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Co-existence of relapsing polychondritis and Crohn disease treated successfully with infliximab

  • Jung, Hye-In;Kim, Hyun Jung;Kim, Ji-Min;Lee, Ju Yup;Park, Kyung Sik;Cho, Kwang Bum;Lee, Yoo Jin
    • Journal of Yeungnam Medical Science
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    • 제38권1호
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    • pp.70-73
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    • 2021
  • Relapsing polychondritis (RP) is a rare, progressive immune-mediated systemic inflammatory disease of unknown etiology, characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with other autoimmune diseases. However, the co-occurrence of RP and Crohn disease (CD) has rarely been reported. Herein, we present a 35-year-old woman diagnosed with RP and CD, who was refractory to initial conventional medications, including azathioprine and glucocorticoid, but who subsequently responded to infliximab (IFX). For both diseases, remission was sustained with IFX. There has been no previous report regarding the successful treatment of co-existing RP and CD with IFX.

기관지 확장증을 동반한 X연관 무감마글로불린혈증 1예 (X-linked Agammaglobulinemia Assiociated with Bronchiectasis : A Case Report)

  • 유창민;고원중;김경찬;이병훈;황정혜;강은해;서지영;정만표;김호중;권오정;기창석;김종원
    • Tuberculosis and Respiratory Diseases
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    • 제54권6호
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    • pp.628-634
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    • 2003
  • 기관지확장증은 일반적으로 원인을 찾기 위한 광범위한 조사없이 증상적 치료를 하는 경우가 많으나 기관지확장증을 유발할 수 있는 원인을 아는 경우 특별한 치료 방침을 정할 수도 있다. X연관 무감마글로불린혈증은 세포질 내 X 염색체에 존재하는 Bruton's tyrosine kinase (Btk) 유전자의 돌연변이에 의해 성숙 B 림프구가 분화하지 못하여 발생하는 체액성 면역결핍질환으로 반복적인 호흡기감염을 통해 기관지확장증을 유발한다. 이는 드문 유전적 질환으로 조기 발견과 주기적인 면역글로불린 치료가 중요하다. 저자들은 반복적인 감염의 과거력과 함께 미만성 기관지확장증을 가진 성인 남성에서 BTK 유전자의 돌연변이를 확인하여 X연관 무감마글로불린혈증을 진단하고 치료한 사례를 경험하여 이를 보고하는 바이다.

Smooth versus Textured Tissue Expanders: Comparison of Outcomes and Complications in 536 Implants

  • Omar Allam;Jacob Dinis;Mariana N. Almeida;Alexandra Junn;Mohammad Ali Mozaffari;Rema Shah;Lauren Chong;Olamide Olawoyin;Sumarth Mehta;Kitae Eric Park;Tomer Avraham;Michael Alperovich
    • Archives of Plastic Surgery
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    • 제51권1호
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    • pp.42-51
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    • 2024
  • Background Increasing concerns regarding the safety of textured surface implants have resulted in surgeons transitioning from textured tissue expanders (TEs) to smooth TEs. Given this change has only recently occurred, this study evaluated outcomes between smooth and textured TEs. Methods Women who underwent two-stage breast reconstruction using TEs from 2013 to 2022 were included. TE-specific variables, perioperative information, pain scores, and complications were collected. Chi-squared, t-test, and linear regression analyses were performed. Results A total of 320 patients received a total of 384 textured and 152 smooth TEs. Note that 216 patients received bilateral reconstruction. TEs were removed in 9 cases. No significant differences existed between groups regarding comorbidities. Smooth TEs had a higher proportion of prepectoral placement (p < 0.001). Smooth TEs had less fills (3±1 vs. 4±2, p < 0.001), shorter expansion periods (60±44 vs. 90±77 days, p < 0.001), smaller expander fill volumes (390±168 vs. 478±177 mL, p < 0.001), and shorter time to exchange (80±43 vs. 104±39 days, p < 0.001). Complication rates between textured and smooth TEs were comparable. Smooth TE had a greater proportion of TE replacements (p = 0.030). On regression analysis, pain scores were more closely associated with age (p = 0.018) and TE texture (p = 0.046). Additional procedures at time of TE exchange (p < 0.001) and textured TE (p = 0.017) led to longer operative times. Conclusion As many surgeons have transitioned away from textured implants, our study shows that smooth TEs have similar outcomes to the textured alternatives.

대량 객혈을 보인 기관지내 아스페르길루스종 1례 (A case of endobronchial aspergilloma with massive hemoptysis)

  • 김태훈;배준용;김양기;이영목;김기업;어수택;김용훈;박춘식;황정화;김동원
    • Tuberculosis and Respiratory Diseases
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    • 제57권6호
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    • pp.589-593
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    • 2004
  • Aspergillus fumigatus causes a variety clinical syndrome in lung including aspergilloma, chronic necrotizing aspergillosis, invasive pulmonary aspergillosis, and allergic bronchopulmonary aspergillosis. Aspergilloma develops by a colonization and growing of Aspergillus inside lung cavities with underlying lung disease. There is a few report of endobronchial aspergilloma without lung parenchymal lesion. We experienced a case of endobronchial aspergilloma did not fit any category of Aspergillus-induced lesion, who show minimal fibrostreaky denstities on chest PA and chest CT. Massive hemoptysis was improved by a removal of the aspergilloma in this patient. Here, we report a rare case of endobronchial aspergilloma showing massive hemoptysis with review of literatures.