• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 1999년도 춘계공동학술대회:정보화시대의 지식경영
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• pp.41-41
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• 1999

• 한국동물위생학회지
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• 제22권1호
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• pp.93-101
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• 1999

This test process on screening method for the detection of residual antibiotics in milk is simple, economic, sensitive to residual antibiotics and was given approval international organs. Thus, this study was carried out the comparison of Disk assay method and TTC-II method for sensitivity and minimum detectable range of antibiotics in raw milk. The results of this study was summarized as follows ; 1. The number of samples requested for treatment of mastitis was 198 samples. Comparison or analytical results among the methods of TTC-II, disk assay and Delve sp was that TTC-II 37 samples(18.6% ), Disk assay 125samples(63.1%), Delve SP 130 samples(65.7% ) reacted positively. Conformity rate of Delve SP and Disk assay was 70%. 2. Detectable limits of disk assay method in some antibiotics were more sensitive than those of official method(0.05-0.0025ppm in the $\beta$-lactams, 1ppm in two aminoglycoside, 0.2 ppm in one tetracycline, similar in one macrolide) 3. For sensitivity of residual sulfonamides TTC-II was much more sensitive than disk assay. Detectable limits of sulfamethazine and sulfadimethoxine were 30 to 50ppm levels. 4. The best medium preservation period is 1-2 days. 5. Concentration of brome cresol purple related to resistance for B stearothermophilus culture was 24ppm/ml. These results show that disk assay method for screening detection of antibiotics residuces in milk is worthy of use.

• 한국환경농학회지
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• 제36권4호
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• pp.269-278
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• 2017

BACKGROUND: The objective of this study was to evaluate screening method of residual multi pesticides in dead birds by Orbitrap high resolution mass spectrometry (HRMS) to identify the cause of death for birds. METHODS AND RESULTS: Extraction and clean-up method of residual pesticides in liver of dead birds was used QuEChERS (Quick Easy Cheap Effective Rugged and Safe) and method validations was conducted using liquid chromatography and gas chroamtography with triple-quadrupole mass spectrometer (LC/MS/MS and GC/MS/MS) Also, we were evaluated screening method for the determination of residual pesticides in liver of dead birds by LC and GC Orbitrap Mass Spectrometry. Results of method validations, Correlation coefficients of the matrix matched calibration curves were >0.978, and the method detection limits (MDLs) and limits of quantitation (LOQ) were 2.8~72.1 ng/g (18.4 ng/g on average) and 9.0~230 ng/g (58.5 ng/g on average). The accuracy ranged from 69.1%to 130% (103% on average), and the precision values were less than 14.8%(3.8%on average). The screening of residual pesticides in liver of dead birds by LC and GC Orbitrap HRMS was detected monocrotophos, carbofuran, carbosulfan, deltametrin, benfuracarb, carbofuran, phosphamidon, prochloraz in investigated samples. CONCLUSION: This results showed that accurate mass were extraction of residual pesticides in dead birds by Orbitrap HRMS. It suggested that this screening method is applicable to the residual pesticide analysis for the cause of death as a main tool.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2245-2249
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• 2014

Background: Human papillomavirus is a well-established cause of the development of a variety of epithelial lesions in the cervix. However, as yet, incorporation of HPV testing into cervical cancer screening either as an adjunct or stand alone test is limited due to its cost. We therefore here ascertained the presence and type specificity of human papilloma virus (HPV) DNA in routine cervical scrapings. Materials and Methods: Cervical scrapings were collected from women attending clinics for routine Pap smear screening. HPV-DNA was detected by PCR using MY09/11 and GP5+/GP6+ primer sets and genotyping was accomplished by cycle-sequencing. Results: A total of 635 women were recruited into the study with $mean{\pm}SD$ age of $43{\pm}10.5$ years. Of these 92.6% (588/635) were reported as within normal limits (WNL) on cytology. The presence of HPV infection detected by nested MY/GP+-PCR was 4.4% (28/635). The overall prevalence of high-risk HPV (HR-HPV) in abnormal Pap smears was 53.8% (7/13). HPVs were also seen in 3.1% (18/588) of smears reported as WNL by cytology and 5.9% (2/34) in smears unsatisfactory for evaluation. Conclusions: The overall percentage of HPV positivity in routine cervical screening samples is comparable with abnormal findings in cytology. Conventional Pap smear 'missed' a few samples. Since HPV testing is expensive, our results may provide valuable information for strategising implementation of effective cervical cancer screening in a country with limited resources like Malaysia. If Pap smear coverage could be improved, HPV testing could be used as an adjunct method on cases with ambiguous diagnoses.

• 한국지반공학회논문집
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• 제20권7호
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• pp.127-140
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• 2004

기존의 액상화 평가법은 대부분 미국, 일본, 그리고 유럽과 같이 지진 발생빈도가 높고 그로 인한 액상화 피해가 빈번한 국가에서 주도적으로 연구되어왔다. 이런 지역적 특성을 토대로 개발된 액상화 평가방법들은 높은 지진규모(M=7.5)에 바탕을 두고 있다. 국내의 경우, 1997년 실제적인 내진 연구가 시작된 이래 액상화 평가의 구체적 규정은 항만시설의 내진설계 표준서(1999)에 언급된 바 있으나 이는 문헌연구를 통해 제시된 것으로 실제적이지 못하다. 그러므로, 국내 적합한 설계기준을 작성하기 위해서는 지진피해자료의 부족을 국내 지반을 대상으로 한 동적실내시험을 통하는 것이 바람직하며, 일반적인 정현하중 진동시험 보다 실제 지진하중 재하 시험이 훨씬 효과적일 수 있다. 본 연구에서는 실제 지진파 고유의 특성을 적용한 진동삼축 시험을 통하여 상대밀도와 세립분함유량의 변화에 따른 액상화 저항강도를 산정하였다. 실험결과를 국내의 대표적인 항만지역의 지진응답 해석 결과와 비교 분석하고 중진지역에 적합한 액상화 평가의 생략기준을 제시하였다. 또한 실제 지진하중 삼축실험 결과를 이용하여 국내 여건에 적합한 지진규모 보정계수를 제안하였다.

• Journal of Mechanical Science and Technology
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• 제18권6호
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• pp.1010-1018
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• 2004

This study presents the methodological aspects of combustion instability modeling and provides the numerical results of the model (sub-scale) combustion chamber, regarding geometrical dimensions and operating conditions, which are for determining the combustion stability boundaries using the model chamber. An approach to determine the stability limits and acoustic characteristics of injectors is described intensively. Procedures for extrapolation of the model operating parameters to the actual conditions are presented, which allow the hot-fire test data to be presented by parameters of the combustion chamber pressure and mixture (oxidizer/fuel) ratio, which are customary for designers. Tests with the model chamber, based on the suggested scaling method, are far more cost-effective than with the actual (full-scale) chamber and useful for injector screening at the initial stage of the combustor development in a viewpoint of combustion instabilities.

• 미생물학회지
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• 제3권1호
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• pp.18-23
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• 1965

It seems like that the characteristics and drug-resistances of fungi are respectively different in various circumstances. Scores of chemicals were applicated to the leather-fungi in this study. M-dinitrobenzene, 2, 4-dinitrochlorobenzene and phenyl mercuric acetate inhibited the growth of Aspergilli which were isolated from Korean-leather. The minimum fungicidal limits of p-nitrophenol, 8-hydroxyquinoline and sodium-pentachlorophenolate against the Korean-originated strains are different from that of other country. In the mass-screening of fungicides, artificial "Leather-extracts media" have been designed and used, and the media contributed to screening-tests. Fat and oils which are the materials of fat-liquoring in leather manufacture affects the drugresistance of the leather-fungi. It is found that the accelerating-method on malt-agar plate is effective to determinate the fungicidal action of chemicals in short time.hort time.

• 방사성폐기물학회지
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• 제4권4호
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• pp.353-363
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• 2006

원자력시설 해체부지를 재이용하는 과정에서 유발될 수 있는 방사선학적 리스크를 사전에 선별하기 위한 목적으로 단순화된 방사선량 평가모델을 개발하고, 이를 Microsoft $Excel{\circledR}$ 스프레드시트와 내장된 Visual Basic 및 마크로 기능을 활용하여 기능별로 모듈화된 평가도구를 구현하였다. 이와 함께 부지 특성자료가 불충분할 경우 신속한 사전평가를 위해 적용할 수 있는 일련의 입력변수 값 목록을 제안하였다. 동일한 조건에서 이 연구에서 개발된 평가도구를 이용해 유도한 사전 선별준위가 RESRAD Ver.6.2를 이용해 계산된 유도농도지침한계 및 독일 방사선방호령에 규정된 핵종별 부지 재이용 기준농도를 합리적으로 근사할 수 있음을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.2059-2065
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• 2013

This goal of this research was to evaluate the cost-effectiveness of the National Cancer Screening Program (NCSP) for breast cancer in the Republic of Korea from a government expenditure perspective. In 2002-2003 (baseline), a total of 8,724,860 women aged 40 years or over were invited to attend breast cancer screening by the NCSP. Those who attended were identified using the NCSP database, and women were divided into two groups, women who attended screening at baseline (screened group) and those who did not (non-screened group). Breast cancer diagnosis in both groups at baseline, and during 5-year follow-up was identified using the Korean Central Cancer Registry. The effectiveness of the NCSP for breast cancer was estimated by comparing 5-year survival and life years saved (LYS) between the screened and the unscreened groups, measured using mortality data from the Korean National Health Insurance Corporation and the National Health Statistical Office. Direct screening costs, indirect screening costs, and productivity costs were considered in different combinations in the model. When all three of these costs were considered together, the incremental cost to save one life year of a breast cancer patient was 42,305,000 Korean Won (KW) (1 USD=1,088 KW) for the screened group compared to the non-screened group. In sensitivity analyses, reducing the false-positive rate of the screening program by half was the most cost-effective (incremental cost-effectiveness ratio, ICER=30,110,852 KW/LYS) strategy. When the upper age limit for screening was set at 70 years, it became more cost-effective (ICER=39,641,823 KW/LYS) than when no upper age limit was set. The NCSP for breast cancer in Korea seems to be accepted as cost-effective as ICER estimates were around the Gross Domestic Product. However, cost-effectiveness could be further improved by increasing the sensitivity of breast cancer screening and by setting appropriate age limits.

• Journal of Radiation Protection and Research
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• 제41권2호
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• pp.101-104
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• 2016

Background: To protect the public from natural radioactive materials, the 'Act on safety control of radioactive rays around living environment" was established in Korea. There is an annual effective dose limit of 1 mSv for products, but the activity concentration limit for products is not established yet. Materials and Methods: To suggest the activity concentration limits for consumer goods containing NORM, in this research, we assumed the "small room model" surrounding the ICRP reference phantom to simulate the consumer goods in contact with the human bodies. Using the Monte Carlo code MCNPX, we evaluate the effective dose rate for the ICRP reference phantom in a small room with dimension of phantom size and derived the activity concentration limit for consumer goods. Results and Discussion: The consumer goods have about 1600, 1200 and $19000Bq{\cdot}kg^{-1}$ for $^{226}Ra$, $^{232}Th$ and $^{40}K$, and the activity concentration limits are about six times comparing with the values of building materials. We applied the index to real samples, though we did not consider radioactivity of $^{40}K$, indexes of the some samples are more than 6. However, this index concept using small room model is very conservative, for the consumer goods over than index 6, it is necessary to reevaluate the absorbed dose considering real usage scenario and material characteristics. Conclusion: In this research, we derived activity concentration limits for consumer goods in contact with bodies and the results can be used as preliminary screening tool for consumer goods as index concept.