• Title/Summary/Keyword: Sam5

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Effects of Ganoderma lucidum Extract on Memory and Oxidative Stress of Senescence-Accelerated Mouse (노화촉진마우스의 기억력 및 산화 스트레스에 미치는 영지 (Ganoderma lucidum) 추출물의 영향)

  • 유제권;최선주;강종구;한상섭
    • Journal of Life Science
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    • v.9 no.5
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    • pp.548-555
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    • 1999
  • Long-term effects of Ganoderma lucidum (GL) on memory and oxidative stress of senescence-accelerated mice (SAM) were investigated. Senescence-resistant (R1) and prone (P8) strains of SAM were fed GL diets, premixed with low (20 mg/kg/day, T1) or high (200 mg/kg/day, T2) levels of GL powder for 9 months starting from young (3 months of age) or for 5 months starting from old (7 months of age). After the final feeding at 12 months of age, all animals were subjected to passive avoidance test for the evaluation of memory function. In addition, the changes in hepatic thiobarbituric acid-reactive substance (TBARS) and glutathione were analyzed. SAMP8 fed GL diets from old age (7 months) exhibited the improvement of memory, although GL rather inhibited the memory function of both SAMR1 and SAMP8 mice fed diets from young (3 months of age). Hepatic TBARS contents were decreased in SAMP8 fed high GL diet for 9 months and in SAMR1 fed low GL diet for 5 months. Hepatic glutathione content was also remarkably increased in SAMR1 following both feeding periods, and less extent in SAMP8 fed diet for 5 months of age. Taken together, it is proposed that GL extracts may play an anti-aging role through antioxidant action, and thereby may improve the senescence-related memory dysfunction.

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Measurement and Analysis of the Dynamics of Peptide-Antibody Interactions Using an Ellipsometric Biosensor Based on a Silicon Substrate (실리콘 기판을 사용한 바이오센서와 회전 타원분광계를 이용한 펩타이드-항체 접합의 동특성 측정과 분석)

  • Lee, Geun-Jae;Cho, Hyun Mo;Jo, Jae Heung
    • Korean Journal of Optics and Photonics
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    • v.28 no.1
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    • pp.9-15
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    • 2017
  • We precisely measured and analyzed the dynamics of peptide-antibody interactions, using an ellipsometric biosensor based on a silicon substrate. To reduce the signal error due to the imperfect flatness of the substrate for extremely low concentrations of peptide, we fabricated the biosensor with a silicon substrate coated with Dextran SAM, instead of a glass prism coated with a thin metallic thin film. At an injection speed of $100{\mu}l/min$ of buffer liquid, we detected the dynamics of antibody-Dextran SAM or peptide-antibody fixed on biosensor, respectively. We detected the dynamics of antibody-Dextran SAM interactions down to a low concentration of 5 ng per liter, and we precisely measured the dynamics of association and dissociation of peptide and antibody down to 100 nM of peptide. We obtained the rate constants for association and dissociation from fitting the data by using deduced dynamical equation. As a result, we obtained an equilibrium constant for dissociation of 97 nM of peptide-antibody complex, which belongs to Class I.

A study on the success factor of the Sam Bo Hwa Seong Co., Ltd. (중소기업 성공요인에 관한 연구)

  • 전영승
    • Journal of Korea Society of Industrial Information Systems
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    • v.5 no.3
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    • pp.56-64
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    • 2000
  • The purpose of this study is to analyze the success factors of the Sam Bo Hwa Seong Co., Ltd. this research is case study. In order to accomplish the objective, 1 had personal interview with the present Kim and reviewed business policy and company regulation. The main success factors of the Sam Bo Hwa Seong corporation are as following: first, a large experience of the top management, second, the artisan spirit and a mission sense of the CEO, third, a strong thrust of the present Kim, fourth, the partnership between labor and management, fifth, an exhaustive credit and a perfect quality control, sixth, research and development investment for the technical improvement. The result of this research will be a useful information to the management in small-medium firms and to the reserve management who wants establishment of the corporation.

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R-S Decoder Design for Single Error Correction and Erasure Generation (단일오류 정정 및 Erasure 발생을 위한 R-S 복호기 설계)

  • Kim, Yong Serk;Song, Dong Il;Kim, Young Woong;Lee, Kuen Young
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.23 no.5
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    • pp.719-725
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    • 1986
  • Reed-solomon(R-S) code is very effective to coerrect both random and burst errors over a noise communication channel. However, the required hardware is very complex if the B/M algorithm was employed. Moreover, when the error correction system consists of two R-S decoder and de-interleave, the I/O data bns lines becomes 9bits because of an erasure flag bit. Thus, it increases the complexity of hardware. This paper describes the R-S decoder which consisits of a error correction section that uses a direct decoding algorithm and erasure generation section and a erasure generation section which does not use the erasure flag bit. It can be shown that the proposed R-S dicoder is very effective in reducing the size of required hardware for error correction.

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Regulation of Sulfur Metabolism in Cephalosporium acremonium (Cephalosporium acremonium에서 황화합물 대사의 조절)

  • Lee, Kyoung;Park, Sang-Ho;Lee, Jung-Joon;Mheen, Tae-Ick
    • Microbiology and Biotechnology Letters
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    • v.15 no.5
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    • pp.361-367
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    • 1987
  • A DL-seleno-methionine resistant mutant, Cephalosporium acremonium MS-92 showed increased activities of sulfate and L-methionine uptake than the parent strain, and accumulated excess methionine and S-adenosylmethionine (SAM) intracellularly. And the sulfate uptake system was severely inhibited by L-cysteine. In crude enzyme extracts, the mutant MS-92 showed lower L-serine sulfhydrylase (identical with cystathionine $\beta$-synthase) activity than the parent. Also, cysteine desulfhydrylase activity, an index of intracellular L-cysteine concentration, of the mutant MS-92 was decreased by about 50% as com-pared with that of the parent. Thus, it was supposed that the mutant MS-92 should have n lower level of L-cysteine than the parent. In C. acremonium like A. nidulans, the enzymes related to the biosynthesis of methionine might be regulated by L-cysteine, but not by methionine or SAM.

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