• 제목/요약/키워드: Sapindus mukorossi

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연명피 사포닌의 독성 및 용혈작용 (Toxicity and Hemolytic Activitiy of Saponin Isolated from Sapindus mukorossi)

  • 박은희
    • 약학회지
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    • 제39권2호
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    • pp.137-140
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    • 1995
  • Saponin isolated from Sapindus mukorossi Gaertn has been shown to contain a strong anti-inflammatory activity. In this study, several pharmacological properties such as acute toxicity, local irritation and hemolytic activity of Sapindus saponin and its genin component, hederagenirl, were examined. The acute toxicity of Sapindus saponin was very low. Estimated from the LD$_{50}$ values, it showed much weaker toxicity in oral administration than in intraperitoneal injection. Hederagenin gave a very high LD$_{50}$ value even in intraperitoneal injection. Sapindus saponin showed a potent local irritation after topical application, whereas hederagenin did a very weak local irritation. Sapindus saponin also gave a high hemolytic activity.

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LPS가 처리된 대식세포에서 Nrf2/HO-1 경로 활성을 통한 무환자나무 열매 추출물의 항산화 효과 (Anti-oxidative Effect of Sapindus mukorossi Fruits Extract in LPS-stimulated macrophages via Activation of Nrf2/HO-1 pathway)

  • 김대용
    • 한국응용과학기술학회지
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    • 제37권5호
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    • pp.1306-1313
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    • 2020
  • 본 연구의 목적은 LPS로 자극된 RAW264.7 대식세포에서 Sapindus mukorossi 열매 추출물(SME)의 항산화 효능을 확인하는 것이다. 그 결과, SME가 LPS로 자극된 RAW264.7 세포에서 ROS 생성을 현저하게 감소시켰고 전염증성 단백질인 COX-2 및 iNOS의 발현을 억제하였다. 또한 SME는 HO-1 및 Nrf2 발현을 상향 조절하였고 Akt 및 GSK-3β의 인산화를 증가시켰다. 이러한 결과는 SME가 Nrf2/HO-1 신호전달 경로의 활성화를 통하여 산화적 스트레스를 완화시킬 수 있음을 시사한다.

Carbon Material from Natural Sources as an Anode in Lithium Secondary Battery

  • Bhardwaj, Sunil;Sharon, Maheshwar;Ishihara, T.;Jayabhaye, Sandesh;Afre, Rakesh;Soga, T.;Sharon, Madhuri
    • Carbon letters
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    • 제8권4호
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    • pp.285-291
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    • 2007
  • Carbon materials of various morphologies were synthesized by pyrolysis of Soap-nut seeds (Sapindus mukorossi), Jack Fruit seeds (Artocarpus heterophyllus), Date-seeds (Phoenix dactylifera), Neem seeds (Azadirachta indica), Tea leaves (Ehretia microphylla), Bamboo stem (Bambusa bambus) and Coconut fiber (Cocos nucifera), without using any catalyst. Carbon materials thus formed were characterized by SEM XRD and Raman. Carbon thus synthesized varied in size (in ${\mu}m$) but all showed highly porous morphology. These carbon materials were utilized as the anode in Lithium secondary battery. Amongst the various precursors, carbon fibers obtained from Soap-nut seeds (Sapindus mukorossi) and Bamboo stem (Bambusa bambus), even after $100^{th}$ cycles, showed the highest capacity of 130.29 mAh/g and 92.74 mAh/g respectively. Morphology, surface areas and porosity of carbon materials obtained from these precursors were analyzed to provide interpretation for their capacity to intercalate lithium. From the Raman studies it is concluded that graphitic nature of carbon materials assist in the intercalation of lithium. Size of cavity (or pore size of channels type structure) present in carbon materials were found to facilitate the intercalation of lithium.

Cryopreservation of Somatic Embryos of Soapbeny (Sapindus mukorossi Gaertn.) by Vitrification

  • Kim, Hyun-Tae;Yang, Byeong-Hoon;Park, Young-Goo
    • 한국자원식물학회지
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    • 제19권6호
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    • pp.665-669
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    • 2006
  • Somatic embryos do not survive at exposure to liquid nitrogen temperatures without cryoprotective treatments. A simplified technique which simultaneously induces and cryoprotects embryogenic calli using plant vitrification solution 2 (PVS2) followed by dehydration was developed for the cryopreservation of Soap berry genetic resources. Vitrification is a way of removing the moisture in vegetation through PVS2. The PVS2 vitrification solution consisted of 30% glycerol (w/v), 15% ethylene glycol (w/v), 15% Dimethylsulfoxide (w/v) in B5 medium containing 0.4M sucrose. Two tests were done. The one was to eliminate moisture at $0^{\circ}C$ and the other at $25^{\circ}C$. In both cases the best results came out at a vitrification time of $10{\sim}20$ minutes. It was also found that the survival rate was higher at $0^{\circ}C$ than at $25^{\circ}C$. In particular, the survival rate reached more than 80%. Water-damaged embryos turned brown and stoped growth, but energetic embryos took on a milky hue and show a very vigorous growth rate. Successful cryopreservation of somatic embryos of soapberry can be used to establish in vitro genebanks for long-term conservation of Soapberry genetic resources to complement field genebanks and other in vitro methods already being used.

Effect of graded levels of soapnut (Sapindus mukorossi) shell powder on reproductive performance in broiler breeders

  • Chaudhary, S.K.;Mandal, A.B.;Bhar, R.;Gopi, M.;Kannan, A.;Jadhav, S.E.;Rokade, J.J.
    • Asian-Australasian Journal of Animal Sciences
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    • 제32권1호
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    • pp.118-125
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    • 2019
  • Objective: This study investigated the effects of soapnut (Sapindus mukorossi) shell powder (SSP) on serum hormone level, egg quality, semen characteristics and reproductive performance of broiler breeders fed with a maize-soybean meal based diet. Methods: Ninety six female and twenty four male CARIBRO-VISHAL broiler breeders, 38-week old, were individually caged and randomly allocated to four treatment groups (24 female breeders/treatment and 6 male breeders/treatment): an un-supplemented control (T1) and three groups with 0.0176% SSP (group T2), 0.026% SSP (group T3) and 0.0528% SSP (group T4), to have supplementary saponin at 0, 50, 75, and 150 ppm, respectively, for 42 days. Results: The results indicated that serum (p<0.001) and seminal plasma (p<0.05) testosterone level, semen volume (p<0.001), mass motility (p<0.001), and live spermatozoa count (p<0.001) was increased in groups T3 and T4 compared to T2 and control groups. Compared with control group, total sperm count was increased (p<0.001) and dead spermatozoa count was decreased (p<0.001) in SSP supplemented groups. Supplementation of SSP did not affected the quality of egg lay. Compared with control group, fertility (p<0.01) and hatchability (total eggs set and fertile eggs set) (p<0.001) were significantly improved in SSP supplemented groups with the highest improvement in T3 treatment group. Embryonic death was decreased (p<0.001) in SSP supplemented groups compared to control; lowest embryonic death was recorded in T3 treatment group. Conclusion: Thus, it was concluded that dietary supplementation of 0.026% SSP (saponin equivalent 75 ppm) improved the reproductive performance of broiler breeders.