• 제목/요약/키워드: Science and Technology University

검색결과 76,446건 처리시간 0.129초

Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes

  • Hewage, Susara Ruwan Kumara Madduma;Piao, Mei Jing;Kang, Kyoung Ah;Ryu, Yea Seong;Fernando, Pattage Madushan Dilhara Jayatissa;Oh, Min Chang;Park, Jeong Eon;Shilnikova, Kristina;Moon, Yu Jin;Shin, Dae O;Hyun, Jin Won
    • Biomolecules & Therapeutics
    • /
    • 제25권4호
    • /
    • pp.427-433
    • /
    • 2017
  • Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved in synthesis of reduced glutathione (GSH), and investigated the associated upstream signaling cascades. By activating nuclear factor-erythroid 2-related factor (Nrf2), galangin treatment significantly increased expression of glutamate-cysteine ligase catalytic subunit (GCLC) and glutathione synthetase (GSS). This activation of Nrf2 depended on extracellular signal-regulated kinases (ERKs) and protein kinase B (AKT) signaling. Inhibition of GSH in galangin-treated cells attenuated the protective effect of galangin against the deleterious effects of UVB. Our results reveal that galangin protects human keratinocytes by activating ERK/AKT-Nrf2, leading to elevated expression of GSH-synthesizing enzymes.

외톨개모자반 (Myagropsis myagroides) 물추출물의 면역 활성 및 이화학적 특성에 미치는 감마선 조사의 영향 (Effect of Gamma Irradiation on Immune Activity and Physicochemical Properties of Myagropsis myagroides Water Extract)

  • 이청조;송유진;김꽃봉우리;정지연;곽지희;최문경;김민지;김동현;선우찬;박진규;김재훈;최종일;이주운;변명우;안동현
    • 한국수산과학회지
    • /
    • 제44권1호
    • /
    • pp.50-57
    • /
    • 2011
  • This study examined the effect of gamma irradiation (3-20 kGy) on the immune activity and physicochemical properties of Myagropsis myagroides (MM) water extracts. MM powder and water extracts were subjected to gamma irradiation at 3, 7, and 20 kGy. The effects of gamma-irradiated MM water extracts on splenocyte proliferation and cytokine IFN-${\gamma}$ and IL-2 secretion were evaluated. The gamma-irradiated MM water extracts resulted in decreased splenocyte proliferation without cytotoxicity. The IFN-${\gamma}$ and IL-2 secretion increased by gamma-irradiated MM water extracts with increasing irradiation dose. For MM powder, the yield and total phenolic compounds (TPC) of water extracts were increased slightly after gamma irradiation. In MM water extracts, the TPC was higher at a dose of 20 kGy, while gamma irradiation decreased the viscosity, pH, and color of the MM extracts. In conclusion, gamma irradiation improved the immunomodulatory activity of MM water extracts, overcoming its potential weakness when applied in the food industry.

Efficient Mean-Shift Tracking Using an Improved Weighted Histogram Scheme

  • Wang, Dejun;Chen, Kai;Sun, Weiping;Yu, Shengsheng;Wang, Hanbing
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • 제8권6호
    • /
    • pp.1964-1981
    • /
    • 2014
  • An improved Mean-Shift (MS) tracker called joint CB-LBWH, which uses a combined weighted-histogram scheme of CBWH (Corrected Background-Weighted Histogram) and LBWH (likelihood-based Background-Weighted Histogram), is presented. Joint CB-LBWH is based on the notion that target representation employs both feature saliency and confidence to form a compound weighted histogram criterion. As the more prominent and confident features mean more significant for tracking the target, the tuned histogram by joint CB-LBWH can reduce the interference of background in target localization effectively. Comparative experimental results show that the proposed joint CB-LBWH scheme can significantly improve the efficiency and robustness of MS tracker when heavy occlusions and complex scenes exist.