• The Korean Journal of Physiology and Pharmacology
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• 제5권4호
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• pp.359-366
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• 2001

We have synthesized a novel platinum(II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,3-dichloropropane (DCP) as a leaving group. A new series of [Pt(cis- DACH)(DCP)](PC) was evaluated for its cytotoxic activity on MKN-45 human gastric adenocarcinoma cells and normal primary cultured kidney cells. The new platinum complex has demonstrated high efficacy in the cytotoxicity against MKN-45/P, MKN-45/ADM and MKN-45/CDDP cell-lines. The cytotoxicity of PC against rabbit proximal renal tubular cells, human renal cortical cells and human renal cortical tissues, determined by MTT assay, the $[^3H]-thymidine$ uptake and glucose consumption tests, was found to be quite less than those of cisplatin. Based on these results, this novel platinum(II) coordination complex appears to be better for improving antitumor activities with low nephrotoxicity and is a valuable lead in the development of new, clinically available anticancer chemotherapeutic agents.

• Korea-Australia Rheology Journal
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• 제15권2호
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• pp.97-105
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• 2003

In the previous paper (Hyun et al.,2002), we have investigated the shape of storage modulus (G') and loss modulus (G") of complex fluids under large amplitude oscillatory shear (LAOS) flow. As the strain amplitude increases, owever, the stress curve becomes distorted and some important information may be smothered during data processing. Thus we need to investigate the stress data more precisely and systematically. In this work, we have obtained the stress data using high performance ADC (analog digital converting) card, and investigated the nonlinear response of complex fluids, 4wt% xanthan gum (XG), 2 wt% PVA/ 1 wt% Borax, and 1 wt% hyaluronic acid (HA) solutions, using Fourier transformation (FT) rheology. Comparing the strain signals in time domain with FT parameters in frequency domain, we could illustrate the sensitivity and importance of FT rheology. Diverse and unique stress patterns were observed depending on the material system as well as flow environment. It was found that they are not the outcome of experimental deficiency like wall slip but characteristics of the material system. When nonlinear response of complex fluids is analyzed, the intensity and phase angle of higher harmonic contributions should be considered together, and the shape of the stress signal was found to be strongly dependent upon phase angle.ngle.

• Journal of Chest Surgery
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• 제50권6호
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• pp.471-473
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• 2017

Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat extrathoracic masses. All the family members met at least 2 major clinical criteria and 1 supplemental criterion. We analyzed their genomic loci, including the protein kinase A regulatory subunit 1 gene. The results revealed no specific mutations, except for a common single nucleotide polymorphism. This case series of Carney complex emphasizes the importance of close longitudinal follow-up because of the high rate of tumor recurrence irrespective of the site. Clinicians should not overlook the specific features of familial myxoma.

• Bulletin of the Korean Chemical Society
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• 제35권7호
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• pp.1965-1969
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• 2014

A new tetranuclear Mn(III) complex $[Mn^{III}{_4}(sae)_4({\mu}_3-O)({\mu}_{1,1}-N_3)(OH)(H_2O)_2]{\cdot}H_2O$ (1) ($H_2sae$ = 2-salicylideneamino-1-ethanol) has been synthesized by the reaction of $MnCl_2{\cdot}4H_2O$, $H_2sae$ and sodium azide in the mixed solvent of methanol, acetonitrile and water. The X-ray diffraction analysis shows that the four Mn(III) ions in complex 1 have a unique adamantine arrangement, whereas the coordination environment of each Mn(III) ions is different. Magnetic studies indicate that complex 1 manifests antiferromagnetic behaviors. The magnetic susceptibilities of complex 1 have been fitted by two magnetic models based on the suitable analysis of its magnetic structural topology.

• 대한전기학회논문지:시스템및제어부문D
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• 제49권2호
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• pp.81-87
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• 2000

This paper presents a new approach to the synthesis of two-dimensional arrays such as Atmel 6000 series FPGAs using internal don't cares. Basically complex terms which fits to the linear array of cells without further routing wires are generated and they are collected by OR/XOR operations. In previous methods, complex terms are collected only by XOR operations, which may not be effective for nearly unate functions. In this paper, we allow complex terms to be collected by OR operations in addition to XOR operations. First, complex terms that lies in the ON-set of the function are generated and collected by OR operations. The sub-function realized by the first stage becomes an internal don't cares and they are exploited in the second stage which generates complex terms collectable by XOR operation. Experimental results shows the efficacy of the proposed method compared to the previous methods.

• KIEAE Journal
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• 제17권1호
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• pp.49-54
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• 2017

Purpose: Temperature in urban areas increase much more than suburban areas and it is called urban heat island (UHI) phenomenon. There are several solutions to control UHI phenomenon such as green roof system, water space construction, and cool roof system. However, application of green roof system and cool roof system to some of the buildings which compose the city has a critical limit. Therefore, in order to diminish the temperature rising and UHI phenomenon due to climate change of the city, it needs to approach from the viewpoint of site or city, rather than the viewpoint of individual buildings. This study is aims at analyzing UHI phenomenon by characteristics of surface materials and suggesting the solutions to reduce UHI phenomenon by types of complex. Method: Literature reviews were conducted to analyze the cause, mitigating plan, and recent trends of UHI phenomenon. For the simulation analysis, the type of complex was classified 3 representative complex. Based on measured reflectivity, simulation about UHI phenomenon was conducted by setting 4 strategies; albedo of roof, road pavement, green roof system, and vegetating around buildings. Result: As the results of simulating the UHI reduction factor by types of complex, it showed that the effect of temperature reduction on the building roof layer is more effective than adjusting the reflectivity of buildings such as green roof system, planting near the buildings in both the detached house complex, apartment complex, and commercial complex.

• 대한약리학회지
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• 제32권1호
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• pp.93-102
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• 1996

일부 malignant tumor에 Pt-complex의 임상 응용 과정에서 신장독성등의 심한 부작용이 문제점으로 지적되고 있다. 이 연구에서는 기존의 cisplatin보다 항암효과는 우수하면서, 부작용을 감소시킨 새로운 Pt complex의 개발에 역점을 두었다. 본 연구에서 합성한 Pt(II) complex는 carrier ligand로서 1,2-diaminocyclohexane(dach)을 사용하였고, leaving group으로는 diphosphine류인 1,3-bis (diphenylphosphine의 propane(DPPP) 을 도입하였으며, 물에 대한 용해도를 높이기 위해 dinitrate로 만들었다. 새로이 합성한 [Pt(II)(cia-dach)(DPPP)].$(NO_3)_2$ 은 원소 분석, IR 및 $^{13}C-NMR$ 분석 data에 의하여 위의 물질임이 확인되었다. PC-1은 MTT assay method에 의한 항암활성 연구를 통하여 SKOV-3, OVCAR-3 human ovarian adenocarcinoma cells에서 항암효과가 인정되었으며, 이 항암효과는 대조 약물로 사용된 cisplatin과 유사하였다. PC-1은 토끼의 신세뇨관 세포와 인체의 신피질 세포를 이용한 cytotoxity 및 thymidine 섭취율과 인체 신피질 조직 배양을 이용한 glucose consumption 실험을 통하여 모두 cisplatin보다 신장독성이 현저히 감소되었다. 이상의 결과로 보아 Pt(II) complex는 carrier ligand와 leaving group의 선택에 따라 항암활성의 증가와 신독성의 감소를 일으키는 요인으로 보여지며, 이 연구에서 만들어진 새로운 Pt(II) complex는 앞으로 다각적인 검토를 거쳐 새로운 anticancer chemotherapeutic agent로 개발될 가능성이 있을 것으로 생각된다.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2008년도 춘계학술발표대회 논문집
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• pp.304-310
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• 2008

Currently energy use planning council system is mandatory especially for the urban development project planned on a specified scale or more. The goal of existing demand prediction was to calculate the maximum load by multiplying energy load per unit area by building size. The result of this method may be exaggerated and has a limit in the information of period load. The paper suggests a new forecasting process based on standard unit household in order to upgrade the limit in demand prediction method of multi-family housing complex. The new process was verified by comparing actual using amount of multi-family housing complex to forecasting value of energy use plan.

• Fibers and Polymers
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• 제2권1호
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• pp.157-162
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• 2001

Dyebath used for metal complex dyeing of nylon microfiber was recycled to reduce the overall amounts of metal complex dyeing effluents. Instead of discharging the dyebath after each dyeing cycle, the residual dyebath was analyzed spectrophotometrically and reconstituted to the required concentration of dyes and auxiliaries. Dyebaths were reused eight times and the CIELAB coordinates of dyed samples were measured after each recycling. Color difference($\Delta$E*) between the sample dyed in the fresh bath and that from reused dyebath was maintained below 1.5. The levelness and fastness of dyed fabrics from recycled dyebath were not impaired either. Chromium content of each recycled dyebath was similar to that of the first residual dyebath.

• Nuclear Engineering and Technology
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• 제49권1호
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• pp.17-28
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• 2017

The modified power method has been studied by many researchers to calculate the higher eigenmodes and accelerate the convergence of the fundamental mode. Its application to multidimensional problems may be unstable due to degenerated or near-degenerated eigenmodes. Complex eigenmode solutions are occasionally encountered in such cases, and the shapes of the corresponding eigenvectors may change during the simulation. These issues must be addressed for the successful implementation of the modified power method. Complex components are examined and an approximation method to eliminate the usage of the complex numbers is provided. A technique to fix the eigenvector shapes is also provided. The performance of the methods for dealing with those aforementioned problems is demonstrated with two dimensional one group and three dimensional one group homogeneous diffusion problems.