• 한국노년학
• /
• v.40 no.2
• /
• pp.239-255
• /
• 2020

The purpose of this study is to examine whether family relationships of elderly single-person households affect community participation and whether these relationships differ by gender. Based on Baltes and Baltes (1990) 's selection, optimization, and compensation theory (SOC) and the argument that family members are a social capital by Prandini (2014), we test whether family relationships can affect community participation in old age. In order to verify this, single-person households were extracted from the 2017 National Survey of Living Conditions and Welfare Needs conducted by the Korea Institute for Health and Social Affairs (Male sample=370, Female sample=1770), multiple regression analysis were conducted with the dependent variables of friends·neighbors and the participation at Kyungrodang·welfare centers for the elderly. The results are as follows. In the case of men, family relations showed no significant effect on their participation in friends·neighbors, or Kyungrodang·welfare centers. However, in the case of women, the frequency of contact with family had a positive effect on the frequency of meeting friends·neighbors. Family contact frequency and child relationship satisfaction had a positive (+) effect on Kyungrodang·welfare center participation, while family meeting frequency had a negative effect on participation in Kyungrodang·welfare centers. For women, although Prandini's (2014) claim that family members are a social capital seems to be supported, it was found that the impact could vary depending on the type of community participation. In addition, practical discussions and suggestions were presented.

• 한국노년학
• /
• v.41 no.4
• /
• pp.455-468
• /
• 2021

This study was performed to utilize for foundation data of research related nursing communication and developing nursing intervention by examining the relationship between nurses' perception of the elderly and communication. This study is a descriptive research using a set of questionnaires that examines the relationship between nurses who provide care to the elderly by confirming their perception of the elderly, communication difficulties with the elderly, communication behavior, and satisfaction with communication. After IRB approval, data were collected either face-to-face survey or by online survey. A total of 292 nurses participated in this study. The collected data were analyzed as descriptive statistics, t-test and ANOVA, Duncan test and Pearson's Correlation Coefficients, Multiple Regression Analysis by using SPSS/WIN 26 program. As a result, a significant correlation was identified between perception of the elderly and communication disorders, communication behavior, and communication satisfaction. We found that nurses who had more positive perceptions about the elderly had less communication disorders, better communication behaviors, and higher communication satisfaction with the elderly. From this result, we suggest that nurses caring for the elderly should receive education on communication methods with elderly to improve their perception. Furthermore, we suggest future studies to improve nurse's perception of the elderly and communication.

• Journal of Naturopathy
• /
• v.11 no.1
• /
• pp.1-8
• /
• 2022

Background: A validation study is needed to make domestic applications of German Kneipp therapy. Purpose: The study aims to test the effect of a Kneipp therapeutic program in a domestic forest environment on the autonomic nervous system. Methods: The program was made considering the 4 key elements ('exercise', 'regulative therapy', 'nutrition', and 'phytotherapy') of the Kneipp therapy. Total 3 sessions (once a week for 5 hours in each session) were performed to 40 domestic adults divided into four groups (10 in each group). HRV was measured on the subjects before and after the intervention, and its 6 characteristic parameters (TP, VLF, LF, HF, LF/HF, CSI: Cumulative Stress Index) were compared for statistical analysis. Results: For 33 subjects excluding 7 who were disturbed by interrupt factors during measurements, significant improvements after the intervention, were observed in TP(8.64%, p < ..001), VLF(6.96%, p < .05), LF(15.86%, p < .001), HF(8.46%, p < .01), LF/HF(5.77%, p < .05) and CSI(-16.06%, p < ..001). Conclusions: The Kneipp therapy performed in the forest environment was shown to activate the autonomic nervous system and in particular the sympathetic and parasympatheric nervous to promote heart activity, and was also shown to most significantly reduce cumulative stress. The present observations would be the first preliminary evidence that the Kneipp therapeutic interventation in a domestic forest environment results in positive responses of the autonomic nervous system including stress relief.

• Journal of Nutrition and Health
• /
• v.55 no.2
• /
• pp.240-249
• /
• 2022

Purpose: Glabridin (GD) is a bio-available isoflavane isolated from the root extract of licorice (Glycyrrhiza glabra L.). It exhibits a variety of pharmacological activities such as anti-inflammatory and anti-oxidant activities. However, extracellular vesicles (EVs) secretion and the anti-cancer mechanism of action remains largely unknown. The present study investigates the anticancer effects of GD by determining the inhibition of EVs secretion in the human breast cancer cell line, MDA-MB-231. Methods: Cell viability, reactive oxygen species (ROS) production, migration, invasion rate, and vascular endothelial growth factor (VEGF) concentration were assessed in MDA-MB-231 cells treated with increasing concentrations of GD (0.1, 1, 5, 10, 20 µM). Subsequently, EV secretion and exosomal DEL-1 protein expression were evaluated to determine the anticancer effects of GD. Results: The results showed that GD significantly inhibited the cell proliferation of MDA-MB-231 cells in a dose- or time-dependent manner. Also, ROS production and apoptosis marker protein cleaved caspase-3 were significantly increased in GD-treated MDA-MB-231, compared to control. Furthermore, GD exposure resulted in significantly decreased not only migration and invasion rates but also the VEGF concentration, thereby contributing to a reduction in angiogenesis. Interestingly, the concentration and number of EVs as well as EV marker proteins, such as CD63 and TSG101, were decreased in GD-treated MDA-MB-231 cells. Markedly, extracellular matrix protein DEL-1 as angiogenesis factor was decreased in EVs from GD-treated MDA-MB-231 cells. Conclusion: This study identifies that the anti-cancer molecular mechanism of GD is exerted via inhibition of angiogenesis and EVs secretion, indicating the potential of GD as a chemotherapeutic agent for breast cancer.

• Journal of Naturopathy
• /
• v.10 no.2
• /
• pp.77-85
• /
• 2021

Background: It is necessary to verify the resilience of the newly improved Kneipp psychotherapy. Purpose: This study assesses whether Kneipp Lebensordnung psychotherapy; KnLP program improves resilience. Methods: The KnLP program, including salutogenesis, logotherapy, meditation, and resilience training, is reorganized in consideration of Korean culture and sentiments. It was conducted 4 times for 25 adults (once a week, 3 hours a time), and data, KRQ-53 (Korean Resilience Quotient-53) measured intervention, before, and after was compared and analyzed. Results: The data for 9 adults were selected to draw reliable analysis, and it concluded that participants' KRQ-53 mean score increased by 14.66 from 191.56 to 206.22 during and after the program. The score increase by factor in resilience training is 5.89 points for self-regulation skills, 4.89 points for in interpersonal skills, and 3.89 points for positive capacity. Conclusions: KnL program improves participants' resilience skill (p<.05), and especially in self-regulation skill. Subsequent studies with more participants are required to achieve statistically significant and generalized results in the future.

• Genomics & Informatics
• /
• v.20 no.3
• /
• pp.29.1-29.12
• /
• 2022

Several studies have shown associations between irinotecan toxicity and UGT1A genetic variations in colorectal and lung cancer, but only limited data are available for gastric cancer patients. We evaluated the frequencies of UGT1A polymorphisms and their relationship with clinicopathologic parameters in 382 Korean gastric cancer patients. Polymorphisms of UGT1A1*6, UGT1A1*27, UGT1A1*28, UGT1A1*60, UGT1A7*2, UGT1A7*3, and UGT1A9*22 were genotyped by direct sequencing. In 98 patients treated with irinotecan-containing regimens, toxicity and response were compared according to the genotype. The UGT1A1*6 and UGT1A9*22 genotypes showed a higher prevalence in Korean gastric cancer patients, while the prevalence of the UG1A1*28 polymorphism was lower than in normal Koreans, as has been found in other studies of Asian populations. The incidence of severe diarrhea after irinotecan-containing treatment was more common in patients with the UGT1A1*6, UGT1A7*3 and UGT1A9*22 polymorphisms than in controls. The presence of the UGT1A1*6 allele also showed a significant association with grade III-IV neutropenia. Upon haplotype and diplotype analyses, almost every patient bearing the UGT1A1*6 or UGT1A7*3 variant also had the UGT1A9*22 polymorphism, and all severe manifestations of UGT1A polymorphism-associated toxicity were related to the UGT1A9*22 polymorphism. By genotyping UGT1A9*22 polymorphisms, we could identify high-risk gastric cancer patients receiving irinotecan-containing chemotherapy, who would experience severe toxicity. When treating high-risk patients with the UGT1A9*22 polymorphism, clinicians should closely monitor them for signs of toxicity such as severe diarrhea or neutropenia.

• Genomics & Informatics
• /
• v.20 no.2
• /
• pp.21.1-21.14
• /
• 2022

The influenza A viruses have high mutation rates and cause a serious health problem worldwide. Therefore, this study focused on genome characterization of the viruses isolated from Thai patients based on the next-generation sequencing technology. The nasal swabs were collected from patients with influenza-like illness in Thailand during 2017-2018. Then, the influenza A viruses were detected by reverse transcription-quantitative polymerase chain reaction and isolated by MDCK cells. The viral genomes were amplified and sequenced by Illumina MiSeq platform. Whole genome sequences were used for characterization, phylogenetic construction, mutation analysis and nucleotide diversity of the viruses. The result revealed that 90 samples were positive for the viruses including 44 of A/H1N1 and 46 of A/H3N2. Among these, 43 samples were successfully isolated and then the viral genomes of 25 samples were completely amplified. Finally, 17 whole genomes of the viruses (A/H1N1, n=12 and A/H3N2, n=5) were successfully sequenced with an average of 232,578 mapped reads and 1,720 genome coverage per sample. Phylogenetic analysis demonstrated that the A/H1N1 viruses were distinguishable from the recommended vaccine strains. However, the A/H3N2 viruses from this study were closely related to the recommended vaccine strains. The nonsynonymous mutations were found in all genes of both viruses, especially in hemagglutinin (HA) and neuraminidase (NA) genes. The nucleotide diversity analysis revealed negative selection in the PB1, PA, HA, and NA genes of the A/H1N1 viruses. High-throughput data in this study allow for genetic characterization of circulating influenza viruses which would be crucial for preparation against pandemic and epidemic outbreaks in the future.

• Journal of Convergence for Information Technology
• /
• v.11 no.5
• /
• pp.199-205
• /
• 2021

This study was done to evaluate the dermatoxicity of zinc sulfate (ZnSO4) and the protective effect of Rubus parvifolius L. (RP) extract on cytotoxicity of ZnSO4, mordant in cultured SK-MEL-3 cells. For this study, it was done an antioxidative effect as DPPH-radical scavenging ability as well as the diminutive ability of total melanin with cell viability. ZnSO4 significantly decreased cell viability in dose-dependently, and it was mid-toxic. The ascorbic acid significantly increased cell viability damaged by ZnSO4-induced cytotoxicity. In the protective effect of RP extract on ZnSO4-induced cytotoxicity, RP extract significantly increased cell viability compared with ZnSO4-treated group, and also it showed both the DPPH-radical scavenging ability and the decrease of total amount of melanin. From these findings, the cytotoxicity of ZnSO4 is correlated with oxidative stress, and also RP extract effectively protected ZnSO4-induced cytotoxicity via antioxidative effect such as DPPH-radical scavenging ability with the whitening effect by the decrement of total amount of melanin. Conclusively, the natural ingredients like RP extract may be a useful agent for the improvement of antioxidative and whitening effects

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.22 no.5
• /
• pp.443-452
• /
• 2021

College students face serious difficulties while seeking jobs, leading to a high degree of stress, which is thought to affect their attitude towards smoking. The purpose of this study was to identify the relationship between hardiness, job-seeking stress, and the attitude towards smoking among students, and to further identify the factors influencing smoking attitude. Data were collected using a structured questionnaire administered to 145 students. Data analysis was performed using the SPSS program, t-test, ANOVA, Kruskal Wallis test, Pearson's Correlation Coefficients, and hierarchical multiple regression analysis. Smokers constituted 22.1% of the sample. The study showed that smoking attitudes varied according to the smoking status (H=28.26, p<.001). The smoking attitude was seen to be desirable in the high group (t=-3.27, p=.001) and low job-seeking stress group (t=4.40, p<.001). There was a positive correlation between hardiness and smoking attitude (r=.18, p=.028). There was a negative correlation between job-seeking stress and smoking attitude (r=-.28, p=.001). Also, the factors affecting the smoking attitude were non-smoker respondent (β=.50, p<.001), job-seeking stress (β=-.23, p=.015), former smoker respondent (β=.22, p=.016) and the explanatory power was 24.3%. Therefore, school and health public center counseling and employment support programs need to help students manage and cope with stressful situations to change their attitude towards smoking in a desirable direction.

• PNF and Movement
• /
• v.19 no.1
• /
• pp.115-125
• /
• 2021

Purpose: This study aimed to investigate basic data on the recognition of rehabilitation robots and self-efficacy through general characteristics of students in the department of physical therapy. Methods: This study surveyed 100 students in the Department of Physical Therapy at E University in Seongnam using Google Form, an online survey tool. The questionnaire consisted of 64 questions including 15 questions on general characteristics, 13 questions regarding recognition of rehabilitative robots, and 36 questions about self-efficacy. General self-efficacy consisted of three sub-factors: confidence, self-regulation efficacy, and task difficulty preference. Results: The recognition of rehabilitative robots according to general characteristics showed significant differences in age, level of education, and experience in searching rehabilitative robots; according to general characteristics, self-efficacy showed significant differences dependent on age and gender (p < 0.05). In addition, recognition of rehabilitation robots for students in the Department of Physical Therapy was found to have a significant effect on robot use self-efficacy (p < 0.05). Conclusion: There were significant differences in the scores of rehabilitation robot recognition and self-efficacy according to the general characteristics of students in the Department of Physical Therapy. For such reasons, it is important for students to have an opportunity to get educated on rehabilitation robots; in order to achieve this goal, domestic studies on rehabilitation robots must be actively conducted. The technological development of rehabilitation robots and the establishment of a system for domestic rehabilitation robots from both social and legal standpoints were found to be necessary based on a volume of domestic research.