• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.17
• /
• pp.7091-7095
• /
• 2014

Background: The study aimed to evaluate the incidence of CpG island promoter methylation of BMP6, a member of the transforming growth factor beta family, in tissue samples from colorectal cancers (CRC) and look for its association with BMP6 expression and clinicopathological correlation. Materials and Methods: Methylation specific PCR for the BMP6 promoter region was performed with 85 frozen tissue samples of CRC and 45 of normal colon. Methylation status of MLH1 was also determined by the same method. Expression of BMP6 was evaluated by immunohistochemistry (IHC), using Allred's scoring system. The methylation status was analyzed against clinical and pathological parameters in CRC. Results: The study revealed BMP6 hypermethylation in 34 of 85 tumor specimens (40%), and 15 out of 45 normal tissue samples from CRC (33%). The incidence of hypermethylation was inversely correlated with IHC score. Allred's scores of 7 or more were correlated with lower frequency of BMP6 hypermethylation (29% compared to 50% in the remaining, p-value 0.049). However, there was no association between hypermethylation status and any clinicopathological parameters. The methylation status of BMP6 was not correlated with that of MLH1, a key methylation determinant in CRC. On survival analysis, there was no significant difference in progress-free survival (PFS) between the cases with and without hypermethylation (2-year PFS 74% and 76%, respectively). Conclusions: CpG island methylation of BMP6 is found in high frequency in CRC and this epigenetic event is associated with suppressed protein expression in the tumor tissue. However, the marker is not associated with tumor progression of the disease.

• Journal of the Korea Convergence Society
• /
• v.9 no.10
• /
• pp.393-406
• /
• 2018

The depression and anxiety are the most popular mental disorders and not easy to distinguish because of their lots of similarities in the diagnostic criteria, related theories, and clinical symptoms. In this article, we developed the affect scale for distinguishable diagnosis, utilized the relationships between the Positive and Negative affect, and the depression and anxiety. We made up the seed scale of the items which selected by partial correlation, and set the scoring up by multiple regression method. The Multi-dimentional affect scale is reliable and working similarly as the scales used before, but less correlated to each other. We conclude that the affect scale achieved the diagnosis for distinguish between depression and anxiety. Our suggestions for the further study are to redeem the cultural differences, modify by the elaborate methods, and validate by the actual clinical data.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.11 no.1
• /
• pp.121-130
• /
• 1984

Childrens between the ages of 13 and 15 years, living in Seoul, were examined in order to determine the prevalence and severity of malocclusion in the permanent dentition. This survey encompassed 981 children and an individual chart was prepared for each subject recording an original HMAR score and classification of occlusion according to Angle. Also, subjective evaluation of "treatment needs" was carried out in 581 children. The results were as follows: 1. Of the 981 children in this survey, 12,1 percent showed excellent occlusion. (0 point) 2. The 14 percent of the children who had a score of 24 and above all appeared to belong to the "treatment highly desirable" or "treatment mandatory" category. 3. The incorporation of SAR (Supplementary Assessment Record) into the HMAR can provide more sensitive method for evaluating severity of malocclusion. 4. According to Angle's classification 77.4 percent of all malocclusion belonged to Class I, 1.3 percent to Class II, Division 1, 0.9 percent to Class II, Division 2, and 11.3 percent to Class III. 5. The mean HMAR score for Class I was significantly lower than for either Class II, Division 1 or Class III. (P < 0.05) 6. A close relationship was found between the degree of "treatment needs" and the value obtained by the HMAR scoring. (chi-square test, p < 0.05) The differences between the mean HMAR scores of the various subjectively defined categories were statistically significant. (P < 0.001)

• Women's Health Nursing
• /
• v.12 no.4
• /
• pp.282-290
• /
• 2006

Purpose: In this research the informational contents of websites related to postnatal care were evaluated. This was done in order to inform people of qualified information on postnatal websites. Method: Instruments from Oh(2001) and the Korea Institute for Health and Social Affairs(2000) were utilized to evaluate the contents in respect to purpose, reliability, easiness, authoritativeness, feedback, and maintenance. Seventy-three postnatal websites were evaluated for this research conducted from June 10 to July 10, 2006. Result: There were no portal sites connected with purely informational postnatal websites. In the evaluation of postnatal websites, the lowest and the highest scores were 11 and 42, respectively. The average score was 24 with 52.1% scoring below the average. By category, the scores of purpose, reliability, and feedback were relatively high while easiness, authoritativeness, and maintenance showed very low scores. As a result, it was revealed that there were no specific postnatal websites with sufficient postnatal care information. Conclusion: Thus, the establishment of a professional postnatal portal system through a professionally certified organization is required in order to supply correct information to people who wish to get information on postnatal care.

• The Journal of Pediatrics of Korean Medicine
• /
• v.20 no.1
• /
• pp.1-14
• /
• 2006

Objective : As prevalence of atopic dermatitis(AD) rises and medicine of atopic dematitis develops, the methods of measurement for atopic dermatitis have developed. Therefore, we aimed to establish a new sconring system in oriental medicine for a childhood atopic dematitis, by comparison, analysis of various sconing systems. Method : We searched for the data related to severity sconing systems of atopic dermatitis in Entrez PubMed on abroad thesis and KISS(Korenstdued Information Service System) on domestic thesis from 1990 to 2005. Result : Severity sconing systems for atopic dermatitis satisfy validity, reliability, sensitivity of change and verification of this. The essential items of severity sconing systems are extent, intensity and subjective symptoms. The lesion is divided into 9 areas(head and neck, upper limbs, elbow, hands, trunk, hip and inguinal, lower limbs, knee, feet). The items of intensity are erythema, oedema and induration and papulation, oozing and weeping and erosion, excorition, scaling, lichenification. The subjective symptom is pruritis, evaluated according to sleep loss and obstruction of play and study. The extent and intensity is evaluated in combination. We suggested that extent and intensity occupied for 70% and subject symptoms accounted for 30% of total score.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.20 no.5
• /
• pp.81-87
• /
• 2012

New car assessment program (NCAP) originated from USNCAP in 1979 has been implemented in several countries or markets, for instance USA, Europe, Korea, Japan, China and Australia. NCAP has contributed greatly to reduce accidental tolls. But recently, NCAP performance has no distinction between cars because manufacturer have been continuously developed to improve NCAP performance. Therefore, NHTSA announced new USNCAP protocol becoming effective from MY2011. NHTSA had carried out many NCAP tests based on the new test protocol and announced these test results. In this paper, USNCAP test results were reviewed by statistical method. This review was focused on passenger cars and frontal crash test results in order to investigate effect of changes in new NCAP protocol. There are two key changes, one is sited female dummy in passenger position, the other is enlarged to 4 scoring body regions in each dummy. Results of this review were summarized as followings. Performance in Passenger (12.5%) is lower than Driver's (50%) for number of 5 star vehicle. Neck injury criterion is dominant to NCAP star rating for both dummies in the mean sense. For standard deviation, chest deflection is showed largest value in driver dummy but neck injury criterion is showed for passenger's. DKAB and PKAB were equipped 28.1% and 6.2%, respectively. Consequently, the countermeasure for new USNCAP frontal crash test is essential to control well dummy kinematics with some safety features including KAB to reduce neck injuries.

• Journal of Korean Foot and Ankle Society
• /
• v.10 no.2
• /
• pp.163-167
• /
• 2006

Purpose: To evaluate the results of extracorporeal shock wave therapy (ESWT) for patients with chronic proximal plantar fascitis. Materials and Methods: Between April 2005 and April 2006, 35 cases (24 patients) who were followed more than 6 months were evaluated. By $EvoTron^{(R)}$, 2 sessions of ESWT (Group 1: 1200 and Group 2: 1500 shock waves / session of $0.12\;mJ/mm^2$) were performed at 2 weeks interval. The mean age was 40.0 (range, 15-59) years. 13 patients were male and 11 patients were female. Visual analogue scale (VAS) on daily activity and a 100-point scoring system including 70 points for pain and 30 points for function were used. The clinical outcomes were rated as follows: excellent, no pain on daily activity; good, less than 50% of previous VAS; fair, 50-75% of previous VAS; or poor, more than 75% of previous VAS. Excellent and good were graded as satisfactory results. We compare clinical results between groups and evaluate the relationships between clinical results and duration of symptom, fascial thickening and previous steroid injection were evaluated. Results: Overall satisfactory rate were 71.4%. There was no significant difference of clinical results between groups. And there were no significant difference between clinical results and duration of symtom, preoperative fascial thickening and previous steroid injection. Conclusions: ESWT for recalcitrant chronic proximal plantar fascitis is useful treatment method with high patient satisfaction and pain relief, but more long-term study must be needed.

• Archives of Plastic Surgery
• /
• v.41 no.5
• /
• pp.513-519
• /
• 2014

Background Currently, breast conservation therapy is commonly performed for the treatment of early breast cancer. Depending on the volume excised, patients may require volume replacement, even in cases of partial mastectomy. The use of the latissimus dorsi muscle is the standard method, but this procedure leaves an unfavorable scar on the donor site. We used an endoscope for latissimus dorsi harvesting to minimize the incision, thus reducing postoperative scars. Methods Ten patients who underwent partial mastectomy and immediate partial breast reconstruction with endoscopic latissimus dorsi muscle flap harvest were reviewed retrospectively. The total operation time, hospital stay, and complications were reviewed. Postoperative scarring, overall shape of the reconstructed breast, and donor site deformity were assessed using a 10-point scale. Results In the mean follow-up of 11 weeks, no tumor recurrence was reported. The mean operation time was 294.5 (${\pm}38.2$) minutes. The postoperative hospital stay was 11.4 days. Donor site seroma was reported in four cases and managed by office aspiration and compressive dressing. Postoperative scarring, donor site deformity, and the overall shape of the neobreast were acceptable, scoring above 7. Conclusions Replacement of 20% to 40% of breast volume in the upper and the lower outer quadrants with a latissimus dorsi muscle flap by using endoscopic harvesting is a good alternative reconstruction technique after partial mastectomy. Short incision benefits from a very acceptable postoperative scar, less pain, and early upper extremity movement.

• The Korean Journal of Pain
• /
• v.10 no.2
• /
• pp.220-224
• /
• 1997

Background: The incidence of pain on injection of propofol varies between 30 and 100%. A variety of pretreatments have been tried to alleviate this problem such as a local anesthetics, cooling and opioids. However, none of these pharmacological maneuvers were satisfactory yet. In a recent study, subhypnotic doses of both thiopental sodium and propofol decrease the acute pain. We report a comparison of thiopental sodium, lidocaine and placebo on the incidence and severity of pain on injection of propofol. Method: A controlled, double-blind study was performed to compare the prior administration of intravenous saline 2 ml(n=30, group S), lidocaine 20 mg(n=30, group L) and thiopental sodium 50 mg(n=30, group T) in alleviating the pain by propofol. Injection pain was assessed with the four-point verbal categorical scoring system. Result: The incidence of injection pain during induction was lower in group L(30%) and T(17%) than group S(77%). The incidence of injection pain was lower in group T(17%) than group L(30%), but not significant statistically. The pain scores for recall of pain in the recovery room was simlar to those pain during propofol induction. Conclusion: The pretreatment of thiopental sodium can be effective in reducing both incidence and severity of propofol injection pain and has similar effect to lidocaine to prevent propofol injection pain.

• Journal of Science Education
• /
• v.37 no.2
• /
• pp.245-260
• /
• 2013

The purpose of the research is to examine the teachers' cognition about the math textbook selecting and to provide the implications about the rational process of the textbook selection and criteria based on the research. In terms of the research result about the inner and outer criteria of the actual process of the textbook selecting, they utilized the standard selection criteria distributed by Office of Education, and they considered 'Organization of learning contents' and 'Learning evaluation' as the most important factors. The selection method was that the answer 'After scoring the grade with matching standards, selecting by adding the total score' was the highest. In case of the actual selection, the most considerable inner criteria appeared 'Learning quantity and propriety of the difficulty level'. The outer criteria showed 'Awareness', and the difficulty in the selection process was 'in sufficient time for reviewing'. Based on this research result, we draw the implication that needs to be improved in the process of the textbook selection and the criteria.