• The Journal of Korean Medical History
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• v.27 no.2
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• pp.127-134
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• 2014

Objectives : The Syndromes of Daecheongryongtang (大靑龍湯證) and Mahwangtang (麻黃湯證) are similar in pathogenesis. However, both syndromes have a different pathogenesis. So we will try to distinguish the difference between the two syndromes. In addition, we'll see about 40 provision. Methods : Examine the claims of the syndrome of Daecheongryongtang in "Sang Han Lon" (傷寒論). The scholar's claims are not all same. Thus, we analysis the claims of many scholars. Results and Conclusions : The Syndromes of Daecheongryongtang and Mahwangtang are similar in pathogenesis. However, the Syndrome of Daecheongryongtang is different from that the sweat purgations in exterior of the body caused by heat in the interior. The pathogenesis of 39 and 40 provisions are different. 40 provision is more severe symptoms than 39 provision in the stagnation. So 40 provision used the term "fazhi (發之)".

• The Journal of the Society of Korean Medicine Diagnostics
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• v.19 no.1
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• pp.55-63
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• 2015

Objectives In order to the review of the Yoon Gil-Young's theory on the "differentiation of syndromes", we studied on the his method and system of classification on the "differentiation of syndromes". Methods We reviewed on "The Clinical Formula Science Traditional Korean Medicine 東醫臨床方劑學", "A study on the Methodology of Traditional Korean Medicine 東醫學의 方法論硏究" "The theory of SaSang Constitution Medicine 四象體質醫學論". From a connected standpoint with the basic theory and clinical medicine, considered on the Yoon Gil-Young's theory of "differentiation of syndromes". Results Yoon Gil-Young's theory of differentiation of syndromes and treatment was widespread so much that he studied on the learning field of Traditional Korean Mediciine and ingenious as well. The main principles of differentiation of syndromes was summarized the three representative syndrome-complexes; BON-HER(original deficiency syndrome), BON-HAN(orginal cold excess syndrome), BON-YEOL(original heat excess syndrome). And also the three representative syndrome-complexes was previously carried out the details of differentiation of syndromes and assigned represent prescription one by one. Conclusions As the results, Yoon Gil-Young insisted the system of differentiation of syndromes closely connecting with Traditional Korean Medical physiology, pathology, diagnosis and prescriptions. And therefore he was a frontier of the field of Traditional Korean Medicine.

• Herbal Formula Science
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• v.14 no.1
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• pp.11-29
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• 2006

This report describes 71 studies related to the use of Radix Saposhnikoviae main blended prescription from Donguibogam. The following conclusion were reached through investigations on the prescriptions that use Radix Saposhnikoviae as a main ingredient. Prescriptions that Radix Saposhnikoviae was taken as a monarch drug are utilized for 20 therapeutic purposes, for example, eye disease, wind disease, head disease and Sang Han syndromes. In particular, 28.1% of prescriptions appear in the chapter of eye, and 25.3% of those appear in the chapter of head. Prescriptions that utilize Radix Saposhnikoviae as the main ingredient are used in the treatment of eye disease. paralysis and tetanus. Radix Saposhnikoviae is used in pathogenic factors such as wind. wind with cold. and used in pathology related to liver system. The dosage of Radix Saposhnikoviae in prescriptions is 7 li(about 0.26 gram) to 2.5 jeon(about 9.38 gram), however 1 jeon(about 3.75 gram) has been taken the most for clinical application. Bangpungtang is the most useful base prescription which use the Radix Saposhnikoviae as the main ingredient.

• The Korean Journal of Pain
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• v.11 no.2
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• pp.201-209
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• 1998

Background: Tricyclic antidepressants (TCA) have been used for various pain syndromes for their analgesic effects. They, however, often have anticholinergic side effects and therefore search for more selective drugs with fewer side effects is justified. Paroxetine, a selective serotonin reuptake inhibitor devoid of autonomic side effects, was evaluated for its role as an analgesic adjuvant in the management of neuropathic pain. Method: According to individual diagnostic group as diabetic neuropathy, postherpetic neuralgia, central pain syndrome and cancer related plexopathy, 10 patients per each group were equally accumulated. Patients have been stabilized in their analgesic regimen at least four weeks prior to enrollment into study. TCA, if taken, was discontinued for two weeks for wash out period. Baseline four point verbal pain intensity score was obtained and oral administration of paroxetine 20 mg was initiated. At two weeks follow-up visit, pain intensity scores, pain improvement scores judged by family, drug efficacy, tolerability and overall evaluation were assessed. The incidence of side effects were also obtained. Result: After two weeks of treatment, pain intensity scores decreased in 77.5% of patients and no patients experienced aggravation. These findings were objectively reflected in pain improvement scores judged by family members. But, the number of nonresponders was different among groups. In drug efficacy, tolerability and overall evaluation, the proportions of patients who scored as excellent or good were 75%, 80% and 80% respectively. Incidence of side effects was 27.5%, but the side effects spontaneously disappeared after discontinuation of medication. Conclusion: Paroxetine, a selective serotonin reuptake inhibitor, appears to be effective as adjuvant analgesic for the management of various neuropathic pain syndromes.

• Herbal Formula Science
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• v.16 no.1
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• pp.39-53
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• 2008

This report describes 68 studies related to the use of Rhizoma Anemarrhenae main blended prescription from Dongeuibogam. The following conclusion were reached through investigations on the prescriptions that use Rhizoma Anemarrhenae as a key ingredient. Prescriptions that Rhizoma Anemarrhenae was taken as a monarch drug are utilized for 21 therapeutic purposes, for example, cough, malaria, Sang Han syndromes and eye disease. In particular, 22.1% of prescriptions appear in the chapter of cough, and 13.2% of those appear in the chapter of malaria. Prescriptions that utilize Rhizoma Anemarrhenae as the main ingredient are used in the treatment of cough, asthma and malaria. Rhizoma Anemarrhenae is used in pathogenic factors such as fire, and used in pathology related to kidny system. The dosage of Rhizoma Anemarrhenae is 3bun(about 1.12 gram) to 3jeon(about 11.25 gram), however 1jeon(about 3.75 gram) has been taken the most for clinical application. Gamlihuan is the most useful base prescription which use the Rhizoma Anemarrhenae as the main ingredient.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1442-1446
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• 2006

This study was wrriten in order to to help understanding of Kyeolhyung(結洶). Kyeolhyung is a syndrome of epigastric pain and fullness due to accumulation of pathogen in the chest mostly caused by too early purgation of Taiyang(太陽) channel syndrome which leads to the exterior syndrome of heat from the exterior into the interior or combines with the original excessive fluid of the chest. The knotted chest can be divided into large, small, heat and substantice, cold and substantice, water and blood Kyeolhyung. Kyeolhyung is basically treated by purgation but practically it is treated by according to its own symptom and syndromes. And we were cured of the Kyeolhyung discriminating from Zanggyul(藏結) and Bijeung(비증).

• The Journal of Internal Korean Medicine
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• v.36 no.1
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• pp.13-21
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• 2015

Objectives : In Korea, Rhus verniciflua Stokes (RVS) has been used in traditional medicine for various diseases such as back pain, syndromes of the blood system in women, gastrointestinal disease, and cancer. However, the molecular mechanisms of its anti-cancer activity have not been clearly elucidated yet. Methods : This study investigated the possible mechanisms by which RVS extract (RVE) exerts its anti-proliferative action in cultured human breast carcinoma MCF-7 cells. Results : Treatment with RVE in MCF-7 cells resulted in inhibition of cell viability through G1 arrest of the cell cycle and induction of apoptosis in a time- and concentration-dependent manner, as determined by MTT assay and flow cytometry analysis. The induction of G1 arrest by RVE treatment was associated with the inhibition of cyclin D1, cyclin-dependent kinase (Cdk) 2, retinoblastoma protein (pRB), and mouse double minute 2 (MDM2) expression. Moreover, RVE treatment concentration dependently increased the levels of tumor suppressor p53, which was associated with the marked induction of Cdk inhibitors such as p21 (Waf1/Cip1) and p27 (Kip1). However, the inhibition of p53 function by the wild-type p53-specific inhibitor, pifithrin-α, abolished the above-mentioned effects of RVE, showing that p53 was responsible for the cytotoxicity of RVE Conclusions : These data indicate that a molecular pathway involving p53-dependent G1 cell cycle arrest plays a pivotal role in the cellular response to RVE, and demonstrate the potential applications of RVE as an anti-cancer drug for breast cancer treatment.

• Journal of The Korean Society of Clinical Toxicology
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• v.16 no.2
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• pp.102-107
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• 2018

Purpose: This study examined the association between smoking and delayed neuropsychological sequelae (DNS) in acute carbon monoxide (CO) poisoning. Methods: Patients admitted to the medical center emergency department from March 2016 to March 2017 because of CO poisoning were examined retrospectively. The patients were divided into two groups: DNS and Non-DNS group. Multiple factors were analyzed to explain DNS, which was assessed by motor disturbances, cognitive impairment, dysphagia, Parkinson-like syndromes, epilepsy, and emotional lability in CO poisoning. Results: A total of 120 patients were included. The factors related to DNS were smoking (pack-years) (p=0.002) and initial carbon monoxide-hemoglobin level (p=0.015). On the other hand, after multivariate logistic regression analysis, smoking (Odds ratio 1.07; 95% CI, 1.02-1.13; p=0.004) was the only factor associated with DNS. Conclusion: Smoking is a very reliable factor for predicting the occurrence of DNS. A history of smoking in patients who suffer from CO intoxication is important. If a patient smokes, treatment should be started actively and as soon as possible.

• The Korean Journal of Pain
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• v.33 no.2
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• pp.131-137
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• 2020

Background: Among various diseases that accompany pain, complex regional pain syndrome (CRPS) is one of the most frustrating for patients and physicians. Recently, many studies have shown functional and anatomical abnormalities in the brains of patients with CRPS. The calcium-related signaling pathway is important in various physiologic processes via calmodulin (CaM) and calcium-calmodulin kinase 2 (CaMK2). To investigate the cerebral mechanism of CRPS, we measured changes in CaM and CaMK2 expression in the cerebrum in CRPS animal models. Methods: The chronic post-ischemia pain model was employed for CRPS model generation. After generation of the animal models, the animals were categorized into three groups based on changes in the withdrawal threshold for the affected limb: CRPS-positive (P), CRPS-negative (N), and control (C) groups. Western blot analysis was performed to measure CaM and CaMK2 expression in the rat cerebrum. Results: Animals with a decreased withdrawal threshold (group P) showed a significant increment in cerebral CaM and CaMK2 expression (P = 0.013 and P = 0.021, respectively). However, groups N and C showed no difference in CaM and CaMK2 expression. Conclusions: The calcium-mediated cerebral process occurs after peripheral injury in CRPS, and there can be a relationship between the cerebrum and the pathogenesis of CRPS.

• Journal of Korean Neurosurgical Society
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• v.48 no.3
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• pp.244-250
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• 2010

Objective : Adequate management of increased intracranial pressure (ICP) is critical in patients with traumatic brain injury (TBI), and decompressive craniectomy is widely used to treat refractory increased ICP. The authors reviewed and analyzed complications following decompressive craniectomy for the management of TBI. Methods : A total of 89 consecutive patients who underwent decompressive craniectomy for TBI between February 2004 and February 2009 were reviewed retrospectively. Incidence rates of complications secondary to decompressive craniectomy were determined, and analyses were performed to identify clinical factors associated with the development of complications and the poor outcome. Results : Complications secondary to decompressive craniectomy occurred in 48 of the 89 (53.9%) patients. Furthermore, these complications occurred in a sequential fashion at specific times after surgical intervention; cerebral contusion expansion ($2.2{\pm}1.2$ days), newly appearing subdural or epidural hematoma contralateral to the craniectomy defect ($1.5{\pm}0.9$ days), epilepsy ($2.7{\pm}1.5$ days), cerebrospinal fluid leakage through the scalp incision ($7.0{\pm}4.2$ days), and external cerebral herniation ($5.5{\pm}3.3$ days). Subdural effusion ($10.8{\pm}5.2$ days) and postoperative infection ($9.8{\pm}3.1$ days) developed between one and four weeks postoperatively. Trephined and post-traumatic hydrocephalus syndromes developed after one month postoperatively (at $79.5{\pm}23.6$ and $49.2{\pm}14.1$ days, respectively). Conclusion : A poor GCS score ($\leq$ 8) and an age of $\geq$ 65 were found to be related to the occurrence of one of the above-mentioned complications. These results should help neurosurgeons anticipate these complications, to adopt management strategies that reduce the risks of complications, and to improve clinical outcomes.