• Journal of Korean Society of Coastal and Ocean Engineers
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• v.33 no.6
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• pp.383-390
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• 2021

The experiments in coastal engineering are very complex and a lot of components should be concerned. The experience has an important role in the successful execution. Hydraulic model experiments have been improved with the development of the wave generator and the advanced measuring apparatus. The hydraulic experiments have the advantage, that is, the stability of coastal structures and the hydraulic characteristics could be observed more intuitively rather than the numerical modelings. However, different experimental results can be drawn depending on the model scale, facilities, apparatus, and experimenters. In this study, two-dimensional hydraulic experiments were performed to suggest the guide of the test wave(random wave) generation, which is the most basic and important factor for the model test. The techniques for generating the random waves with frequency energy spectrum and the range for the incident wave height [(H_S)_M/(H_S)_T = 1~1.05] were suggested. The proposed guide for the test wave generation will contribute to enhancing the reliability of the experimental results in coastal engineering.

• Journal of Gastric Cancer
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• v.22 no.2
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• pp.94-106
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• 2022

Purpose: Laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) is a function-preserving procedure performed for treating upper early gastric cancer (EGC). However, few studies have compared the outcomes of LPG-DTR with those of laparoscopic total gastrectomy (LTG). This study aimed at comparing the short-term outcomes of LPG-DTR between LTG and upper EGC. Materials and Methods: For upper-third EGC, a multicenter, prospective, randomized trial was performed to compare those who underwent LPG-DTR with those who underwent LTG. Short-term outcomes, including clinicopathologic results, morbidity, mortality, and postoperative courses, were evaluated using a full analysis set based on the intention-to-treat principle and the per-protocol set. Results: Of the patients, 138 who fulfilled the criteria were randomized to each group. One patient in the LPG-DTR group withdrew consent. Sixty-eight patients underwent LPG-DTR and 69 underwent LTG. The operative time (LPG-DTR=219.4 minutes; LTG=201.8 minutes; P=0.085), estimated blood loss (LPG-DTR=76.0 mL; LTG=66.1 mL; P=0.413), and the morbidity rate (LPG-DTR=23.5%; LTG=17.4%; P=0.373) between the groups were not significantly different. No mortality occurred in either of the study groups. Two weeks post operation, the Visick scores for postprandial symptoms, including reflux symptoms, were not significantly different between the groups (P=0.749). Laboratory findings on postoperative day 5 were not significantly different between the groups. Conclusions: The short-term outcomes of LPG-DTR for upper EGC were comparable to those of LTG.

• Journal of the Microelectronics and Packaging Society
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• v.29 no.2
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• pp.113-119
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• 2022

In order to improve the mechanical reliability of next-generation electronic devices including flexible, wearable devices, a high level of mechanical reliability is required at various flexible joints. Organic adhesive materials such as epoxy for bonding existing polymer substrates inevitably have an increase in the thickness of the joint and involve problems of thermodynamic damage due to repeated deformation and high temperature hardening. Therefore, it is required to develop a low-temperature bonding process to minimize the thickness of the joint and prevent thermal damage for flexible bonding. This study developed flexible laser transmission welding (f-LTW) that allows bonding of flexible substrates with flexibility, robustness, and low thermal damage. Carbon nanotube (CNT) is thin-film coated on a flexible substrate to reduce the thickness of the joint, and a local melt bonding process on the surface of a polymer substrate by heating a CNT dispersion beam laser has been developed. The laser process conditions were constructed to minimize the thermal damage of the substrate and the mechanism of forming a CNT junction with the polymer substrate. In addition, lap shear adhesion test, peel test, and repeated bending experiment were conducted to evaluate the strength and flexibility of the flexible bonding joint.

• Journal of Korea Entertainment Industry Association
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• v.15 no.1
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• pp.87-97
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• 2021

This study is to identify the effects of pilates exercise on the body composition, blood biochemical factor, isokinetic knee and trunk muscle function in menopause middle-aged women. In order to carry out this study, Twenty menopause middle-aged women were divided into two groups: pilates exercise group (PEG; n=10) and control group (CG; n=10). PEG group performed pilates exercise for 50 min per day, 2days/week for 12 weeks. As a result, first, there was an interaction effect on body fat mass in body composition. Second, there was no significant result in blood lipid and serotonin, but there was a positive trend. Third, in the isokinetic knee and trunk muscle function, the interaction effect was found in the flexor peak torque of trunk strength. The effect of the 12-week Pilates exercise on body composition, bone density, blood biochemical factor, and isokinetic muscular strength of menopause middle-aged women is partially insignificant, but the overall effect tends to be positive. In conclusion, the Pilates exercise conducted in this study is appropriate for menopause middle-aged women.

• Animal Bioscience
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• v.35 no.11
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• pp.1787-1799
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• 2022

Objective: Choline deficiency, one main trigger for nonalcoholic fatty liver disease (NAFLD), is closely related to lipid metabolism disorder. Previous study in a choline-deficient model has largely focused on gene expression rather than gene structure, especially sparse are studies regarding to alternative splicing (AS). In modern life science research, primary hepatocytes culture technology facilitates such studies, which can accurately imitate liver activity in vitro and show unique superiority. Whereas limitations to traditional hepatocytes culture technology exist in terms of efficiency and operability. This study pursued an optimization culture method for duck primary hepatocytes to explore AS in choline-deficient model. Methods: We performed an optimization culture method for duck primary hepatocytes with multi-step digestion procedure from Pekin duck embryos. Subsequently a NAFLD model was constructed with choline-free medium. RNA-seq and further analysis by rMATS were performed to identify AS events alterations in choline-deficency duck primary hepatocytes. Results: The results showed E13 (embryonic day 13) to E15 is suitable to obtain hepatocytes, and the viability reached over 95% by trypan blue exclusion assay. Primary hepatocyte retained their biological function as well identified by Periodic Acid-Schiff staining method and Glucose-6-phosphate dehydrogenase activity assay, respectively. Meanwhile, genes of alb and afp and specific protein of albumin were detected to verify cultured hepatocytes. Immunofluorescence was used to evaluate purity of hepatocytes, presenting up to 90%. On this base, choline-deficient model was constructed and displayed significantly increase of intracellular triglyceride and cholesterol as reported previously. Intriguingly, our data suggested that AS events in choline-deficient model were implicated in pivotal biological processes as an aberrant transcriptional regulator, of which 16 genes were involved in lipid metabolism and highly enriched in glycerophospholipid metabolism. Conclusion: An effective and rapid protocol for obtaining duck primary hepatocytes was established, by which our findings manifested choline deficiency could induce the accumulation of lipid and result in aberrant AS events in hepatocytes, providing a novel insight into various AS in the metabolism role of choline.

• Journal of Korea Entertainment Industry Association
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• v.14 no.6
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• pp.259-267
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• 2020

This study is to identify the effects of pilates mat exercise on the body composition, lumbar muscle strength, low back pain and pregnancy stress in pregnant women. In order to carry out this study, nineteen pregnant women were divided into two groups: pilates mat exercise group (n=11) and control group (n=8). EXE group performed pilates mat exercise for 60 min per day, 2days/week for 12 weeks. Our results showed that there was no significant changes in total body water, body fat mass, BMI, body fat percent, and BMR, but the EXE group showed significant increase in skeletal muscle mass. Furthermore, EXE group was significantly increased in hip extension and lumbar extension ROM. Analysis of low back pain and pregnancy stress level showed no significant difference between group. In conclusion, our study suggest that pilates mat exercise can be safely applied to pregnant women by increasing the muscle mass of pregnant women and by showing a positive effect on the lumbar muscle strength.

• Journal of Internet of Things and Convergence
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• v.7 no.4
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• pp.35-41
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• 2021

Natural dyeing has traditionally been used in many countries around the world, and as natural dyes are diversified, the diversity of dyeing patterns is also expanding. This study tried to establish standardization by providing numerical values that could provide quantified information to the Internet of Things by more accurately analyzing the color changes of dyes and mordants for the four natural dyes. The addition of copper acetate, iron II sulfate and potassium dichromate to the dye extracted from Juglans regia Linn changed the original color of brown to other colors of purple, khaki and dark brown, respectively. Except for potassium dichromate added to Sophora japonica L. or Phellodendron amurense Ruprecht, the concentration of other mordants was reduced, but the color difference of the dyed silk was very large. However, although there is a difference in degree, copper acetate and iron sulfate induced color changes of 35% and 15%, respectively. In summary, it was confirmed that the highest color change was induced when 15 grams of copper acetate was added to J. regia Linn, S. japonica L. and P. amurense Ruprecht and 150 grams of iron to Phytolacca americana. The results of this study suggested that the accurate color change by various mordants can be utilized as important information that enables more accurate color induction by dyes and mordants.

• Tunnel and Underground Space
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• v.32 no.6
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• pp.568-585
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• 2022

In the present study, we proposed a numerical method for simulating thermally induced fracture slip using a grain-based distinct element model (GBDEM). As a part of DECOVALEX-2023, the thermo-mechanical loading test on a saw-cut rock fracture conducted at the Korea Institute of Civil Engineering and Building Technology was simulated. In the numerical model, the rock sample including a saw-cut fracture was represented as a group of random Voronoi polyhedra. Then, the coupled thermo-mechanical behavior of grains and their interfaces was calculated using 3DEC. The key concerns focused on the temperature evolution, thermally induced principal stress increment, and fracture normal and shear displacements under thermo-mechanical loading. The comparisons between laboratory experimental results and the numerical results revealed that the numerical model reasonably captured the heat transfer and heat loss characteristics of the rock specimen, the horizontal stress increment due to constrained displacement, and the progressive shear failure of the fracture. However, the onset of the fracture slip and the magnitudes of stress increment and fracture displacement showed discrepancies between the numerical and experimental results. We expect the numerical model to be enhanced by continuing collaboration and interaction with other research teams of DECOVALEX-2023 Task G and validated in further study.

• Animal Bioscience
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• v.36 no.2
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• pp.218-228
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• 2023

Objective: This study investigated the effects of feeding anthocyanin-rich black cane treated with ferrous sulfate and molasses on animal performance, rumen fermentation, microbial composition, blood biochemical indices, and carcass characteristics in meat goats. Methods: Thirty-two Thai-native×Anglo-Nubian crossbred male goats (14.47±2.3 kg) were divided equally into two groups (n = 16) to investigate the effect of feeding diet containing 50% untreated anthocyanin-rich black cane silage (BS) vs diet containing anthocyaninrich black cane silage treated with 0.03% ferrous sulfate and 4% molasses (TBS) on average daily gain (ADG) and dry matter intake (DMI). At the end of 90 d feeding trial, the goats were slaughtered to determine blood biochemical indices, rumen fermentation, microbial composition, and carcass characteristics differences between the two dietary groups. Results: Goats fed the TBS diet had greater ADG and ADG to DMI ratio (p<0.05). TBS diet did not affect rumen fluid pH; however, goats in the TBS group had lower rumen ammonia N levels (p<0.05) and higher total volatile fatty acid concentrations (p<0.05). Goats in the TBS group had a higher (p<0.05) concentration of Ruminococcus albus but a lower (p<0.05) concentration of methanogenic bacteria. The TBS diet also resulted in lower (p<0.05) thiobarbituric acid-reactive substances concentration but higher (p<0.05) total antioxidant capacity, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase concentrations in blood plasma, while having no effect on plasma protein, glucose, lipid, immunoglobin G, alanine transaminase, and aspartate aminotransferase. Meat from goats fed the TBS diet contained more intramuscular fat (p<0.05) and was more tender (p<0.05). Conclusion: In comparison to goats fed a diet containing 50% untreated anthocyanin-rich black cane silage, feeding a diet containing 50% anthocyanin-rich black cane silage treated with 0.03% ferrous sulfate and 4% molasses improved rumen fermentation and reduced oxidative stress, resulting in higher growth and more tender meat.

• The Korea Journal of Herbology
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• v.33 no.2
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• pp.1-7
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• 2018

Objectives : This study was conducted to evaluate the antioxidant activity and inhibitory activity of pancreatic lipase in vitro using natural products sangju dungsi, chungdo bansi, kabju baekmok three kind of young persimmon fruit extracts and to develop a high - functional anti - obesity substance with reduced body fat. Methods : The antioxidative effect of the three kind of young persimmon fruit extracts was determined by hot water extraction, 30% EtOH extraction and 70% EtOH extraction. The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. Furthermore, we examined total phenol and flavonoids contents. And the pancreatic lipase inhibition was measured by selecting the sangju dungsi extract with antioxidant effect. Results : The yield of water, 30% and 70% EtOH extract from young persimmon fruit was sangju dungsi (water 8.3%, 30% EtOH 18.1%, 70% EtOH 16.9%), chungdo bansi (water 16.2%, 30% EtOH 16.1%, 70% EtOH 11.6%), kabju baekmok (water 16%, 30% EtOH 16.8%, 70% EtOH 11.5%). The sangju dungsi 30% EtOH extract eminent DPPH ($IC_{50}$, $19.25{\pm}2.94{\mu}g/m{\ell}$) and ABTS ($IC_{50}$, $19.94{\pm}4.07{\mu}g/m{\ell}$) radical scavenging activity, and total phenol $52.37{\pm}0.78mg/g$ and flavonoid $7.97{\pm}0.13mg/g$ contents were also excellent. It also showed excellent pancreatic lipase inhibition efficacy. Conclusion : The extracts from the three kind of young persimmon fruit extracts showed excellent antioxidant activity. sangju dungsi 30% EtOH extract may be a new anti-obesity material by reducing fat absorption through the inhibition of pancreatic lipase.