• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.12 no.2
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• pp.63-75
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• 2013

Roundabouts have been operated in Europe, America and Australia since the 1970s, and many relevant researches continually was carried out. Though many studies regarding roundabout have been recently conducted in korea, most of them have focused on its operational safety and efficiency. Moreover, roundabout design guideline did not define a clear criteria related to pedestrian in roundabout, but seldom investigate the influences of pedestrian on crosswalk. In this study, we seek ways to operate the pedestrian crosswalk signal on roundabout maximizing their operational effects in exceptional case such as rush hour or intersection near the special facilities. We proved that roundabout signal operation is effective under certain circumstances in according to the number of pedestrian, and suggested the optimal signal timing plan for signalized roundabouts. For pursuing the above, we conducted the simulation test using the VISSIM model. The results show that the operational effectiveness of signalized roundabout was evaluated to be better than non-signalized roundabout in specific pedestrian volume condition. In addition, those results are confirmed using simulation analysis conducted on the real roundabout.

• Journal of Environmental Health Sciences
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• v.42 no.1
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• pp.10-18
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• 2016

Objectives: Microcystin (MC) produced during cyanobacterial blooms is a worldwide problem presenting a serious health threats to humans and ecosystems. During July through October of 2013, the Ilwol Reservoir experienced a high biomass of phytoplankton (maximum $211.7mg/m^3$ of Chlorophyll-a) containing the toxigenic cyanobacterium Oscillatoria sp. The aim of this study is to analyze MC concentration in the reservoir water, as well as in representative fish species (Carassius cuvieri, Carassius auratus, Channa argus). We also evaluated the human health risk of exposure to MCs accumulated in the fish. Methods: Concentrations of MCs in the water and fish samples were analyzed by liquid chromatography with a triple quadrupole tandem mass spectrometer (LC/MS/MS) and enzyme-linked immunosorbent assay (ELISA). Results: The total levels of four MC variants, including MC-LR, MC-RR, MC-YR and MC-LA were below the WHO drinking water guideline limit (1 ug MC-LR per liter) both for the dissolved and particulate fraction present in the water samples. The mean MC concentrations in the livers of all species were significantly higher than in the gills (p < 0.01) and muscles (p < 0.05). The values of estimated daily intake of MCs in muscles, the edible part of the fish, would be only $0.005-0.015{\mu}g/kg{\cdot}day$, much lower than WHO's provisional tolerable daily intake of $0.04{\mu}g/kg{\cdot}day$. Conclusion: This study suggests that, owing to the spatial distribution or temporal variation of MC, there is a need for careful monitoring of cyanotoxin in reservoir water and aquatic animals to protect public health.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5289-5296
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• 2015

Background: Despite the decreased incidence, gastric cancer is still a frequent cause of cancer related death. The 1st line 2 or 3 drugs regimen is still a debatable issue. HER2 targeted therapy has emerged as the standard of care, but it is unavailable in the Brazilian Public Health System. The end-point of this trial was overall survival (OS) in patients with metastatic gastric cancer treated in a public university hospital in Brazil. The secondary end-points were efficacy and safety of regimens with 2 (F+P) or 3 (EOX) drugs to develop an institutional guideline to facilitate optimal treatments. Materials and Methods: In this retrospective study, 1st line regimens were evaluated for OS and PFS stratified by age and ECOG using Cox regression. Results: 47 patients were treated over the last 3 years. In 1st line, 29 were treated with F+P (mean 59.3 years, 34.5% ECOG 2 and a mean of 5.69 cycles) and 16 with EOX (mean 47 years, 18.8% ECOG 2 and a mean of 5.44 cycles). The median OS was 13.8 months (95%CI 10.7-16.9). Response was evaluated in 40 cases and was 64.3% for EOX and 37.5% for F+P (p=0.25). The median PFS was 9.5 months for EOX and 5.6 months for F+P (HR 0.85, 95%CI 0.41-1.74). However, among patients with ECOG 2 mPFS was 3.70 vs 5.40 months, respectively (p=0.86). Regimens showed similar manageable adverse events. A total of 34 patients suffered progression and 14 received $2^{nd}$ line therapy. Diffuse histology (HR 1.89, 95%CI 1.22-2.88), achieving 2nd line (HR: 0.25, 95%CI 0.11-0.58) and treatment response (HR 0.23, 95%CI 0.12-0.47) were OS prognostic factors. Conclusions: Patients treated in our hospital had outcomes compatible with the literature. The regimen choice should be related to patient features. Second line treatment should be considered.

• Korean Journal of Community Nutrition
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• v.19 no.6
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• pp.550-557
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• 2014

Objectives: This study was conducted to examine the preferences and needs of typical Korean females adults for food and nutrition information provided by the mass media. Methods: A total of 343 females (77 in their 20s, 85 in their 30s, 88 in their 40s and 93 in their 50s) residing in the Seoul/Gyeonggido area was surveyed on general characteristics, main sources of food and nutrition information and needs for sources and contents of nutrition information. Results: The survey showed that typical Korean females obtained knowledge of food and nutrition mainly through the Internet (30.4%) and broadcasting (29.0%). Typical Korean females were interested in 'dietary management for weight control' (21.9%), 'the prevention and treatment of disease' (20.0%), 'food safety' (16.8%), 'proper dietary habits' (14.6%), 'cookery' (11.8%), 'functional foods' (9.6%), 'restaurant details' (3.5%) and 'life-cycle-specific dietary guideline' (1.6%). Needs for food and nutrition program forms on TV were 'educational programs' (34.3%), 'documentaries' (20.8), 'expert lecture-style' (13.0%), 'entertainment programs' (11.9%), 'expert conversation' (11.4%), 'news-style' (4.6%) and 'public campaign advertisements' (4.0%). On the Internet, 38.6% of the respondents preferred to get information provided by food and nutrition-related institutions (38.6%) while 26.1% preferred webtoons for nutritional information. The favored forms in mobile applications were 'monitoring their diets' (29.5%), 'data-based texts information' (21.4%), 'experts feedback' (20.6%), 'communities' (15.1%) and 'games' (13.1%). The rates of the preference to obtain information from experts such as nutritionists and dietitians and doctorsor dietitian turned reporters increased markedly with older ages. Conclusions: Since the mass media is a main source of food and nutrition information for the general public, the effectiveness and accuracy of the information provided should be enhanced by taking the needs of the public into account. The quality of information should be improved by involving more nutrition experts.

• The Korean Journal of Pesticide Science
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• v.16 no.4
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• pp.395-400
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• 2012

In order to survey the actual pesticide usage, this survey was carried out on the growers of 3 plant groups, fruit vegetables, fruits and rice field, from 2009 to 2011. 390 farmers were selected from main production areas to investigate their pesticide application during the growing seasons. Input amounts per area of domestic fruit vegetables was surveyed as 11.6 kg a.i./ha for red pepper of field culture, 2.0 kg a.i./ha for red pepper of greenhouse, 2.3 kg a.i./ha for strawberry, 2.2 kg a.i./ha for watermelon, 4.8 kg a.i./ha for cucumber, 1.5 kg a.i./ha for oriental melon and 2.1 kg a.i./ha for tomato, respectively. Input amounts per area on fruits and on rice field were surveyed as 11.7 kg a.i./ha for apple, 12.5 kg a.i./ha for pear, 7.7 kg a.i./ha for peach, 4.5 kg a.i./ha for grape, 40.0 kg a.i./ha for citrus 5.4 kg a.i./ha for persimmon, and 3.46 kg a.i./ha for rice, respectively. As a result of the actual pesticide usage survey, The safety guideline for pesticide use is generally kept well by all farmers of fruits vegetables, fruits and rice.

• Journal of radiological science and technology
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• v.33 no.2
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• pp.85-91
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• 2010

Digital radiography has been replacing rapidly the analog radiography for diagnosis of pneumoconiosis. The purpose of this study is to compare quality control of digital radiography (DR) and analog radiography (AR) for chest radiography in medical institution for pneumoconiosis (MIP) For the first time, we visited MIP to evaluate the chest radiography which is used for patients with pneumoconiosis, including equipment, technical parameters and reading environment. There were 33 institutions. DR and AR were installed in 24 and 9 institutions, respectively. Between DR and AR, we compared the radiological technique (RT), image quality (IQ) and reading environment (RE) to use the guideline published by Occupational Safety and Health Research Institute (OSHRI). The image quality was rated by two experienced chest radiologists for pneumoconiosis with certified from OSHRI. The chest radiography equipment was not significantly difference between AR and DR, but there were significantly difference in tube voltage and grid ratio used for chest radiography except to tube current, exposure time. Statistically, DR is significantly higher in RT(70.3 vs. 43.8, p = 0.009), RE(77.7 vs. 33.3, p = 0.004) than AR, but it's not significantly difference in IQ (65.6 vs. 52.8, p = 0.050). AR and DR in RT were passed 33.3%, 75.0% respectively (p = 0.044) and 44.4%, 79.2% (p = 0.090) in IQ and 44.4%, 91.7% (p = 0.009) in RE. In MIP, DR needs to replace AR in diagnosis of pneumoconiosis.

• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.3
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• pp.133-142
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• 2014

Recently, more focus is shift to imbalances in aggregate market supply and demand and an exhaustion of natural resources. In this situation, Electric arc furnace oxidizing slag (EAF Slag) has high application possibility as aggregate for concrete due to similar property with general aggregate. In this study, We've got the plan to assure the chemical stability of EAF Slag, and then experimentally tested the mechanical performance and durability for the fine aggregate used EAF Slag. On this test result, we suggest the application plan. At the result of this study, it shows that EAF slag would reduce the surface defect such as pop-out due to natural aging for the fixed hour and adjustment the grain size of EAF Slag. And mechanical performance and durability according to the replacement rate of concrete service, were revealed more than equal or equal compare to general aggregate. Hereafter, quality control must precede not to impede the beauty of concrete surface as assure the safety for aging and processing. And, to establish the environmental resource recycling system for by-products of steel, it should be made development of various application and guideline of quality control for the EAF slag aggregate. Moreover, it must be constantly studied all kind of engineering performance and durability for related to this study.

• Journal of the Korean Geotechnical Society
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• v.33 no.12
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• pp.81-92
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• 2017

According to the revision of the Housing Act in 2013, it has been possible to carry out an apartment remodeling project involving two to three floor vertical extension. The remodeling project with vertical extension requires foundation reinforcement because structural safety due to additional load and enhanced seismic criteria must be met. In this case, structural analysis is performed to analyze the load distributed to existing PC pile and reinforced additional pile. The vertical stiffness ($K_v$) of the pile is required for structural analysis, but the research on the 20~30 year old PC pile stiffness is very limited. In this paper, the stiffness of the PC pile in accordance with the change of diameter and length was analyzed by examining the results of 38 field pile load tests performed during the construction of the apartments in the 1990's. As a result of the analysis, the pile stiffness decreases with the increase of the length-diameter ratio (L/D). In addition, the results of on-site pile load test are compared with the coefficient 'a' for estimating pile stiffness proposed in Korea Highway Bridge Design Standard (2008) and the Pile Foundation Design Guideline of Korea Railroad Corporation (2012). It shows that 'a' obtained through the estimation of the literature is very similar to the field test results in the range of 10

• Journal of Radiation Protection and Research
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• v.38 no.1
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• pp.44-51
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• 2013

ICRP recommended that cosmic ray exposure to the pilot and cabin crew would be considered as an occupational exposure due to their relatively high exposure. Since 2012 with the Act No. 10908 (Natural radiation management), the guideline of cosmic ray exposure to the pilot was established in Korea. The applicability of the solid-state nuclear track detector for personal dose assessment of pilot and cabin crew was evaluated. Dose linearity and angle dependence of dosimeters to the neutron were evaluated by $^{252}Cf$ neutron emitting source. The track density has a good agreement with the dose ($r^2$=0.99) and highly dependent on the degree of an angular of the dosimeter to the neutron source. In addition, the dosimeters (SSNTD) were exposed to cosmic ray in an aircraft during its cruising for more than two months in collaboration with Airline Pilots Association of Korea. Although the correlation between the track density from aircraft cruising altitude and expected neutron dose is low, however RSNS dosimeter could be used for personal neutron dosimeter. For application of RSNS as a personal dosimeter for pilot and cabin crew, additional studies are required.

• Korean Journal of Clinical Pharmacy
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• v.18 no.1
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• pp.38-44
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• 2008

Rebamipide, ($\pm$)-2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl] propionic acid, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals and temporarily activating genes encoding cyclooxygenase-2. The purpose of the present study was to evaluate the bioequivalence of two rebamipide tablets, $Mucosta^{(R)}$ (Korea Otsuca Pharmaceuticals Co., Ltd.) and Mustar (Korean Drug Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of rebamipide from the two rebamipide formulations in vitro was tested using KP VIII Apparatus II method with pH 6.8 dissolution medium. Twenty six healthy male subjects, $23.46{\pm}2.63$ years in age and $66.62{\pm}8.97\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 100 mg as rebamipide was orally administered, blood samples were taken at predetermined time intervals and the concentrations of rebamipide in serum were determined using HPLC with fluorescence detector. The dissolution profiles of two formulations were similar in the tested dissolution medium. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated, and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Mucosta^{(R)}$ were -5.08, 3.52 and -9.71 % for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.84$\sim$log 1.07 and log 0.90$\sim$log 1.17 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Mustar tablet was bioequivalent to $Mucosta^{(R)}$ tablet.