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Acute Subcutaneous Toxicity of DWP-311 in Rats (랫드에 대한 DWP-311의 급성피하독성시험)

  • Kwack, Seung-Jun;Kim, Hyung-Sik;Chun, Sun-Ah;Lim, So-Young;Park, Hyun-Sun;Han, Ha-Su;Hong, Chae-Young;Ahn, Mi-Young;Lee, Byung-Mu
    • Toxicological Research
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    • v.14 no.3
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    • pp.411-414
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    • 1998
  • The acute toxicity of DWP-311 was investigated in Sprague-Dawley rats. DWP-311 was subcutaneously administratered at dose levels of 595, 1,070, 1,930, 3,470, and 6,250mg/kg. In this study, we daily examined numbers of deaths, clinical signs, body weights, and pathological examinations for 7 days after administration of DWP-311. The results indicate that DWP-311 did not show any toxic effect in rats and the oral $LD_{50}$ value was over 6,250mg/kg in Sprague-Dawley rats.

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Acute oral and subcutaneous toxicity of Aloewhite in Mice

  • Kim, Hyung-Sik;Ahn, Mi-Young;Kwack, Seung-Jun;Kim, Kyu-Bong;Lee, Seung-Ki;Chun, Sun-Ah;Lim, So-Young;Park, Hyun-Sun;Hong, Che-Young
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1996.04a
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    • pp.251-251
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    • 1996
  • -Acute oral and subcutaneous toxicity of Aloewhite(30% aloesine) were carried out in ICR mice. In this study, we daily examined number of deaths, clinical signs, body weights, and pathological examinations for 14 days after single oral and subcutaneous administration of Aloewhite with different dose levels. Aloewhite did not show any remarkable toxic effect in mice. These results suggest that oral and subcutaneous LD$\sub$50/ values in mice were over 6.8g/kg and 10g/kg, respectively.

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Severe Endobronchial Inflammation Induced by Aspiration of a Ferrous Sulfate Tablet

  • Lim, Sang Youn;Sohn, Sung Birm;Lee, Jung Min;Lee, Ji Ae;Chung, Sangmi;Kim, Junga;Choi, Juwhan;Kim, Sehwa;Yoo, Ah Young;Roh, Jong Ah;Park, Haein;Kim, Won Shik;Sim, Jae Kyeom;Shim, Jae Jeong;Min, Kyung Hoon
    • Tuberculosis and Respiratory Diseases
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    • v.79 no.1
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    • pp.37-41
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    • 2016
  • Iron supplements such as ferrous sulfate tablets are usually used to treat iron-deficiency anemia in some elderly patients with primary neurologic disorders or decreased gag reflexes due to stroke, senile dementia, or parkinsonism. While the aspiration of ferrous sulfate is rarely reported, it is a potentially life-threatening condition that can lead to airway necrosis and bronchial stenosis. A detailed history and high suspicion of aspiration are required to avoid delays in diagnosis and treatment. The diagnosis can be confirmed by bronchoscopic examination and a tissue biopsy. Early removal of the aspirated tablet prevents acute complications, such as bronchial necrosis, hemoptysis, and lobar consolidation. Tablet removal is also necessary to prevent late bronchial stenosis. We presented the first case in Korea of a ferrous sulfate tablet aspiration that induced severe endobronchial inflammation.

A Case of Possible Doxycycline-Resistant Scrub Typhus (Doxycycline 내성이 의심된 Scrub Tybhus)

  • Na, Dong Jib;Han, Sang Hoon;Moon, Kyung Min;Kim, Dong Jin;Lee, Yang Deok;Cho, Yong Seon;Han, Min Soo;Yoon, Hee Jung
    • Tuberculosis and Respiratory Diseases
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    • v.62 no.6
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    • pp.545-548
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    • 2007
  • 쯔쯔가무시병은 추수 시기에 유행하는 대표적인 급성 열성질환으로 여전히 증가 추세에 있다. 의심되는 환자에게 Doxycycline 투여 후 급속한 해열이 질환의 독특한 특징이기도 한데 Doxycycline 투여 96시간 후에도 지속적인 고열과 근육통이 있었던 환자에게 Clarithromycin으로 변경 후 급속한 해열과 함께 증상이 호전된 증례를 보고한다.