• Journal of the Korean Society for Library and Information Science
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• v.12
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• pp.165-200
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• 1985

We have come to the time when we no longer ask why we computerize, but we need to concentrate on how to effectively accomplish the task. Application of computers has been very active in many fields in Korea during the last few years. And yet libraries are rather slow in taking adventage of computers most likely due to the lack of adequate funds and proper understanding of administrators, but also it seems that the majority of librarians are not quite prepared to adopt it. The purpose of this paper is to study the various aspects of computerization of library work, mainly for library administrators and librarians; although they need not understand the electronical and technical aspects of computers, but they should prepare themselves enough at least to be able to make proper requests to computer specialists in relation to what they want to accomplish with computers in order to improve the work of the library. In preparing this paper, not only successful cases of computer application which had been carried out in many libraries of advanced countries have been studied, but also various reasons for failure have been reviewed in order not to make the same mistakes. The paper covers those areas of library work where computers can be applied, such as feasibility, cost effectiveness, planning, implementation and some other aspects of computerization. As a conclusion, two viewpoints need to be discussed. First, each library should work cooperatively with other libraies instead of trying to develop its own computer programs, since we cannot affort to waste financial and technical resources as well as time. Computer applicable library work can be divided and assumed by certain libraries with responsibility to develop turn-key systems applicable to Korean university libraries. In order to carry out this task, there should be complete financial assistance from government, and in turn those libraries shouldf be required to offer assistance to any other interested libaries in Korea. Secondly, library school curriculum should offer such courses where future librarians can learn decision making, business administration and independent thinking in addition to traditional courses. Future librarians as well as those who are already in the profession should prepare themselves to meet the challenge of the professional requirements in order to meet the ever increasing and diverse needs for good quality service generated from the library users.

• Journal of Microbiology and Biotechnology
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• v.21 no.3
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• pp.236-242
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• 2011

A psychrotrophic bacterium, Arthrobacter sp. ON14, isolated from Antarctica, was shown to exhibit a high ${\beta}$-galactosidase activity at a low temperature. A genomic library of ON14 was constructed and screened for ${\beta}$-galactosidase genes on functional plates containing 5-bromo-4-chloro-3-indolyl-${\beta}$-D-galactopyranoside (X-gal) as the substrate. Two different ${\beta}$-galactosidase genes, named as galA, galB, were found in ON14. Computational analyses of the genes revealed that the encoded protein GalA belongs to family 2 of glycosyl hydrolysases and is a cold-active protein, whereas GalB belongs to family 42 of glycosyl hydrolysases and is a mesophilic protein. Reverse transcription analyses revealed that the expression of galA is highly induced at a low temperature ($4^{\circ}C$ ) and repressed at a high temperature ($28^{\circ}C$ ) when lactose is used as the sole carbon source. Conversely, the expression of galB is inhibited at a low temperature and induced at a high temperature. The purified GalA showed its peak activity at $15^{\circ}C$ and pH 8. The mineral ions $Na^+$, $K^+$, $Mg^{2+}$, and $Mn^{2+}$ were identified as enzyme activators, whereas $Ca^{2+}$ had no influence on the enzyme activity. An enzyme stability assay revealed that the activity of GalA is significantly decreased when it is incubated at $45^{\circ}C$ for 2 h, and all its activity is lost when it is incubated at $50^{\circ}C$.

• Journal of Dental Anesthesia and Pain Medicine
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• v.16 no.3
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• pp.165-173
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• 2016

Dentists often sedate patients in order to reduce their dental phobia and stress during dental treatment. Sedatives are administered through various routes such as oral, inhalation, and intravenous routes. Intravenous administration has the advantage of rapid onset of action, predictable duration of action, and easy titration. Typically, midazolam, propofol or dexmedetomidine are used as intravenous sedatives. Administration of these sedatives via infusion by using a syringe pump is more effective and successful than infusing them as a bolus. However, during intravenous infusion of sedatives or opioids using a syringe pump, fatal accidents may occur due to the clinician's carelessness. To prevent such risks, smart syringe pumps have been introduced clinically. They allow clinicians to perform effective sedation by using a computer to control the dose of the drug being infused. To ensure patient safety, various alarm features along with a drug library, which provides drug information and prevents excessive infusion by limiting the dose, have been added to smart pumps. In addition, programmed infusion systems and target-controlled infusion systems have also been developed to enable effective administration of sedatives. Patient-controlled infusion, which allows a patient to control his/her level of sedation through self-infusion, has also been developed. Safer and more successful sedation may be achieved by fully utilizing these new features of the smart pump.

• Applied Biological Chemistry
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• v.50 no.4
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• pp.262-267
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• 2007

To access the natural product antibiotics produced by uncultured microorganisms, six cosmid libraries of DNA extracted directly from soil samples (environmental DNA, eDNA) were constructed and screened for the production of antibacterial active molecules. Of the approximately 60,000 clones screened, one antibacterial clone (YS92B) was detected. Ethyl acetate extracts of clone YS92B showed antibacterial activity against various pathogenic bacteria (Listeria monocytogenes, Bacillus subtilis, Pseudomonas syringae, Xanthomonas campestris pv. oryzae, Staphylococcus epidemis). Active constituents from cultures of YS92B were isolated and purified using a bioassay-guided fractionation against B. subtilis through a series of procedures (ethyl acetate extraction, Sephadex LH20 column chromatography, High Performance Liquid Chromatography). NMR (Nuclear Magnetic Resonance) spectral analysis of a major antibacterial active YS92B-VII indicated that it is a lauric acid linked to tyrosine. This report describes the characterization of antibacterially active long chain N-acyl derivatives of tyrosine that are produced by eDNA clones hosted in Escherichia coli from Korean soils.

• Journal of the Korean Society for information Management
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• v.2 no.2
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• pp.71-114
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• 1985

Medical libraries in Korea consume most of their budget and efforts of staffs for acquisition and administration of foreign medical journals. Annualy the rise in prices of the journals oppress the library budget. Because of these reasons, this paper studied and analyzed the possibility of cooperative acquisition of foreign medical journals between the medical libraries in Korea and several basic informations for cooperative acquisition by citation analysis method. The 5 source medical school journals were selected from our country's medical school journals: Seoul, Yonsei, Catholic, Chonnam, Kyungbook.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2006.06a
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• pp.629-655
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• 2006

A business process specification (BPS) plays the role of a contracted business scenario in the execution of the B2B business process instances. XML-based specification languages, such as BPSS, WS-BPEL, etc., are usually adopted for the specifications. However, composing complex XML-based specifications are not easy for humans. As an alternative, graphical modeling languages such as UML and BPMN can be employed. This paper presents an UML-based modeling method for graphically specifying ebXML BPSS instances (namely, business process specifications). UML diagrams, directly matching with ebXML BPSS, can be reused for understanding and generating ebXML BPSS instances. We discuss the value of tile method by developing a business reference library in the area of supply chain management.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.3
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• pp.102-115
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• 2019

Objectives: The purpose of this study is to confirm the effectiveness and safety of acupuncture for treating breast cancer-related lymphedema (BCRL), thus providing a clinical basis for acupuncture treatment and helping to develop clinical practice guideline through consideration of used meridians and acupoints. Methods: Clinical studies applying acupuncture on breast cancer-related lymphedema were searched through 7 databases such as The Cochrane Library Central, Embase, Pubmed and CAJ. Interventions and results of the selected clinical studies were analyzed. Results: 8 Clinical studies were finally included according to inclusion and exclusion criteria. There were 6 randomized controlled studies and 2 single-arm pilot studies. All of those studies were searched in The Cochrane Library Central, Embase, Pubmed and CAJ and written in English and Chinese. Treatment group applied acupuncture as a Korean medicine intervention. Interventions of control group were made with non-treatment, upper limb exercise, and oral administration of capillary stabilizer or diuretics. Outcome measurements varied from paper to paper but every study measured reduction in arm circumference. Among 8 studies, 6 studies reported statistically significant reduction in arm circumference in treatment group and there were no serious adverse effects. Conclusions: This study suggested that acupuncture has few side effects as well as statistically significant effects on many aspects in treating breast cancer-related lymphedema. However the results should be taken cautiously as more clinical studies are needed.

• Journal of Dental Anesthesia and Pain Medicine
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• v.18 no.4
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• pp.205-221
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• 2018

This systematic review aimed to analyze the efficacy of corticosteroid premedication compared to placebo or no treatment to reduce postoperative pain in endodontic patients. Randomized controlled trials (RCTs) assessing corticosteroids via oral, intramuscular, subperiosteal, intraligamentary or intracanal route compared to passive or active placebo, or no treatment were included. Four databases were searched: PubMed, Web of Science, Cochrane Library and Embase up to 2/21/2018. Risk of bias was assessed with Cochrane Risk of bias tool. Fourteen RCTs with 1,462 generally healthy adults in need of endodontic treatment were included. 50% of the studies were at unclear risk and 50% at high risk of bias. Meta-analysis showed Visual Analog Scale (VAS) pain at 4-6 hours after Inferior Alveolar Nerve Block (IANB) was significantly lower by 21 points (0-100 scale) in the corticosteroid group compared to the control group (95% CI -35 to -7; P = 0.003), however this difference was not statistically significant after 24 hours (P = 0.116). The route of administration was oral and intraligament injection. Patients who received corticosteroids prior to IANB were 70.7% more likely to have none or mild pain 4-8 hours after treatment (P = 0.001) and 13.5% more likely 24 hours after IANB (P = 0.013) than patients in the control group. In conclusion, corticosteroid administration (oral or intraligamental) may clinically reduce the level of postoperative pain at 4-8 hours after IANB, however the quality of the evidence was low/moderate due to risk of bias and heterogeneity. Further studies are recommended.

• The Korean Journal of Pain
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• v.33 no.1
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• pp.3-12
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• 2020

Neuropathic pain after spinal cord injury (SCI) has a significant negative impact on the patients' quality of life. The objective of this systematic review is to examine the safety and efficacy of pregabalin (PGB) and gabapentin (GBP) in the treatment of neuropathic pain due to SCI. PubMed, the Cochrane Library, Embase, Scopus, and the Web of Science were searched up to December 2018. The reference lists of key and review studies were reviewed for additional citations. The quality of the studies was evaluated using the Cochrane Collaboration's tools for assessing the risk of bias. A meta-analysis was performed for primary and secondary outcomes. Eight studies were eligible for inclusion. Meta-analysis of PGB vs. placebo showed that PGB was effective for neuropathic pain (standardized mean difference [SMD] = -0.40; 95% confidence interval [CI]: -0.78, -0.01), anxiety (MD = -0.68; 95% CI: -0.77, -0.59), depression (mean difference [MD] = -0.99; 95% CI: -1.08, -0.89), and sleep interference (MD = -1.08; 95% CI: -1.13, -1.02). Also, GBP was more effective than a placebo for reducing pain. No significant difference was observed between the efficacy of the two drugs (MD = -0.37; 95% CI: -1.67, 0.93). There was no significant difference between the two drugs for discontinuation due to adverse events (risk ratio = 3.00; 95% CI: 0.81, 11.15). PGB and GBP were effective vs. placebos in decreasing neuropathic pain after SCI. Also, there was no significant difference between the two drugs for decreasing pain and adverse events.

• Journal of Information Management
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• v.35 no.2
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• pp.41-55
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• 2004

This study is expected to discuss some methods regarding the uplift of user's use convenience and the efficiency of material management by constructing the multimedia database through the digitalization of the especial audiotape-typed materials among accompanying materials. In order to do that, this paper dealt with the present management conditions of accompanying materials, the sorts of audio data formats, data format transformation, the methods of administration and utilization, etc. And this paper also presented the expected effect and problems caused by multimedia databases construction of accompanying materials.