• International Journal of Oral Biology
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• 제49권1호
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• pp.10-17
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• 2024

Glutamate-mediated oxidative stress causes neuronal cell death by increasing intracellular Ca²⁺ uptake, reactive oxidative species (ROS) generation, mitogen-activated protein kinase (MAPK) activation, and translocation of apoptosis-inducing factor (AIF) to the nucleus. In the current study, we demonstrated that corydaline exerts potent neuroprotective effects against glutamate-induced neurotoxicity. Treatment with 5 mmol/L glutamate increased cellular Ca²⁺ influx, ROS generation, MAPK activation, and AIF translocation. In contrast, corydaline treatment decreased cellular Ca²⁺ influx and ROS generation. Western blot analysis revealed that glutamate-mediated MAPK activation was attenuated by corydaline treatment. We further demonstrated that corydaline treatment inhibited the glutamate-mediated translocation of AIF to the nucleus. We propose that corydaline is a promising lead structure for the development of safe and effective neuroprotectants.

• Asian-Australasian Journal of Animal Sciences
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• 제16권6호
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• pp.867-872
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• 2003

This experiment was conducted to determine the optimum level of green tea by-product (GTB) in diets without antibiotics and to evaluate its effect on broiler performances. A total of 140 Ross broilers were kept in battery cages for a period of 6 weeks. Dietary treatments used in this experiment were antibiotic free group (basal diet as a control), antibiotic added group (basal+0.05% chlortetracycline), GTB 0.5% (basal+GTB 0.5%), GTB 1% (basal+GTB 1%) and GTB 2% (basal+GTB 2%). Antibiotic added group showed significantly higher body weight gain than other treatments (p<0.05). However, no significant differences were observed in feed intake and feed efficiency among treatments (p>0.05). The addition of green tea by-product to diets tended to decrease blood LDL cholesterol content compared to control group although there were no significant differences among treatments (p>0.05). Addition of green tea by-product increased docosahexaenoic acid (DHA) in blood plasma and tended to decrease cholesterol content in chicken meat, but a significant difference was not observed (p>0.05). The values of TBA in chicken meat decreased in groups fed diets with green tea-by product and antibiotics compared to control group (p<0.05). The crude protein content in chicken meat was decreased slightly in treatments with green tea by-product and antibiotics supplementation. The abdominal fat was increased in chickens fed with diets with green tea by-product compared to the control (p<0.05).

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2006년도 추계학술대회
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• pp.36-39
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• 2006

This paper examines critical successful facts related with the digital new product development with product innovation. For this, we have selected a Xcanvas time-machine TV of LG electronics and we have done case-study. We have performed in-depth interviews with engineers, team managers, marketers to get facts on the product development process and analyzed huge amount of data obtained from web-sites and related firms' materials. We have concluded that CSFs of Xcanvas time-machine TV are customer-centered product innovation, new perspective of considering technology and product, managing innovative team and motivation to team member.

• 대한안전경영과학회지
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• 제11권3호
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• pp.105-112
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• 2009

오늘날 치열한 글로벌 마켓의 경쟁환경에서 많은 회사들이 제품의 경쟁우위를 확보하기 위해 고객에 대한 빠른 대응과 유연하고 효율적인 새로운 제품을 적기에 개발하기 위한 방법으로 product family 기반의 제품개발과 고객 맞춤형 제품개발 방법을 도입하고 있다. 많은 제품들의 가장 중요한 비즈니스 프로세스 요소는 제품의 전체 라이프 씨이들동안 제품 데이터를 관리하는 것이다. 서로 다른 저장 구조를 가지는 이기종 소프트웨어 시스템에 의해 수집되는 제품 정보는 서로 다른 조직의 정보시스템내에서 인덱싱, 탐색, 정제, 재사용, 분배되는 것이 어렵다. 본 연구에서는 현재의 제품 설계 저장소의 이러한 문제점을 해결하기 위해, 시맨틱 웹 패러다임을 사용하여 product family를 대상으로 지식 관리 프레임워크를 개발하고자 한다. 시맨틱 웹 패러다임의 formal product represention은 제품 플랫폼의 구조를 저장할 수 있고, product family의 서로 다른 부품들을 공용으로 사용할 수 있도록 도와 줄 수 있을 뿐만 아니라, product family 기반의 제품개발과 고객맞춤형 제품개발이 가능하다. 본 연구에서는 일회용 카메라를 대상으로 제안한 프레임워크의 타당성의 입증을 위한 프로토타입을 제시한다.

• 대한안전경영과학회지
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• 제3권4호
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• pp.19-34
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• 2001

Since the introduction of product liability law from America in 1960s, product liability has been on the rise as an important problem to the quality management of company and consumer's safety. Together with this, before the legislation of product liability system in Korea, the sense and level of company and consumer about product safety are rapidly changing, In times like the present, ensuring more systematic product safety and consumer safety, and the buildup need of competitive power in accordance with product liability prevention of company grows raising. Therefore, this study presents the most effectively manageable ways of product liability the side of safety management of consumers and companies through the ensuring ways and activity models of product safety and certification system in company.

• Food Science and Biotechnology
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• 제17권6호
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• pp.1376-1378
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• 2008

Tachioside (4-hydroxy-3-methoxy-phenyl-1-O-glucoside), a known phenolic glycoside, was isolated from various bamboo species. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and Trolox equivalent antioxidant capacity determined a significant antioxidant activity of tachioside which was comparable to L-ascorbic acid. Each culm and leaf extracts were tested and the culm of Phyllostachys bambusoides appeared to contain the highest amount of tachioside.

• 대한지역사회영양학회:학술대회논문집
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• 대한지역사회영양학회 2005년도 춘계학술대회
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• pp.181-181
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• 2005

• 대한지역사회영양학회:학술대회논문집
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• 대한지역사회영양학회 2005년도 춘계학술대회
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• pp.180-180
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• 2005

• 대한지역사회영양학회:학술대회논문집
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• 대한지역사회영양학회 2005년도 춘계학술대회
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• pp.179-179
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• 2005

• 대한지역사회영양학회:학술대회논문집
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• 대한지역사회영양학회 2004년도 추계학술대회
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• pp.114-114
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• 2004