• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.4
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• pp.357-365
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• 2021

Purpose: A change in diagnosis from ulcerative colitis (UC) to Crohn's disease (CD) has been reported in pediatric inflammatory bowel disease; however, only a few clinical characteristics and predictors of this diagnostic change have been reported. We aimed to describe the clinical characteristics of patients with UC who underwent a change in diagnosis to CD and identify variables associated with the change. Methods: The medical records of pediatric patients with UC who were followed up at the National Center for Child Health and Development between 2006 and 2019 were retrospectively reviewed. Clinical data on disease phenotype, laboratory parameters, endoscopic findings, and treatment of patients whose diagnosis changed to CD (cCD) were compared to those of patients whose diagnosis remained UC (rUC). Results: Among the 111 patients initially diagnosed with UC, 11 (9.9%) patients were subsequently diagnosed with CD during follow-up. There was no significant difference between the cCD and rUC groups in terms of sex, age at initial diagnosis, and the extent and severity of disease at initial diagnosis. Albumin and hemoglobin levels were significantly lower in the cCD group than in the rUC group. The proportion of patients who required biologics was significantly higher in the cCD group than in the rUC group (p<0.05). Conclusion: Approximately 10% children initially diagnosed with UC were subsequently diagnosed with CD. Hypoalbuminemia and anemia at initial diagnosis and use of biologics could be predictors of this diagnostic change.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.22 no.3
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• pp.192-197
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• 2011

Objectives: This study was conducted to examine the prevalence and characteristics of savant skills and the relationship between the savant skills and autistic symptoms in Korean ASD children. Methods: 141 ASD subjects participated in this study and they were divided in to two groups based on the presence or lack of savant skills. The domain scores and total scores of the K-ADI-R, K-ASDS and SRS were used for evaluating the ASD symptoms between the groups. Results: Memory (N=47) was the most prevalent savant skill in the savant ASD group (N=60). The savant ASD group had a statistically higher mean age and IQ score than did the nonsavant ASD group. Despite their high IQ profile, the savant ASD group showed a higher restricted, repetitive and stereotype behavior score on the K-ADI-R and higher language and cognitive scores on the K-ASDS than did the nonsavant ASD group. Conclusions: These results suggest savant syndrome in ASD might be related to the severity of some subdomain of autistic symptoms even though their IQ scores were higher than nonsavant ASD patients.

• Parasites, Hosts and Diseases
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• v.54 no.3
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• pp.345-348
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• 2016

Although intestinal protozoans are common etiologies of diarrhea, few studies have been conducted in Myanmar. This study planned to investigate the prevalence of Giardia lamblia, Entamoeba coli, Entamoeba histolytica, and Endolimax nana among schoolchildren and their guardians in suburban areas near Yangon, Myanmar. We performed a cross-sectional survey among schoolchildren and their guardians from 7 primary schools in South Dagon and Hlaing Thar Yar districts, Yangon, Myanmar. Stool samples were observed with a microscope after concentration technique and iodine staining. Total 821 stool samples, including 556 from schoolchildren and 265 from guardians, were examined. The median age was 6 years old for schoolchildren and 36 years old for guardians. A 53.1% of the school children and 14.6 % of the guardians were males. The overall prevalence of each intestinal protozoan species was as follows: 3.4% (28/821) for G. lamblia; 3.5% (29/821) for E. coli; 1.2% (10/821) for E. histoytica, and 3.0% for E. nana. This study showed that intestinal protozoans are common in primary schoolchildren and their guardians in suburban areas near Yangon, Myanmar. Health interventions, such as hand washing education, improvement of sanitation, and establishment of water purification systems are urgently needed in this area.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.280-289
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• 2018

This study investigated the effects of spousal intervention in housework on female depression. To achieve this, an empirical 10-day field survey of 119 mothers of children after school age was conducted in Suwon, Incheon, Yeoju and Gwangju, Gyeonggi-do through structured questionnaires. The findings were as follows. Spousal intervention in housework had a significant effect on female depression, but there were different prevalence rates of female depression according to the status of spousal childcare on weekdays and weekends. In other words, there was a difference in the effects of spousal intervention in housework on female depression according to weekday childcare and weekend childcare. These findings indicate that reducing housework burdens by spousal intervention in housework helps to lower and prevent female depression. Consequently, because there is a difference in the effects of spousal intervention in housework on female depression according to the level of simple weekday or weekend childcare and the degree of intervention, spousal intervention and sharing all family management duties, including housework and childcare, can maximize the effect.

• Journal of Microbiology and Biotechnology
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• v.30 no.1
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• pp.38-43
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• 2020

Hand, foot, and mouth disease (HFMD) is caused by enterovirus 71 (EV71) in infants and children under six years of age. HFMD is characterized by fever, mouth ulcers, and vesicular rashes on the palms and feet. EV71 also causes severe neurological manifestations, such as brainstem encephalitis and aseptic meningitis. Recently, frequent outbreaks of EV71 have occurred in the Asia-Pacific region, but currently, no effective antiviral drugs have been developed to treat the disease. In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the Salvia miltiorrhiza root and has been shown to be an effective treatment for subarachnoid hemorrhages and myocardial infarctions. HeLa cells were cultured in 12-well plates and treated with SalB (100 or 10 ㎍/ml) and 10⁶ PFU/ml of EV71. SalB treatment (100 ㎍/ml) significantly decreased the cleavage of the eukaryotic eIF4G1 protein and reduced the expression of the EV71 capsid protein VP1. In addition, SalB treatment showed a dramatic decrease in viral infection, measured by immunofluorescence staining. The Akt signaling pathway, a key component of cell survival and proliferation, was significantly increased in EV71-infected HeLa cells treated with 100 ㎍/ml SalB. RT-PCR results showed that the mRNA for anti-apoptotic protein Bcl-2 and the cell cycle regulator Cyclin-D1 were significantly increased by SalB treatment. These results indicate that SalB activates Akt/PKB signaling and inhibits apoptosis in infected HeLa cells. Taken together, these results suggest that SalB could be used to develop a new therapeutic drug for EV71-induced HFMD.

• Journal of Korean Academy of Nursing
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• v.6 no.1
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• pp.41-50
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• 1976

This study was carried out to collect basic information on the knowledge and attributes and behavior related to the prevention of breast cancer of a Sample Seoul women. Similar studies had dealt with samples of tumor clinic patients and their families and with non-professional hospital welters. The sample for this study was drawn by women out patients from eight centrally located general hospitals, in Seoul where the number of annual out patients exceeded 100,000, and the number of beds exceeded 100. The interview schedule consisted 33 questions related to knowledge, attitude, and behavior related to prevention of breast cancer. It was modified from the previous on cancer studies. The investigator interviewed 665 women over 20 years of age, from those who visited these eight hospitals from 24, June to 20, August 1975. More than half of the respondents were housewives and primarily in the 20 to 29 ages group. They had a mean level of 3.562 pregnancies and 1,986 children. 33.4% were high-school graduates, 32.2% had a monthly family income in the 50,000 to 100,000 won range. 75% of the respondents had heard about breast cancer through mass media or personal media, but the majority of respondents did not have an accurate understanding of it. This varied according to educational, economical income and occupations. The primary reason given for maintaining distance from a patient with breast cancer was not because of cancer but simply because person was a patient. 74.7% of the respondents thought that early cancer of the breast could be cured with early treatment. Only 5.3% of the respondents had ever had a physical examination and only 6.3% practised self examination of the breast.

• Journal of Digital Contents Society
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• v.18 no.1
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• pp.35-46
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• 2017

The purpose of the study was to review the recent literature on applying augmented reality based educational contents for students with autism spectrum disorders and to identify research trends and implications. The search procedures through the Web-database system were implemented to find the proper research and a total of 12 studies were included in this review. The results indicated that most of subjects were elementary school-age children, also single subject design was mostly implemented. Mobile devices were used mostly for augmented reality, and most of data collection methods was behavioral observation. Results founded several contents types: objects manipulation, manipulation for self-modeling, on-site problem solving program, and location-based learning guide. Additionally, the results indicated that the educational effectiveness was the improvements of social behaviors, play and imitation behaviors, and emotion recognition. Furthermore, considerations to develop and apply augmented reality based educational contents for students with autism spectrum disorders were suggested.

• Journal of the Korean housing association
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• v.20 no.3
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• pp.37-45
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• 2009

For the young period, privacy is a crucial factor in establishing one's own identities, values and relationships. The capacity of residential environment to protect individual's privacy takes considerable part in influencing psychological and physiological development of adolescents. This study analyzed adolescents residential values and the elements of spatial plans for the passage and outdoor in Apartment Design Competition of Suwon A district in 2008. One hundred and ten middle and high school students living in Metropolitan area were selected and questionnaire was conducted during February 7 to February 15 in 2009. The data was analyzed by SPSS 11.0 program using one-way ANOVA and crosstab. The study results were summarized as follows; First, the adolescents valued 'safety' the most, regardless of their age and gender and the safety of adolescents commuting should be considered. Second, protecting their own private territories was next important element among other elements. Privacy can be protected by using movable walls, changing the doorway, dividing parents' and adolescents independent territory. Third, in terms of convenience, choosing location of children's room and walking way should be considered. Forth, from the survey, demand for indoors leisure activity was highly valued and required for aesthetic point of view. Considering the sculptures and facilities must satisfy the aesthetics and practicality. Fifth, in terms of social needs, 61.6% of people answered positively to the community facilities for social relationship. Residential environment affects enormous part of adolescents emotional and academic development. Therefore, designing residential areas for adolescents friendly should reflect the demands for safety, territory, convenience, aesthetic and social life.

• The Korean Journal of Community Living Science
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• v.23 no.3
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• pp.277-289
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• 2012

This study was conducted to find the nutrition status and the effects of nutrition education by comparing the condition of the subjects before and after the education among elementary students attending a community child center(CCC). The subjects of the study were 70 elementary school students in CCC in Donggu, Ulsan as a control group compared to other 87 elementary students in the same age and the same area. The result were as follows. The students in CCC showed higher rate of skipping breakfasts and less rate of having snacks, compared with control students. Also they showed lower scores of both nutrition knowledge and dietary belief. The CCC group had higher rate of skipping meals, especially on weekends(72.9%), and showed less nutrient intakes than the control group. After the nutrition education, nutrition knowledge and dietary beliefs of the nutrition group showed better results but no difference in their dietary attitudes. The education did not make significant differences in the rate of skipping meals and in the nutrient intakes. Considering all the results above, an adequate plan for providing meals is required as well as a nutrition education for improvement of the poor nutrition condition of children in CCC.

• Clinical and Experimental Pediatrics
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• v.53 no.10
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• pp.892-897
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• 2010

Purpose: This study evaluated the prevalence of the metabolic syndrome (MetS) and risk factors for metabolic derangement in young adults with childhood-onset hypopituitary growth hormone deficiency (ACOHGHD). Methods: Thirty patients with ACOHGHD who were treated with hormone-replacement therapy, aged 18 to 29 years, who visited the Seoul National University Children's Hospital between September 2009 and February 2010 were enrolled. Height, weight, waist circumference, hip circumference, and blood pressure were measured, and the clinical and hormonal features were reviewed retrospectively. We evaluated measures of metabolic derangement in the enrolled patients and in the data of healthy adults aged 20 to 29 years taken from the 2005 Korean National Health and Nutrition Examination Survey (KNHANES) as part of the National Cholesterol Education Program-the Adult Treatment Panel III. Results: Compared with the KNHANES participants, patients with ACOHGHD had significantly large waist circumference (men and women), high systolic blood pressure (BP) (women) and diastolic BP (men), and high serum triglyceride levels (women). The duration of illness correlated significantly with central obesity ($r^2$=0.546, $P$=0.003). The prevalence of MetS was 10% in patients with ACOHGHD and 2.3% in KNHANES participants. The prevalence of central obesity and MetS was higher in patients with ACOHGHD than in KNHANES participants ($P$<0.001 and $P$=0.042, respectively). Conclusion: Abdominal obesity correlated with the duration of illness in patients with ACOHGHD. Waist circumference should be measured in the clinic to prevent MetS, particularly in patients with a long history of ACOHGHD, regardless of age or sex.