KIISE:Databases
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    • v.34 no.2
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    • pp.109-118
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    • 2007
  • Recently, flash memory is used to store data in mobile computing devices such as PDAs, SmartCards, mobile phones and MP3 players. These devices need index structures like the B-tree to efficiently support some operations like insertion, deletion and search. The BFTL(B-tree Flash Translation Layer) technique was first introduced which is for implementing the B-tree on flash memory. Flash memory has characteristics that a write operation is more costly than a read operation and an overwrite operation is impossible. Therefore, the BFTL method focuses on minimizing the number of write operations resulting from building the B-tree. However, we indicate in this paper that there are many rooms of improving the performance of the I/O cost in building the B-tree using this method and it is not practical since it increases highly the usage of the SRAM memory storage. In this paper, we propose a BOF(the B-tree On Flash memory) approach for implementing the B-tree on flash memory efficiently. The core of this approach is to store index units belonging to the same B-tree node to the same sector on flash memory in case of the replacement of the buffer used to build the B-tree. In this paper, we show that our BOF technique outperforms the BFTL or other techniques.

A Study on Automatic Classification of Newspaper Articles Based on Unsupervised Learning by Departments (비지도학습 기반의 행정부서별 신문기사 자동분류 연구)

  • Kim, Hyun-Jong;Ryu, Seung-Eui;Lee, Chul-Ho;Nam, Kwang Woo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.9
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    • pp.345-351
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    • 2020
  • Administrative agencies today are paying keen attention to big data analysis to improve their policy responsiveness. Of all the big data, news articles can be used to understand public opinion regarding policy and policy issues. The amount of news output has increased rapidly because of the emergence of new online media outlets, which calls for the use of automated bots or automatic document classification tools. There are, however, limits to the automatic collection of news articles related to specific agencies or departments based on the existing news article categories and keyword search queries. Thus, this paper proposes a method to process articles using classification glossaries that take into account each agency's different work features. To this end, classification glossaries were developed by extracting the work features of different departments using Word2Vec and topic modeling techniques from news articles related to different agencies. As a result, the automatic classification of newspaper articles for each department yielded approximately 71% accuracy. This study is meaningful in making academic and practical contributions because it presents a method of extracting the work features for each department, and it is an unsupervised learning-based automatic classification method for automatically classifying news articles relevant to each agency.

Current Status of Registered Korean Patents Related to the Health Functional Food for Skin Care (피부미용 관련 건강기능식품 국내 특허 등록현황)

  • Chung, Kap-Taeck;Lee, Sang-Hyun
    • The Korean Journal of Food And Nutrition
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    • v.25 no.2
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    • pp.308-316
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    • 2012
  • Proper skin care promotes good metabolism and the biological activity of skin, helps maintain the skin in a healthy and beautiful state when combined with nutritional nourishment. Health functional foods are being used for the purpose of enhancing efficient skin care. Health functional foods related to skin care maintain the epidermis, dermal fibroblast layer and subcutaneous tissue that form the skin. Efficient functional foods alleviate the signs of endogenous aging that come with getting older and exogenous aging caused by sunlight. Even though the field of skin care related to health functional foods has received less attention and been the subject of less research compared to functional cosmetics which are developing widely, this area of skin care that maintains and improves the layer of dermal fibroblast through the intake of food, is expected to progress with the commercialization of products in many fields when the related technical research development is galvanized and the related patents are applied for. Research into health functional foods related to skin care in Korea started rather late in comparison to other advanced countries where patents for relevant techniques have been applied for since 1990's together with research conducted on how they might be used for practical purposes. This study used the key words 'skin care, health functional food' to search for Korean patents that have been applied for at the Korean Intellectual Property Office from 1983 to 2011 using the KIPRIS database, in order to help researchers in the related fields by organizing the patented formulas for health functional foods for skin care which have gained attention recently. According to the number of registrations in each industry field, the total number of patents was 1,120 we screened the major patents among them, the field with the largest number was food foodstuff non-alcoholic beverage and preparation or treatment(A23L) with 135, then natural plant medicine & medical supplies and cosmetics(A61K) with 112, microorganisms or enzymes(C12N) with 63, heterocyclic compounds(C07D) with 44, horticulture or cultivation of sea weeds, forestry(A01G) 16 times, listed from the highest to the lowest number of applications. It has been revealed that food, foodstuff, non-alcoholic beverage and preparation or treatment(A23L) was the industry field where the most patents for health functional foods related to skin care were registered.

Partial Dimensional Clustering based on Projection Filtering in High Dimensional Data Space (대용량의 고차원 데이터 공간에서 프로젝션 필터링 기반의 부분차원 클러스터링 기법)

  • 이혜명;정종진
    • The Journal of Society for e-Business Studies
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    • v.8 no.4
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    • pp.69-88
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    • 2003
  • In high dimensional data, most of clustering algorithms tend to degrade the performance rapidly because of nature of sparsity and amount of noise. Recently, partial dimensional clustering algorithms have been studied, which have good performance in clustering. These algorithms select the dimensional data closely related to clustering but discard the dimensional data which are not directly related to clustering in entire dimensional data. However, the traditional algorithms have some problems. At first, the algorithms employ grid based techniques but the large amount of grids make worse the performance of algorithm in terms of computational time and memory space. Secondly, the algorithms explore dimensions related to clustering using k-medoid but it is very difficult to determine the best quality of k-medoids in large amount of high dimensional data. In this paper, we propose an efficient partial dimensional clustering algorithm which is called CLIP. CLIP explores dense regions for cluster on a certain dimension. Then, the algorithm probes dense regions on a next dimension. dependent on the dense regions of the explored dimension using incremental projection. CLIP repeats these probing work in all dimensions. Clustering by Incremental projection can prune the search space largely and reduce the computational time considerably. We evaluate the performance(efficiency, effectiveness and accuracy, etc.) of the proposed algorithm compared with other algorithms using common synthetic data.

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A Clustering Technique to Minimize Energy Consumption of Sensor networks by using Enhanced Genetic Algorithm (진보된 유전자 알고리즘 이용하여 센서 네트워크의 에너지 소모를 최소화하는 클러스터링 기법)

  • Seo, Hyun-Sik;Oh, Se-Jin;Lee, Chae-Woo
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.46 no.2
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    • pp.27-37
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    • 2009
  • Sensor nodes forming a sensor network have limited energy capacity such as small batteries and when these nodes are placed in a specific field, it is important to research minimizing sensor nodes' energy consumption because of difficulty in supplying additional energy for the sensor nodes. Clustering has been in the limelight as one of efficient techniques to reduce sensor nodes' energy consumption in sensor networks. However, energy saving results can vary greatly depending on election of cluster heads, the number and size of clusters and the distance among the sensor nodes. /This research has an aim to find the optimal set of clusters which can reduce sensor nodes' energy consumption. We use a Genetic Algorithm(GA), a stochastic search technique used in computing, to find optimal solutions. GA performs searching through evolution processes to find optimal clusters in terms of energy efficiency. Our results show that GA is more efficient than LEACH which is a clustering algorithm without evolution processes. The two-dimensional GA (2D-GA) proposed in this research can perform more efficient gene evolution than one-dimensional GA(1D-GA)by giving unique location information to each node existing in chromosomes. As a result, the 2D-GA can find rapidly and effectively optimal clusters to maximize lifetime of the sensor networks.

A Novel QoS Provisoning Scheme Based on User Mobility Patterns in IP-based Next-Generation Mobile Networks (IP기반 차세대 모바일 네트워크에서 사용자 이동패턴에 기반한 QoS 보장기법)

  • Yang, Seungbo;Jeong, Jongpil
    • Journal of the Institute of Electronics and Information Engineers
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    • v.50 no.5
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    • pp.25-38
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    • 2013
  • Future wireless systems will be required to support the increasingly nomadic lifestyle of people. This support will be provided through the use of multiple overlaid networks which have very different characteristics. Moreover, these networks will be required to support the seamless delivery of today's popular desktop services, such as web browsing, interactive multimedia and video conferencing to the mobile devices. Thus one of the major challenges in the design of these mobile systems will be the provision of the quality of service (QoS) guarantees that the applications demand under this diverse networking infrastructure. We believe that it is necessary to use resource reservation and adaptation techniques to deliver these QoS guarantee to applications. However, reservation and pre-configuration in the entire service region is overly aggressive, and results in schemes that are extremely inefficient and unreliable. To overcome this, the mobility pattern of a user can be exploited. If the movement of a user is known, the reservation and configuration procedure can be limited to the regions of the network a user is likely to visit. Our proposed Proxy-UMP is not sensitive to increase of the search cost than other schemes and shows that the increasing rate of total cost is low as the SMR increases.

Exploration of the Path Model among Goal Orientation, Self-efficacy, Achievement Need, Entity Theory of Intelligence, Learning Strategy, and Self-handicapping Tendency in Chemistry Education (화학교육의 목표지향성, 자기효능감, 성취욕구, 지능신념, 자기핸디캡경향 및 학습전략 간의 경로모형 탐색)

  • Ko, Young Chun
    • Journal of the Korean Chemical Society
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    • v.57 no.1
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    • pp.147-158
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    • 2013
  • This study is to search an optimal model on causal relationships of the motivations to learn and motivation strategy in chemistry education. The participants in this study are consisted of G and I high schools students (487) in Gwangju. They all answered to the questionnaire. Model I is hypothesized to be path model of the mediation between 'self-efficacy, achievement need, and entity theory of intelligence' and 'learning strategy and self-handicapping tendency of motivation strategy' by goal orientation to explore variables of study effecting the motivation strategy. And Model II is hypothesized path model of the mediation between goal orientation and 'learning strategy and self-handicapping tendency' by 'self-efficacy, achievement need, and entity theory' to explore variables of study effecting the motivation strategy. Based on these models, structural equation modeling techniques are used to evaluate for the path model among goal orientation(learning, performance approach, and performance approach goal orientation), self-efficacy, achievement need, entity theory of intelligence, self-handicapping tendency, and learning strategy in chemistry education. As the results, Model II is considered. Goodness-of-fit indexes of this model related modification models are identified and analyzed in phases. And this model is accomplished by correcting the model the fifth time to enhance goodness-of-fit indexes. In this optimal model II-5 (Fig. 3) on causal relationships of the motivations to learn and learning strategy (p