• Journal of Digital Convergence
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• v.13 no.1
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• pp.135-149
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• 2015

The purpose of this study is, through journal review, to introduce and analyze the success factor and programs of CONNECT which have made key contributions in the construction of San diego Bio-cluster and thereby show directions business incubators in Korea should try to follow. CONNECT is a most popular bench-marking case over the world for bio-venture incubation. In this paper, core success factors and incubating programs of CONNECT are analyzed in detailed way for local govenments and incubating institutions to develop enterprise promotion policy. CONNECT is famous for its tailored services to meet the varying needs of entrepreneurs at all stages of their business life cycles and growth. CONNECT is a pioneer which provide mainly software services by using network while it provide hardware supports like space at minimun level. CONNECT has provided early stage corporations with diverse software services on which business incubators in Korea should have focus Since its inception, CONNECT has assisted more than 800 technology companies. Leadership of policy makers, network and software services have been key success factors of UCSD CONNECT.

• Journal of Microbiology and Biotechnology
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• v.29 no.5
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• pp.667-686
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• 2019

Streptomyces are attractive microbial cell factories that have industrial capability to produce a wide array of bioactive secondary metabolites. However, the genetic potential of the Streptomyces species has not been fully utilized because most of their secondary metabolite biosynthetic gene clusters (SM-BGCs) are silent under laboratory culture conditions. In an effort to activate SM-BGCs encoded in Streptomyces genomes, synthetic biology has emerged as a robust strategy to understand, design, and engineer the biosynthetic capability of Streptomyces secondary metabolites. In this regard, diverse synthetic biology tools have been developed for Streptomyces species with technical advances in DNA synthesis, sequencing, and editing. Here, we review recent progress in the development of synthetic biology tools for the production of novel secondary metabolites in Streptomyces, including genomic elements and genome engineering tools for Streptomyces, the heterologous gene expression strategy of designed biosynthetic gene clusters in the Streptomyces chassis strain, and future directions to expand diversity of novel secondary metabolites.