Browse > Article
http://dx.doi.org/10.12701/yujm.2020.00304

Co-existence of relapsing polychondritis and Crohn disease treated successfully with infliximab  

Jung, Hye-In (Division of Gastroenterology, Department of Internal Medicine, Keimyung University School of Medicine)
Kim, Hyun Jung (Division of Gastroenterology, Department of Internal Medicine, Keimyung University School of Medicine)
Kim, Ji-Min (Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine)
Lee, Ju Yup (Division of Gastroenterology, Department of Internal Medicine, Keimyung University School of Medicine)
Park, Kyung Sik (Division of Gastroenterology, Department of Internal Medicine, Keimyung University School of Medicine)
Cho, Kwang Bum (Division of Gastroenterology, Department of Internal Medicine, Keimyung University School of Medicine)
Lee, Yoo Jin (Division of Gastroenterology, Department of Internal Medicine, Keimyung University School of Medicine)
Publication Information
Journal of Yeungnam Medical Science / v.38, no.1, 2021 , pp. 70-73 More about this Journal
Abstract
Relapsing polychondritis (RP) is a rare, progressive immune-mediated systemic inflammatory disease of unknown etiology, characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with other autoimmune diseases. However, the co-occurrence of RP and Crohn disease (CD) has rarely been reported. Herein, we present a 35-year-old woman diagnosed with RP and CD, who was refractory to initial conventional medications, including azathioprine and glucocorticoid, but who subsequently responded to infliximab (IFX). For both diseases, remission was sustained with IFX. There has been no previous report regarding the successful treatment of co-existing RP and CD with IFX.
Keywords
Crohn disease; Inflammatory bowel diseases; Infliximab; Relapsing polychondritis;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Vitale A, Sota J, Rigante D, Lopalco G, Molinaro F, Messina M, et al. Relapsing polychondritis: an update on pathogenesis, clinical features, diagnostic tools, and therapeutic perspectives. Curr Rheumatol Rep 2016;18:3.   DOI
2 Michet CJ Jr, McKenna CH, Luthra HS, O'Fallon WM. Relapsing polychondritis: survival and predictive role of early disease manifestations. Ann Intern Med 1986;104:74-8.   DOI
3 Horvath A, Pall N, Molnar K, Kovats T, Surjan G, Vicsek T, et al. A nationwide study of the epidemiology of relapsing polychondritis. Clin Epidemiol 2016;8:211-30.   DOI
4 Rodriguez-Reyna TS, Martinez-Reyes C, Yamamoto-Furusho JK. Rheumatic manifestations of inflammatory bowel disease. World J Gastroenterol 2009;15:5517-24.   DOI
5 Orchard TR, Wordsworth BP, Jewell DP. Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history. Gut 1998;42:387-91.   DOI
6 Borgia F, Giuffrida R, Guarneri F, Cannavo SP. Relapsing polychondritis: an updated review. Biomedicines 2018;6:84.   DOI
7 Fousekis FS, Saridi M, Albani E, Daniel F, Katsanos KH, Kastanioudakis IG, et al. Ear involvement in inflammatory bowel disease: a review of the literature. J Clin Med Res 2018;10:609-14.   DOI
8 Mathian A, Miyara M, Cohen-Aubart F, Haroche J, Hie M, Pha M, et al. Relapsing polychondritis: a 2016 update on clinical features, diagnostic tools, treatment and biological drug use. Best Pract Res Clin Rheumatol 2016;30:316-33.   DOI
9 Kemta Lekpa F, Kraus VB, Chevalier X. Biologics in relapsing polychondritis: a literature review. Semin Arthritis Rheum 2012;41:712-9.   DOI
10 Rednic S, Damian L, Talarico R, Scire CA, Tobias A, Costedoat-Chalumeau N, et al. Relapsing polychondritis: state of the art on clinical practice guidelines. RMD Open 2018;4(Suppl 1):e000788.   DOI
11 Touma DJ, Gross EJ, Karmody CS, Fawaz KA. Relapsing polychondritis in association with Crohn's disease. Am J Otolaryngol 1996;17:424-6.   DOI
12 Vavricka SR, Schoepfer A, Scharl M, Lakatos PL, Navarini A, Rogler G. Extraintestinal manifestations of inflammatory bowel disease. Inflamm Bowel Dis 2015;21:1982-92.   DOI